"Gelsolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
| Descriptor ID |
D018260
|
| MeSH Number(s) |
D05.750.078.730.350 D12.644.360.372.437 D12.776.157.125.412.437 D12.776.220.525.350 D12.776.476.387.437
|
| Concept/Terms |
Gelsolin- Gelsolin
- Gelsolin Protein
- Serum Actin Inhibitory Protein
|
Below are MeSH descriptors whose meaning is more general than "Gelsolin".
Below are MeSH descriptors whose meaning is more specific than "Gelsolin".
This graph shows the total number of publications written about "Gelsolin" by people in this website by year, and whether "Gelsolin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gelsolin" by people in Profiles.
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Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. J Neurosci. 2022 03 02; 42(9):1679-1691.
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Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018 04; 154(5):1405-1420.e2.
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Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin. Am J Respir Cell Mol Biol. 2017 05; 56(5):628-636.
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A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants. Int J Cancer. 2016 11 01; 139(9):2012-20.
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Urinary proteome analysis of irritable bowel syndrome (IBS) symptom subgroups. J Proteome Res. 2012 Dec 07; 11(12):5650-62.
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Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res. 2012 Mar 02; 11(3):1937-48.
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The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence. Biochemistry. 2007 Jun 26; 46(25):7488-96.
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Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer. 2006 Aug 01; 6:203.
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Ewing sarcoma family of tumors. Adv Anat Pathol. 2005 Jul; 12(4):212-20.
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Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer. Lung Cancer. 2004 Oct; 46(1):29-42.