Polypyrimidine Tract-Binding Protein
"Polypyrimidine Tract-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
| Descriptor ID |
D038941
|
| MeSH Number(s) |
D12.776.157.725.829.250 D12.776.664.962.829.250
|
| Concept/Terms |
Polypyrimidine Tract-Binding Protein- Polypyrimidine Tract-Binding Protein
- Polypyrimidine Tract Binding Protein
- Tract-Binding Protein, Polypyrimidine
- p57 Cytoplasmic RNA-Binding Protein
- p57 Cytoplasmic RNA Binding Protein
- PTB Splicing Factor
- Splicing Factor, PTB
- pPTB
- PTB Protein
|
Below are MeSH descriptors whose meaning is more general than "Polypyrimidine Tract-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "Polypyrimidine Tract-Binding Protein".
This graph shows the total number of publications written about "Polypyrimidine Tract-Binding Protein" by people in this website by year, and whether "Polypyrimidine Tract-Binding Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polypyrimidine Tract-Binding Protein" by people in Profiles.
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A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression. J Cancer Res Clin Oncol. 2023 Nov; 149(16):14927-14940.
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Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort. Environ Res. 2021 03; 194:110668.
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NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells. Oncogene. 2019 04; 38(16):2937-2952.
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The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma. Neuro Oncol. 2018 06 18; 20(7):930-941.
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MRG15 is required for pre-mRNA splicing and spermatogenesis. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5408-15.
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CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. Eur J Immunol. 2016 06; 46(6):1490-503.
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MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma. Cancer Lett. 2016 Feb 28; 371(2):214-24.
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A deep learning framework for modeling structural features of RNA-binding protein targets. Nucleic Acids Res. 2016 Feb 29; 44(4):e32.
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EGFR-induced and PKCe monoubiquitylation-dependent NF-?B activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell. 2012 Dec 14; 48(5):771-84.
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Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. PLoS One. 2012; 7(7):e41099.