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ARUN SAINI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
Houston, TX 77030
Email
ORCID ORCID Icon0000-0001-7501-4720 Additional info
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    Collapse Biography 
    Collapse education and training
    University College of Medical Sciences, DelhiMBBS02/2001Medicine
    Lady Hardinge Medical College, DelhiMD04/2005Pediatrics
    Wayne State University, Detroit Residency6/2011Pediatrics
    Washington University in St Louis, St LouisFellowship6/2014Pediatric Critica Care Medicine
    University of Tennessee Health Science Center, MemphisMS5/2018Epidemiology (Clinical Investigator)
    Collapse awards and honors
    2024FCCM , American College of Critical Care
    2021President Citation Award, Society of Critical Care Medicine
    2019Service Appreciation Award, SCCM (Texas Chapter)
    2018Employee of the Month Award , PICU Staff, Le Bonheur Children's Hospital
    2014Fellow of the Year Award , PICU staff, St Louis Children’s Hospital
    2011FAAP Designation, American Academy of Pediatrics
    2011Pediatric Critical Care Medicine Outstanding Resident Award , Children’s Hospital of Michigan
    2009Emergency Care Medicine Clinical Excellence Award , Children’s Hospital of Michigan
    2004Dr. Satya Gupta Award, Lady Hardinge Medical College
    2007Dr. V K Gujral Award , Lady Hardinge Medical College

    Collapse Research 
    Collapse research activities and funding
    68468-I     (Arun Saini)Oct 1, 2022 - Sep 30, 2023
    Michael E. DeBakey Department of Veterans Affairs Medical Center
    Role of Fibrin Clot Characteristics in Neuropsychological Performance after Traumatic Brain Injury
    Role Description: Traumatic brain injury (TBI)-the "silent epidemic"-contributes to death and disability with an estimated 69 million people worldwide suffering TBI yearly. We and others have reported increased risk for neurocognitive decline, including stress-related psychopathology, memory loss, dementia, and Parkinson's syndrome in patients after TBI. Fibrinogen and fibrin deposition leading to microglia and astrocytes-driven neuroinflammation in the brain tissue has been implicated in neurocognitive decline after TBI. It is unknown if aberrations in fibrin clot characteristics (FCC), including fibrin clot function and structure, alter the fibrinogen/fibrin deposition and determine the severity of neurocognitive decline after TBI. Our preliminary data suggest an increase in fibrin clot porosity and a decrease in fibrin fibers density in patients after TBI compared to healthy controls. Our central hypothesis is that aberrations in FCC contribute to a decline in neuropsychological performance in patients after mild to moderate TBI.This novel translational study will demonstrate distinct FCC aberrations in patients with TBI and link FCC with neuropsychological performance. Identifying unique aberrations in FCC will provide novel strategies to treat patients with TBI to diminish neurocognitive decline.
    Role: PI
    67509     (Arun Saini)Jul 1, 2022 - Jun 30, 2023
    Texas Children’s Hospital
    Fibrin Clot Characteristics in Thromboinflammation
    Role Description: Sepsis, coronavirus disease 2019 (COVID-19), multisystem inflammatory syndrome (MIS-C), and hemophagocytic lymphohistiocytosis (HLH) cause clotting abnormalities in the bloodstream. Despite the economic burden and human toll, treatment of impaired clotting in these diseases remains suboptimal. Clotting leads to clot plugs in small and large blood vessels, which impede blood and nutrient supply to vital organs, leading to their failure and eventually death. It is well known that fibrin is the essential component of clots. Fibrin clot structure and function determine the properties of the formed clot. Abnormalities in fibrin clot formation and clot structure may lead to unstable clots. An abnormal fibrin network can make clots either excessively resistant to degradation or too fragile. Clots with fine fibrin (dense) mesh are slower to degrade than those with coarse fibrin (loose) mesh. We think fibrin structure and function abnormalities can be unique to the disease process. Understanding the differences and similarities in fibrin structure and function will allow us to understand the clotting burden in children with sepsis, COVID-19, MIS-C, and HLH. This knowledge will guide treatment to lower the clot burden for faster recovery of sick children with sepsis, COVID-19, MIS-C, and HLH.
    Role: PI
    3U01HL116383-04S1     (Philip Spinella)Jul 1, 2016 - Jul 31, 2018
    NHLBI - US sites
    Age of blood in children in pediatric intensive care units (ABC-PICU)
    Role: Sub-award - Site PI

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Keith P, Bohn RIC, Nguyen T, Scott LK, Richmond M, Day M, Choe C, Perkins L, Burnside R, Pyke R, Rikard B, Guffey A, Saini A, Park HJ, Carcillo J. Improved survival in COVID-19 related sepsis and ARDS treated with a unique "triple therapy" including therapeutic plasma exchange: A single center retrospective analysis. J Clin Apher. 2024 Feb; 39(1):e22107. PMID: 38404046.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    2. Karki KB, Towbin JA, Shah SH, Philip RR, West AN, Tadphale SD, Saini A. Elevated Copeptin Levels Are Associated with Heart Failure Severity and Adverse Outcomes in Children with Cardiomyopathy. Children (Basel). 2023 Jun 30; 10(7). PMID: 37508636; PMCID: PMC10377870.
      Citations:    
    3. Nguyen TC, Marini JC, Guillory B, Valladolid-Brown C, Martinez-Vargas M, Subramanyam D, Cohen D, Cirlos SC, Lam F, Stoll B, Didelija IC, Vonderohe C, Orellana R, Saini A, Pradhan S, Bashir D, Desai MS, Flores S, Virk M, Tcharmtchi H, Navaei A, Kaplan S, Lamberth L, Hulten KG, Scull BP, Allen CE, Akcan-Arikan A, Vijayan KV, Cruz MA. Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries. Crit Care Explor. 2023 Jun; 5(6):e0916. PMID: 37255626; PMCID: PMC10226618.
      Citations:    
    4. Ettinger NA, Guffey D, Anum SJ, Fasipe T, Katkin J, Bhar S, Airewele G, Saini A, Tubman VN. Multi-center retrospective study of children with sickle cell disease admitted to pediatric intensive care units in the United States. Sci Rep. 2023 04 25; 13(1):6758. PMID: 37185357; PMCID: PMC10130031.
      Citations:    Fields:    Translation:Humans
    5. Bartlett R, Arachichilage DJ, Chitlur M, Hui SR, Neunert C, Doyle A, Retter A, Hunt BJ, Lim HS, Saini A, Renn? T, Kostousov V, Teruya J. The History of Extracorporeal Membrane Oxygenation and the Development of Extracorporeal Membrane Oxygenation Anticoagulation. Semin Thromb Hemost. 2024 Feb; 50(1):81-90. PMID: 36750217.
      Citations: 1     Fields:    
    6. Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 09 01; 7(5):1108-1119. PMID: 35587709.
      Citations:    Fields:    
    7. Cashen K, Regling K, Saini A. Extracorporeal Membrane Oxygenation in Critically Ill Children. Pediatr Clin North Am. 2022 06; 69(3):425-440. PMID: 35667755.
      Citations:    Fields:    Translation:HumansPHPublic Health
    8. Regling K, Saini A, Cashen K. Viscoelastic Testing in Pediatric Mechanical Circulatory Support. Front Med (Lausanne). 2022; 9:854258. PMID: 35602480; PMCID: PMC9120594.
      Citations:    
    9. Brubaker LS, Saini A, Nguyen TC, Martinez-Vargas M, Lam FW, Yao Q, Loor MM, Rosengart TK, Cruz MA. Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Crit Care Med. 2022 06 01; 50(6):e557-e568. PMID: 35170535; PMCID: PMC9112654.
      Citations:    Fields:    Translation:Humans
    10. Morparia K, Spinella PC, McQueen D, Kalyanaraman M, Bergel M, Lin J, Narang S, Saini A. Thromboelastography profiles in critically ill children with multisystem inflammatory syndrome. Pediatr Blood Cancer. 2022 05; 69(5):e29426. PMID: 34941014.
      Citations: 1     Fields:    Translation:Humans
    11. Ghafoor S, Fan K, Talleur AC, Saini A, Potera RM, Lehmann L, Annich G, Wang F, McArthur J, Sandhu H, Di Nardo M. Extracorporeal Membrane Oxygenation Candidacy in Pediatric Patients Treated With Hematopoietic Stem Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy: An International Survey. Front Oncol. 2021; 11:798236. PMID: 35004323; PMCID: PMC8727600.
      Citations: 1     
    12. Fan K, Hurley C, McNeil MJ, Agulnik A, Federico S, Qudeimat A, Saini A, McArthur J, Morrison RR, Sandhu H, Shah S, Ghafoor S. Case Report: Management Approach and Use of Extracorporeal Membrane Oxygenation for Diffuse Alveolar Hemorrhage After Pediatric Hematopoietic Cell Transplant. Front Pediatr. 2020; 8:587601. PMID: 33520888; PMCID: PMC7838496.
      Citations: 3     
    13. Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Stanworth SJ, Karam O, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood, Demaret P, Leteurtre S. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatr Crit Care Med. 2020 03; 21(3):267-275. PMID: 31644453; PMCID: PMC7060816.
      Citations: 1     Fields:    Translation:Humans
    14. Cashen K, Dalton H, Reeder RW, Saini A, Zuppa AF, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Dean JM, Meert KL, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediat. Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med. 2020 02; 21(2):178-185. PMID: 31568245; PMCID: PMC7007856.
      Citations: 12     Fields:    Translation:Humans
    15. Barker EE, Saini A, Gazit AZ, Shea SM, Baltagi S, Gage BF, Spinella PC. TEG Platelet Mapping and Impedance Aggregometry to Predict Platelet Transfusion During Cardiopulmonary Bypass in Pediatric Patients. Front Pediatr. 2019; 7:509. PMID: 31921722; PMCID: PMC6921926.
      Citations: 3     
    16. Spinella PC, Fergusson DA, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and, Tucci M, Lacroix J, H?bert PC, Leteurtre S, Chiusolo F, Clayton L, Turgeon AF. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 12 10; 322(22):2179-2190. PMID: 31821429; PMCID: PMC7081749.
      Citations: 14     Fields:    Translation:Humans
    17. Saini A, Spinella PC, Ignell SP, Lin JC. Thromboelastography Variables, Immune Markers, and Endothelial Factors Associated With Shock and NPMODS in Children With Severe Sepsis. Front Pediatr. 2019; 7:422. PMID: 31681719; PMCID: PMC6814084.
      Citations: 1     
    18. Karki KB, Towbin JA, Harrell C, Tansey J, Krebs J, Bigelow W, Saini A, Tadphale SD. Concurrent Use of Calcium Chloride and Arginine Vasopressin Infusions in Pediatric Patients with Acute Cardiocirculatory Failure. Pediatr Cardiol. 2019 Jun; 40(5):1046-1056. PMID: 31065757.
      Citations: 2     Fields:    Translation:Humans
    19. Saini A, Joshi AD, Cowan KM, Wayne Gatewood C, Kumar STK, Allen J, Shah SH, Nouer SS, Jones T, Knott-Craig CJ, Boston US. High acetylsalicylic acid dosing in infants after modified Blalock-Taussig shunt. Cardiol Young. 2019 Mar; 29(3):389-397. PMID: 30739623.
      Citations: 1     Fields:    Translation:Humans
    20. Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood, P3T Investigators. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children. Pediatr Crit Care Med. 2019 02; 20(2):e61-e69. PMID: 30422914; PMCID: PMC6709973.
      Citations: 3     Fields:    Translation:Humans
    21. Saini A, West AN, Harrell C, Jones TL, Nellis ME, Joshi AD, Cowan KM, Gatewood CW, Ryder AB, Reiss UM. Platelet Transfusions in the PICU: Does Disease Severity Matter? Pediatr Crit Care Med. 2018 09; 19(9):e472-e478. PMID: 29927877.
      Citations: 5     Fields:    Translation:Humans
    22. Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood. Platelet Transfusion Practices in Critically Ill Children. Crit Care Med. 2018 08; 46(8):1309-1317. PMID: 29727368; PMCID: PMC6476545.
      Citations: 21     Fields:    Translation:Humans
    23. Remy KE, Yazer MH, Saini A, Mehanovic-Varmaz A, Rogers SR, Cap AP, Spinella PC. Effects of platelet-sparing leukocyte reduction and agitation methods on in vitro measures of hemostatic function in cold-stored whole blood. J Trauma Acute Care Surg. 2018 06; 84(6S Suppl 1):S104-S114. PMID: 29554042; PMCID: PMC8242931.
      Citations: 4     Fields:    Translation:HumansCells
    24. Rajkumar R, Bhaya B, Mamilla D, Czech T, Kisseih E, Saini A, Chouthai N. A preliminary evaluation of glial cell line-derived neurotrophic factor (GDNF) levels in cerebrospinal fluid across various gestational ages and clinical conditions of the neonate. Int J Dev Neurosci. 2018 Apr; 65:61-65. PMID: 29031644.
      Citations: 5     Fields:    Translation:Humans
    25. Cowan K, Landman RA, Saini A. Dexmedetomidine as an Adjunct to Treat Anticholinergic Toxidrome in Children. Glob Pediatr Health. 2017; 4:2333794X17704764. PMID: 28491929; PMCID: PMC5406198.
      Citations: 1     
    26. Saini A, Hartman ME, Gage BF, Said A, Gazit AZ, Eghtesady P, Boston US, Spinella PC. Incidence of Platelet Dysfunction by Thromboelastography-Platelet Mapping in Children Supported with ECMO: A Pilot Retrospective Study. Front Pediatr. 2015; 3:116. PMID: 26779465; PMCID: PMC4702183.
      Citations: 20     
    27. Saini A. Work-Life Balance: Keep the Cycle Moving?-?Find a Purpose, Set Priorities, and Manage Time Well Then Reassess and Reset. Front Pediatr. 2015; 3:118. PMID: 26779467; PMCID: PMC4700273.
      Citations: 1     
    28. Saini A, Spinella PC. Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation. Clin Lab Med. 2014 Sep; 34(3):655-73. PMID: 25168949.
      Citations: 14     Fields:    Translation:Humans
    29. Diaz-Miron JL, Dillon PA, Saini A, Balzer DT, Singh J, Kolovos NS, Duncan JG, Keller MS. Left main coronary artery dissection in pediatric sport-related chest trauma. J Emerg Med. 2014 Aug; 47(2):150-4. PMID: 24928544; PMCID: PMC4537366.
      Citations: 2     Fields:    Translation:Humans
    30. Saini A, Emke AR, Silva MC, Perlman SJ. Response to Eculizumab in Escherichia coli O157: H7-induced hemolytic uremic syndrome with severe neurological manifestations. Clin Pediatr (Phila). 2015 Apr; 54(4):387-9. PMID: 24817079.
      Citations: 6     Fields:    Translation:HumansCells
    31. Saini A, Karmarkar SA, Rongkavilit C, Bolton J, Roth C, English R, Ceri A. Index of suspicion. Pediatr Rev. 2013 Jan; 34(1):41-6. PMID: 23281361.
      Citations:    Fields:    Translation:Humans
    32. Saini A, Karmakar SA, Kannikeswaran N. Concomitant hypercalcemia and hyperammonemia associated with distal renal tubular acidosis. Pediatr Emerg Care. 2012 Mar; 28(3):280-2. PMID: 22391925.
      Citations: 3     Fields:    Translation:Humans
    33. Saini A, Delius RE, Seshadri S, Walters H, Mastropietro CW. Passive peritoneal drainage improves fluid balance after surgery for congenital heart disease. Eur J Cardiothorac Surg. 2012 Feb; 41(2):256-60. PMID: 21715181.
      Citations: 8     Fields:    Translation:Humans
    34. Arya SO, Saini A, El-Baba M, Salimnia H, Abdel-Haq N. Epstein Barr virus-associated acute acalculous cholecystitis: a rare occurrence but favorable outcome. Clin Pediatr (Phila). 2010 Aug; 49(8):799-804. PMID: 20356920.
      Citations: 12     Fields:    Translation:HumansCells
    35. Saini A, Singh V, Chandra J, Dutta AK. Kimura's disease: an unusual glandular involvement with blood and tissue eosinophilia. Indian J Pediatr. 2009 Jun; 76(6):647-8. PMID: 19618146.
      Citations: 3     Fields:    Translation:Humans
    36. Karmarkar SA, Aneja S, Khare S, Saini A, Seth A, Chauhan BK. A study of acute febrile encephalopathy with special reference to viral etiology. Indian J Pediatr. 2008 Aug; 75(8):801-5. PMID: 18769890.
      Citations: 14     Fields:    Translation:Humans
    37. Saini A, Chandra J, Goswami U, Singh V, Dutta AK. Case control study of psychosocial morbidity in beta thalassemia major. J Pediatr. 2007 May; 150(5):516-20. PMID: 17452227.
      Citations: 6     Fields:    Translation:Humans
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