"CD3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
| Descriptor ID |
D017252
|
| MeSH Number(s) |
D23.050.301.264.894.095 D23.101.100.894.095
|
| Concept/Terms |
CD3 Complex- CD3 Complex
- T3 Antigens
- Antigens, T3
- T3 Complex
- CD3 Antigens
- Antigens, CD3
- T3 Antigen
- Antigen, T3
- CD3 Antigen
- Antigen, CD3
|
Below are MeSH descriptors whose meaning is more general than "CD3 Complex".
Below are MeSH descriptors whose meaning is more specific than "CD3 Complex".
This graph shows the total number of publications written about "CD3 Complex" by people in this website by year, and whether "CD3 Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1998 | 1 | 2 | 3 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 2 | 3 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "CD3 Complex" by people in Profiles.
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Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg-microglia crosstalk. Nat Neurosci. 2025 Mar; 28(3):499-516.
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Gene editing of CD3 epsilon to redirect regulatory T?cells for adoptive T?cell transfer. Mol Ther. 2025 Mar 05; 33(3):997-1013.
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Integrated Imaging Probe and Bispecific Antibody Development Enables In Vivo Targeting of Glypican-3-Expressing Hepatocellular Carcinoma. Mol Cancer Ther. 2024 Dec 03; 23(12):1815-1826.
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Integration of ?-deficient CARs into the CD3? gene conveys potent cytotoxicity in T and NK cells. Blood. 2024 06 20; 143(25):2599-2611.
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A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor. Cancer Immunol Res. 2020 01; 8(1):57-69.
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Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells. J Immunol. 2017 07 01; 199(1):348-362.
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CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016 09 29; 24(9):1615-26.
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IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 07; 139(Pt 7):1939-57.
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HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators Inflamm. 2016; 2016:1478340.
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Quantitative activation suppression assay to evaluate human bone marrow-derived mesenchymal stromal cell potency. Cytotherapy. 2015 Dec; 17(12):1675-86.