"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
| Descriptor ID |
D016874
|
| MeSH Number(s) |
A08.675.609.520 A11.284.430.214.190.750.640.520 A11.671.573.520
|
| Concept/Terms |
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
|
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in this website by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 2 | 3 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019 04; 15(4):583-598.
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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep; 6(9):1142-60.
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Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014 Mar 19; 34(12):4260-72.
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Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease. Neurosci Lett. 2010 Nov 26; 485(3):222-7.
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Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders. Curr Opin Immunol. 2009 Jun; 21(3):359-63.
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The genetics of very early onset Alzheimer disease. Cogn Behav Neurol. 2007 Sep; 20(3):149-56.
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Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors. J Mol Neurosci. 2003; 20(3):339-43.
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Truncated apoE forms tangle-like structures in a neuronal cell line. Neuroreport. 2002 May 07; 13(6):867-70.
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Suicide and Alzheimer's pathology in the elderly: a case-control study. Biol Psychiatry. 2001 Jan 15; 49(2):137-45.
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Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology. Brain Res. 1998 Jun 15; 796(1-2):209-21.