"Puromycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.
| Descriptor ID |
D011691
|
| MeSH Number(s) |
D02.241.223.200.380 D03.633.100.759.590.138.711 D09.408.051.788 D13.570.583.138.711
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Puromycin".
Below are MeSH descriptors whose meaning is more specific than "Puromycin".
This graph shows the total number of publications written about "Puromycin" by people in this website by year, and whether "Puromycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Puromycin" by people in Profiles.
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Optimized culture of retinal ganglion cells and amacrine cells from adult mice. PLoS One. 2020; 15(12):e0242426.
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Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 01; 509(7498):49-54.
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Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19; 45(50):15111-9.
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Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood. 1993 Jan 01; 81(1):143-50.
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Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12063-7.
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Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis. J Biol Chem. 1992 Jan 15; 267(2):1072-80.
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Active tumor cell resistance to human natural killer lymphocyte attack. Cancer Res. 1981 Jul; 41(7):2803-8.
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Rhodopsin biosynthesis in vitro. Biochemistry. 1973 May 08; 12(10):1996-2003.
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The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes. J Clin Invest. 1971 Apr; 50(4):818-26.
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Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. Biochemistry. 1969 Apr; 8(4):1488-95.