Prolyl-Hydroxylase Inhibitors

"Prolyl-Hydroxylase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that inhibit the action of HYDROXYLASES that act on PROLINE to form HYDROXYPROLINE.

Descriptor ID	D064800
MeSH Number(s)	D27.505.519.389.740
Concept/Terms	Prolyl-Hydroxylase Inhibitors Prolyl-Hydroxylase Inhibitors Inhibitors, Prolyl-Hydroxylase Prolyl Hydroxylase Inhibitors Proline Dioxygenase Inhibitors Dioxygenase Inhibitors, Proline Inhibitors, Proline Dioxygenase Proline Hydroxylase Inhibitors Hydroxylase Inhibitors, Proline Inhibitors, Proline Hydroxylase

Below are MeSH descriptors whose meaning is more general than "Prolyl-Hydroxylase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Prolyl-Hydroxylase Inhibitors [D27.505.519.389.740]

Below are MeSH descriptors whose meaning is related to "Prolyl-Hydroxylase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Prolyl-Hydroxylase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Prolyl-Hydroxylase Inhibitors" by people in this website by year, and whether "Prolyl-Hydroxylase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 4 publications over 2 distinct years, with a maximum of 3 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	0	1	1
2021	3	0	3

Below are the most recent publications written about "Prolyl-Hydroxylase Inhibitors" by people in Profiles.

Eckardt KU, Agarwal R, Aswad A, Awad A, Block GA, Bacci MR, Farag YMK, Fishbane S, Hubert H, Jardine A, Khawaja Z, Koury MJ, Maroni BJ, Matsushita K, McCullough PA, Lewis EF, Luo W, Parfrey PS, Pergola P, Sarnak MJ, Spinowitz B, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Zwiech R, Chertow GM. Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis. N Engl J Med. 2021 04 29; 384(17):1601-1612.

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Chertow GM, Pergola PE, Farag YMK, Agarwal R, Arnold S, Bako G, Block GA, Burke S, Castillo FP, Jardine AG, Khawaja Z, Koury MJ, Lewis EF, Lin T, Luo W, Maroni BJ, Matsushita K, McCullough PA, Parfrey PS, Roy-Chaudhury P, Sarnak MJ, Sharma A, Spinowitz B, Tseng C, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Eckardt KU. Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD. N Engl J Med. 2021 04 29; 384(17):1589-1600.

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Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Malyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2021 06; 99(6):1280-1295.

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Olcina MM, Giaccia AJ. Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis. J Clin Invest. 2016 10 03; 126(10):3708-3715.

View in: PubMed
Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 2014 May 14; 6(236):236ra64.

View in: PubMed

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