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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.
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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015 Nov 05; 527(7576):100-104.
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PubMed
subject areas
Adaptation, Physiological
Animals
Astrocytes
Brain
Brain Neoplasms
Calcium-Binding Proteins
Cell Proliferation
Chemokine CCL2
DNA-Binding Proteins
Down-Regulation
Evolution, Molecular
Exosomes
Female
Gene Expression Regulation, Neoplastic
Gene Silencing
Genes, Tumor Suppressor
Humans
Male
Mice
Microfilament Proteins
MicroRNAs
PTEN Phosphohydrolase
RNA, Messenger
Tumor Microenvironment
Tumor Suppressor Proteins