Receptor-CD3 Complex, Antigen, T-Cell
"Receptor-CD3 Complex, Antigen, T-Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Molecule composed of the non-covalent association of the T-cell antigen receptor (RECEPTORS, ANTIGEN, T-CELL) with the CD3 complex (CD3 COMPLEX). This association is required for the surface expression and function of both components. The molecule consists of up to seven chains: either the alpha/beta or gamma/delta chains of the T-cell receptor, and four or five chains in the CD3 complex.
| Descriptor ID |
D017260
|
| MeSH Number(s) |
D12.776.543.750.705.816.824.800 D23.050.301.264.894.095.800 D23.101.100.894.095.800
|
| Concept/Terms |
Receptor-CD3 Complex, Antigen, T-Cell- Receptor-CD3 Complex, Antigen, T-Cell
- TCR-CD3 Complex
- Complex, TCR-CD3
- TCR CD3 Complex
- T-Cell Antigen Receptor-CD3 Complex
- T Cell Antigen Receptor CD3 Complex
|
Below are MeSH descriptors whose meaning is more general than "Receptor-CD3 Complex, Antigen, T-Cell".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Antigen [D12.776.543.750.705.816]
- Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
- Receptor-CD3 Complex, Antigen, T-Cell [D12.776.543.750.705.816.824.800]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD3 Complex [D23.050.301.264.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.050.301.264.894.095.800]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD3 Complex [D23.101.100.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.101.100.894.095.800]
Below are MeSH descriptors whose meaning is more specific than "Receptor-CD3 Complex, Antigen, T-Cell".
This graph shows the total number of publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in this website by year, and whether "Receptor-CD3 Complex, Antigen, T-Cell" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in Profiles.
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Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma. Mol Ther. 2017 Jan 04; 25(1):285-295.
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Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J. 2010 Apr 07; 29(7):1285-98.
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Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation. J Cell Biol. 2006 Jan 02; 172(1):127-37.
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The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology. 2002 Oct 10; 302(1):106-22.
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The Src family kinase Fyn mediates signals induced by TCR antagonists. J Immunol. 2002 May 01; 168(9):4480-7.
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Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. J Immunol. 1998 Apr 01; 160(7):3269-73.
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Cross-linking the TCR complex induces apoptosis in CD4+8+ thymocytes in the presence of cyclosporin A. Dev Immunol. 1996; 5(1):1-15.
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Clonal expansion of germline B-lineage acute lymphoblastic leukemia in severe combined immunodeficient mice. Oncogene. 1995 Nov 02; 11(9):1753-9.