"Pyruvate Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
| Descriptor ID |
D011770
|
| MeSH Number(s) |
D08.811.913.696.620.695
|
| Concept/Terms |
Pyruvate Kinase L- Pyruvate Kinase L
- L-Type Pyruvate Kinase
- L Type Pyruvate Kinase
- Pyruvate Kinase, L-Type
|
Below are MeSH descriptors whose meaning is more general than "Pyruvate Kinase".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Kinase".
This graph shows the total number of publications written about "Pyruvate Kinase" by people in this website by year, and whether "Pyruvate Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyruvate Kinase" by people in Profiles.
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Diagnosis, monitoring, and management of pyruvate kinase deficiency in children. Pediatr Blood Cancer. 2022 08; 69(8):e29696.
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Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration. Proc Natl Acad Sci U S A. 2021 02 09; 118(6).
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Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2020 06; 121:103366.
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Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
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PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat Commun. 2014 Nov 21; 5:5566.
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Estradiol-17? upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-a and to integrate metabolic reprogramming with the mitogenic response in endometrial cells. J Clin Endocrinol Metab. 2014 Oct; 99(10):3790-9.
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Nuclear PKM2 regulates ?-catenin transactivation upon EGFR activation. Nature. 2011 Dec 01; 480(7375):118-22.
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Study of the molecular defects in pyruvate kinase deficient patients affected by nonspherocytic hemolytic anemia. Blood Cells Mol Dis. 1995; 21(1):49-55.
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Harvest of young red cells on an automated cell separator. Transfusion. 1984 Jul-Aug; 24(4):330-2.
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The progeny of a single progenitor cell can develop characteristics of either a tissue or an alveolar macrophage. Blood. 1981 Jan; 57(1):95-8.