Ribonucleoprotein, U2 Small Nuclear
"Ribonucleoprotein, U2 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.
| Descriptor ID |
D017413
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| MeSH Number(s) |
D12.776.157.725.500.875.605 D12.776.157.725.829.344 D12.776.664.962.500.875.605 D12.776.664.962.829.344
|
| Concept/Terms |
Ribonucleoprotein, U2 Small Nuclear- Ribonucleoprotein, U2 Small Nuclear
- U2 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U2
- Small Nuclear Ribonucleoproteins, U2
- U2 snRNP
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U2 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U2 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U2 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Profiles.
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De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders. Nat Commun. 2026 Jan 23; 17(1):1569.
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8.
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Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood. 2011 Dec 08; 118(24):6239-46.
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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011 Oct 13; 365(15):1384-95.
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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008 Apr 10; 452(7188):713-8.
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WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10602-7.