Immunoglobulin Joining Region
"Immunoglobulin Joining Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
| Descriptor ID |
D007133
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| MeSH Number(s) |
D12.644.541.500.650.500.590 D12.776.124.486.485.680.650.500.590 D12.776.124.486.485.797.590 D12.776.124.790.651.680.650.500.590 D12.776.124.790.651.797.590 D12.776.377.715.548.680.650.500.590 D12.776.377.715.548.797.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Joining Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Joining Region".
This graph shows the total number of publications written about "Immunoglobulin Joining Region" by people in this website by year, and whether "Immunoglobulin Joining Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Joining Region" by people in Profiles.
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Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes. PLoS One. 2012; 7(5):e36750.
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Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med. 2007 Jun 11; 204(6):1371-81.
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Molecular signatures of anti-nuclear antibodies: contributions of specific light chain residues and a novel New Zealand Black V kappa 1 germline gene. J Immunol. 2003 Oct 01; 171(7):3886-94.
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Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors. J Immunol. 2003 Jan 01; 170(1):5-9.
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Quantification of bcl-2/JH fusion sequences and a control gene by multiplex real-time PCR coupled with automated amplicon sizing by capillary electrophoresis. J Mol Diagn. 2002 Nov; 4(4):223-9.
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Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells. Eur J Immunol. 2002 Oct; 32(10):2792-9.
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The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study. BMC Immunol. 2002 Aug 22; 3:10.
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Real-Time t(14;18)(q32;q21) PCR assay combined with high-resolution capillary electrophoresis: a novel and rapid approach that allows accurate quantitation and size determination of bcl-2/JH fusion sequences. Mod Pathol. 2002 Apr; 15(4):448-53.
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Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Mar; 34(2):149-57.
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Real-time 5'-->3' exonuclease-based PCR assay for detection of the t(11;14)(q13;q32). Am J Clin Pathol. 1999 Oct; 112(4):524-30.