Ribonucleoprotein, U2 Small Nuclear
"Ribonucleoprotein, U2 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.
| Descriptor ID |
D017413
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| MeSH Number(s) |
D12.776.157.725.500.875.605 D12.776.157.725.829.344 D12.776.664.962.500.875.605 D12.776.664.962.829.344
|
| Concept/Terms |
Ribonucleoprotein, U2 Small Nuclear- Ribonucleoprotein, U2 Small Nuclear
- U2 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U2
- Small Nuclear Ribonucleoproteins, U2
- U2 snRNP
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U2 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U2 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U2 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 3 | 0 | 3 |
| 2015 | 1 | 2 | 3 |
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Below are the most recent publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Profiles.
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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point. Cell Rep. 2015 Nov 03; 13(5):1033-45.
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8.
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Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission. Am J Hematol. 2015 Jul; 90(7):E134-5.
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SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value. Blood. 2012 Jan 12; 119(2):569-72.
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Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood. 2011 Dec 08; 118(24):6239-46.
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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011 Oct 13; 365(15):1384-95.
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CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA. Nucleic Acids Res. 2009 Jul; 37(13):4275-86.
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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008 Apr 10; 452(7188):713-8.
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Splicing potentiation by growth factor signals via estrogen receptor phosphorylation. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8126-31.
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A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Mol Cell Biol. 1998 Sep; 18(9):5425-34.