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GEORGE RODNEY JR.

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    R21NS085208     (RODNEY, GEORGE G)May 15, 2014 - Apr 30, 2017
    NIH
    MANGANESE ENHANCED MRI: NON-INVASIVE MEASURE OF PATHOGENESIS OF DYSTROPHINOPATHY
    Role: Principal Investigator
    R01AR061370     (RODNEY, GEORGE G)Aug 1, 2012 - Jul 31, 2022
    NIH/NIAMS
    NADPH Oxidase and Autophagic Dysfunction in Duchenne Muscular Dystrophy
    Role: Principal Investigator
    R01AR053349     (HAMILTON, SUSAN L)Dec 1, 2005 - Mar 31, 2021
    NIH
    Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core Disease
    Role: Co-Principal Investigator
    K01AR051519     (RODNEY, GEORGE G)May 1, 2005 - Apr 30, 2011
    NIH/NIAMS
    Calmodulin &Calmodulin Binding Domains in E-C Coupling
    Role: Principal Investigator
    F32NS044636     (RODNEY, GEORGE G)Mar 21, 2003
    NIH/NINDS
    Regulation of Calcium Release by Calmodulin in Muscle
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang C, Joshi A, Liu Y, Sert O, Haddix SG, Teliska LH, Rasband A, Rodney GG, Rasband MN. Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. Curr Biol. 2021 09 13; 31(17):3810-3819.e4. PMID: 34289389; PMCID: PMC8440394.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Cheng N, Mo Q, Donelson J, Wang L, Breton G, Rodney GG, Wang J, Hirschi KD, Wehrens XHT, Nakata PA. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883. PMID: 34345213; PMCID: PMC8326124.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Cully TR, Rodney GG. Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle. Redox Biol. 2020 09; 36:101557. PMID: 32506037; PMCID: PMC7283154.
      Citations: 8     Fields:    Translation:Animals
    4. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071. PMID: 31033205; PMCID: PMC6487472.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Ferguson DP, Monroe TO, Heredia CP, Fleischmann R, Rodney GG, Taffet GE, Fiorotto ML. Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity. J Physiol. 2019 04; 597(7):1855-1872. PMID: 30730556; PMCID: PMC6441894.
      Citations: 4     Fields:    Translation:Animals
    6. Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF. YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7. PMID: 30773489; PMCID: PMC6435425.
      Citations: 62     Fields:    Translation:AnimalsCells
    7. Kitagawa MG, Reynolds JO, Durgan D, Rodney G, Karmouty-Quintana H, Bryan R, Pandit LM. Twik-2-/- mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility. Physiol Rep. 2019 01; 7(1):e13950. PMID: 30632293; PMCID: PMC6328926.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Olthoff JT, Lindsay A, Abo-Zahrah R, Baltgalvis KA, Patrinostro X, Belanto JJ, Yu DY, Perrin BJ, Garry DJ, Rodney GG, Lowe DA, Ervasti JM. Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle. Nat Commun. 2018 11 30; 9(1):5104. PMID: 30504831; PMCID: PMC6269445.
      Citations: 13     Fields:    Translation:Animals
    9. Pal R, Palmieri M, Chaudhury A, di Ronza A, Neilson JR, Rodney GG, Sardiello M, Klisch TJ. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 10 19; 9(1):4351. PMID: 30341294; PMCID: PMC6195609.
      Citations: 15     Fields:    Translation:Cells
    10. Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH. Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet. 2018 08 02; 103(2):276-287. PMID: 30075114; PMCID: PMC6080833.
      Citations: 6     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    11. Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682. PMID: 29654126; PMCID: PMC5903581.
      Citations: 18     Fields:    Translation:AnimalsCells
    12. Loehr JA, Wang S, Cully TR, Pal R, Larina IV, Larin KV, Rodney GG. NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife. 2018 01 30; 7. PMID: 29381135; PMCID: PMC5812717.
      Citations: 15     Fields:    Translation:AnimalsCells
    13. Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17). PMID: 28878117; PMCID: PMC5621883.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    14. Sopariwala DH, Yadav V, Badin PM, Likhite N, Sheth M, Lorca S, Vila IK, Kim ER, Tong Q, Song MS, Rodney GG, Narkar VA. Long-term PGC1? overexpression leads to apoptosis, autophagy and muscle wasting. Sci Rep. 2017 08 31; 7(1):10237. PMID: 28860475; PMCID: PMC5578977.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA. Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 08 11; 6. PMID: 28826478; PMCID: PMC5577920.
      Citations: 28     Fields:    Translation:AnimalsCells
    16. Pal R, Bondar VV, Adamski CJ, Rodney GG, Sardiello M. Inhibition of ERK1/2 Restores GSK3? Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis. Sci Rep. 2017 06 23; 7(1):4174. PMID: 28646232; PMCID: PMC5482840.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659. PMID: 28337975; PMCID: PMC5376670.
      Citations: 34     Fields:    Translation:AnimalsCells
    18. Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 02 06; 8:14338. PMID: 28165011; PMCID: PMC5303831.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    19. Giudice J, Loehr JA, Rodney GG, Cooper TA. Alternative Splicing of Four Trafficking Genes Regulates Myofiber Structure and Skeletal Muscle Physiology. Cell Rep. 2016 11 15; 17(8):1923-1933. PMID: 27851958; PMCID: PMC5140099.
      Citations: 17     Fields:    Translation:AnimalsCells
    20. Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639; PMCID: PMC5133989.
      Citations: 10     Fields:    Translation:HumansCells
    21. Loehr JA, Stinnett GR, Roten WT, Wilson LJ, Pautler RG, Rodney GG, Hern?ndez-Rivera M. Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese-enhanced magnetic resonance imaging. J Physiol. 2016 11 01; 594(21):6395-6405. PMID: 27555555; PMCID: PMC5088246.
      Citations: 10     Fields:    Translation:Animals
    22. Rodney GG, Pal R, Abo-Zahrah R. Redox regulation of autophagy in skeletal muscle. Free Radic Biol Med. 2016 09; 98:103-112. PMID: 27184957; PMCID: PMC4975974.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    23. Pal R, Bajaj L, Sharma J, Palmieri M, Di Ronza A, Lotfi P, Chaudhury A, Neilson J, Sardiello M, Rodney GG. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease. Sci Rep. 2016 Mar 10; 6:22866. PMID: 26960433; PMCID: PMC4785399.
      Citations: 25     Fields:    Translation:HumansCells
    24. Wang Q, Wang W, Wang G, Rodney GG, Wehrens XH. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84. PMID: 26555638; PMCID: PMC4689641.
      Citations: 20     Fields:    Translation:AnimalsCells
    25. Pham K, Pal R, Qu Y, Liu X, Yu H, Shiao SL, Wang X, O'Brian Smith E, Cui X, Rodney GG, Cheng N. Nuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell death. Free Radic Biol Med. 2015 Aug; 85:197-206. PMID: 25975981; PMCID: PMC4902114.
      Citations: 7     Fields:    Translation:HumansCells
    26. Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL, Poch? RA. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skelet Muscle. 2015; 5:4. PMID: 25717360; PMCID: PMC4340672.
      Citations: 29     Fields:    
    27. Loehr JA, Abo-Zahrah R, Pal R, Rodney GG. Sphingomyelinase promotes oxidant production and skeletal muscle contractile dysfunction through activation of NADPH oxidase. Front Physiol. 2014; 5:530. PMID: 25653619; PMCID: PMC4300905.
      Citations: 12     
    28. Pal R, Palmieri M, Loehr JA, Li S, Abo-Zahrah R, Monroe TO, Thakur PB, Sardiello M, Rodney GG. Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nat Commun. 2014 Jul 16; 5:4425. PMID: 25028121; PMCID: PMC4101811.
      Citations: 81     Fields:    Translation:Animals
    29. Pal R, Monroe TO, Palmieri M, Sardiello M, Rodney GG. Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. FEBS Lett. 2014 Jan 31; 588(3):472-81. PMID: 24374334; PMCID: PMC3932663.
      Citations: 14     Fields:    Translation:HumansCells
    30. Pal R, Basu Thakur P, Li S, Minard C, Rodney GG. Real-time imaging of NADPH oxidase activity in living cells using a novel fluorescent protein reporter. PLoS One. 2013; 8(5):e63989. PMID: 23704967; PMCID: PMC3660327.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    31. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Jan 08; 18(2):244-51. PMID: 22231556; PMCID: PMC3274651.
      Citations: 55     Fields:    Translation:AnimalsCells
    32. Xiong LW, Newman RA, Rodney GG, Thomas O, Zhang JZ, Persechini A, Shea MA, Hamilton SL. Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin. J Biol Chem. 2002 Oct 25; 277(43):40862-70. PMID: 12185083.
      Citations: 27     Fields:    Translation:AnimalsCells
    33. Rodney GG, Krol J, Williams B, Beckingham K, Hamilton SL. The carboxy-terminal calcium binding sites of calmodulin control calmodulin's switch from an activator to an inhibitor of RYR1. Biochemistry. 2001 Oct 16; 40(41):12430-5. PMID: 11591164.
      Citations: 10     Fields:    Translation:AnimalsCells
    34. Pate P, Mochca-Morales J, Wu Y, Zhang JZ, Rodney GG, Serysheva II, Williams BY, Anderson ME, Hamilton SL. Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J Biol Chem. 2000 Dec 15; 275(50):39786-92. PMID: 11005820.
      Citations: 53     Fields:    Translation:AnimalsCells
    35. Rodney GG, Moore CP, Williams BY, Zhang JZ, Krol J, Pedersen SE, Hamilton SL. Calcium binding to calmodulin leads to an N-terminal shift in its binding site on the ryanodine Receptor. J Biol Chem. 2001 Jan 19; 276(3):2069-74. PMID: 11035044.
      Citations: 36     Fields:    Translation:Cells
    36. Rodney GG, Williams BY, Strasburg GM, Beckingham K, Hamilton SL. Regulation of RYR1 activity by Ca(2+) and calmodulin. Biochemistry. 2000 Jul 04; 39(26):7807-12. PMID: 10869186.
      Citations: 43     Fields:    Translation:AnimalsCells
    37. Moore CP, Rodney G, Zhang JZ, Santacruz-Toloza L, Strasburg G, Hamilton SL. Apocalmodulin and Ca2+ calmodulin bind to the same region on the skeletal muscle Ca2+ release channel. Biochemistry. 1999 Jun 29; 38(26):8532-7. PMID: 10387100.
      Citations: 41     Fields:    Translation:AnimalsCells
    38. Zhang JZ, Wu Y, Williams BY, Rodney G, Mandel F, Strasburg GM, Hamilton SL. Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding. Am J Physiol. 1999 Jan; 276(1 Pt 1):C46-53. PMID: 9886919.
      Citations: 14     Fields:    Translation:AnimalsCells
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