"CD3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Descriptor ID |
D017252
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MeSH Number(s) |
D23.050.301.264.894.095 D23.101.100.894.095
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Concept/Terms |
CD3 Complex- CD3 Complex
- T3 Antigens
- Antigens, T3
- T3 Complex
- CD3 Antigens
- Antigens, CD3
- T3 Antigen
- Antigen, T3
- CD3 Antigen
- Antigen, CD3
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Below are MeSH descriptors whose meaning is more general than "CD3 Complex".
Below are MeSH descriptors whose meaning is more specific than "CD3 Complex".
This graph shows the total number of publications written about "CD3 Complex" by people in this website by year, and whether "CD3 Complex" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 3 | 4 |
1995 | 1 | 3 | 4 |
1996 | 0 | 3 | 3 |
1997 | 3 | 1 | 4 |
1998 | 1 | 5 | 6 |
1999 | 2 | 4 | 6 |
2000 | 2 | 6 | 8 |
2001 | 1 | 2 | 3 |
2002 | 2 | 2 | 4 |
2003 | 0 | 5 | 5 |
2004 | 1 | 8 | 9 |
2005 | 1 | 8 | 9 |
2006 | 1 | 6 | 7 |
2007 | 0 | 5 | 5 |
2008 | 0 | 4 | 4 |
2009 | 1 | 2 | 3 |
2010 | 3 | 3 | 6 |
2011 | 1 | 3 | 4 |
2012 | 2 | 4 | 6 |
2013 | 0 | 7 | 7 |
2014 | 0 | 4 | 4 |
2015 | 1 | 3 | 4 |
2016 | 0 | 4 | 4 |
2017 | 1 | 0 | 1 |
2018 | 1 | 4 | 5 |
2019 | 1 | 0 | 1 |
2020 | 2 | 0 | 2 |
2021 | 0 | 1 | 1 |
2022 | 1 | 0 | 1 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "CD3 Complex" by people in Profiles.
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Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL. Leukemia. 2023 10; 37(10):2006-2016.
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Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes. J Immunother Cancer. 2022 02; 10(2).
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Effector memory cytotoxic CD3+/CD8+/CD45RO+ T cells are predictive of good survival and a lower risk of recurrence in triple-negative breast cancer. Mod Pathol. 2022 05; 35(5):601-608.
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ALK+ large B-cell lymphoma with aberrant expression of CD3. Blood. 2020 12 24; 136(26):3086.
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CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma. Hum Pathol. 2020 04; 98:1-9.
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A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor. Cancer Immunol Res. 2020 01; 8(1):57-69.
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Characterizing parathyroid carcinomas and atypical neoplasms based on the expression of programmed death-ligand 1 expression and the presence of tumor-infiltrating lymphocytes and macrophages. Surgery. 2018 11; 164(5):960-964.
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Kinetics of Intratumoral Immune Cell Activation During Chemoradiation for Cervical Cancer. Int J Radiat Oncol Biol Phys. 2018 11 01; 102(3):593-600.
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T-cell prolymphocytic leukemia negative for surface CD3 and CD45. Blood. 2018 07 05; 132(1):111.
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Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer. Int J Radiat Oncol Biol Phys. 2018 08 01; 101(5):1222-1225.