Pleckstrin Homology Domains
"Pleckstrin Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.
| Descriptor ID |
D000070539
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| MeSH Number(s) |
G02.111.570.820.709.275.750.469
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| Concept/Terms |
Pleckstrin Homology Domains- Pleckstrin Homology Domains
- Domain, Pleckstrin Homology
- Domains, Pleckstrin Homology
- Homology Domain, Pleckstrin
- Homology Domains, Pleckstrin
- PH Domain
- Domain, PH
- Domains, PH
- PH Domains
- Pleckstrin Homology Domain
|
Below are MeSH descriptors whose meaning is more general than "Pleckstrin Homology Domains".
Below are MeSH descriptors whose meaning is more specific than "Pleckstrin Homology Domains".
This graph shows the total number of publications written about "Pleckstrin Homology Domains" by people in this website by year, and whether "Pleckstrin Homology Domains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pleckstrin Homology Domains" by people in Profiles.
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An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors. Cancer Res. 2019 06 15; 79(12):3100-3111.
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De novo PHIP-predicted deleterious variants are associated with developmental delay, intellectual disability, obesity, and dysmorphic features. Cold Spring Harb Mol Case Stud. 2016 11; 2(6):a001172.