X-Linked Inhibitor of Apoptosis Protein
"X-Linked Inhibitor of Apoptosis Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitor of apoptosis protein that is translated by a rare cap-independent mechanism. It blocks caspase-mediated cellular destruction by inhibiting CASPASE 3; CASPASE 7; and CASPASE 9.
| Descriptor ID |
D051636
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| MeSH Number(s) |
D08.811.464.938.750.210.750 D12.644.360.075.437.750 D12.776.476.075.437.750
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "X-Linked Inhibitor of Apoptosis Protein".
Below are MeSH descriptors whose meaning is more specific than "X-Linked Inhibitor of Apoptosis Protein".
This graph shows the total number of publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in this website by year, and whether "X-Linked Inhibitor of Apoptosis Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "X-Linked Inhibitor of Apoptosis Protein" by people in Profiles.
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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 09 03; 37(17).
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Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res. 2015 Nov 01; 21(21):4831-44.
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Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482.
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XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells. Leuk Res. 2013 Aug; 37(8):974-9.
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MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML. Leukemia. 2012 Mar; 26(3):443-50.
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The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in?Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors. Exp Hematol. 2011 Oct; 39(10):1007-1017.e1.
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Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study. Clin Lymphoma Myeloma Leuk. 2011 Oct; 11(5):433-8.
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Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells. Cancer Biol Ther. 2010 Nov 01; 10(9):885-92.
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Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest New Drugs. 2011 Oct; 29(5):818-26.
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Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. Stroke. 2009 Oct; 40(10):3362-8.