Complementarity Determining Regions
"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
| Descriptor ID |
D022801
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| MeSH Number(s) |
D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
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| Concept/Terms |
Complementarity Determining Regions- Complementarity Determining Regions
- Region, Complementarity Determining
- Regions, Complementarity Determining
- Hypervariable Regions, Immunoglobulin
- Hypervariable Region, Immunoglobulin
- Immunoglobulin Hypervariable Region
- Immunoglobulin Hypervariable Regions
- Region, Immunoglobulin Hypervariable
- Regions, Immunoglobulin Hypervariable
- Complementarity Determining Region
- Complementarity-Determining Region
- Complementarity-Determining Regions
- Regions, Complementarity-Determining
Complementarity Determining Region 3- Complementarity Determining Region 3
- Complementarity-Determining Region 3
- Complementarity-Determining Region 3s
- Third Complementarity-Determining Region
- Complementarity-Determining Region, Third
- Complementarity-Determining Regions, Third
- Third Complementarity Determining Region
- Third Complementarity-Determining Regions
- Complementarity Determining Region III
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Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".
Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".
This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 2 | 4 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.
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Convergent antibody responses are associated with broad neutralization of hepatitis C virus. Front Immunol. 2023; 14:1135841.
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Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals. Nat Commun. 2022 06 08; 13(1):3178.
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The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta. MAbs. 2022 Jan-Dec; 14(1):2068212.
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Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail. Nat Microbiol. 2021 10; 6(10):1233-1244.
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Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes. Front Immunol. 2021; 12:659625.
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Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures. Front Immunol. 2021; 12:664344.
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Discovery of Marburg virus neutralizing antibodies from virus-na?ve human antibody repertoires using large-scale structural predictions. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31142-31148.
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Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2020 Sep 02; 31(9):1783-1802.
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Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring. Structure. 2020 10 06; 28(10):1124-1130.e5.
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Computationally Designed Cyclic Peptides Derived from an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure. 2020 10 06; 28(10):1114-1123.e4.