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MILLS, GORDON B
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Academic Article Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer.
Academic Article Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Academic Article WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome.
Academic Article Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.
Academic Article Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward.
Academic Article Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Academic Article Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
Academic Article Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
Academic Article Integrative epidemiology: from risk assessment to outcome prediction.
Academic Article Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival.
Academic Article ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.
Academic Article Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer.
Academic Article Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
Academic Article Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Academic Article Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Academic Article The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Academic Article Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Academic Article Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Academic Article The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Academic Article Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells.
Academic Article Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Academic Article A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Academic Article Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
Academic Article Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Academic Article Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
Academic Article Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment.
Academic Article CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
Academic Article Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.
Academic Article Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer.
Academic Article A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility.
Academic Article Lysophosphatidic acid production and action: validated targets in cancer?
Academic Article The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
Academic Article Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Academic Article Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
Academic Article Exploratory analysis of the copy number alterations in glioblastoma multiforme.
Academic Article Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study.
Academic Article Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
Academic Article High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Academic Article Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
Academic Article Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
Concept Neoplasms, Basal Cell
Concept Gastrointestinal Stromal Tumors
Concept Thyroid Neoplasms
Concept Nerve Sheath Neoplasms
Concept Genital Neoplasms, Female
Concept Central Nervous System Neoplasms
Concept Tumor Necrosis Factors
Concept Breast Neoplasms, Male
Concept Mammary Neoplasms, Experimental
Concept Mammary Tumor Virus, Mouse
Concept Tumor Burden
Concept Esophageal Neoplasms
Concept Brain Neoplasms
Concept Lung Neoplasms
Concept Uterine Neoplasms
Concept Neoplasms, Germ Cell and Embryonal
Concept Tumor Suppressor Protein p53
Concept Prostatic Neoplasms
Concept Neoplasm Metastasis
Concept Genes, Tumor Suppressor
Concept Hematologic Neoplasms
Concept Tumor Necrosis Factor Receptor Superfamily, Member 7
Concept Mammary Neoplasms, Animal
Concept Neoplasms, Cystic, Mucinous, and Serous
Concept Biomarkers, Tumor
Concept Antigens, Neoplasm
Concept Gallbladder Neoplasms
Concept Ovarian Neoplasms
Concept Nasopharyngeal Neoplasms
Concept Antigens, Tumor-Associated, Carbohydrate
Concept Laryngeal Neoplasms
Concept DNA, Neoplasm
Concept Mediastinal Neoplasms
Concept Prostatic Intraepithelial Neoplasia
Concept Urinary Bladder Neoplasms
Concept Uveal Neoplasms
Concept Retroperitoneal Neoplasms
Concept Neoplasms, Experimental
Concept Colorectal Neoplasms
Concept Pancreatic Neoplasms
Concept Neoplasm Proteins
Concept Neoplasm Staging
Concept Tumor Escape
Concept Kidney Neoplasms
Concept Drug Resistance, Neoplasm
Concept Neoplasm Transplantation
Concept Mouth Neoplasms
Concept Breast Neoplasms
Concept Stomach Neoplasms
Concept Bone Neoplasms
Concept Tumor Stem Cell Assay
Concept Antibodies, Neoplasm
Concept Tumor Cells, Cultured
Concept Head and Neck Neoplasms
Concept Lymphocytes, Tumor-Infiltrating
Concept Oropharyngeal Neoplasms
Concept Neoplasms, Glandular and Epithelial
Concept Neoplasms, Hormone-Dependent
Concept Tumor Necrosis Factor-alpha
Concept Von Hippel-Lindau Tumor Suppressor Protein
Concept Neoplasms
Concept Skin Neoplasms
Concept Neoplasm, Residual
Concept Tongue Neoplasms
Concept Colonic Neoplasms
Concept Cell Line, Tumor
Concept Tumor Suppressor Proteins
Concept Neoplasm Recurrence, Local
Concept Peritoneal Neoplasms
Concept Genes, Neoplasm
Concept RNA, Neoplasm
Concept Liver Neoplasms
Concept Uterine Cervical Neoplasms
Concept Soft Tissue Neoplasms
Concept Liver Neoplasms, Experimental
Concept Neoplasm Invasiveness
Concept Testicular Neoplasms
Concept Endometrial Neoplasms
Academic Article HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Academic Article ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Academic Article PTK6 regulates IGF-1-induced anchorage-independent survival.
Academic Article Exposing the cancer genome atlas as a SPARQL endpoint.
Academic Article Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
Academic Article A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.
Academic Article Comprehensive molecular characterization of clear cell renal cell carcinoma.
Academic Article The Cancer Genome Atlas Pan-Cancer analysis project.
Academic Article The somatic genomic landscape of glioblastoma.
Academic Article Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer.
Academic Article A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes.
Academic Article LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
Academic Article Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.
Academic Article Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
Academic Article Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Academic Article Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Academic Article Integrated genomic analyses of ovarian carcinoma.
Academic Article Molecular characterization of gallbladder cancer using somatic mutation profiling.
Academic Article Genome-wide transcriptome profiling of homologous recombination DNA repair.
Academic Article Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Academic Article Unraveling the regulatory connections between two controllers of breast cancer cell fate.
Academic Article Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.
Academic Article Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels.
Academic Article Assessing the clinical utility of cancer genomic and proteomic data across tumor types.
Academic Article Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.
Academic Article Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
Academic Article Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival.
Academic Article Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Academic Article Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.
Academic Article Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.
Academic Article A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.
Academic Article Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.
Academic Article Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Academic Article RET fusion as a novel driver of medullary thyroid carcinoma.
Academic Article Functional consequence of the MET-T1010I polymorphism in breast cancer.
Academic Article Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.
Academic Article Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c).
Academic Article Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
Academic Article Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus.
Academic Article XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.
Academic Article Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells.
Academic Article Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
Academic Article Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.
Academic Article Early detection of ovarian cancer: promise and reality.
Academic Article Mechanisms underlying chemoprevention of ovarian cancer.
Academic Article Use of proteomic patterns in serum to identify ovarian cancer.
Academic Article Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Academic Article Specific keynote: molecular therapeutics in ovarian cancer.
Academic Article The emerging role of lysophosphatidic acid in cancer.
Academic Article Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
Academic Article Determinants of rapamycin sensitivity in breast cancer cells.
Academic Article Analysis of molecular aberrations in ovarian cancer allows novel target identification.
Academic Article Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Academic Article The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Academic Article Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Academic Article Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
Academic Article Assay of Rab25 function in ovarian and breast cancers.
Academic Article Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers.
Academic Article Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling.
Academic Article Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein.
Academic Article Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
Academic Article An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.
Academic Article Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Academic Article Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Academic Article Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Academic Article Pharmacodynamic markers of perifosine efficacy.
Academic Article Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
Academic Article Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer.
Academic Article AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Academic Article The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Academic Article Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
Academic Article Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Academic Article Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Academic Article Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma.
Academic Article Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Academic Article Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Academic Article Vimentin is a novel AKT1 target mediating motility and invasion.
Academic Article Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.
Academic Article Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.
Academic Article Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Academic Article Drosophila in cancer research: to boldly go where no one has gone before.
Academic Article ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Academic Article Androgen regulation of 5a-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.
Academic Article Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
Academic Article An emerging toolkit for targeted cancer therapies.
Academic Article Detection algorithm for the validation of human cell lines.
Academic Article MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
Academic Article Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Academic Article Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
Academic Article Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Academic Article Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy.
Academic Article Rab25 in cancer: a brief update.
Academic Article Repurposing the Pap smear: one step closer to gynecologic cancer screening.
Academic Article Systematic identification of combinatorial drivers and targets in cancer cell lines.
Academic Article Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.
Academic Article TCPA: a resource for cancer functional proteomics data.
Academic Article Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women.
Academic Article Modeling precision treatment of breast cancer.
Academic Article Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations.
Academic Article Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes.
Academic Article Promising rationally derived combination therapy with PI3K and CDK4/6 inhibitors.
Academic Article Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma.
Academic Article Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells.
Academic Article Expression of TTK, a novel human protein kinase, is associated with cell proliferation.
Academic Article Expression of ras oncogene leads to down-regulation of protein kinase C.
Academic Article Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells.
Academic Article Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Academic Article A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action.
Academic Article CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
Academic Article Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro.
Academic Article CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.
Academic Article Elevated levels and altered fatty acid composition of plasma lysophosphatidylcholine(lysoPC) in ovarian cancer patients.
Academic Article The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Academic Article Expression of p16 induces transcriptional downregulation of the RB gene.
Academic Article p202 prevents apoptosis in murine AKR-2B fibroblasts.
Academic Article Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.
Academic Article Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Academic Article NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Academic Article PIK3CA is implicated as an oncogene in ovarian cancer.
Academic Article Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Academic Article The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
Academic Article Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors.
Academic Article Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
Academic Article In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).
Academic Article Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Academic Article Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Academic Article A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells.
Academic Article Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Academic Article Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
Academic Article Genetic analysis of early- versus late-stage ovarian tumors.
Academic Article Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
Academic Article Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
Academic Article Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.
Academic Article General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer.
Academic Article Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
Academic Article Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
Academic Article ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Academic Article Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
Academic Article Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Academic Article Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Academic Article Promising directions for the diagnosis and management of gynecological cancers.
Academic Article Molecular therapeutics: promise and challenges.
Academic Article Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Academic Article Emerging role of RAB GTPases in cancer and human disease.
Academic Article Stem cell-ness: a "magic marker" for cancer.
Academic Article mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Academic Article Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages.
Academic Article Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Academic Article Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
Academic Article Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Academic Article Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Academic Article Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Academic Article The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Academic Article Prevention and early detection of ovarian cancer: mission impossible?
Academic Article Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
Academic Article Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.
Academic Article A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.
Academic Article International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers.
Academic Article Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
Academic Article A sequence-based survey of the complex structural organization of tumor genomes.
Academic Article Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.
Academic Article Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Academic Article Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients.
Academic Article Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Academic Article Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Academic Article Uniparental disomy in cancer.
Academic Article Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Academic Article Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
Academic Article Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Academic Article Genomic amplicons target vesicle recycling in breast cancer.
Academic Article Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Academic Article The emerging role of the RAB25 small GTPase in cancer.
Academic Article miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells.
Academic Article Ras-superfamily GTP-ases in ovarian cancer.
Academic Article ATX-LPA receptor axis in inflammation and cancer.
Academic Article Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Academic Article Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set.
Academic Article Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.
Academic Article Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.
Academic Article PI3K pathway-directed therapeutic strategies in cancer.
Academic Article Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
Academic Article Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer.
Academic Article Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Academic Article Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
Academic Article Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.
Academic Article Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
Academic Article Quantitative proteomic analysis in breast cancer.
Academic Article Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
Academic Article PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.
Academic Article Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.
Academic Article MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.
Academic Article HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.
Academic Article Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
Academic Article Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
Academic Article Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.
Academic Article Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Academic Article Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.
Academic Article Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Academic Article cMET and phospho-cMET protein levels in breast cancers and survival outcomes.
Academic Article PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors.
Academic Article Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.
Academic Article Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.
Academic Article Overcoming implementation challenges of personalized cancer therapy.
Academic Article Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Academic Article Targeting the hepatocyte growth factor-cMET axis in cancer therapy.
Academic Article Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
Academic Article Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Academic Article Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.
Academic Article EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol.
Academic Article High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients.
Academic Article Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Academic Article Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.
Academic Article Building a personalized medicine infrastructure at a major cancer center.
Academic Article Integrated genomic characterization of endometrial carcinoma.
Academic Article AMPK: a contextual oncogene or tumor suppressor?
Academic Article Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.
Academic Article Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer.
Academic Article Predicting time to ovarian carcinoma recurrence using protein markers.
Academic Article PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Academic Article An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.
Academic Article Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.
Academic Article Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer.
Academic Article Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.
Academic Article Comprehensive molecular profiling of lung adenocarcinoma.
Academic Article Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Academic Article Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells.
Academic Article Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells.
Academic Article Characterization of the requirements for human T cell mitogenesis by using suboptimal concentrations of phytohemagglutinin.
Academic Article Interleukin 2 activates a receptor-associated protein kinase.
Academic Article Generation of cytotoxic lymphocytes to syngeneic tumor by using co-stimulator (Interleukin 2).
Academic Article Lysophospholipids activate ovarian and breast cancer cells.
Academic Article The v-raf oncogene enhances tumorigenicity and suppresses differentiation in vivo in a rat hepatocyte cell line.
Academic Article Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites.
Academic Article Role of aberrant sialylation of chronic myeloid leukemia granulocytes on binding and signal transduction by chemotactic peptides and colony stimulating factors.
Academic Article Genomic components of carcinogenesis.
Academic Article Cell cycle dependent regulation of the protein kinase TTK.
Academic Article Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.
Academic Article The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
Academic Article Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition.
Academic Article p202 self-associates through a sequence conserved among the members of the 200-family proteins.
Academic Article Physiologic and pathologic drug resistance in ovarian carcinoma--a hypothesis based on a clonal progression model.
Academic Article Markedly elevated levels of vascular endothelial growth factor in malignant ascites.
Academic Article Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
Academic Article Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Academic Article Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Academic Article Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Academic Article In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Academic Article Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells.
Academic Article Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics.
Academic Article The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Academic Article Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Academic Article Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Academic Article Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Academic Article Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.
Academic Article Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
Academic Article The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Academic Article Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Academic Article Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.
Academic Article Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Academic Article Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust.
Academic Article Targeting PI3K-AKT pathway for cancer therapy.
Academic Article A genetically defined model for human ovarian cancer.
Academic Article Mammalian target of rapamycin.
Academic Article Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Academic Article A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Academic Article ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.
Academic Article Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma.
Academic Article Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Academic Article Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Academic Article BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Academic Article Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
Academic Article Point mutations of protein kinases and individualised cancer therapy.
Academic Article Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Academic Article Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Academic Article A new mutational AKTivation in the PI3K pathway.
Academic Article Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
Academic Article Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Academic Article Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
Academic Article Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Academic Article A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Academic Article Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Academic Article An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Academic Article A novel AKT3 mutation in melanoma tumours and cell lines.
Academic Article Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
Academic Article A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Academic Article A systems approach to analysis of molecular complexity in breast cancer.
Academic Article Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
Academic Article Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.
Academic Article Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
Academic Article Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Academic Article Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.
Academic Article 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Academic Article Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
Academic Article ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Academic Article Future of personalized medicine in oncology: a systems biology approach.
Academic Article Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Academic Article Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy.
Academic Article PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.
Academic Article Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Academic Article Personalizing therapy for ovarian cancer: BRCAness and beyond.
Academic Article Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
Academic Article Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.
Academic Article Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.
Academic Article Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
Academic Article Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis.
Academic Article Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
Academic Article Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer.
Academic Article A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Academic Article Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals.
Academic Article Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
Academic Article Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.
Academic Article Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis.
Academic Article A time-series DDP for functional proteomics profiles.
Academic Article Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Academic Article Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Academic Article MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.
Academic Article Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
Academic Article Bioinformatics and systems biology.
Academic Article Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Academic Article Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer.
Academic Article AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
Academic Article Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
Academic Article Development and validation of a prognostic gene-expression signature for lung adenocarcinoma.
Academic Article An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Academic Article Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.
Academic Article Mask is required for the activity of the Hippo pathway effector Yki/YAP.
Academic Article EVI1 splice variants modulate functional responses in ovarian cancer cells.
Academic Article Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.
Academic Article Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer.
Academic Article Inferring tumour purity and stromal and immune cell admixture from expression data.
Academic Article CanDrA: cancer-specific driver missense mutation annotation with optimized features.
Academic Article A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Academic Article Perturbation biology: inferring signaling networks in cellular systems.
Academic Article Cancer Systems Biology: a peek into the future of patient care?
Academic Article A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.
Academic Article End stage renal disease serum contains a specific renal cell growth factor.
Academic Article Generation of cytotoxic lymphocytes to syngeneic tumors by using co-stimulator (Interleukin 2): in vivo activity.
Academic Article CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C.
Academic Article Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Academic Article Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Academic Article Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells.
Academic Article CA 125: the past and the future.
Academic Article The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Academic Article Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms.
Academic Article Differential signaling by an anti-p185(HER2) antibody and heregulin.
Academic Article Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
Academic Article Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
Academic Article Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Academic Article Specific keynote: genome copy number abnormalities in ovarian cancer.
Academic Article General keynote: molecular therapeutics and pharmocogenomics.
Academic Article Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Academic Article Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
Academic Article Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Academic Article Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine.
Academic Article Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
Academic Article Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.
Academic Article Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Academic Article Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms.
Academic Article PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Academic Article Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers.
Academic Article A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Academic Article DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Academic Article Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.
Academic Article Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.
Academic Article Systematic analysis of genotype-specific drug responses in cancer.
Academic Article Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer.
Academic Article Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected].
Academic Article Bayesian inference of signaling network topology in a cancer cell line.
Academic Article Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis.
Academic Article Proteomic classification of breast cancer.
Academic Article The impact of tumor heterogeneity on patient treatment decisions.
Academic Article BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Academic Article Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps.
Academic Article The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin.
Academic Article Levels of soluble interleukin-2 receptor-alpha are elevated in serum and ascitic fluid from epithelial ovarian cancer patients.
Academic Article Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.
Academic Article MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Academic Article Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines.
Academic Article An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer.
Academic Article Translational research--traffic on the bridge.
Academic Article Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Academic Article Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Academic Article Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line.
Academic Article Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
Academic Article Assessing BRCA carrier probabilities in extended families.
Academic Article Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Academic Article Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
Academic Article Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
Academic Article Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.
Academic Article Derailed endocytosis: an emerging feature of cancer.
Academic Article Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Academic Article Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
Academic Article Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Academic Article AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Academic Article Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.
Academic Article Subtype and pathway specific responses to anticancer compounds in breast cancer.
Academic Article Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.
Academic Article Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.
Academic Article Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy.
Academic Article Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
Academic Article Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Academic Article Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.
Academic Article Intramural squamous cell carcinoma of the esophagus.
Academic Article Phase II trial of amonafide in previously treated patients with advanced ovarian cancer: a Southwest Oncology Group study.
Academic Article Phase II evaluation of diaziquone in pancreatic carcinoma: a Southwest Oncology Group Study.
Academic Article Comparison of the skin tumor-initiating activities of dihydrodiols and diol-epoxides of various polycyclic aromatic hydrocarbons.
Academic Article The 10th International Conference on Monoclonal Antibody Immunoconjugates for Cancer: Radiodosimetry and Radiopharmaceuticals for Therapy.
Academic Article A phase II trial of topotecan in esophageal carcinoma: a Southwest Oncology Group study (SWOG 9339).
Academic Article Alterations in oncogenes, tumor suppressor genes, and growth factors associated with epithelial ovarian cancers.
Academic Article Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer.
Academic Article Regulation of mRNA expression in breast cancer - a cis-tematic trans-action.
Academic Article Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Academic Article LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.
Academic Article Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
Academic Article A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Academic Article Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.
Academic Article Concordance of genomic alterations between primary and recurrent breast cancer.
Academic Article YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.
Academic Article Open-label randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC versus the combination of paclitaxel and everolimus followed by FEC in women with triple receptor-negative breast cancer?.
Academic Article Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
Academic Article A pan-cancer proteomic perspective on The Cancer Genome Atlas.
Academic Article Influence of biospecimen variables on proteomic biomarkers in breast cancer.
Academic Article A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.
Academic Article Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Academic Article Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis.
Academic Article Peroxiredoxin-1 protects estrogen receptor a from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Academic Article The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Academic Article Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent?) a VEGFR2/PDGFR?/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial.
Academic Article PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Academic Article Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.
Academic Article Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.
Academic Article hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.
Academic Article RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?
Academic Article Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.
Academic Article Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.
Academic Article P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
Academic Article Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma.
Academic Article OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.
Academic Article LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Academic Article In silico prediction of physical protein interactions and characterization of interactome orphans.
Academic Article Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.
Academic Article Spatial normalization of reverse phase protein array data.
Academic Article a-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.
Academic Article Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
Academic Article Clinical actionability enhanced through deep targeted sequencing of solid tumors.
Academic Article Prognostic relevance of acquired uniparental disomy in serous ovarian cancer.
Academic Article Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
Academic Article SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer.
Academic Article Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.
Academic Article Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Academic Article Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance.
Academic Article A decision support framework for genomically informed investigational cancer therapy.
Academic Article An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.
Academic Article Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure.
Academic Article Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.
Academic Article Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials.
Academic Article Clinical next generation sequencing to identify actionable aberrations in a phase I program.
Academic Article PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.
Academic Article Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
Academic Article ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.
Academic Article Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Academic Article Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.
Academic Article Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition.
Academic Article The right drugs at the right time for the right patient: the MD Anderson precision oncology decision support platform.
Academic Article Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.
Academic Article Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma.
Academic Article Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.
Academic Article Integrative Protein-Based Prognostic Model for Early-Stage Endometrioid Endometrial Cancer.
Academic Article Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women.
Academic Article Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.
Academic Article Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma.
Academic Article Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women.
Academic Article The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Academic Article Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Academic Article Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Academic Article Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.
Academic Article A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
Academic Article Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers.
Academic Article TransVar: a multilevel variant annotator for precision genomics.
Academic Article Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines.
Academic Article Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Academic Article Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
Academic Article Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
Academic Article Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Academic Article mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
Academic Article Functional annotation of rare gene aberration drivers of pancreatic cancer.
Academic Article Inferring causal molecular networks: empirical assessment through a community-based effort.
Academic Article Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Academic Article BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System.
Academic Article Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Academic Article Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
Academic Article Multiplatform-based molecular subtypes of non-small-cell lung cancer.
Academic Article Role of RPL39 in Metaplastic Breast Cancer.
Academic Article The degree of intratumor mutational heterogeneity varies by primary tumor sub-site
Academic Article PKCiota promotes ovarian tumor progression through deregulation of cyclin E
Academic Article Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects
Academic Article Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
Academic Article Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
Academic Article Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression
Academic Article An integrated molecular analysis of lung adenocarcinomas identifies potential therapeutic targets among TTF1-negative tumors, including DNA Repair Proteins and Nrf2
Academic Article Messenger rna expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis
Academic Article Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
Academic Article Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set
Academic Article Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers.
Academic Article Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.
Academic Article A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
Academic Article Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Academic Article Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.
Academic Article A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Academic Article Systematic Functional Annotation of Somatic Mutations in Cancer.
Academic Article Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Academic Article The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Academic Article Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
Academic Article A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
Academic Article Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Academic Article Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
Academic Article An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.
Academic Article Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.
Academic Article MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer.
Academic Article PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Academic Article Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
Academic Article Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.
Academic Article Reply to M.P. Decatris et al.
Academic Article New era of integrated cancer biomarker discovery using reverse-phase protein arrays.
Academic Article Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
Academic Article Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
Academic Article Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.
Academic Article Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.
Academic Article Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression.
Academic Article Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol.
Academic Article The degree of intratumor mutational heterogeneity varies by primary tumor sub-site.
Academic Article The ErbB2?Ex16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
Academic Article Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer.
Academic Article Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients.
Academic Article RCP induces Slug expression and cancer cell invasion by stabilizing ?1 integrin.
Academic Article Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types.
Academic Article Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Academic Article Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.
Academic Article Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.
Academic Article AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Academic Article Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway.
Academic Article HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Academic Article Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.
Academic Article Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials.
Academic Article High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype.
Academic Article Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.
Academic Article Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Academic Article Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Academic Article Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer.
Academic Article Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p.
Academic Article Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.
Academic Article Clinical outcomes based on multigene profiling in metastatic breast cancer patients.
Academic Article Loss-of-function screens of druggable targetome against cancer stem-like cells.
Academic Article Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy.
Academic Article Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer.
Academic Article Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.
Academic Article Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.
Academic Article YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.
Academic Article Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Academic Article The rise of genomic profiling in ovarian cancer.
Academic Article Neomorphic mutations create therapeutic challenges in cancer.
Academic Article ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.
Academic Article A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.
Academic Article Integrated Molecular Characterization of Uterine Carcinosarcoma.
Academic Article A murine preclinical syngeneic transplantation model for breast cancer precision medicine.
Academic Article Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer.
Academic Article Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.
Academic Article A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.
Academic Article Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.
Academic Article Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer.
Academic Article Molecular heterogeneity at the network level: high-dimensional testing, clustering and a TCGA case study.
Academic Article Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer.
Academic Article CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.
Academic Article Functional variomics and network perturbation: connecting genotype to phenotype in cancer.
Academic Article Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets.
Academic Article Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.
Academic Article PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Academic Article Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma.
Academic Article PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
Academic Article Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
Academic Article Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.
Academic Article Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.
Academic Article Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening.
Academic Article Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.
Academic Article Precision oncology: neither a silver bullet nor a dream.
Academic Article Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Academic Article A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Academic Article Explore, Visualize, and Analyze Functional Cancer Proteomic Data Using the Cancer Proteome Atlas.
Academic Article "Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource.
Academic Article A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors.
Academic Article Physician interpretation of genomic test results and treatment selection.
Academic Article Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
Academic Article ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Academic Article Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1.
Academic Article Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
Academic Article Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
Academic Article The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
Academic Article Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies.
Academic Article BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
Academic Article EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
Academic Article ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.
Academic Article Cancer driver mutation prediction through Bayesian integration of multi-omic data.
Academic Article Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo.
Academic Article Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing.
Academic Article Rab25 augments cancer cell invasiveness through a ?1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
Academic Article Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2a-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression.
Academic Article Precision Oncology Decision Support: Current Approaches and Strategies for the Future.
Academic Article Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.
Academic Article Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.
Academic Article BRD4 facilitates replication stress-induced DNA damage response.
Academic Article Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p.
Academic Article Targeting gamma secretase: has progress moved up a Notch?
Academic Article The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
Academic Article RNA editing derived epitopes function as cancer antigens to elicit immune responses.
Academic Article Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.
Academic Article Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Academic Article ?-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
Academic Article Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.
Academic Article BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.
Academic Article Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Academic Article Credentialing Individual Samples for Proteogenomic Analysis.
Academic Article Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Academic Article Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.
Academic Article Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Academic Article MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology.
Academic Article State-of-the-art strategies for targeting the DNA damage response in cancer.
Academic Article Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer.
Academic Article Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer.
Academic Article Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Academic Article PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness.
Academic Article Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.
Academic Article Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.
Academic Article Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.
Academic Article Implementing a comprehensive translational oncology platform: from molecular testing to actionability.
Academic Article Personalized Integrated Network Modeling of the Cancer Proteome Atlas.
Academic Article PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Academic Article Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations.
Academic Article Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.
Academic Article Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.
Academic Article AKT isoform-specific expression and activation across cancer lineages.
Academic Article Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.
Academic Article Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium.
Academic Article Prospective Clinical Sequencing of Adult Glioma.
Academic Article Protein Kinase C Quality Control by Phosphatase PHLPP1?Unveils Loss-of-Function Mechanism in Cancer.
Academic Article Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.
Academic Article GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and ?-catenin activity.
Academic Article Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer.
Academic Article In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
Academic Article Breast cancer quantitative proteome and proteogenomic landscape.
Academic Article Integrated transcriptomic-genomic tool Texomer profiles cancer tissues.
Academic Article Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors.
Academic Article Next-generation characterization of the Cancer Cell Line Encyclopedia.
Concept Tumor Suppressor p53-Binding Protein 1
Concept Tumor Hypoxia
Concept Circulating Tumor DNA
Concept Tumor Microenvironment
Concept Neoplasm Grading
Concept Triple Negative Breast Neoplasms
Concept Response Evaluation Criteria in Solid Tumors
Academic Article Advancing Drug Development in Gynecologic Malignancies.
Academic Article The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Academic Article Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Academic Article TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data.
Academic Article Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Academic Article Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.
Academic Article COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms.
Academic Article Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases.
Academic Article Comprehensive characterization of circular RNAs in ~?1000 human cancer cell lines.
Academic Article Identification and validation of a prognostic proteomic signature for cervical cancer.
Academic Article Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion.
Academic Article Proteomics advances for precision therapy in ovarian cancer.
Academic Article Expanded analysis of secondary germline findings from matched tumor/normal sequencing identifies additional clinically significant mutations.
Academic Article Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer.
Academic Article Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study.
Academic Article MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
Academic Article A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis.
Academic Article Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer.
Academic Article Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma.
Academic Article Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers.
Academic Article Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance.
Academic Article miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer.
Academic Article Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy.
Academic Article PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Academic Article Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma.
Academic Article Comprehensive assessment of computational algorithms in predicting cancer driver mutations.
Academic Article Immuno-genomic landscape of osteosarcoma.
Academic Article Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer.
Academic Article Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens.
Academic Article Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.
Academic Article Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.
Academic Article Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
Academic Article Sex-associated molecular differences for cancer immunotherapy.
Academic Article Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer.
Academic Article Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays.
Academic Article Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients.
Academic Article Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-?B1 Target SerpinE1 in Aggressive Glioblastoma Tumors.
Academic Article Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Academic Article p85? regulates autophagic degradation of AXL to activate oncogenic signaling.
Academic Article Systems approach to rational combination therapy: PARP inhibitors.
Academic Article MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.
Academic Article BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis.
Academic Article Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
Academic Article Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Academic Article RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
Academic Article Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
Academic Article The roles of MAGEA6 variants in pancreatic cancer development and their potential impact on cancer immunotherapy.
Academic Article Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma.
Academic Article Integrated Genomic Characterization of the Human Immunome in Cancer.
Academic Article Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response.
Academic Article Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy.
Academic Article Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors.
Academic Article Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA.
Academic Article Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling.
Academic Article Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer.
Academic Article Transient commensal clonal interactions can drive tumor metastasis.
Academic Article Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.
Academic Article Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer.
Academic Article Hormonal modulation of ESR1 mutant metastasis.
Academic Article Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Academic Article MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.
Academic Article Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling.
Academic Article Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy.
Academic Article Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer.
Academic Article Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Academic Article mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.
Academic Article Spatially interacting phosphorylation sites and mutations in cancer.
Academic Article Phase 1 trial of nelfinavir added to standard cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer.
Academic Article Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers.
Academic Article Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.
Academic Article Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials.
Academic Article In Situ Tumor Vaccination with Nanoparticle Co-Delivering CpG and STAT3 siRNA to Effectively Induce Whole-Body Antitumor Immune Response.
Academic Article Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors.
Academic Article Ex Vivo Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics.
Academic Article Exceptional Response to Trastuzumab in a Heavily Pretreated Patient With ERBB3-Mutated Metastatic Breast Cancer.
Academic Article Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers.
Academic Article Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.
Academic Article Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer.
Academic Article Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer.
Academic Article TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.
Academic Article CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models.
Academic Article A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.
Academic Article BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators.
Academic Article The PRO-ACTIVE trial protocol: a randomized study comparing the effectiveness of PROphylACTic swallow InterVEntion for patients receiving radiotherapy for head and neck cancer.
Academic Article Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.
Academic Article Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma.
Academic Article Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
Academic Article WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Academic Article Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II.
Academic Article Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer.
Academic Article Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation.
Academic Article An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.
Academic Article Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Academic Article Adjuvant treatment in early-stage endometrial cancer: context-dependent impact of somatic CTNNB1 mutation on recurrence-free survival.
Academic Article Characterization of anticancer drug resistance by reverse-phase protein array: new targets and strategies.
Academic Article Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Academic Article PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia.
Academic Article Inhibiting the IRE1a Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
Academic Article A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.
Academic Article HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors.
Academic Article Biomolecular Condensation: A New Phase in Cancer Research.
Academic Article Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment.
Academic Article A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells.
Academic Article Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets.
Academic Article BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer.
Academic Article Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance.
Academic Article In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma.
Academic Article Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer.
Academic Article Panobinostat Induced Spatial In Situ Biomarkers Predictive of Anti-PD-1 Efficacy in Mouse Mammary Carcinoma.
Academic Article IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles.
Academic Article [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study.
Academic Article PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models.
Academic Article Stiff matrix induces exosome secretion to promote tumour growth.
Academic Article Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma.
Academic Article BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors.
Academic Article Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes.
Academic Article Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles.
Academic Article MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.
Academic Article Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer.
Academic Article Common and distinct patterns of acquired uniparental disomy and homozygous deletions between lung squamous cell carcinomas and lung adenocarcinoma.
Academic Article Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity.
Academic Article Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins.
Academic Article Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance.
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