"Cathepsin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
| Descriptor ID |
D002402
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| MeSH Number(s) |
D08.811.277.656.074.500.180 D08.811.277.656.224.187 D08.811.277.656.300.048.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin D".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin D".
This graph shows the total number of publications written about "Cathepsin D" by people in this website by year, and whether "Cathepsin D" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsin D" by people in Profiles.
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Deletion of the olfactomedin 4 gene is associated with progression of human prostate cancer. Am J Pathol. 2013 Oct; 183(4):1329-38.
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Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med (Maywood). 2008 Feb; 233(2):155-62.
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American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 2007 Nov 20; 25(33):5287-312.
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Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004 Sep 27; 166(7):1041-54.
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Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity. FASEB J. 2002 Sep; 16(11):1458-60.
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A prospective prognostic study of the hormonal milieu at the time of surgery in premenopausal breast carcinoma. Cancer. 2001 May 15; 91(10):1854-61.
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Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. J Exp Med. 1999 May 17; 189(10):1649-58.
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Expression of cathepsin D during the progression of human gliomas. Neurosci Lett. 1996 Apr 26; 208(3):171-4.
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Cathepsin D by western blotting and immunohistochemistry: failure to confirm correlations with prognosis in node-negative breast cancer. J Clin Oncol. 1994 Mar; 12(3):467-74.
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Prognostic factors in breast cancer. Semin Oncol. 1992 Jun; 19(3):244-53.