"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
| Descriptor ID |
D016335
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985
|
| Concept/Terms |
Zinc Fingers- Zinc Fingers
- Finger, Zinc
- Fingers, Zinc
- Zinc Finger
- Zinc Finger Motifs
- Motif, Zinc Finger
- Motifs, Zinc Finger
- Zinc Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".
This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 2 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Zinc Fingers" by people in Profiles.
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De Novo Truncating Variants in ZNF865 Cause a Novel Neurodevelopmental Disorder. Am J Med Genet A. 2026 Jan; 200(1):244-252.
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Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis. Nat Cell Biol. 2025 Sep; 27(9):1496-1509.
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DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders. Am J Hum Genet. 2025 Feb 06; 112(2):394-413.
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Neurodevelopmental and other phenotypes recurrently associated with heterozygous BAZ2B loss-of-function variants. Am J Med Genet A. 2024 03; 194(3):e63445.
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An Integrated Phenotypic and Genotypic Approach Reveals a High-Risk Subtype Association for EBF3 Missense Variants Affecting the Zinc Finger Domain. Ann Neurol. 2022 07; 92(1):138-153.
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Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579.
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Nuclear localization signal region in nuclear receptor PXR governs the receptor association with mitotic chromatin. Chromosome Res. 2018 12; 26(4):255-276.
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Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail. J Thorac Cardiovasc Surg. 2017 11; 154(5):1601-1610.e3.
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Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability. Nucleic Acids Res. 2017 02 17; 45(3):1130-1143.
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A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3. Am J Hum Genet. 2017 Jan 05; 100(1):128-137.