"CD3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Descriptor ID |
D017252
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MeSH Number(s) |
D23.050.301.264.894.095 D23.101.100.894.095
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Concept/Terms |
CD3 Complex- CD3 Complex
- T3 Antigens
- Antigens, T3
- T3 Complex
- CD3 Antigens
- Antigens, CD3
- T3 Antigen
- Antigen, T3
- CD3 Antigen
- Antigen, CD3
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Below are MeSH descriptors whose meaning is more general than "CD3 Complex".
Below are MeSH descriptors whose meaning is more specific than "CD3 Complex".
This graph shows the total number of publications written about "CD3 Complex" by people in this website by year, and whether "CD3 Complex" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1996 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 2 | 2 |
2001 | 2 | 0 | 2 |
2002 | 2 | 0 | 2 |
2003 | 0 | 3 | 3 |
2004 | 0 | 2 | 2 |
2005 | 0 | 4 | 4 |
2006 | 1 | 3 | 4 |
2007 | 0 | 2 | 2 |
2008 | 0 | 2 | 2 |
2009 | 1 | 0 | 1 |
2010 | 1 | 2 | 3 |
2011 | 0 | 1 | 1 |
2012 | 0 | 2 | 2 |
2013 | 0 | 4 | 4 |
2014 | 0 | 1 | 1 |
2015 | 0 | 2 | 2 |
2016 | 0 | 2 | 2 |
2017 | 1 | 0 | 1 |
2019 | 1 | 0 | 1 |
2023 | 0 | 1 | 1 |
2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "CD3 Complex" by people in Profiles.
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Integrated Imaging Probe and Bispecific Antibody Development Enables In Vivo Targeting of Glypican-3-Expressing Hepatocellular Carcinoma. Mol Cancer Ther. 2024 Dec 03; 23(12):1815-1826.
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CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3?/ZAP70 Signaling Axis. Cancer Discov. 2024 Oct 04; 14(10):1879-1900.
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Integration of ?-deficient CARs into the CD3? gene conveys potent cytotoxicity in T and NK cells. Blood. 2024 06 20; 143(25):2599-2611.
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CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials. Nat Commun. 2024 May 15; 15(1):4091.
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Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL. Leukemia. 2023 10; 37(10):2006-2016.
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Activation of T Lymphocytes with Anti-PDL1-BiTE in the Presence of Adipose-Derived Mesenchymal Stem Cells (ASCs). Biomed Res Int. 2023; 2023:7692726.
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Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes. J Immunother Cancer. 2022 02; 10(2).
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Effector memory cytotoxic CD3+/CD8+/CD45RO+ T cells are predictive of good survival and a lower risk of recurrence in triple-negative breast cancer. Mod Pathol. 2022 05; 35(5):601-608.
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ALK+ large B-cell lymphoma with aberrant expression of CD3. Blood. 2020 12 24; 136(26):3086.
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CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma. Hum Pathol. 2020 04; 98:1-9.