"CD4 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
| Descriptor ID |
D015704
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.810.500 D12.776.543.750.830.700.025 D23.050.301.264.894.100 D23.101.100.894.100
|
| Concept/Terms |
CD4 Antigens- CD4 Antigens
- Antigens, CD4
- CD4 Molecule
- T4 Antigens, T-Cell
- Antigens, T-Cell T4
- T-Cell T4 Antigens
- T4 Antigens, T Cell
- Receptors, CD4
- Surface CD4 Receptor
- CD4 Receptor, Surface
- Receptors, Surface CD4
- CD4 Receptors, Surface
- Surface CD4 Receptors
- CD4 Antigen
- Antigen, CD4
- CD4 Receptors
|
Below are MeSH descriptors whose meaning is more general than "CD4 Antigens".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Interleukin [D12.776.543.750.705.852.420]
- Receptors, Interleukin-16 [D12.776.543.750.705.852.420.810]
- CD4 Antigens [D12.776.543.750.705.852.420.810.500]
- Receptors, Virus [D12.776.543.750.830]
- Receptors, HIV [D12.776.543.750.830.700]
- CD4 Antigens [D12.776.543.750.830.700.025]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD4 Antigens [D23.050.301.264.894.100]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD4 Antigens [D23.101.100.894.100]
Below are MeSH descriptors whose meaning is more specific than "CD4 Antigens".
This graph shows the total number of publications written about "CD4 Antigens" by people in this website by year, and whether "CD4 Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 3 | 0 | 3 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2016 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "CD4 Antigens" by people in Profiles.
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CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 07; 125(2):176-189.
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Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
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Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. Traffic. 2020 02; 21(2):250-264.
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A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017 02; 16(2):157-167.
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Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies. J Med Chem. 2016 Mar 24; 59(6):2633-47.
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Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation. PLoS Biol. 2014 Dec; 12(12):e1002011.
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Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. Chest. 2014 Dec; 146(6):1543-1553.
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Intrauterine growth restriction and prematurity influence regulatory T cell development in newborns. J Pediatr Surg. 2014 May; 49(5):727-32.
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Immunophenotypic shift of CD4 and CD8 antigen expression in primary cutaneous T-cell lymphomas: a clinicopathologic study of three cases. J Cutan Pathol. 2014 Jan; 41(1):51-7.
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[Advances in blastic plasmacytoid dendritic cell neoplasm]. Zhonghua Bing Li Xue Za Zhi. 2013 Feb; 42(2):131-4.