"Filamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
| Descriptor ID |
D064448
|
| MeSH Number(s) |
A11.284.430.214.190.750.050.414 D05.750.078.730.315 D12.776.210.249 D12.776.220.525.315
|
| Concept/Terms |
Filamin B- Filamin B
- beta-Filamin
- beta Filamin
- beta-Filamins
- Filamin 1-Like Protein
- 1-Like Protein, Filamin
- 1-Like Proteins, Filamin
- Filamin 1 Like Protein
- Filamin 1-Like Proteins
- Protein, Filamin 1-Like
- Proteins, Filamin 1-Like
Filamin A- Filamin A
- Filamin 1
- alpha-Filamin
- alpha Filamin
- alpha-Filamins
- 280 kDa Actin-Binding Protein
- 280 kDa Actin Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Filamins".
Below are MeSH descriptors whose meaning is more specific than "Filamins".
This graph shows the total number of publications written about "Filamins" by people in this website by year, and whether "Filamins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 2 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Filamins" by people in Profiles.
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Wandering Spleen in a Pediatric Lung Transplant Patient With Filamin A Deficiency: An Incidental Finding. Pediatr Transplant. 2025 09; 29(6):e70161.
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Application of lung volume reduction surgery for a child with filamin A (FLNA) mutations. Pediatr Pulmonol. 2022 01; 57(1):224-230.
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Pulmonary growth abnormalities as etiologies for pediatric pulmonary hypertension. Pediatr Pulmonol. 2021 03; 56(3):678-685.
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Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach. Molecules. 2020 Nov 26; 25(23).
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RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. Int J Cardiol. 2020 03 01; 302:124-130.
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Lung Transplantation for FLNA-Associated Progressive Lung Disease. J Pediatr. 2017 07; 186:118-123.e6.
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Arterial tortuosity in patients with Filamin A- associated vascular aneurysms. Am J Med Genet A. 2014 Nov; 164A(11):2961-3.
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Altered A-to-I RNA editing in human embryogenesis. PLoS One. 2012; 7(7):e41576.
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Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins. PLoS One. 2012; 7(7):e40826.
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Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011; 6(8):e22956.