"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
| Descriptor ID |
D016874
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| MeSH Number(s) |
A08.675.609.520 A11.284.430.214.190.750.640.520 A11.671.573.520
|
| Concept/Terms |
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
|
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in this website by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 2 | 3 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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Combinatorial model of amyloid ? and tau reveals synergy between amyloid deposits and tangle formation. Neuropathol Appl Neurobiol. 2022 02; 48(2):e12779.
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Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111.
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Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults. JAMA Neurol. 2020 10 01; 77(10):1299-1307.
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Brain Bromine Levels Associated with Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2020; 73(1):327-332.
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Association of Cortical ?-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease. JAMA Neurol. 2019 07 01; 76(7):818-826.
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Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives. J Alzheimers Dis. 2019; 70(1):153-161.
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The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019 04; 15(4):583-598.
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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018 08 01; 75(8):989-998.
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Practical considerations for choosing a mouse model of Alzheimer's disease. Mol Neurodegener. 2017 12 22; 12(1):89.
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Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging. 2018 01; 61:138-145.