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JEFFREY NOEBELS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
Address6501 Fannin St
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R01NS124145     (CHIN, JEANNIE)Dec 15, 2021 - Nov 30, 2026
    NIH
    Mechanism and role of mTORC2 in seizure reduction
    Role: Co-Principal Investigator
    R01NS110767     (JIANG, XIAOLONG)Jun 15, 2020 - Mar 31, 2025
    NIH
    Development of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsy
    Role: Co-Principal Investigator
    R13NS116945     (NOEBELS, JEFFREY)May 1, 2020 - Apr 30, 2021
    NIH
    2020 Mechanisms of Epilepsy and Neuronal Synchronization GRC/GRS
    Role: Principal Investigator
    R13NS110308     (NOEBELS, JEFFREY)Sep 30, 2018 - Sep 29, 2019
    NIH
    Jasper's Basic Mechanisms of the Epilepsies Workshops
    Role: Principal Investigator
    R01CA223388     (DENEEN, BENJAMIN ;NOEBELS, JEFFREY)Dec 15, 2017 - Nov 30, 2023
    NIH
    MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMA
    Role: Principal Investigator
    R21NS088457     (NOEBELS, JEFFREY)May 1, 2015 - Apr 30, 2018
    NIH
    In vivo recruitment of neocortical neurons in stargazer absence seizures
    Role: Principal Investigator
    U01NS090405     (LHATOO, SAMDEN)Sep 30, 2014 - Jul 31, 2021
    NIH
    The Administrative Core of the Center of SUDEP Research
    Role: Co-Principal Investigator
    U01NS090340     (NOEBELS, JEFFREY)Sep 30, 2014 - Jul 31, 2020
    NIH
    SUDEP Research Alliance: Cardiac Gene and Circuit Mechanisms; Application 7 of 7
    Role: Principal Investigator
    P20NS076916     (NOEBELS, JEFFREY)Sep 26, 2011 - Aug 31, 2014
    NIH
    PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEP
    Role: Principal Investigator
    R25NS054767     (GARDEN, GWENN A)May 1, 2006 - Jan 31, 2017
    NIH
    Neurobiology of Disease Workshop -- Teaching Workshop
    Role: Co-Principal Investigator
    R25MH076764     (NOEBELS, JEFFREY)Sep 30, 2005 - Aug 31, 2008
    NIH
    Course Development in the Neurobiology of Disease
    Role: Principal Investigator
    R01NS049130     (NOEBELS, JEFFREY)Aug 15, 2004 - May 31, 2010
    NIH
    Parallel Sequence Profiling of Ion Channels in Epilepsy
    Role: Principal Investigator
    R01NS040233     (NOEBELS, JEFFREY)Sep 30, 1999 - Jun 30, 2004
    NIH
    NEUROPHYSIOLOGY DATABASE OF INBRED MUTANT STRAINS
    Role: Principal Investigator
    R01NS029709     (NOEBELS, JEFFREY)Sep 1, 1991 - May 31, 2026
    NIH
    Excitability and Plasticity of Developing Epileptic Brain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abreo TJ, Thompson EC, Madabushi A, Park KL, Soh H, Varghese N, Vanoye CG, Springer K, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi AR, Lutz CM, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis A, Cooper EC. Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy. Elife. 2025 Jan 06; 13. PMID: 39761077.
      Citations:    Fields:    
    2. Aiba I, Ning Y, Noebels JL, Aiba I, Ning Y, Noebels JL. Persistent Na+ current couples spreading depolarization to seizures in Scn8a gain of function mice. bioRxiv. 2024 Dec 23. PMID: 39416109; PMCID: PMC11482884.
      Citations:    
    3. Casillas-Espinosa PM, Wong JC, Grabon W, Gonzalez-Ramos A, Mantegazza M, Yilmaz NC, Patel M, Staley K, Sankar R, O'Brien TJ, Akman ?, Balagura G, Numis AL, Noebels JL, Baulac S, Auvin S, Henshall DC, Galanopoulou AS. WONOEP appraisal: Targeted therapy development for early onset epilepsies. Epilepsia. 2024 Nov 19. PMID: 39560633.
      Citations:    Fields:    
    4. Quatraccioni A, Cases-Cunillera S, Balagura G, Coleman M, Rossini L, Mills JD, Casillas-Espinosa PM, Mosh? SL, Sankar R, Baulac S, Noebels JL, Auvin S, O'Brien TJ, Henshall DC, Akman ?, Galanopoulou AS. WONOEP appraisal: Genetic insights into early onset epilepsies. Epilepsia. 2024 Nov; 65(11):3138-3154. PMID: 39302576.
      Citations:    Fields:    Translation:Humans
    5. Chen S, Abou-Khalil BW, Afawi Z, Ali QZ, Amadori E, Anderson A, Anderson J, Andrade DM, Annesi G, Arslan M, Auce P, Bahlo M, Baker MD, Balagura G, Balestrini S, Banks E, Barba C, Barboza K, Bartolomei F, Bass N, Baum LW, Baumgartner TH, Baykan B, Bebek N, Becker F, Bennett CA, Beydoun A, Bianchini C, Bisulli F, Blackwood D, Blatt I, Borggr?fe I, Bosselmann C, Braatz V, Brand H, Brockmann K, Buono RJ, Busch RM, Caglayan SH, Canafoglia L, Canavati C, Castellotti B, Cavalleri GL, Cerrato F, Chassoux F, Cherian C, Cherny SS, Cheung CL, Chou IJ, Chung SK, Churchhouse C, Ciullo V, Clark PO, Cole AJ, Cosico M, Cossette P, Cotsapas C, Cusick C, Daly MJ, Davis LK, Jonghe P, Delanty N, Dennig D, Depondt C, Derambure P, Devinsky O, Di Vito L, Dickerson F, Dlugos DJ, Doccini V, Doherty CP, El-Naggar H, Ellis CA, Epstein L, Evans M, Faucon A, Feng YA, Ferguson L, Ferraro TN, Da Silva IF, Ferri L, Feucht M, Fields MC, Fitzgerald M, Fonferko-Shadrach B, Fortunato F, Franceschetti S, French JA, Freri E, Fu JM, Gabriel S, Gagliardi M, Gambardella A, Gauthier L, Giangregorio T, Gili T, Glauser TA, Goldberg E, Goldman A, Goldstein DB, Granata T, Grant R, Greenberg DA, Guerrini R, Gundogdu-Eken A, Gupta N, Haas K, Hakonarson H, Haryanyan G, H?usler M, Hegde M, Heinzen EL, Helbig I, Hengsbach C, Heyne H, Hirose S, Hirsch E, Ho CJ, Hoeper O, Howrigan DP, Hucks D, Hung PC, Iacomino M, Inoue Y, Inuzuka LM, Ishii A, Jehi L, Johnson MR, Johnstone M, K?lvi?inen R, Kanaan M, Kara B, Kariuki SM, Kegele J, Kesim Y, Khoueiry-Zgheib N, Khoury J, King C, Klein KM, Kluger G, Knake S, Kok F, Korczyn AD, Korinthenberg R, Koupparis A, Kousiappa I, Krause R, Krenn M, Krestel H, Krey I, Kunz WS, Kurlemann G, Kuzniecky RI, Kwan P, La Vega-Talbott M, Labate A, Lacey A, Lal D, La??uthov? P, Lauxmann S, Lawthom C, Leech SL, Lehesjoki AE, Lemke JR, Lerche H, Lesca G, Leu C, Lewin N, Lewis-Smith D, Li GH, Liao C, Licchetta L, Lin CH, Lin KL, Linnankivi T, Lo W, Lowenstein DH, Lowther C, Lubbers L, Lui CHT, Macedo-Souza LI, Madeleyn R, Madia F, Magri S, Maillard L, Marcuse L, Marques P, Marson AG, Matthews AG, May P, Mayer T, McArdle W, McCarroll SM, McGoldrick P, McGraw CM, McIntosh A, McQuillan A, Meador KJ, Mei D, Michel V, Millichap JJ, Minardi R, Montomoli M, Mostacci B, Muccioli L, Muhle H, M?ller-Schl?ter K, Najm IM, Nasreddine W, Neaves S, Neubauer BA, Newton CRJC, Noebels JL, Northstone K, Novod S, O'Brien TJ, Owusu-Agyei S, ?zkara ?, Palotie A, Papacostas SS, Parrini E, Pato C, Pato M, Pendziwiat M, Pennell PB, Petrovski S, Pickrell WO, Pinsky R, Pinto D, Pippucci T, Piras F, Piras F, Poduri A, Pondrelli F, Posthuma D, Powell RHW, Privitera M, Rademacher A, Ragona F, Ramirez-Hamouz B, Rau S, Raynes HR, Rees MI, Regan BM, Reif A, Reinthaler E, Rheims S, Ring SM, Riva A, Rojas E, Rosenow F, Ryvlin P, Saarela A, Sadleir LG, Salman B, Salmon A, Salpietro V, Sammarra I, Scala M, Schachter S, Schaller A, Schankin CJ, Scheffer IE, Schneider N, Schubert-Bast S, Schulze-Bonhage A, Scudieri P, Sedl?ckov? L, Shain C, Sham PC, Shiedley BR, Siena SA, Sills GJ, Sisodiya SM, Smoller JW, Solomonson M, Spalletta G, Sparks KR, Sperling MR, Stamberger H, Steinhoff BJ, Stephani U, ?terbov? K, Stewart WC, Stipa C, Striano P, Strzelczyk A, Surges R, Suzuki T, Talarico M, Talkowski ME, Taneja RS, Tanteles GA, Timonen O, Timpson NJ, Tinuper P, Todaro M, Topaloglu P, Tsai MH, Tumiene B, Turkdogan D, Ugur-Iseri S, Utkus A, Vaidiswaran P, Valton L, van Baalen A, Vari MS, Vetro A, Vlckov? M, von Brauchitsch S, von Spiczak S, Wagner RG, Watts N, Weber YG, Weckhuysen S, Widdess-Walsh P, Wiebe S, Wolf SM, Wolff M, Wolking S, Wong I, von Wrede R, Wu D, Yamakawa K, Yapici Z, Yis U, Yolken R, Y?cesan E, Zagaglia S, Zahnert F, Zara F, Zimprich F, Zizovic M, Zsurka G, Neale BM, Berkovic SF. Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes. medRxiv. 2024 Sep 20. PMID: 36865150; PMCID: PMC9980234.
      Citations:    
    6. Soeung V, Puchalski RB, Noebels JL. The complex molecular epileptogenesis landscape of glioblastoma. Cell Rep Med. 2024 Aug 20; 5(8):101691. PMID: 39168100; PMCID: PMC11384957.
      Citations: 1     Fields:    Translation:HumansCells
    7. Chen HC, He P, McDonald M, Williamson MR, Varadharajan S, Lozzi B, Woo J, Choi DJ, Sardar D, Huang-Hobbs E, Sun H, Ippagunta SM, Jain A, Rao G, Merchant TE, Ellison DW, Noebels JL, Bertrand KC, Mack SC, Deneen B. Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024 Aug; 632(8026):903-910. PMID: 39085609.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Thompson EC, Madabushi A, Soh H, Varghese N, Vanoye CG, Springer K, Park KL, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi A, Lutz C, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis AV, Cooper EC, Abreo TJ, Abreo TJ, Thompson EC, Madabushi A, Soh H, Varghese N, Vanoye CG, Springer K, Park KL, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi AR, Lutz C, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis AV, Cooper EC, Zuberi AR, Lutz C. Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy. bioRxiv. 2024 Jun 26. PMID: 38260608; PMCID: PMC10802467.
      Citations:    
    9. Meyer J, Yu K, Luna-Figueroa E, Deneen B, Noebels J. Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales. Nat Commun. 2024 May 27; 15(1):4503. PMID: 38802334; PMCID: PMC11130179.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Jing J, Athukuri P, Wang S, Harmanci AO, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci AS, Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Athukuri P, Jing J, Wang S, Harmanci AO, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci AS. Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma. bioRxiv. 2024 May 10. PMID: 38496434; PMCID: PMC10942290.
      Citations:    
    11. Fox PM, Malepati S, Manaster L, Rossignol E, Noebels JL. Developing a pathway to clinical trials for CACNA1A-related epilepsies: A patient organization perspective. Ther Adv Rare Dis. 2024 Jan-Dec; 5:26330040241245725. PMID: 38681799; PMCID: PMC11047245.
      Citations: 3     
    12. Villacres JE, Riveira N, Kim S, Colgin LL, Noebels JL, Lopez AY. Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity. Transl Psychiatry. 2023 Dec 20; 13(1):403. PMID: 38123552; PMCID: PMC10733341.
      Citations:    Fields:    Translation:HumansAnimals
    13. Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ, Imanbeyev K, Doladilhe M, Zhou H, Jafar-Nejad P, Burlingame A, Noebels J, Baulac S, Costa-Mattioli M. Targeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun. 2023 11 14; 14(1):7364. PMID: 37963879; PMCID: PMC10645975.
      Citations: 3     Fields:    Translation:HumansAnimals
    14. Aiba I, Ning Y, Noebels JL. A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice. JCI Insight. 2023 08 08; 8(15). PMID: 37551713; PMCID: PMC10445687.
      Citations: 1     Fields:    Translation:Animals
    15. Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul; 619(7971):844-850. PMID: 37380778; PMCID: PMC10840127.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    16. Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson M, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma infiltration via Sema4f. bioRxiv. 2023 Mar 16. PMID: 36993539; PMCID: PMC10055154.
      Citations:    
    17. Hussain T, Sanchez K, Crayton J, Saha D, Jeter C, Lu Y, Abba M, Seo R, Noebels JL, Fonken L, Aldaz CM. WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12. Prog Neurobiol. 2023 04; 223:102425. PMID: 36828035; PMCID: PMC10835625.
      Citations: 1     Fields:    Translation:HumansAnimals
    18. Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen B. Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron. 2023 03 01; 111(5):682-695.e9. PMID: 36787748; PMCID: PMC9991983.
      Citations: 4     Fields:    Translation:HumansAnimals
    19. Goethe EA, Deneen B, Noebels J, Rao G. The Role of Hyperexcitability in Gliomagenesis. Int J Mol Sci. 2023 Jan 01; 24(1). PMID: 36614191; PMCID: PMC9820922.
      Citations:    Fields:    
    20. Aloi MS, Thompson SJ, Quartapella N, Noebels JL. Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice. Cell Rep. 2022 11 22; 41(8):111696. PMID: 36417872; PMCID: PMC9753929.
      Citations: 2     Fields:    Translation:Animals
    21. Ning Y, Noebels JL, Aiba I. Emx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions. eNeuro. 2022 Sep-Oct; 9(5). PMID: 36192157; PMCID: PMC9581573.
      Citations: 1     Fields:    Translation:Animals
    22. Liang JH, Alevy J, Akhanov V, Seo R, Massey CA, Jiang D, Zhou J, Sillitoe RV, Noebels JL, Samuel MA. Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Dis Model Mech. 2022 09 01; 15(9). PMID: 35972048; PMCID: PMC9509889.
      Citations:    
    23. Aiba I, Noebels JL. Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization. Brain. 2021 10 22; 144(9):2863-2878. PMID: 33768249; PMCID: PMC8536937.
      Citations: 3     Fields:    Translation:Animals
    24. Massey CA, Thompson SJ, Ostrom RW, Drabek J, Sveinsson OA, Haas EA, Mena OJ, Goldman AM, Noebels JL, Tomson T. X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy. Brain Commun. 2021; 3(3):fcab149. PMID: 34396109; PMCID: PMC8361391.
      Citations: 1     
    25. Buchanan GF, Gluckman BJ, Kalume FK, Lhatoo S, Maganti RK, Noebels JL, Simeone KA, Quigg MS, Pavlova MK. Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP. Epilepsy Curr. 2021 Mar 31; 15357597211004556. PMID: 33787378; PMCID: PMC8609595.
      Citations:    
    26. Loring KE, Mattiske T, Lee K, Zysk A, Jackson MR, Noebels JL, Shoubridge C. Early 17?-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX). Neurobiol Dis. 2021 06; 153:105329. PMID: 33711494.
      Citations: 1     Fields:    Translation:HumansAnimals
    27. Lam AD, Noebels J. Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease. Epilepsy Curr. 2020 Nov-Dec; 20(6):369-374. PMID: 33081517; PMCID: PMC7818196.
      Citations: 3     
    28. Liu CH, Seo R, Ho TS, Stankewich M, Mohler PJ, Hund TJ, Noebels JL, Rasband MN. ? spectrin-dependent and domain specific mechanisms for Na+ channel clustering. Elife. 2020 05 19; 9. PMID: 32425157; PMCID: PMC7237202.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. 2020 05 01; 130(5):2286-2300. PMID: 32250339; PMCID: PMC7190940.
      Citations: 18     Fields:    Translation:AnimalsCells
    30. Siehr MS, Massey CA, Noebels JL. Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome. Dis Model Mech. 2020 03 30; 13(3). PMID: 32033960; PMCID: PMC7132796.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    31. Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171. PMID: 31996845; PMCID: PMC7577741.
      Citations: 38     Fields:    Translation:Animals
    32. Miao QL, Herlitze S, Mark MD, Noebels JL. Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms. Brain. 2020 01 01; 143(1):161-174. PMID: 31800012; PMCID: PMC6935748.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Noebels JL. Predicting the impact of sodium channel mutations in human brain disease. Epilepsia. 2019 12; 60 Suppl 3:S8-S16. PMID: 31904123; PMCID: PMC6953257.
      Citations: 4     Fields:    Translation:HumansCells
    34. Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M. Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nat Med. 2019 11; 25(11):1684-1690. PMID: 31636454; PMCID: PMC7082835.
      Citations: 28     Fields:    Translation:HumansAnimals
    35. Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow K. 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia. 2019 06; 60(6):1045-1053. PMID: 31087652.
      Citations: 1     Fields:    Translation:Humans
    36. Noebels JL. Brainstem spreading depolarization: rapid descent into the shadow of SUDEP. Brain. 2019 02 01; 142(2):231-233. PMID: 30698758; PMCID: PMC6351772.
      Citations: 4     Fields:    Translation:Animals
    37. Aiba I, Noebels JL. Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability. J Neurophysiol. 2019 04 01; 121(4):1266-1278. PMID: 30699052; PMCID: PMC6485744.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018; 1:96. PMID: 30175250; PMCID: PMC6115194.
      Citations: 33     
    39. Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL. Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Ann Clin Transl Neurol. 2018 Aug; 5(8):982-987. PMID: 30128323; PMCID: PMC6093838.
      Citations: 1     Fields:    
    40. Meyer J, Maheshwari A, Noebels J, Smirnakis S. Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938. PMID: 29769525; PMCID: PMC5955878.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    41. Moyer JT, Gnatkovsky V, Ono T, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS, Ot?hal J. Standards for data acquisition and software-based analysis of in?vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67. PMID: 29105070; PMCID: PMC5683416.
      Citations: 10     Fields:    Translation:Animals
    42. Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Rasband MN, Leterrier C. aII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017 11 22; 37(47):11311-11322. PMID: 29038240; PMCID: PMC5700417.
      Citations: 34     Fields:    Translation:AnimalsCells
    43. Maheshwari A, Akbar A, Wang M, Marks RL, Yu K, Park S, Foster BL, Noebels JL. Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models. J Physiol. 2017 12 01; 595(23):7249-7260. PMID: 28901011; PMCID: PMC5709336.
      Citations: 8     Fields:    Translation:Animals
    44. Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease. Nat Med. 2017 Jun; 23(6):678-680. PMID: 28459436; PMCID: PMC5461182.
      Citations: 118     Fields:    Translation:Humans
    45. Noebels J. Precision physiology and rescue of brain ion channel disorders. J Gen Physiol. 2017 May 01; 149(5):533-546. PMID: 28428202; PMCID: PMC5412535.
      Citations: 7     Fields:    Translation:HumansAnimals
    46. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219; PMCID: PMC5824716.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    47. Tang M, Gao G, Rueda CB, Yu H, Thibodeaux DN, Awano T, Engelstad KM, Sanchez-Quintero MJ, Yang H, Li F, Li H, Su Q, Shetler KE, Jones L, Seo R, McConathy J, Hillman EM, Noebels JL, De Vivo DC, Monani UR. Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein. Nat Commun. 2017 01 20; 8:14152. PMID: 28106060; PMCID: PMC5263887.
      Citations: 38     Fields:    Translation:HumansAnimals
    48. Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper EC. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry. 2017 10; 22(10):1464-1472. PMID: 27956739; PMCID: PMC5798616.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    49. Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016; 11(11):e0167264. PMID: 27870904; PMCID: PMC5117773.
      Citations: 2     Fields:    
    50. Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016; 11(9):e0162883. PMID: 27622563; PMCID: PMC5021343.
      Citations: 13     Fields:    Translation:HumansCells
    51. Aiba I, Wehrens XH, Noebels JL. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903. PMID: 27482086; PMCID: PMC4995941.
      Citations: 26     Fields:    Translation:AnimalsCells
    52. Holmes GL, Noebels JL. The Epilepsy Spectrum: Targeting Future Research Challenges. Cold Spring Harb Perspect Med. 2016 07 01; 6(7). PMID: 27371672; PMCID: PMC4930917.
      Citations: 12     Fields:    Translation:Humans
    53. Noebels J. Hippocampal abnormalities and sudden childhood death. Forensic Sci Med Pathol. 2016 06; 12(2):198-9. PMID: 27094436; PMCID: PMC5535270.
      Citations: 7     Fields:    Translation:Humans
    54. Szucs A, Noebels JL, Kamondi A, Horv?th A, Barcs G. Epileptic Seizures in Alzheimer Disease: A Review. Alzheimer Dis Assoc Disord. 2016 Apr-Jun; 30(2):186-92. PMID: 26756385.
      Citations: 30     Fields:    Translation:HumansAnimals
    55. Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL. Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy. J Neurosci. 2016 Jan 13; 36(2):405-18. PMID: 26758833; PMCID: PMC4710767.
      Citations: 25     Fields:    Translation:AnimalsCells
    56. Maheshwari A, Marks RL, Yu KM, Noebels JL. Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy. Epilepsia. 2016 Jan; 57(1):79-88. PMID: 26663261; PMCID: PMC5551895.
      Citations: 13     Fields:    Translation:Animals
    57. Noebels JL. Single-Gene Determinants of Epilepsy Comorbidity. Cold Spring Harb Perspect Med. 2015 Nov 02; 5(11). PMID: 26525453; PMCID: PMC4632859.
      Citations: 10     Fields:    Translation:Humans
    58. Siehr MS, Noebels JL. Early rescue of interneuron disease trajectory in developmental epilepsies. Curr Opin Neurobiol. 2016 Feb; 36:82-8. PMID: 26517286; PMCID: PMC4738159.
      Citations:    Fields:    Translation:HumansAnimalsCells
    59. Lhatoo S, Noebels J, Whittemore V, NINDS Center for SUDEP Research. Sudden unexpected death in epilepsy: Identifying risk and preventing mortality. Epilepsia. 2015 Nov; 56(11):1700-6. PMID: 26494436; PMCID: PMC4852129.
      Citations: 21     Fields:    Translation:Humans
    60. Kole MJ, Qian J, Waase MP, Klassen TL, Chen TT, Augustine GJ, Noebels JL. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12; 35(32):11433-44. PMID: 26269648; PMCID: PMC4532768.
      Citations: 9     Fields:    Translation:AnimalsCells
    61. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324; PMCID: PMC5109931.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    62. Aiba I, Noebels JL. Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med. 2015 Apr 08; 7(282):282ra46. PMID: 25855492; PMCID: PMC4852131.
      Citations: 111     Fields:    Translation:Animals
    63. Noebels J. Pathway-driven discovery of epilepsy genes. Nat Neurosci. 2015 Mar; 18(3):344-50. PMID: 25710836; PMCID: PMC4852130.
      Citations: 64     Fields:    Translation:HumansAnimals
    64. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211; PMCID: PMC4877174.
      Citations: 48     Fields:    Translation:AnimalsCells
    65. Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering. Pflugers Arch. 2015 Apr; 467(4):737-52. PMID: 24947601.
      Citations: 3     Fields:    Translation:AnimalsCells
    66. Ozkan ED, Creson TK, Rojas C, Seese RR, Babyan AH, Shi Y, Xu X, Miller CA, Lynch G, Rumbaugh G, Kram?r EA, Lucero R, Noebels JL. Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron. 2014 Jun 18; 82(6):1317-33. PMID: 24945774; PMCID: PMC4104574.
      Citations: 42     Fields:    Translation:AnimalsCells
    67. Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J. Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy. Neurobiol Aging. 2014 Sep; 35(9):2091-5. PMID: 24767949; PMCID: PMC4053509.
      Citations: 27     Fields:    Translation:Animals
    68. Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40. PMID: 24623762; PMCID: PMC3951689.
      Citations: 78     Fields:    Translation:HumansAnimals
    69. Olivetti PR, Maheshwari A, Noebels JL. Neonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome. Sci Transl Med. 2014 Jan 22; 6(220):220ra12. PMID: 24452264; PMCID: PMC4034383.
      Citations: 23     Fields:    Translation:AnimalsCells
    70. Guerrini R, Noebels J. How can advances in epilepsy genetics lead to better treatments and cures? Adv Exp Med Biol. 2014; 813:309-17. PMID: 25012387.
      Citations: 8     Fields:    Translation:Humans
    71. Maheshwari A, Noebels JL. Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits. Prog Brain Res. 2014; 213:223-52. PMID: 25194492.
      Citations: 35     Fields:    Translation:HumansAnimals
    72. Klassen TL, Bomben VC, Patel A, Drabek J, Chen TT, Gu W, Zhang F, Chapman K, Lupski JR, Noebels JL, Goldman AM. High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile. Epilepsia. 2014 Feb; 55(2):e6-12. PMID: 24372310; PMCID: PMC4195652.
      Citations: 39     Fields:    Translation:HumansCells
    73. Maheshwari A, Nahm WK, Noebels JL. Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice. Front Cell Neurosci. 2013; 7:156. PMID: 24065886; PMCID: PMC3776135.
      Citations: 26     
    74. Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Noebels JL, Privitera MD, Rogawski MA, Mosh? SL. Issues related to development of new antiseizure treatments. Epilepsia. 2013 Aug; 54 Suppl 4:24-34. PMID: 23909851; PMCID: PMC3947404.
      Citations: 32     Fields:    Translation:HumansAnimals
    75. Cole AJ, Eskandar E, Mela T, Noebels JL, Gonzalez RG, McGuone D. Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness. N Engl J Med. 2013 Jun 13; 368(24):2304-12. PMID: 23758236.
      Citations: 4     Fields:    Translation:Humans
    76. Maejima T, Wollenweber P, Teusner LU, Noebels JL, Herlitze S, Mark MD. Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice. J Neurosci. 2013 Mar 20; 33(12):5162-74. PMID: 23516282; PMCID: PMC3641643.
      Citations: 31     Fields:    Translation:AnimalsCells
    77. Klassen TL, Drabek J, Sveinsson O, Noebels JL, Goldman AM, Tomson T, von D?beln U. Visual automated fluorescence electrophoresis provides simultaneous quality, quantity, and molecular weight spectra for genomic DNA from archived neonatal blood spots. J Mol Diagn. 2013 May; 15(3):283-90. PMID: 23518217; PMCID: PMC3644733.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    78. Chen TT, Klassen TL, Goldman AM, Marini C, Guerrini R, Noebels JL. Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy. Neurology. 2013 Mar 19; 80(12):1078-85. PMID: 23408874; PMCID: PMC3662306.
      Citations: 24     Fields:    Translation:HumansAnimals
    79. Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013 Jan 23; 33(4):1651-9. PMID: 23345237; PMCID: PMC3711605.
      Citations: 111     Fields:    Translation:Animals
    80. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RB. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013 Jan 22; 2:e00178. PMID: 23359859; PMCID: PMC3552424.
      Citations: 53     Fields:    Translation:AnimalsCells
    81. Shah M, Beck H, Noebels J, Johnston D, Vincent A, Lerche H. Ion channels in genetic and acquired forms of epilepsy. J Physiol. 2013 Feb 15; 591(4):753-64. PMID: 23090947; PMCID: PMC3591694.
      Citations: 52     Fields:    Translation:HumansAnimals
    82. Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB. Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron. 2012 Sep 20; 75(6):1067-80. PMID: 22998874; PMCID: PMC3517991.
      Citations: 100     Fields:    Translation:AnimalsCells
    83. Klassen TL, Drabek J, Noebels JL, Goldman AM, von R?den EL. Comparative analytical utility of DNA derived from alternative human specimens for molecular autopsy and diagnostics. J Mol Diagn. 2012 Sep; 14(5):451-7. PMID: 22796560; PMCID: PMC5803546.
      Citations: 4     Fields:    Translation:Humans
    84. Glasscock E, Qian J, Kole MJ, Noebels JL. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012 Aug 15; 590(16):3913-26. PMID: 22641786; PMCID: PMC3476640.
      Citations: 20     Fields:    Translation:Animals
    85. de Curtis M, Nehlig A, Noebels J, Sankar R, Vezzani A. WONOEP XI: Workshop summary by the Scientific Organizing Committee. Epilepsia. 2012 Jul; 53(7):1275-6. PMID: 22578186.
      Citations:    Fields:    Translation:HumansAnimals
    86. Olivetti PR, Noebels JL. Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms. Curr Opin Neurobiol. 2012 Oct; 22(5):859-65. PMID: 22565167; PMCID: PMC3437236.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    87. York B, Reineke EL, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW, Sagen JV. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012 May 02; 15(5):752-63. PMID: 22560224; PMCID: PMC3349072.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    88. Galanopoulou AS, Buckmaster PS, Staley KJ, Perucca E, Engel J, Noebels JL, Stables J, White HS, O'Brien TJ, Simonato M, American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Work, Mosh? SL, L?scher W, Pitk?nen A. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82. PMID: 22292566; PMCID: PMC3551973.
      Citations: 78     Fields:    Translation:HumansAnimals
    89. Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Noebels JL, Costa-Mattioli M, Krnjevic K. Suppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition. Cell. 2011 Dec 09; 147(6):1384-96. PMID: 22153080; PMCID: PMC3569515.
      Citations: 99     Fields:    Translation:AnimalsCells
    90. McGuire AL, Oliver JM, Slashinski MJ, Graves JL, Wang T, Kelly PA, Fisher W, Lau CC, Goss J, Okcu M, Treadwell-Deering D, Goldman AM, Noebels JL, Hilsenbeck SG. To share or not to share: a randomized trial of consent for data sharing in genome research. Genet Med. 2011 Nov; 13(11):948-55. PMID: 21785360; PMCID: PMC3203320.
      Citations: 48     Fields:    Translation:Humans
    91. Ward CS, Arvide EM, Huang TW, Yoo J, Noebels JL, Neul JL. MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan. J Neurosci. 2011 Jul 13; 31(28):10359-70. PMID: 21753013; PMCID: PMC3175623.
      Citations: 50     Fields:    Translation:AnimalsCells
    92. Klassen T, Davis C, Goldman A, Burgess D, Chen T, Wheeler D, McPherson J, Bourquin T, Lewis L, Villasana D, Morgan M, Muzny D, Gibbs R, Noebels J. Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell. 2011 Jun 24; 145(7):1036-48. PMID: 21703448; PMCID: PMC3131217.
      Citations: 161     Fields:    Translation:HumansCells
    93. Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Mol Neurodegener. 2011 Jun 10; 6:42. PMID: 21663635; PMCID: PMC3141554.
      Citations: 14     Fields:    
    94. Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR. Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy. Neurology. 2011 May 31; 76(22):1932-8. PMID: 21543734; PMCID: PMC3115809.
      Citations: 20     Fields:    Translation:Humans
    95. Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci. 2011 Mar 16; 31(11):4311-26. PMID: 21411672; PMCID: PMC3065835.
      Citations: 52     Fields:    Translation:AnimalsCells
    96. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. Amyloid-?/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):700-11. PMID: 21228179; PMCID: PMC3325794.
      Citations: 329     Fields:    Translation:AnimalsCells
    97. Qian J, Xu K, Yoo J, Chen TT, Andrews G, Noebels JL. Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. J Neurosci. 2011 Jan 05; 31(1):97-104. PMID: 21209194; PMCID: PMC3078714.
      Citations: 32     Fields:    Translation:AnimalsCells
    98. Noebels J. A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia. 2011 Jan; 52 Suppl 1:39-46. PMID: 21214538; PMCID: PMC3058398.
      Citations: 108     Fields:    Translation:HumansAnimals
    99. Noebels JL, Avoli M, Rogawski M, Olsen R, Delgado-Escueta AV. "Jasper's Basic Mechanisms of the Epilepsies" Workshop. Epilepsia. 2010 Dec; 51 Suppl 5:1-5. PMID: 21208201; PMCID: PMC4651849.
      Citations: 9     Fields:    Translation:HumansAnimals
    100. Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9. PMID: 21068835; PMCID: PMC3057962.
      Citations: 585     Fields:    Translation:AnimalsCells
    101. Peebles CL, Yoo J, Thwin MT, Palop JJ, Noebels JL, Finkbeiner S. Arc regulates spine morphology and maintains network stability in vivo. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18173-8. PMID: 20921410; PMCID: PMC2964216.
      Citations: 113     Fields:    Translation:AnimalsCells
    102. Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet AL. Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One. 2010 Aug 20; 5(8):e12278. PMID: 20808828; PMCID: PMC2924885.
      Citations: 75     Fields:    Translation:HumansAnimals
    103. Zhang X, Bertaso F, Yoo JW, Clancy SM, Lee V, Cienfuegos C, Wilmot C, Avis J, Hunyh T, Daguia C, Schmedt C, Noebels J, Jegla T, Baumg?rtel K. Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep; 13(9):1056-8. PMID: 20676103; PMCID: PMC2928878.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    104. Glasscock E, Yoo JW, Chen TT, Klassen TL, Noebels JL. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010 Apr 14; 30(15):5167-75. PMID: 20392939; PMCID: PMC2874941.
      Citations: 88     Fields:    Translation:Animals
    105. Ottman R, Hirose S, Jain S, Lerche H, Lopes-Cendes I, Noebels JL, Zara F, Scheffer IE, Serratosa J. Genetic testing in the epilepsies--report of the ILAE Genetics Commission. Epilepsia. 2010 Apr; 51(4):655-70. PMID: 20100225; PMCID: PMC2855784.
      Citations: 55     Fields:    Translation:Humans
    106. Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 2009 Oct 14; 1(2):2ra6. PMID: 20368164; PMCID: PMC2951754.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    107. Price MG, Yoo JW, Burgess DL, Deng F, Hrachovy RA, Frost JD, Noebels JL. A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci. 2009 Jul 08; 29(27):8752-63. PMID: 19587282; PMCID: PMC2782569.
      Citations: 73     Fields:    Translation:AnimalsCells
    108. Ernst WL, Noebels JL. Expanded alternative splice isoform profiling of the mouse Cav3.1/alpha1G T-type calcium channel. BMC Mol Biol. 2009 May 29; 10:53. PMID: 19480703; PMCID: PMC2696442.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    109. Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar; 14(3):438-45. PMID: 19341977; PMCID: PMC2822433.
      Citations: 41     Fields:    Translation:Humans
    110. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL. Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci. 2009 Feb 11; 29(6):1615-25. PMID: 19211869; PMCID: PMC2660673.
      Citations: 58     Fields:    Translation:Animals
    111. Ernst SJ, Aguilar-Bryan L, Noebels JL. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology. 2009 Mar; 150(3):1132-9. PMID: 18988673; PMCID: PMC2654754.
      Citations: 15     Fields:    Translation:AnimalsCells
    112. Shuba YM, Perez-Reyes E, Lory P, Noebels J. T-type calcium channels: from discovery to channelopathies, 25 years of research. Channels (Austin). 2008 Jul-Aug; 2(4):299-302. PMID: 18769138.
      Citations: 1     Fields:    Translation:HumansAnimals
    113. Singh NA, Otto JF, Dahle EJ, Pappas C, Leslie JD, Vilaythong A, Noebels JL, White HS, Wilcox KS, Leppert MF. Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15; 586(14):3405-23. PMID: 18483067; PMCID: PMC2538806.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    114. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75. PMID: 18215623; PMCID: PMC2293283.
      Citations: 169     Fields:    Translation:AnimalsCells
    115. Noebels JL. 2006 Merritt Putnam Symposium: mapping epileptic circuitry. Epilepsia. 2008; 49 Suppl 3:1-2. PMID: 18304250.
      Citations:    Fields:    Translation:Humans
    116. Glasscock E, Qian J, Yoo JW, Noebels JL. Masking epilepsy by combining two epilepsy genes. Nat Neurosci. 2007 Dec; 10(12):1554-8. PMID: 17982453.
      Citations: 64     Fields:    Translation:Animals
    117. Noebels JL, Sidman RL. Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse. J Neurogenet. 2007 Oct-Dec; 21(4):253-6. PMID: 18161587.
      Citations:    Fields:    
    118. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711. PMID: 17785178; PMCID: PMC8055171.
      Citations: 669     Fields:    Translation:HumansAnimalsCells
    119. Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007 Nov; 43(5):636-47. PMID: 17884088; PMCID: PMC2099572.
      Citations: 72     Fields:    Translation:AnimalsCells
    120. Sisodiya S, Cross JH, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C, Nabbout R, Nashef L, Noebels JL, Ottman R, Pirmohamed M, Scheffer I, Shorvon S, Sills G, Wood N, Zuberi S, Bl?mcke I, Pitk?nen A. Genetics of epilepsy: epilepsy research foundation workshop report. Epileptic Disord. 2007 Jun; 9(2):194-236. PMID: 17525034.
      Citations: 4     Fields:    Translation:Humans
    121. Bi W, Yan J, Shi X, Yuva-Paylor LA, Antalffy BA, Goldman A, Yoo JW, Noebels JL, Armstrong DL, Paylor R, Lupski JR. Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes. Hum Mol Genet. 2007 Aug 01; 16(15):1802-13. PMID: 17517686.
      Citations: 38     Fields:    Translation:Animals
    122. Noebels JL. The Judith Hoyer Lecture: genes, pixels, patterns, and prevention. Epilepsy Behav. 2006 Nov; 9(3):379-85. PMID: 17029973; PMCID: PMC1866169.
      Citations: 2     Fields:    Translation:Humans
    123. Goldman A, Noebels J. Invited comments on the Shostak and Ottman review. Epilepsia. 2006 Oct; 47(10):1750-1; author reply 1755-6. PMID: 17054704.
      Citations:    Fields:    Translation:Humans
    124. Qian J, Noebels JL. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. J Neurosci. 2006 May 31; 26(22):6089-95. PMID: 16738253; PMCID: PMC6675221.
      Citations: 32     Fields:    Translation:AnimalsCells
    125. Wang D, Pascual JM, Yang H, Engelstad K, Mao X, Cheng J, Yoo J, Noebels JL, De Vivo DC. A mouse model for Glut-1 haploinsufficiency. Hum Mol Genet. 2006 Apr 01; 15(7):1169-79. PMID: 16497725.
      Citations: 85     Fields:    Translation:HumansAnimals
    126. Goldman AM, Potocki L, Walz K, Lynch JK, Glaze DG, Lupski JR, Noebels JL. Epilepsy and chromosomal rearrangements in Smith-Magenis Syndrome [del(17)(p11.2p11.2)]. J Child Neurol. 2006 Feb; 21(2):93-8. PMID: 16566870.
      Citations: 13     Fields:    Translation:HumansCells
    127. Brenner R, Chen QH, Vilaythong A, Toney GM, Noebels JL, Aldrich RW. BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005 Dec; 8(12):1752-9. PMID: 16261134.
      Citations: 201     Fields:    Translation:AnimalsCells
    128. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68. PMID: 16007083.
      Citations: 257     Fields:    Translation:AnimalsCells
    129. Qian J, Noebels JL. Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse. J Physiol. 2005 Aug 01; 566(Pt 3):747-58. PMID: 15919713; PMCID: PMC1464795.
      Citations: 82     Fields:    Translation:AnimalsCells
    130. Noebels JL. Calcium channel "gaiting" and absence epilepsy. Epilepsy Curr. 2005 May-Jun; 5(3):95-7. PMID: 16145613; PMCID: PMC1198627.
      Citations: 1     
    131. Senechal KR, Thaller C, Noebels JL. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Hum Mol Genet. 2005 Jun 15; 14(12):1613-20. PMID: 15857855.
      Citations: 65     Fields:    Translation:AnimalsCells
    132. Jankovic J, Noebels JL. Genetic mouse models of essential tremor: are they essential? J Clin Invest. 2005 Mar; 115(3):584-6. PMID: 15765140; PMCID: PMC1052020.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    133. Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MG, Noebels JL. Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Cell Death Differ. 2004 Nov; 11(11):1223-33. PMID: 15286683.
      Citations: 30     Fields:    Translation:AnimalsCells
    134. Rohlmann A, Bock HH, Zurhove K, Marth JD, Schomburg ED, Noebels JL, Beffert U, Sweatt JD, Weeber EJ, Herz J, May P. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004 Oct; 24(20):8872-83. PMID: 15456862; PMCID: PMC517900.
      Citations: 111     Fields:    Translation:AnimalsCells
    135. Collins AL, Levenson JM, Vilaythong AP, Richman R, Armstrong DL, Noebels JL, David Sweatt J, Zoghbi HY. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet. 2004 Nov 01; 13(21):2679-89. PMID: 15351775.
      Citations: 253     Fields:    Translation:HumansAnimalsCells
    136. Zhang Y, Vilaythong AP, Yoshor D, Noebels JL. Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci. 2004 Jun 02; 24(22):5239-48. PMID: 15175394; PMCID: PMC6729193.
      Citations: 39     Fields:    Translation:AnimalsCells
    137. Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21; 24(16):4030-42. PMID: 15102918; PMCID: PMC6729427.
      Citations: 120     Fields:    Translation:AnimalsCells
    138. Houseweart MK, Vilaythong A, Yin XM, Turk B, Noebels JL, Myers RM. Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1). Cell Death Differ. 2003 Dec; 10(12):1329-35. PMID: 12934064.
      Citations: 17     Fields:    Translation:AnimalsCells
    139. Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15; 56(4):315-27. PMID: 12918016.
      Citations: 41     Fields:    Translation:HumansAnimals
    140. Qian J, Noebels JL. Topiramate alters excitatory synaptic transmission in mouse hippocampus. Epilepsy Res. 2003 Aug; 55(3):225-33. PMID: 12972176.
      Citations: 14     Fields:    Translation:AnimalsCells
    141. Noebels JL. Stiff Goats, Chloride Ions, and Idiopathic Generalized Epilepsy (IGE). Epilepsy Curr. 2003 Jul; 3(4):146-147. PMID: 15309062; PMCID: PMC321205.
      Citations:    
    142. Walz K, Caratini-Rivera S, Bi W, Fonseca P, Mansouri DL, Lynch J, Vogel H, Noebels JL, Bradley A, Lupski JR. Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May; 23(10):3646-55. PMID: 12724422; PMCID: PMC154242.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    143. Kantheti P, Diaz ME, Peden AE, Seong EE, Dolan DF, Robinson MS, Noebels JL, Burmeister ML. Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion. Mamm Genome. 2003 Mar; 14(3):157-67. PMID: 12647238.
      Citations: 13     Fields:    Translation:AnimalsCells
    144. Noebels JL. How a Sodium Channel Mutation Causes Epilepsy. Epilepsy Curr. 2003 Mar; 3(2):70-71. PMID: 15309091; PMCID: PMC321176.
      Citations: 1     
    145. Powell EM, Campbell DB, Stanwood GD, Davis C, Noebels JL, Levitt P. Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci. 2003 Jan 15; 23(2):622-31. PMID: 12533622; PMCID: PMC6741866.
      Citations: 146     Fields:    Translation:AnimalsCells
    146. Noebels JL. Exploring new gene discoveries in idiopathic generalized epilepsy. Epilepsia. 2003; 44 Suppl 2:16-21. PMID: 12752457.
      Citations: 13     Fields:    Translation:HumansAnimals
    147. Noebels JL. The biology of epilepsy genes. Annu Rev Neurosci. 2003; 26:599-625. PMID: 14527270.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    148. Stables JP, Bertram EH, White HS, Coulter DA, Dichter MA, Jacobs MP, Loscher W, Lowenstein DH, Moshe SL, Noebels JL, Davis M. Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia. 2002 Nov; 43(11):1410-20. PMID: 12423393.
      Citations: 38     Fields:    Translation:HumansAnimals
    149. Anderson E, Berkovic S, Dulac O, Gardiner M, Jain S, Laue Friis M, Lindhout D, Noebels J, Ottman R, Scaramelli A, Serratosa J, Steinlein O, Avanzini G, Bailey-Wilson J, Cardon L, Fischbach R, Gwinn-Hardy K, Leppert M, Ott J, Lindblad-Toh K, Weiss K, Laue-Friis M, ILAE Genetics Commission. ILAE genetics commission conference report: molecular analysis of complex genetic epilepsies. Epilepsia. 2002 Oct; 43(10):1262-7. PMID: 12366744.
      Citations: 8     Fields:    Translation:Humans
    150. Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci. 2002 Aug 01; 22(15):6362-71. PMID: 12151514; PMCID: PMC6758149.
      Citations: 86     Fields:    Translation:AnimalsCells
    151. Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, Armstrong D, Paylor R, Zoghbi H. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron. 2002 Jul 18; 35(2):243-54. PMID: 12160743.
      Citations: 338     Fields:    Translation:HumansAnimalsCells
    152. Noebels JL. A Gene for JME at Last: The alpha1 GABA Receptor Subunit. Epilepsy Curr. 2002 Jul; 2(4):131-132. PMID: 15309143; PMCID: PMC321040.
      Citations: 1     
    153. Poolos NP, Das S, Clark GD, Lardizabal D, Noebels JL, Wyllie E, Dobyns WB. Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX. Neurology. 2002 May 28; 58(10):1559-62. PMID: 12034802.
      Citations: 11     Fields:    Translation:Humans
    154. Noebels JL. Human Epilepsy Can Be Linked to a Defective Calcium Channel. Epilepsy Curr. 2002 May; 2(3):95. PMID: 15309155; PMCID: PMC321025.
      Citations:    
    155. Noebels JL. Sodium channel gene expression and epilepsy. Novartis Found Symp. 2002; 241:109-20; discussion 120-3, 226-32. PMID: 11771641.
      Citations: 9     Fields:    Translation:HumansAnimals
    156. Jacobs MP, Fischbach GD, Davis MR, Dichter MA, Dingledine R, Lowenstein DH, Morrell MJ, Noebels JL, Rogawski MA, Spencer SS, Theodore WH. Future directions for epilepsy research. Neurology. 2001 Nov 13; 57(9):1536-42. PMID: 11706087.
      Citations: 19     Fields:    Translation:HumansAnimals
    157. Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, Shapira SK. Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome. Epilepsia. 2001 Sep; 42(9):1103-11. PMID: 11580756.
      Citations: 29     Fields:    Translation:HumansCells
    158. Qian J, Noebels JL. Presynaptic Ca2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron. J Neurosci. 2001 Jun 01; 21(11):3721-8. PMID: 11356859; PMCID: PMC6762720.
      Citations: 39     Fields:    Translation:AnimalsCells
    159. Qiao X, Suri C, Knusel B, Noebels JL. Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor. J Neurosci Res. 2001 May 01; 64(3):268-76. PMID: 11319771.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    160. Zwingman TA, Neumann PE, Noebels JL, Herrup K. Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J Neurosci. 2001 Feb 15; 21(4):1169-78. PMID: 11160387; PMCID: PMC6762232.
      Citations: 41     Fields:    Translation:AnimalsCells
    161. Burgess DL, Gefrides LA, Foreman PJ, Noebels JL. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics. 2001 Feb 01; 71(3):339-50. PMID: 11170751.
      Citations: 49     Fields:    Translation:HumansCells
    162. Noebels JL. Modeling human epilepsies in mice. Epilepsia. 2001; 42 Suppl 5:11-5. PMID: 11887961.
      Citations: 3     Fields:    Translation:HumansAnimals
    163. Lau D, Vega-Saenz de Miera EC, Contreras D, Ozaita A, Harvey M, Chow A, Noebels JL, Paylor R, Morgan JI, Leonard CS, Rudy B. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15; 20(24):9071-85. PMID: 11124984; PMCID: PMC6773003.
      Citations: 93     Fields:    Translation:AnimalsCells
    164. Matsuura T, Yamagata T, Burgess DL, Rasmussen A, Grewal RP, Watase K, Khajavi M, McCall AE, Davis CF, Zu L, Achari M, Pulst SM, Alonso E, Noebels JL, Nelson DL, Zoghbi HY, Ashizawa T. Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet. 2000 Oct; 26(2):191-4. PMID: 11017075.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    165. Kellaway P, Mizrahi EM, Noebels JL. Benign focal epilepsies of childhood: genetically determined pathophysiology. Report of an international workshop. Epilepsia. 2000 Aug; 41(8):1049-50. PMID: 10961636.
      Citations:    Fields:    Translation:Humans
    166. Burgess DL, Noebels JL. Calcium channel defects in models of inherited generalized epilepsy. Epilepsia. 2000 Aug; 41(8):1074-5. PMID: 10961647.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    167. Steinlein OK, Noebels JL. Ion channels and epilepsy in man and mouse. Curr Opin Genet Dev. 2000 Jun; 10(3):286-91. PMID: 10826987.
      Citations: 15     Fields:    Translation:HumansAnimals
    168. Liu M, Pleasure SJ, Collins AE, Noebels JL, Naya FJ, Tsai MJ, Lowenstein DH. Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):865-70. PMID: 10639171; PMCID: PMC15422.
      Citations: 116     Fields:    Translation:AnimalsCells
    169. Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45. PMID: 10670432.
      Citations: 55     Fields:    Translation:Animals
    170. Qian J, Noebels JL. Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations. J Neurosci. 2000 Jan 01; 20(1):163-70. PMID: 10627593; PMCID: PMC6774110.
      Citations: 44     Fields:    Translation:AnimalsCells
    171. Burgess DL, Matsuura T, Ashizawa T, Noebels JL. Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13. Epilepsia. 2000 Jan; 41(1):24-7. PMID: 10643919.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    172. Burgess DL, Davis CF, Gefrides LA, Noebels JL. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec; 9(12):1204-13. PMID: 10613843; PMCID: PMC311002.
      Citations: 25     Fields:    Translation:HumansCells
    173. Burgess DL, Noebels JL. Single gene defects in mice: the role of voltage-dependent calcium channels in absence models. Epilepsy Res. 1999 Sep; 36(2-3):111-22. PMID: 10515159.
      Citations: 22     Fields:    Translation:HumansAnimals
    174. Hartmann HA, Colom LV, Sutherland ML, Noebels JL. Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain. Nat Neurosci. 1999 Jul; 2(7):593-5. PMID: 10404176.
      Citations: 44     Fields:    Translation:AnimalsCells
    175. Burgess DL, Noebels JL. Voltage-dependent calcium channel mutations in neurological disease. Ann N Y Acad Sci. 1999 Apr 30; 868:199-212. PMID: 10414295.
      Citations: 20     Fields:    Translation:AnimalsCells
    176. Burgess DL, Biddlecome GH, McDonough SI, Diaz ME, Zilinski CA, Bean BP, Campbell KP, Noebels JL. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999 Apr; 13(4):293-311. PMID: 10328888.
      Citations: 31     Fields:    Translation:AnimalsCells
    177. Sutherland ML, Williams SH, Abedi R, Overbeek PA, Pfaffinger PJ, Noebels JL. Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2451-5. PMID: 10051663; PMCID: PMC26805.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    178. Clark GD, Noebels JL. Cortin disaster: lissencephaly genes spell double trouble for the developing brain. Ann Neurol. 1999 Feb; 45(2):141-2. PMID: 9989613.
      Citations: 1     Fields:    Translation:Humans
    179. Noebels JL. Single-gene models of epilepsy. Adv Neurol. 1999; 79:227-38. PMID: 10514817.
      Citations: 9     Fields:    Translation:HumansAnimals
    180. Nahm WK, Noebels JL. Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting. J Neurosci. 1998 Nov 15; 18(22):9245-55. PMID: 9801364; PMCID: PMC6792870.
      Citations: 10     Fields:    Translation:AnimalsCells
    181. Pennacchio LA, Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RM. Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Nat Genet. 1998 Nov; 20(3):251-8. PMID: 9806543.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    182. Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 1998 Oct; 21(4):799-811. PMID: 9808466.
      Citations: 377     Fields:    Translation:AnimalsCells
    183. Noebels JL. Ion Channelopathies and Heritable Epilepsy. News Physiol Sci. 1998 Oct; 13:255-256. PMID: 11390799.
      Citations:    Fields:    
    184. Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M. Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Neuron. 1998 Jul; 21(1):111-22. PMID: 9697856.
      Citations: 136     Fields:    Translation:AnimalsCells
    185. Westenbroek RE, Bausch SB, Lin RC, Franck JE, Noebels JL, Catterall WA. Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia. J Neurosci. 1998 Apr 01; 18(7):2321-34. PMID: 9502793; PMCID: PMC6793103.
      Citations: 34     Fields:    Translation:AnimalsCells
    186. Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14060-5. PMID: 9391152; PMCID: PMC28432.
      Citations: 118     Fields:    Translation:Animals
    187. Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WN. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 03; 91(1):139-48. PMID: 9335342.
      Citations: 81     Fields:    Translation:AnimalsCells
    188. Cattanach BM, Barr JA, Beechey CV, Martin J, Noebels J, Jones J. A candidate model for Angelman syndrome in the mouse. Mamm Genome. 1997 Jul; 8(7):472-8. PMID: 9195990.
      Citations: 25     Fields:    Translation:HumansAnimals
    189. Burgess DL, Jones JM, Meisler MH, Noebels JL. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 1997 Feb 07; 88(3):385-92. PMID: 9039265.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    190. Di Pasquale E, Keegan KD, Noebels JL. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. J Neurophysiol. 1997 Feb; 77(2):621-31. PMID: 9065835.
      Citations: 25     Fields:    Translation:AnimalsCells
    191. Noebels JL, Qiao X, Nahm WK. Neurogenetic approaches to axon sprouting in the hippocampus. Adv Neurol. 1997; 72:35-44. PMID: 8993682.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    192. Sutherland ML, Delaney TA, Noebels JL. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS. J Neurosci. 1996 Apr 01; 16(7):2191-207. PMID: 8601800; PMCID: PMC6578530.
      Citations: 33     Fields:    Translation:AnimalsCells
    193. Noebels JL. Targeting epilepsy genes. Neuron. 1996 Feb; 16(2):241-4. PMID: 8789939.
      Citations: 19     Fields:    Translation:HumansCells
    194. Qiao X, Hefti F, Knusel B, Noebels JL. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. J Neurosci. 1996 Jan 15; 16(2):640-8. PMID: 8551348; PMCID: PMC6578657.
      Citations: 24     Fields:    Translation:Animals
    195. Noebels JL, Sutherland ML, Nahm WK, DiPasquale E. Molecular and cellular plasticity in developing epileptic brain. Cold Spring Harb Symp Quant Biol. 1996; 61:319-26. PMID: 9246461.
      Citations:    Fields:    Translation:HumansAnimals
    196. Wang H, Allen ML, Grigg JJ, Noebels JL, Tempel BL. Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler. Neuron. 1995 Dec; 15(6):1337-47. PMID: 8845157.
      Citations: 26     Fields:    Translation:AnimalsCells
    197. Sutherland ML, Delaney TA, Noebels JL. Molecular characterization of a high-affinity mouse glutamate transporter. Gene. 1995 Sep 11; 162(2):271-4. PMID: 7557442.
      Citations: 2     Fields:    Translation:AnimalsCells
    198. Chafetz RS, Nahm WK, Noebels JL. Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization. Brain Res Mol Brain Res. 1995 Jul; 31(1-2):111-21. PMID: 7476019.
      Citations: 15     Fields:    Translation:AnimalsCells
    199. Noebels JL. Single locus mutations in mice expressing generalized spike-wave absence epilepsies. Ital J Neurol Sci. 1995 Feb-Mar; 16(1-2):107-11. PMID: 7642343.
      Citations: 2     Fields:    Translation:Animals
    200. Frankel WN, Taylor BA, Noebels JL, Lutz CM. Genetic epilepsy model derived from common inbred mouse strains. Genetics. 1994 Oct; 138(2):481-9. PMID: 7828829; PMCID: PMC1206164.
      Citations: 13     Fields:    Translation:Animals
    201. Helekar SA, Noebels JL. Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering. J Neurophysiol. 1994 Jan; 71(1):1-10. PMID: 8158221.
      Citations: 6     Fields:    Translation:AnimalsCells
    202. Wu SM, Qiao X, Noebels JL, Yang XL. Localization and modulatory actions of zinc in vertebrate retina. Vision Res. 1993 Dec; 33(18):2611-6. PMID: 8296456.
      Citations: 26     Fields:    Translation:AnimalsCells
    203. Qiao X, Noebels JL. Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures. J Neurosci. 1993 Nov; 13(11):4622-35. PMID: 8229188; PMCID: PMC6576361.
      Citations: 21     Fields:    Translation:AnimalsCells
    204. Buckwalter MS, Testa CM, Noebels JL, Camper SA. Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics. 1993 Aug; 17(2):279-86. PMID: 8406478.
      Citations:    Fields:    Translation:HumansAnimalsCells
    205. Westenbroek RE, Noebels JL, Catterall WA. Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J Neurosci. 1992 Jun; 12(6):2259-67. PMID: 1318958; PMCID: PMC6575941.
      Citations: 42     Fields:    Translation:AnimalsCells
    206. Helekar SA, Noebels JL. A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant. Brain Res Dev Brain Res. 1992 Feb 21; 65(2):205-10. PMID: 1572065.
      Citations: 2     Fields:    Translation:Animals
    207. Noebels JL, Marcom PK, Jalilian-Tehrani MH. Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. Nature. 1991 Aug 01; 352(6334):431-4. PMID: 1713650.
      Citations: 14     Fields:    Translation:AnimalsCells
    208. Qiao XX, Noebels JL. Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects. Brain Res. 1991 Jul 26; 555(1):43-50. PMID: 1933329.
      Citations: 5     Fields:    Translation:Animals
    209. Helekar SA, Noebels JL. Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation. Proc Natl Acad Sci U S A. 1991 Jun 01; 88(11):4736-40. PMID: 2052555; PMCID: PMC51741.
      Citations: 4     Fields:    Translation:AnimalsCells
    210. Noebels JL. Mutational analysis of spike-wave epilepsy phenotypes. Epilepsy Res Suppl. 1991; 4:201-12. PMID: 1815603.
      Citations: 1     Fields:    Translation:AnimalsCells
    211. Noebels JL, Qiao X, Bronson RT, Spencer C, Davisson MT. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 1990 Nov; 7(2):129-35. PMID: 2289471.
      Citations: 72     Fields:    Translation:AnimalsCells
    212. Noebels JL, Rutecki PA. Altered hippocampal network excitability in the hypernoradrenergic mutant mouse tottering. Brain Res. 1990 Aug 06; 524(2):225-30. PMID: 2292005.
      Citations: 4     Fields:    Translation:Animals
    213. Noebels JL, Sidman RL. Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse. J Neurogenet. 1989 Sep; 6(1):53-6. PMID: 2778559.
      Citations: 8     Fields:    Translation:AnimalsCells
    214. Noebels JL. Mutational analysis of inherited epilepsies. Adv Neurol. 1986; 44:97-113. PMID: 2871726.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    215. Noebels JL. A single gene error of noradrenergic axon growth synchronizes central neurones. Nature. 1984 Aug 2-8; 310(5976):409-11. PMID: 6462226.
      Citations: 18     Fields:    Translation:Animals
    216. Noebels JL. Isolating single genes of the inherited epilepsies. Ann Neurol. 1984; 16 Suppl:S18-21. PMID: 6095738.
      Citations: 7     Fields:    Translation:AnimalsCells
    217. Levitt P, Noebels JL. Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4630-4. PMID: 6945603; PMCID: PMC319847.
      Citations: 19     Fields:    Translation:Animals
    218. Noebels JL. Analysis of inherited epilepsy using single locus mutations in mice. Fed Proc. 1979 Sep; 38(10):2405-10. PMID: 383515.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    219. Noebels JL, Sidman RL. Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science. 1979 Jun 22; 204(4399):1334-6. PMID: 572084.
      Citations: 75     Fields:    Translation:HumansAnimals
    220. Noebels JL, Prince DA. Excitability changes in thalamocortical relay neurons during synchronous discharges in cat neocortex. J Neurophysiol. 1978 Sep; 41(5):1282-96. PMID: 212538.
      Citations: 3     Fields:    Translation:AnimalsCells
    221. Noebels JL, Prince DA. Development of focal seizures in cerebral cortex: role of axon terminal bursting. J Neurophysiol. 1978 Sep; 41(5):1267-81. PMID: 702194.
      Citations: 15     Fields:    Translation:AnimalsCells
    222. Noebels JL, Roth WT, Kopell BS. Cortical slow potentials and the occipital EEG in congenital blindness. J Neurol Sci. 1978 Jun; 37(1-2):51-8. PMID: 690664.
      Citations: 5     Fields:    Translation:Humans
    223. Noebels JL, Prince DA. Presynaptic origin of penicillin after discharges at mammalian nerve terminals. Brain Res. 1977 Dec 09; 138(1):59-74. PMID: 201346.
      Citations: 4     Fields:    Translation:AnimalsCells
    224. Noebels JL, Pedley TA. Anatomic localization of topically applied [14C]penicillin during experimental focal epilepsy in cat neocortex. Brain Res. 1977 Apr 15; 125(2):293-303. PMID: 404001.
      Citations: 1     Fields:    Translation:AnimalsCells
    225. Schwartzkroin PA, Futamachi KJ, Noebels JL, Prince DA. Transcallosal effects of a cortical epileptiform focus. Brain Res. 1975 Nov 28; 99(1):59-68. PMID: 1188986.
      Citations: 2     Fields:    Translation:Animals
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