Nuclear Receptor Subfamily 4, Group A, Member 1
"Nuclear Receptor Subfamily 4, Group A, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
| Descriptor ID |
D057105
|
| MeSH Number(s) |
D12.776.260.643.400 D12.776.826.209.400
|
| Concept/Terms |
Nuclear Receptor Subfamily 4, Group A, Member 1- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nerve Growth Factor-inducible B Protein
- Nerve Growth Factor inducible B Protein
- Orphan Nuclear Receptor HMR
- Orphan Nuclear Receptor NGFI-B
- Orphan Nuclear Receptor NGFI B
- Orphan Nuclear Receptor NR4A1
- Nuclear Receptor NR4A1
- TR3 Orphan Nuclear Receptor
- Nur77 Orphan Nuclear Receptor
- NGFI-B Orphan Nuclear Receptor
- NGFI B Orphan Nuclear Receptor
- Early Response Protein NAK1
- Orphan Nuclear Receptor TR3
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 1".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in this website by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in Profiles.
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Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer. Cell Death Dis. 2025 Nov 03; 16(1):776.
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Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Nonhormonal Endometriosis Therapy. Endocrinology. 2025 Oct 09; 166(11).
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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology. 2023 08 28; 164(10).
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Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis. Endocrinology. 2020 04 01; 161(4).
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Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors. Sci Rep. 2020 02 18; 10(1):2851.
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Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia. Leukemia. 2019 01; 33(1):52-63.
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NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPa and inflammatory signaling. Blood. 2018 03 08; 131(10):1081-1093.
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Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells. PLoS One. 2016; 11(3):e0150450.
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The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015 Apr; 35(7):1125-38.
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Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013 Mar; 54(3):806-815.