"Interleukin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
| Descriptor ID |
D007375
|
| MeSH Number(s) |
D12.644.276.374.465.010 D12.644.276.374.500.400 D12.776.467.374.465.010 D12.776.467.374.500.400 D23.529.374.465.131 D23.529.374.500.400
|
| Concept/Terms |
Interleukin-1- Interleukin-1
- Interleukin 1
- IL-1
- T Helper Factor
- Lymphocyte-Activating Factor
- Lymphocyte Activating Factor
- Macrophage Cell Factor
- Epidermal Cell Derived Thymocyte-Activating Factor
- Epidermal Cell Derived Thymocyte Activating Factor
- Interleukin I
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-1".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1".
This graph shows the total number of publications written about "Interleukin-1" by people in this website by year, and whether "Interleukin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 3 | 4 |
| 1997 | 1 | 2 | 3 |
| 1998 | 0 | 5 | 5 |
| 1999 | 2 | 3 | 5 |
| 2000 | 3 | 2 | 5 |
| 2001 | 4 | 4 | 8 |
| 2002 | 3 | 10 | 13 |
| 2003 | 4 | 10 | 14 |
| 2004 | 2 | 5 | 7 |
| 2005 | 4 | 7 | 11 |
| 2006 | 3 | 3 | 6 |
| 2007 | 1 | 2 | 3 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 2 | 3 |
| 2025 | 1 | 0 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-1" by people in Profiles.
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Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease. Ocul Surf. 2025 04; 36:83-93.
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IL-36 in chronic inflammation and fibrosis - bridging the gap? J Clin Invest. 2021 01 19; 131(2).
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Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats. Diab Vasc Dis Res. 2012 Oct; 9(4):315-9.
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Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4592-7.
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Constitutive aberrant endogenous interleukin-1 facilitates inflammation and growth in human melanoma. Mol Cancer Res. 2011 Nov; 9(11):1537-50.
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Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling. J Virol. 2011 Jul; 85(13):6212-9.
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Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain. 2010 Sep; 150(3):550-560.
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Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions. Clin Cancer Res. 2010 Jan 01; 16(1):34-44.
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MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma. Cancer. 2009 Sep 01; 115(17):3897-908.
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Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem. 2009 Jun 26; 284(26):17766-74.