Retinal Pigment Epithelium
"Retinal Pigment Epithelium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
| Descriptor ID |
D055213
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| MeSH Number(s) |
A09.371.670.500 A09.371.729.887
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Retinal Pigment Epithelium".
Below are MeSH descriptors whose meaning is more specific than "Retinal Pigment Epithelium".
This graph shows the total number of publications written about "Retinal Pigment Epithelium" by people in this website by year, and whether "Retinal Pigment Epithelium" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 4 | 6 |
| 2019 | 3 | 1 | 4 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Retinal Pigment Epithelium" by people in Profiles.
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Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling. EMBO Rep. 2025 12; 26(24):6096-6120.
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Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis. Redox Biol. 2022 08; 54:102375.
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Expanding the clinical phenotype in patients with disease causing variants associated with atypical Usher syndrome. Ophthalmic Genet. 2021 12; 42(6):664-673.
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MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. FASEB J. 2020 09; 34(9):12502-12520.
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Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance. EMBO J. 2020 04 15; 39(8):e102468.
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Diffuse Outer Layer Opacification: A Novel Finding in Patients With Autosomal Recessive Bestrophinopathy. Asia Pac J Ophthalmol (Phila). 2019 Nov-Dec; 8(6):469-475.
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Low-Luminance Blue Light-Enhanced Phototoxicity in A2E-Laden RPE Cell Cultures and Rats. Int J Mol Sci. 2019 Apr 11; 20(7).
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Large Combined Hamartoma of the Retina and the Retinal Pigment Epithelium in a Healthy Young Boy. JAMA Ophthalmol. 2019 Mar 01; 137(3):e184201.
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Flavin Imbalance as an?Important Player in Diabetic Retinopathy. Adv Exp Med Biol. 2019; 1185:575-579.
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Vigabatrin: Lessons Learned From the United States Experience. J Neuroophthalmol. 2018 12; 38(4):442-450.