Immunoglobulin Variable Region
"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
| Descriptor ID |
D007135
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| MeSH Number(s) |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
|
| Concept/Terms |
Immunoglobulin Variable Region- Immunoglobulin Variable Region
- Immunoglobulin Variable Regions
- Regions, Immunoglobulin Variable
- Variable Regions, Immunoglobulin
- Ig Variable Region
- Variable Region, Ig
- Ig Variable Regions
- Variable Regions, Ig
- Variable Region, Immunoglobulin
- Immunoglobulin V
Immunoglobulin Fv Fragments- Immunoglobulin Fv Fragments
- Fragment, Immunoglobulin Fv
- Fragments, Immunoglobulin Fv
- Fv Fragment, Immunoglobulin
- Fv Fragments, Immunoglobulin
- Immunoglobulin Fv Fragment
- Fv Antibody Fragments
- Antibody Fragment, Fv
- Antibody Fragments, Fv
- Fragment, Fv Antibody
- Fragments, Fv Antibody
- Fv Antibody Fragment
- Fv Fragments
- Fragment, Fv
- Fragments, Fv
- Fv Fragment
Framework Region, Immunoglobulin- Framework Region, Immunoglobulin
- Framework Regions, Immunoglobulin
- Immunoglobulin Framework Regions
- Ig Framework Region
- Framework Region, Ig
- Framework Regions, Ig
- Ig Framework Regions
- Immunoglobulin Framework Region
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".
This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 2 | 5 |
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 2 | 2 |
| 1998 | 2 | 2 | 4 |
| 1999 | 4 | 1 | 5 |
| 2000 | 3 | 1 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 5 | 7 |
| 2004 | 4 | 5 | 9 |
| 2005 | 1 | 3 | 4 |
| 2006 | 3 | 3 | 6 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 5 | 7 |
| 2009 | 2 | 2 | 4 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 5 | 5 |
| 2016 | 0 | 3 | 3 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
To return to the timeline,
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Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.
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Deuterated water labeling in ibrutinib-treated patients with CLL: leukemia cell kinetics correlate with IGHV, ZAP-70, and MRD. Blood. 2024 Dec 19; 144(25):2678-2681.
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Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe. 2023 08 09; 31(8):1288-1300.e6.
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Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genet. 2022 11; 54(11):1664-1674.
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Ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab (iFCG) regimen for chronic lymphocytic leukemia (CLL) with mutated IGHV and without TP53 aberrations. Leukemia. 2021 12; 35(12):3421-3429.
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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Rep. 2021 04 06; 35(1):108950.
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Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis. Cochrane Database Syst Rev. 2020 07 31; 7:CD012022.
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Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis. PLoS One. 2020; 15(7):e0235713.
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Treatment algorithm for Japanese patients with chronic lymphocytic leukemia in the era of novel targeted therapies. J Clin Exp Hematop. 2020 Dec 15; 60(4):130-137.
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Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires. MAbs. 2020 Jan-Dec; 12(1):1758291.
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98% IGHV gene identity is the optimal cutoff to dichotomize the prognosis of Chinese patients with chronic lymphocytic leukemia. Cancer Med. 2020 02; 9(3):999-1007.