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Institute for Clinical and Translational Research

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QIANG TONG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang Y, Gao R, Li J, Tang S, Li S, Tong Q, Mao Y. Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis. Aging (Albany NY). 2020 May 28; 12(10):9793-9806. PMID: 32464601.
      View in: PubMed
    2. Liu Z, Liu H, He J, Lin P, Tong Q, Yang J. Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells. Sci Signal. 2020 May 26; 13(633). PMID: 32457115.
      View in: PubMed
    3. Hong M, He J, Li D, Chu Y, Pu J, Tong Q, Joshi HC, Tang S, Li S. Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo. J Exp Clin Cancer Res. 2020 Mar 20; 39(1):52. PMID: 32197643.
      View in: PubMed
    4. Li H, Yang F, Hu A, Wang X, Fang E, Chen Y, Li D, Song H, Wang J, Guo Y, Liu Y, Li H, Huang K, Zheng L, Tong Q. Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression. EMBO Mol Med. 2019 12; 11(12):e10835. PMID: 31709724.
      View in: PubMed
    5. Zhang T, Liu J, Shen S, Tong Q, Ma X, Lin L. SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. Cell Death Differ. 2020 01; 27(1):329-344. PMID: 31160717.
      View in: PubMed
    6. Liu H, He J, Koh SP, Zhong Y, Liu Z, Wang Z, Zhang Y, Li Z, Tam BT, Lin P, Xiao M, Young KH, Amini B, Starbuck MW, Lee HC, Navone NM, Davis RE, Tong Q, Bergsagel PL, Hou J, Yi Q, Orlowski RZ, Gagel RF, Yang J. Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. Sci Transl Med. 2019 05 29; 11(494). PMID: 31142679.
      View in: PubMed
    7. Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, Tong Q, Krystkowiak I, Bondy-Chorney E, Davey NE, Krogan N, Downey M, Harper ME. SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Mol Metab. 2019 07; 25:35-49. PMID: 31060926.
      View in: PubMed
    8. Yang F, Fang E, Mei H, Chen Y, Li H, Li D, Song H, Wang J, Hong M, Xiao W, Wang X, Huang K, Zheng L, Tong Q. Cis-Acting circ-CTNNB1 Promotes ß-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1. Cancer Res. 2019 02 01; 79(3):557-571. PMID: 30563889.
      View in: PubMed
    9. Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, Li D, Song H, Wang J, Hong M, Wang X, Huang K, Zheng L, Tong Q. Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ. 2019 07; 26(7):1346-1364. PMID: 30341421.
      View in: PubMed
    10. Liu JX, Shen SN, Tong Q, Wang YT, Lin LG. Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3. Eur J Pharmacol. 2018 Sep 05; 834:176-187. PMID: 30036533.
      View in: PubMed
    11. Li Q, Lei F, Tang Y, Pan JS, Tong Q, Sun Y, Sheikh-Hamad D. Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism. Cell Mol Life Sci. 2018 Nov; 75(21):4021-4040. PMID: 29916093.
      View in: PubMed
    12. Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, Feillet-Coudray C. Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition. J Bioenerg Biomembr. 2018 04; 50(2):131-142. PMID: 29589261.
      View in: PubMed
    13. Liu J, Li D, Zhang T, Tong Q, Ye RD, Lin L. SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity. Cell Death Dis. 2017 10 26; 8(10):e3158. PMID: 29072685.
      View in: PubMed
    14. Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. 2018 01; 67(1):46-57. PMID: 28851713.
      View in: PubMed
    15. Li GL, Chen HJ, Zhang WX, Tong Q, Yan YE. Effects of maternal omega-3 fatty acids supplementation during pregnancy/lactation on body composition of the offspring: A systematic review and meta-analysis. Clin Nutr. 2018 10; 37(5):1462-1473. PMID: 28830700.
      View in: PubMed
    16. Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570265.
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    17. de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017 03; 15(3):e2000374. PMID: 28257421.
      View in: PubMed
    18. Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ. A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell Rep. 2016 10 25; 17(5):1414-1425. PMID: 27783953.
      View in: PubMed
    19. Liu Z, Xu J, He J, Liu H, Lin P, Wan X, Navone NM, Tong Q, Kwak LW, Orlowski RZ, Yang J. Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation. Oncotarget. 2015 Oct 27; 6(33):34329-41. PMID: 26455377.
      View in: PubMed
    20. Nosavanh L, Yu DH, Jaehnig EJ, Tong Q, Shen L, Chen MH. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5069-74. PMID: 25848030.
      View in: PubMed
    21. Cheung KG, Cole LK, Xiang B, Chen K, Ma X, Myal Y, Hatch GM, Tong Q, Dolinsky VW. Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes. J Biol Chem. 2015 Apr 24; 290(17):10981-93. PMID: 25759382.
      View in: PubMed
    22. Pan JS, Huang L, Belousova T, Lu L, Yang Y, Reddel R, Chang A, Ju H, DiMattia G, Tong Q, Sheikh-Hamad D. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol. 2015 Feb; 26(2):364-78. PMID: 25012175.
      View in: PubMed
    23. Lin L, Chen K, Abdel Khalek W, Ward JL, Yang H, Chabi B, Wrutniak-Cabello C, Tong Q. Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3. PLoS One. 2014; 9(1):e85636. PMID: 24454908.
      View in: PubMed
    24. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479.
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    25. Serrano L, Martínez-Redondo P, Marazuela-Duque A, Vazquez BN, Dooley SJ, Voigt P, Beck DB, Kane-Goldsmith N, Tong Q, Rabanal RM, Fondevila D, Muñoz P, Krüger M, Tischfield JA, Vaquero A. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 2013 Mar 15; 27(6):639-53. PMID: 23468428.
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    26. Pang WJ, Xiong Y, Wang Y, Tong Q, Yang GS. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Exp Cell Res. 2013 Mar 10; 319(5):670-83. PMID: 23313858.
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    27. Miao-Hsueh Chen, Qiang Tong . Drug Discovery Today: Disease Mechanisms. An Update on the Regulation of Adipogenesis. 2013; 10:e15-e19.
    28. Lin L, Pang W, Chen K, Wang F, Gengler J, Sun Y, Tong Q. Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1550-9. PMID: 22454293.
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    29. Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell. 2011 Dec; 10(6):996-1010. PMID: 21895961.
      View in: PubMed
    30. Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012 Mar 22; 31(12):1546-57. PMID: 21841822.
      View in: PubMed
    31. Yang Y, Chen KY, Tong Q. Murine Sirt3 protein isoforms have variable half-lives. Gene. 2011 Nov 15; 488(1-2):46-51. PMID: 21840382.
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    32. Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010 Nov 16; 5(11):e14005. PMID: 21103374.
      View in: PubMed
    33. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010 Nov 01; 111(4):1051-8. PMID: 20677216.
      View in: PubMed
    34. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4. PMID: 20798296.
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    35. Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry. 2010 Jan 19; 49(2):304-11. PMID: 20000467.
      View in: PubMed
    36. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 2010 Mar 05; 285(10):7417-29. PMID: 20042612.
      View in: PubMed
    37. Bellizzi D, Covello G, Di Cianni F, Tong Q, De Benedictis G. Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene. Mol Cells. 2009 Aug 31; 28(2):87-92. PMID: 19714312.
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    38. Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL, Goodyear LJ, Tong Q. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY). 2009 Aug 15; 1(9):771-83. PMID: 20157566.
      View in: PubMed
    39. Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, Brechlin AM, Schambach A, Hinrichsen L, Meyer G, Gaestel M, Stanulla M, Tong Q, Welte K. NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med. 2009 Feb; 15(2):151-8. PMID: 19182797.
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    40. Wang F, Tong Q. SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009 Feb; 20(3):801-8. PMID: 19037106.
      View in: PubMed
    41. Wang F, Tong Q. Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C213-20. PMID: 18463231.
      View in: PubMed
    42. Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 2007 Aug; 6(4):505-14. PMID: 17521387.
      View in: PubMed
    43. Tong Q, Hotamisligil GS. Developmental biology: cell fate in the mammary gland. Nature. 2007 Feb 15; 445(7129):724-6. PMID: 17301782.
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    44. Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GS. Regulation of adiponectin in adipocytes upon exposure to HIV-1. HIV Med. 2006 May; 7(4):268-74. PMID: 16630040.
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    45. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep. 2005 Sep; 6(9):879-84. PMID: 16082385.
      View in: PubMed
    46. Shi T, Wang F, Stieren E, Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem. 2005 Apr 08; 280(14):13560-7. PMID: 15653680.
      View in: PubMed
    47. Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Biol. 2005 Jan; 25(2):706-15. PMID: 15632071.
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    48. Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Drug News Perspect. 2003 Nov; 16(9):585-8. PMID: 14702139.
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    49. Tong Q, Sankalé JL, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GS. Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metab. 2003 Apr; 88(4):1559-64. PMID: 12679439.
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    50. Tong Q, Hotamisligil GS. Molecular mechanisms of adipocyte differentiation. Rev Endocr Metab Disord. 2001 Oct; 2(4):349-55. PMID: 11725721.
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    51. Way JM, Görgün CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2001 Jul 13; 276(28):25651-3. PMID: 11373275.
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    52. Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 2000 Oct 06; 290(5489):134-8. PMID: 11021798.
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    53. Ryu KY, Tong Q, Jhiang SM. Promoter characterization of the human Na+/I- symporter. J Clin Endocrinol Metab. 1998 Sep; 83(9):3247-51. PMID: 9745437.
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    54. Xing S, Furminger TL, Tong Q, Jhiang SM. Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J Biol Chem. 1998 Feb 27; 273(9):4909-14. PMID: 9478934.
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    55. Jhiang SM, Cho JY, Furminger TL, Sagartz JE, Tong Q, Capen CC, Mazzaferri EL. Thyroid carcinomas in RET/PTC transgenic mice. Recent Results Cancer Res. 1998; 154:265-70. PMID: 10027006.
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    56. Tong Q, Ryu KY, Jhiang SM. Promoter characterization of the rat Na+/I- symporter gene. Biochem Biophys Res Commun. 1997 Oct 09; 239(1):34-41. PMID: 9345265.
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    57. Tong Q, Xing S, Jhiang SM. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity. J Biol Chem. 1997 Apr 04; 272(14):9043-7. PMID: 9083029.
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    58. Sagartz JE, Jhiang SM, Tong Q, Capen CC. Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene. Lab Invest. 1997 Mar; 76(3):307-18. PMID: 9121114.
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    59. Jhiang SM, Sagartz JE, Tong Q, Parker-Thornburg J, Capen CC, Cho JY, Xing S, Ledent C. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology. 1996 Jan; 137(1):375-8. PMID: 8536638.
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    60. Jossart GH, O'Brien B, Cheng JF, Tong Q, Jhiang SM, Duh Q, Clark OH, Weier HU. A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1. Cytogenet Cell Genet. 1996; 75(4):254-7. PMID: 9067436.
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    61. Tong Q, Li Y, Smanik PA, Fithian LJ, Xing S, Mazzaferri EL, Jhiang SM. Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. Oncogene. 1995 May 04; 10(9):1781-7. PMID: 7753554.
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    62. Xing S, Tong Q, Suzuki T, Jhiang SM. Alternative splicing of the ret proto-oncogene at intron 4. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1526-32. PMID: 7811232.
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    63. Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL. Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. FEBS Lett. 1993 Mar 01; 318(2):139-44. PMID: 8382624.
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    64. Qiang Tong and Xi-rui Ge. The effect of neuropeptides substance K and substance P on murine spenocytes and thymocytes. Chinese Journal of Immunology. 1991; 7(5):263-267.
    65. Xi-rui Ge, Jue Wang, Yu-fang Che, Qiang Tong, Shu LZ, Zhang TM, and Lo JM . Monoclonal antibodies distinguishing human small cell lung cancer from non-small cell lung cancer. Acta Biologiae Experimentalis Sinica. 1988; 21(2):251-255.
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