X-Linked Inhibitor of Apoptosis Protein
"X-Linked Inhibitor of Apoptosis Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitor of apoptosis protein that is translated by a rare cap-independent mechanism. It blocks caspase-mediated cellular destruction by inhibiting CASPASE 3; CASPASE 7; and CASPASE 9.
| Descriptor ID |
D051636
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| MeSH Number(s) |
D08.811.464.938.750.210.750 D12.644.360.075.437.750 D12.776.476.075.437.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "X-Linked Inhibitor of Apoptosis Protein".
Below are MeSH descriptors whose meaning is more specific than "X-Linked Inhibitor of Apoptosis Protein".
This graph shows the total number of publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in this website by year, and whether "X-Linked Inhibitor of Apoptosis Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 10 | 10 |
| 2005 | 0 | 4 | 4 |
| 2006 | 1 | 4 | 5 |
| 2007 | 3 | 1 | 4 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 5 | 6 |
| 2010 | 1 | 4 | 5 |
| 2011 | 2 | 3 | 5 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in Profiles.
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Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact. Clin Epigenetics. 2019 05 07; 11(1):71.
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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 09 03; 37(17).
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XIAP Regulation by MNK Links MAPK and NF?B Signaling to Determine an Aggressive Breast Cancer Phenotype. Cancer Res. 2018 04 01; 78(7):1726-1738.
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Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nat Commun. 2017 08 28; 8(1):365.
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Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic. Oncotarget. 2016 Jun 28; 7(26):39458-39472.
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ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. Cell Death Dis. 2015 Aug 06; 6:e1836.
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Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res. 2015 Nov 01; 21(21):4831-44.
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Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482.
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XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells. Leuk Res. 2013 Aug; 37(8):974-9.
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XIAP antisense therapy with AEG 35156 in acute myeloid leukemia. Expert Opin Investig Drugs. 2013 May; 22(5):663-70.