Folic Acid Antagonists

"Folic Acid Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

Descriptor ID	D005493
MeSH Number(s)	D27.505.519.389.350
Concept/Terms	Folic Acid Antagonists Folic Acid Antagonists Acid Antagonists, Folic Antagonists, Folic Acid Dihydrofolate Reductase Inhibitors Inhibitors, Dihydrofolate Reductase Reductase Inhibitors, Dihydrofolate Antifolates Folic Acid Metabolism Inhibitors Folic Acid Metabolism Inhibitors

Below are MeSH descriptors whose meaning is more general than "Folic Acid Antagonists".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Folic Acid Antagonists [D27.505.519.389.350]

Below are MeSH descriptors whose meaning is related to "Folic Acid Antagonists".

Below are MeSH descriptors whose meaning is more specific than "Folic Acid Antagonists".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Folic Acid Antagonists" by people in this website by year, and whether "Folic Acid Antagonists" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1997	1	0	1
1999	1	0	1
2000	1	0	1
2001	1	0	1
2002	2	1	3
2003	1	1	2
2005	0	1	1
2006	1	0	1
2007	1	3	4
2008	0	1	1
2010	1	0	1
2013	1	0	1
2014	1	0	1
2022	1	0	1

Below are the most recent publications written about "Folic Acid Antagonists" by people in Profiles.

Alhalabi O, Chen J, Zhang Y, Lu Y, Wang Q, Ramachandran S, Tidwell RS, Han G, Yan X, Meng J, Wang R, Hoang AG, Wang WL, Song J, Lopez L, Andreev-Drakhlin A, Siefker-Radtke A, Zhang X, Benedict WF, Shah AY, Wang J, Msaouel P, Zhang M, Guo CC, Czerniak B, Behrens C, Soto L, Papadimitrakopoulou V, Lewis J, Rinsurongkawong W, Rinsurongkawong V, Lee J, Roth J, Swisher S, Wistuba I, Heymach J, Wang J, Campbell MT, Efstathiou E, Titus M, Logothetis CJ, Ho TH, Zhang J, Wang L, Gao J. MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers. Nat Commun. 2022 04 04; 13(1):1797.

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Dawadi S, Kordus SL, Baughn AD, Aldrich CC. Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates. Org Lett. 2017 10 06; 19(19):5220-5223.

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Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME. Methotrexate for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2014 Jun 10; (6):CD000957.

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Simon GR, Manegold C, Barker SS, Treat JA, Visseren-Grul C, Obasaju C. Pemetrexed use in the adjuvant setting for completely resectable non-small-cell lung cancer. Clin Lung Cancer. 2013 Nov; 14(6):601-8.

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Finnell RH, Blom HJ, Shaw GM. Does global hypomethylation contribute to susceptibility to neural tube defects? Am J Clin Nutr. 2010 May; 91(5):1153-4.

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Jänne PA, Simon GR, Langer CJ, Taub RN, Dowlati A, Fidias P, Monberg M, Obasaju C, Kindler H. Phase II trial of pemetrexed and gemcitabine in chemotherapy-naive malignant pleural mesothelioma. J Clin Oncol. 2008 Mar 20; 26(9):1465-71.

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Krull KR, Brouwers P, Jain N, Zhang L, Bomgaars L, Dreyer Z, Mahoney D, Bottomley S, Okcu MF. Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr. 2008 Jan; 152(1):101-5.

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Melnikova VO, Bar-Eli M. Searching for the Achilles' heel of melanoma cells: new treatment modalities. Pigment Cell Melanoma Res. 2008 Oct; 21(5):505-6.

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Malempati S, Nicholson HS, Reid JM, Blaney SM, Ingle AM, Krailo M, Stork LC, Melemed AS, McGovern R, Safgren S, Ames MM, Adamson PC. Phase I trial and pharmacokinetic study of pemetrexed in children with refractory solid tumors: the Children's Oncology Group. J Clin Oncol. 2007 Apr 20; 25(12):1505-11.

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Apostolidou E, Swords R, Alvarado Y, Giles FJ. Treatment of acute lymphoblastic leukaemia : a new era. Drugs. 2007; 67(15):2153-71.

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