"Allosteric Site" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
| Descriptor ID |
D000495
|
| MeSH Number(s) |
G02.111.570.120.147
|
| Concept/Terms |
Allosteric Site- Allosteric Site
- Allosteric Sites
- Site, Allosteric
- Sites, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Site".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Site".
This graph shows the total number of publications written about "Allosteric Site" by people in this website by year, and whether "Allosteric Site" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Allosteric Site" by people in Profiles.
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Computational design of dynamic receptor-peptide signaling complexes applied to chemotaxis. Nat Commun. 2023 05 19; 14(1):2875.
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Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target. Curr Top Med Chem. 2021; 21(10):841-848.
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Computational design of G Protein-Coupled Receptor allosteric signal transductions. Nat Chem Biol. 2020 01; 16(1):77-86.
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Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Am Chem Soc. 2019 05 01; 141(17):6832-6836.
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Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 10; 94(4):1197-1209.
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Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
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Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):2952-7.
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Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry. 2013 Mar 12; 52(10):1725-36.
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Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1. J Am Chem Soc. 2011 Nov 16; 133(45):18280-8.
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Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem. 2007 Nov 01; 50(22):5357-63.