"Glucokinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.
| Descriptor ID |
D005941
|
| MeSH Number(s) |
D08.811.913.696.620.250
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Glucokinase".
Below are MeSH descriptors whose meaning is more specific than "Glucokinase".
This graph shows the total number of publications written about "Glucokinase" by people in this website by year, and whether "Glucokinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 2001 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glucokinase" by people in Profiles.
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GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated. Acta Diabetol. 2016 Oct; 53(5):703-8.
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SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E6068-77.
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Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PLoS One. 2013; 8(8):e74340.
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The anorectic effect of GLP-1 in rats is nutrient dependent. PLoS One. 2012; 7(12):e51870.
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Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients. J Med Chem. 2012 Aug 23; 55(16):7021-36.
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Glucose metabolism gene variants modulate the risk of pancreatic cancer. Cancer Prev Res (Phila). 2011 May; 4(5):758-66.
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A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome. Diabetes Care. 2009 May; 32(5):873-7.
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Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem. 2005 Nov 18; 280(46):38689-99.
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Endocrine pancreas in insulin receptor-deficient mouse pups. Diabetes. 2001 Feb; 50 Suppl 1:S146-9.
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Partial structure of the mouse glucokinase gene. Genomics. 1995 Oct 10; 29(3):751-4.