"Thymidine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
| Descriptor ID |
D013937
|
| MeSH Number(s) |
D08.811.913.696.620.750
|
| Concept/Terms |
Thymidine Kinase- Thymidine Kinase
- Kinase, Thymidine
- Deoxypyrimidine Kinase
- Kinase, Deoxypyrimidine
- Deoxythymidine Kinase
- Kinase, Deoxythymidine
|
Below are MeSH descriptors whose meaning is more general than "Thymidine Kinase".
Below are MeSH descriptors whose meaning is more specific than "Thymidine Kinase".
This graph shows the total number of publications written about "Thymidine Kinase" by people in this website by year, and whether "Thymidine Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 4 | 3 | 7 |
| 1996 | 8 | 3 | 11 |
| 1997 | 6 | 3 | 9 |
| 1998 | 5 | 2 | 7 |
| 1999 | 5 | 4 | 9 |
| 2000 | 2 | 5 | 7 |
| 2001 | 3 | 8 | 11 |
| 2002 | 8 | 5 | 13 |
| 2003 | 1 | 3 | 4 |
| 2004 | 7 | 2 | 9 |
| 2005 | 3 | 0 | 3 |
| 2006 | 1 | 2 | 3 |
| 2007 | 4 | 2 | 6 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 2 | 2 | 4 |
| 2011 | 3 | 3 | 6 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Thymidine Kinase" by people in Profiles.
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A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2022 10 14; 28(20):4392-4401.
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Selection of human single domain antibodies (sdAb) against thymidine kinase 1 and their incorporation into sdAb-Fc antibody constructs for potential use in cancer therapy. PLoS One. 2022; 17(3):e0264822.
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Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor-positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT). Eur J Cancer. 2019 06; 114:55-66.
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Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol. 2018 12; 16(12):e2005907.
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Clinical and molecular spectrum of thymidine kinase 2-related mtDNA maintenance defect. Mol Genet Metab. 2018 06; 124(2):124-130.
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Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib. Breast Cancer Res. 2017 Nov 21; 19(1):123.
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Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. Mol Imaging Biol. 2016 12; 18(6):838-848.
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Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. Neurosurgery. 2016 Sep; 79(3):481-91.
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[(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility. Mol Ther. 2015 Jun; 23(6):1110-1122.
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Microchip immunoaffinity electrophoresis of antibody-thymidine kinase 1 complex. Electrophoresis. 2015 Mar; 36(5):813-7.