Receptor-Interacting Protein Serine-Threonine Kinase 2
"Receptor-Interacting Protein Serine-Threonine Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RIP serine-theonine kinase that contains a C-terminal caspase activation and recruitment domain. It can signal by associating with other CARD-signaling adaptor proteins and INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.
| Descriptor ID |
D053475
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| MeSH Number(s) |
D08.811.913.696.620.682.700.801.500 D12.644.360.024.131.750 D12.644.360.024.500.186.500 D12.644.360.075.358.750 D12.776.157.057.006.750 D12.776.157.057.500.186.500 D12.776.476.024.139.750 D12.776.476.024.500.186.500 D12.776.476.075.358.750
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| Concept/Terms |
Receptor-Interacting Protein Serine-Threonine Kinase 2- Receptor-Interacting Protein Serine-Threonine Kinase 2
- Receptor Interacting Protein Serine Threonine Kinase 2
- CARDIAK
- Receptor-Interacting Serine-Threonine Kinase 2
- Receptor Interacting Serine Threonine Kinase 2
- RIPK2 Protein
- RICK Protein
- CARD-containing Interleukin (IL)-1 beta Converting Enzyme
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Below are MeSH descriptors whose meaning is more general than "Receptor-Interacting Protein Serine-Threonine Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Receptor-Interacting Protein Serine-Threonine Kinase 2".
This graph shows the total number of publications written about "Receptor-Interacting Protein Serine-Threonine Kinase 2" by people in this website by year, and whether "Receptor-Interacting Protein Serine-Threonine Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor-Interacting Protein Serine-Threonine Kinase 2" by people in Profiles.
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Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem. 2021 Apr 05; 215:113252.
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Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15; 200:112417.
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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 09 03; 37(17).
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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorg Med Chem Lett. 2018 02 15; 28(4):577-583.
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Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 06 02; 534(7605):55-62.
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Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem Biol. 2015 Sep 17; 22(9):1174-84.
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A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. J Biol Chem. 2012 Jul 20; 287(30):25565-76.
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The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb; 8(2):198-205.