"Single-Chain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
| Descriptor ID |
D057127
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| MeSH Number(s) |
D12.644.541.500.650.500.800 D12.776.124.486.485.114.224.785 D12.776.124.486.485.680.650.500.800 D12.776.124.790.651.680.650.500.800 D12.776.377.715.548.680.650.500.795
|
| Concept/Terms |
Single-Chain Antibodies- Single-Chain Antibodies
- Antibodies, Single-Chain
- Single Chain Antibodies
- ScFv Antibodies
- Antibodies, ScFv
- Single-Chain Fv
- Fv, Single-Chain
- Single Chain Fv
- Single-Chain Fv Antibody
- Antibody, Single-Chain Fv
- Fv Antibody, Single-Chain
- Single Chain Fv Antibody
- Single-Chain Variable Fragment
- Fragment, Single-Chain Variable
- Single Chain Variable Fragment
- Variable Fragment, Single-Chain
- Single-Chain Variable Fragment Antibodies
- Single Chain Variable Fragment Antibodies
- Single-Chain Variable Fragment Antibody
- Single Chain Variable Fragment Antibody
- Single-Chain Variable Fragments
- Fragments, Single-Chain Variable
- Single Chain Variable Fragments
- Variable Fragments, Single-Chain
- Fv Antibody Fragments, Single-Chain
- Fv Antibody Fragments, Single Chain
- Single-Chain Fv Antibody Fragments
- Single Chain Fv Antibody Fragments
|
Below are MeSH descriptors whose meaning is more general than "Single-Chain Antibodies".
Below are MeSH descriptors whose meaning is more specific than "Single-Chain Antibodies".
This graph shows the total number of publications written about "Single-Chain Antibodies" by people in this website by year, and whether "Single-Chain Antibodies" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 2 | 0 | 2 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Single-Chain Antibodies" by people in Profiles.
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Anti-CD8/IL-15 (N72D)/sushi fusion protein: A promising strategy for improvement of cancer immunotherapy. Cytokine. 2025 Jan; 185:156822.
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Breast cancer immunotherapy using scFv antibody-based approaches, a systematic review. Hum Immunol. 2024 Sep; 85(5):111090.
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Hu8F4-CAR T cells with mutated Fc spacer segment improve target specificity and mediate anti-leukemia activity in vivo. Cytotherapy. 2024 Nov; 26(11):1331-1340.
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Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms. Front Immunol. 2023; 14:1167965.
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CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity. Blood. 2021 07 29; 138(4):318-330.
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Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors. Commun Biol. 2021 03 19; 4(1):368.
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High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. J Virol. 2020 12 09; 95(1).
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Broad dengue neutralization in mosquitoes expressing an engineered antibody. PLoS Pathog. 2020 01; 16(1):e1008103.
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A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions. MAbs. 2019 04; 11(3):593-605.
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Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Nat Biotechnol. 2018 10; 36(9):847-856.