"Folic Acid Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
| Descriptor ID |
D005493
|
| MeSH Number(s) |
D27.505.519.389.350
|
| Concept/Terms |
Folic Acid Antagonists- Folic Acid Antagonists
- Acid Antagonists, Folic
- Antagonists, Folic Acid
- Dihydrofolate Reductase Inhibitors
- Inhibitors, Dihydrofolate Reductase
- Reductase Inhibitors, Dihydrofolate
- Antifolates
|
Below are MeSH descriptors whose meaning is more general than "Folic Acid Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Antagonists".
This graph shows the total number of publications written about "Folic Acid Antagonists" by people in this website by year, and whether "Folic Acid Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 3 | 4 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Folic Acid Antagonists" by people in Profiles.
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Methotrexate-based PROTACs as DHFR-specific chemical probes. Cell Chem Biol. 2024 Feb 15; 31(2):221-233.e14.
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MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers. Nat Commun. 2022 04 04; 13(1):1797.
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Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates. Org Lett. 2017 10 06; 19(19):5220-5223.
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Methotrexate for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2014 Jun 10; (6):CD000957.
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Pemetrexed use in the adjuvant setting for completely resectable non-small-cell lung cancer. Clin Lung Cancer. 2013 Nov; 14(6):601-8.
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Does global hypomethylation contribute to susceptibility to neural tube defects? Am J Clin Nutr. 2010 May; 91(5):1153-4.
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Phase II trial of pemetrexed and gemcitabine in chemotherapy-naive malignant pleural mesothelioma. J Clin Oncol. 2008 Mar 20; 26(9):1465-71.
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Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr. 2008 Jan; 152(1):101-5.
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Searching for the Achilles' heel of melanoma cells: new treatment modalities. Pigment Cell Melanoma Res. 2008 Oct; 21(5):505-6.
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Phase I trial and pharmacokinetic study of pemetrexed in children with refractory solid tumors: the Children's Oncology Group. J Clin Oncol. 2007 Apr 20; 25(12):1505-11.