Ribonucleoprotein, U1 Small Nuclear
"Ribonucleoprotein, U1 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
Descriptor ID |
D017412
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MeSH Number(s) |
D12.776.157.725.500.875.600 D12.776.157.725.829.313 D12.776.664.962.500.875.600 D12.776.664.962.829.313
|
Concept/Terms |
Ribonucleoprotein, U1 Small Nuclear- Ribonucleoprotein, U1 Small Nuclear
- U1 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U1
- Small Nuclear Ribonucleoproteins, U1
- U1 snRNP
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U1 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U1 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U1 Small Nuclear" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 1 | 0 | 1 |
2000 | 1 | 0 | 1 |
2006 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in Profiles.
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Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression. Proteomics. 2016 12; 16(23):3042-3053.
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U1A regulates 3' processing of the survival motor neuron mRNA. J Biol Chem. 2014 Feb 07; 289(6):3703-12.
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Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum. 2010 Feb; 62(2):589-98.
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Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera. J Immunol Methods. 2006 May 30; 312(1-2):79-93.
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An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites. Mol Cell Biol. 2000 Dec; 20(24):9225-35.
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Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol. 1998 Sep; 18(9):4977-85.
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An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev. 1996 Jan 15; 10(2):208-19.