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JUAN C. MARINI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Critical Care
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    K01RR024173     (MARINI, JUAN)Jul 6, 2007 - Jun 30, 2012
    NIH/NCRR
    Mouse models for studying citrulline recycling for sustaining NO production
    Role: Principal Investigator

    R03HD078447     (MARINI, JUAN)Sep 25, 2013 - Aug 31, 2015
    NIH/NICHD
    Comparative Efficacy of Phenylbutyrate vs. Benzoate in Urea Cycle Disorders
    Role: Principal Investigator

    R01GM108940     (MARINI, JUAN)Aug 1, 2014 - Mar 31, 2018
    NIH/NIGMS
    Therapeutic and Metabolic Responses of Citrulline vs. Arginine Supplementation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Blesson CS, Schutt A, Chacko S, Marini JC, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli C. Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats. Front Endocrinol (Lausanne). 2019; 10:538. PMID: 31447783.
      View in: PubMed
    2. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 Apr; 7(8):e14071. PMID: 31033205.
      View in: PubMed
    3. Lin S, Stoll B, Robinson J, Pastor JJ, Marini JC, Ipharraguerre IR, Hartmann B, Holst JJ, Cruz S, Lau P, Olutoye O, Fang Z, Burrin DG. Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model. Am J Physiol Gastrointest Liver Physiol. 2019 May 01; 316(5):G641-G652. PMID: 30920308.
      View in: PubMed
    4. Mohammad MA, Didelija IC, Stoll B, Marini JC. Citrulline Generation Test: What Does It Measure? JPEN J Parenter Enteral Nutr. 2019 Aug; 43(6):726-733. PMID: 30357864.
      View in: PubMed
    5. Wang X, Yuan Y, Didelija IC, Mohammad MA, Marini JC. Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice. J Nutr. 2018 09 01; 148(9):1415-1420. PMID: 30184221.
      View in: PubMed
    6. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115.
      View in: PubMed
    7. Robinson JL, Smith VA, Stoll B, Agarwal U, Premkumar MH, Lau P, Cruz SM, Manjarin R, Olutoye O, Burrin DG, Marini JC. Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets. Am J Physiol Gastrointest Liver Physiol. 2018 10 01; 315(4):G638-G649. PMID: 30048597.
      View in: PubMed
    8. Yuan Y, Mohammad MA, Betancourt A, Didelija IC, Yallampalli C, Marini JC. The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge. J Nutr. 2018 06 01; 148(6):844-850. PMID: 29878271.
      View in: PubMed
    9. Nagamani SCS, Agarwal U, Tam A, Azamian M, McMeans A, Didelija IC, Mohammad MA, Marini JC. A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers. Genet Med. 2018 07; 20(7):708-716. PMID: 29693650.
      View in: PubMed
    10. Didelija IC, Mohammad MA, Marini JC. Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice. J Nutr. 2017 08; 147(8):1510-1516. PMID: 28679627.
      View in: PubMed
    11. Marini JC, Agarwal U, Robinson JL, Yuan Y, Didelija IC, Stoll B, Burrin DG. The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig. Am J Physiol Endocrinol Metab. 2017 08 01; 313(2):E233-E242. PMID: 28611027.
      View in: PubMed
    12. Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC. Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study. J Nutr. 2017 04; 147(4):549-555. PMID: 28275102.
      View in: PubMed
    13. Agarwal U, Didelija IC, Yuan Y, Wang X, Marini JC. Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice. J Nutr. 2017 04; 147(4):596-602. PMID: 28179487.
      View in: PubMed
    14. Achreja A, Zhao H, Yang L, Yun TH, Marini J, Nagrath D. Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism. Metab Eng. 2017 09; 43(Pt B):156-172. PMID: 28087332.
      View in: PubMed
    15. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063.
      View in: PubMed
    16. Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T, Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metab. 2016 11 08; 24(5):685-700. PMID: 27829138.
      View in: PubMed
    17. Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 2016 Feb 27; 5:e10250. PMID: 26920219.
      View in: PubMed
    18. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-540.e7. PMID: 26874300.
      View in: PubMed
    19. Marini JC. Interrelationships between glutamine and citrulline metabolism. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):62-6. PMID: 26560519.
      View in: PubMed
    20. Marini JC, Agarwal U, Didelija IC. Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. J Nutr. 2015 Jun; 145(6):1227-31. PMID: 25855119.
      View in: PubMed
    21. Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? Am J Clin Nutr. 2015 Apr; 101(4):890-2. PMID: 25833987.
      View in: PubMed
    22. Marini JC, Didelija IC. Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PLoS One. 2015; 10(3):e0119801. PMID: 25775142.
      View in: PubMed
    23. Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Lauridsen C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2016 07; 40(5):656-71. PMID: 25596209.
      View in: PubMed
    24. Castro D., G. Briassoulis, J.W. Hsu, J.C. Marini, M. Wu, W.E. Gordon, I.D. Esangbedo, J. Palmattan and L. Castillo. The effect of Fentanyl administration on plasma agmatine concentration in critically ill patients. J. Pediatr. Neonatal Care. 2015; (3):00118.
    25. Marini JC. Protein requirements: are we ready for new recommendations? J Nutr. 2015 Jan; 145(1):5-6. PMID: 25342701.
      View in: PubMed
    26. Marini JC, Didelija IC, Fiorotto ML. Extrarenal citrulline disposal in mice with impaired renal function. Am J Physiol Renal Physiol. 2014 Sep 15; 307(6):F660-5. PMID: 25056350.
      View in: PubMed
    27. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol. 2014 May 05; 10:728. PMID: 24799285.
      View in: PubMed
    28. Radley-Crabb HG, Marini JC, Sosa HA, Castillo LI, Grounds MD, Fiorotto ML. Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy. PLoS One. 2014; 9(2):e89277. PMID: 24586653.
      View in: PubMed
    29. Marini JC, Stoll B, Didelija IC, Burrin DG. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1348-53. PMID: 23074237.
      View in: PubMed
    30. Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, Kleppe S, Erez A, O'Brian Smith E, Marini JC, Lee B. A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria. Mol Genet Metab. 2012 Nov; 107(3):315-21. PMID: 23040521.
      View in: PubMed
    31. Benight NM, Stoll B, Marini JC, Burrin DG. Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jul; 303(1):G71-82. PMID: 22556140.
      View in: PubMed
    32. Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B. Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet. 2012 May 04; 90(5):836-46. PMID: 22541557.
      View in: PubMed
    33. Chacko SK, Haymond MW, Sun Y, Marini JC, Sauer PJ, Ma X, Sunehag AL. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab. 2012 May 15; 302(9):E1055-62. PMID: 22338071.
      View in: PubMed
    34. Marini JC. Arginine and ornithine are the main precursors for citrulline synthesis in mice. J Nutr. 2012 Mar; 142(3):572-80. PMID: 22323761.
      View in: PubMed
    35. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Nov 13; 17(12):1619-26. PMID: 22081021.
      View in: PubMed
    36. Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59. PMID: 21596995.
      View in: PubMed
    37. Marini JC. Quantitative analysis of 15N-labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid Commun Mass Spectrom. 2011 May 15; 25(9):1291-6. PMID: 21491530.
      View in: PubMed
    38. Marini JC, Lanpher BC, Scaglia F, O'Brien WE, Sun Q, Garlick PJ, Jahoor F, Lee B. Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase-deficient patients. Am J Clin Nutr. 2011 Jun; 93(6):1248-54. PMID: 21490144.
      View in: PubMed
    39. Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B. Phenylbutyrate therapy for maple syrup urine disease. Hum Mol Genet. 2011 Feb 15; 20(4):631-40. PMID: 21098507.
      View in: PubMed
    40. Thame MM, Fletcher HM, Baker TM, Marini JC, Kao CC, Jahoor F. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. J Nutr. 2011 Jan; 141(1):71-4. PMID: 21084652.
      View in: PubMed
    41. Marini JC, Keller B, Didelija IC, Castillo L, Lee B. Enteral arginase II provides ornithine for citrulline synthesis. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E188-94. PMID: 20978229.
      View in: PubMed
    42. Marini JC, Didelija IC, Castillo L, Lee B. Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets. J Nutr. 2010 Aug; 140(8):1432-7. PMID: 20573946.
      View in: PubMed
    43. Marini JC, Didelija IC, Castillo L, Lee B. Glutamine: precursor or nitrogen donor for citrulline synthesis? Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E69-79. PMID: 20407005.
      View in: PubMed
    44. Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Butte NF, Marini J, Jahoor F, Sterchi EE. Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice. J Nutr. 2009 Apr; 139(4):684-90. PMID: 19193815.
      View in: PubMed
    45. Marini JC, Fox DG, Murphy MR. Nitrogen transactions along the gastrointestinal tract of cattle: A meta-analytical approach. J Anim Sci. 2008 Mar; 86(3):660-79. PMID: 18073282.
      View in: PubMed
    46. Marini JC, Erez A, Castillo L, Lee B. Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1764-71. PMID: 17925451.
      View in: PubMed
    47. Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB, Loor JJ, Marini JC, Rund LA, Schook LB, Van Kessel AG, Gaskins HR. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genomics. 2007 Jul 05; 8:215. PMID: 17615075.
      View in: PubMed
    48. Marini JC, Lee B, Garlick PJ. Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice. J Nutr. 2006 Jul; 136(7):1834-8. PMID: 16772445.
      View in: PubMed
    49. Imoberdorf R, Garlick PJ, McNurlan MA, Casella GA, Marini JC, Turgay M, Bärtsch P, Ballmer PE. Skeletal muscle protein synthesis after active or passive ascent to high altitude. Med Sci Sports Exerc. 2006 Jun; 38(6):1082-7. PMID: 16775549.
      View in: PubMed
    50. Marini JC, Lee B, Garlick PJ. Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice. J Nutr. 2006 Apr; 136(4):1017-20. PMID: 16549467.
      View in: PubMed
    51. Marini JC, Broussard SR. Hyperammonemia increases sensitivity to LPS. Mol Genet Metab. 2006 Jun; 88(2):131-7. PMID: 16497529.
      View in: PubMed
    52. Marini JC, Attene-Ramos MS. An improved analytical method for the determination of urea nitrogen isotopomers in biological samples utilizing continuous flow isotope ratio mass spectrometry. Rapid Commun Mass Spectrom. 2006; 20(24):3736-40. PMID: 17099932.
      View in: PubMed
    53. Marini JC, Lee B, Garlick PJ. In vivo urea kinetic studies in conscious mice. J Nutr. 2006 Jan; 136(1):202-6. PMID: 16365083.
      View in: PubMed
    54. Scaglia F, Brunetti-Pierri N, Kleppe S, Marini J, Carter S, Garlick P, Jahoor F, O'Brien W, Lee B. Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. J Nutr. 2004 10; 134(10 Suppl):2775S-2782S; discussion 2796S-2797S. PMID: 15465784.
      View in: PubMed
    55. Scaglia F, Marini J, Rosenberger J, Henry J, Garlick P, Lee B, Reeds P. Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers. Am J Clin Nutr. 2003 Oct; 78(4):749-55. PMID: 14522733.
      View in: PubMed
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