"Ionophores" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.
| Descriptor ID |
D007476
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| MeSH Number(s) |
D27.505.519.562.374 D27.720.395
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ionophores".
Below are MeSH descriptors whose meaning is more specific than "Ionophores".
This graph shows the total number of publications written about "Ionophores" by people in this website by year, and whether "Ionophores" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 2 | 1 | 3 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ionophores" by people in Profiles.
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Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies. Mol Cell Biochem. 2021 Jan; 476(1):417-423.
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Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Mol Oncol. 2015 Jun; 9(6):1155-68.
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Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology. 2007 May; 148(5):2085-94.
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Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J. 2005 Dec; 19(14):2069-71.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J. 2005 Jun 15; 24(12):2104-13.
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Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis. J Cell Physiol. 2004 Aug; 200(2):223-34.
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The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol. 2002 Mar; 22(6):1734-41.
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Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J Biol Chem. 2002 May 17; 277(20):18002-9.
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Calcium ionophore activation of chronic myelogenous leukemia progenitor cells into dendritic cells is mediated by calcineurin phosphatase. Leuk Res. 2000 Oct; 24(10):795-804.
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Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell. 2000 Sep; 6(3):539-50.