HUGO BELLEN

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
Address1250 MOURSUND STREET
Houston, TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    Investigator, Howard Hughes Medical Institute, Baylor College of Medicine
    Professor, Departments of Molecular and Human Genetics and Neuroscience
    Director, Program in Developmental Biology

    I am interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.

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    R01GM053571     (BELLEN, HUGO J)Jul 1, 1996 - Jun 30, 2001
    NIH/NIGMS
    NEUROTRANSMITTER RELEASE IN DROSOPHILA
    Role: Principal Investigator

    T32ES007332     (BELLEN, HUGO J)Jul 1, 2000 - Jun 30, 2007
    NIH/NIEHS
    DEVELOPMENT BIOLOGY TRAINING PROGRAM
    Role: Principal Investigator

    R01GM067858     (BELLEN, HUGO J.)May 1, 2003 - May 31, 2021
    NIH/NIGMS
    A Comprehensive Resource for Manipulating the Drosophila Genome
    Role: Principal Investigator

    R01GM068949     (BELLEN, HUGO J)Jul 1, 2003 - Jun 30, 2007
    NIH/NIGMS
    Hrs and Endocytic Regulation of Notch and Wingless
    Role: Principal Investigator

    T32HD055200     (BELLEN, HUGO J.)Jun 5, 2007 - Apr 30, 2013
    NIH/NICHD
    Developmental Biology Training Program
    Role: Principal Investigator

    R01GM080415     (BELLEN, HUGO J.)Aug 1, 2007 - Nov 30, 2010
    NIH/NIGMS
    Molecularly defined duplications for the X-chromosome and large autosomal genes
    Role: Principal Investigator

    RC4GM096355     (BELLEN, HUGO J.)Sep 30, 2010 - Sep 29, 2013
    NIH/NIGMS
    Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Role: Principal Investigator

    U54NS093793     (BELLEN, HUGO J.)Sep 15, 2015 - Jun 30, 2022
    NIH/NINDS
    Center for functional analysis of human UDN gene homologs in Drosophila and zebrafish
    Role: Principal Investigator

    R24OD022005     (BELLEN, HUGO J.)Jun 1, 2016 - May 31, 2020
    NIH
    A Human cDNA Library for Functional Gene Replacement in Drosophila
    Role: Principal Investigator

    R01DC014932     (GROVES, ANDREW K)Dec 1, 2016 - Nov 30, 2021
    NIH/NIDCD
    A multi-species approach to find regulators of deafness genes
    Role: Co-Principal Investigator

    R24OD026435     (PERRIMON, NORBERT)Jul 1, 2018 - Jun 30, 2022
    NIH
    Using CRISPR technology to study the function of paralogous genes
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Link N, Bellen HJ. Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Development. 2020 Sep 28; 147(21). PMID: 32988995.
      Citations:    Fields:    
    2. Martelli F, Zhongyuan Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Venkatachalam K, Perry T, Bellen HJ, Batterham P. Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila. Proc Natl Acad Sci U S A. 2020 Oct 13; 117(41):25840-25850. PMID: 32989137.
      Citations:    Fields:    
    3. Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes TC, Aerts S, Bellen HJ. Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains. J Neurosci. 2020 Oct 14; 40(42):7999-8024. PMID: 32928889.
      Citations:    Fields:    
    4. Ding X, Jo J, Wang CY, Cristobal CD, Zuo Z, Ye Q, Wirianto M, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen HJ, Yoo SH, Lee HK. The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Genes Dev. 2020 Sep 01; 34(17-18):1177-1189. PMID: 32792353.
      Citations:    Fields:    
    5. Kao CY, Xu M, Wang L, Lin SC, Lee HJ, Duraine L, Bellen HJ, Goldstein DS, Tsai SY, Tsai MJ. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS Genet. 2020 06; 16(6):e1008868. PMID: 32579581.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Huang Y, Mao X, van Jaarsveld RH, Shu L, Terhal PA, Jia Z, Xi H, Peng Y, Yan H, Yuan S, Li Q, Wang H, Bellen HJ. Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay. Hum Mol Genet. 2020 Jun 03; 29(9):1537-1546. PMID: 32338762.
      Citations:    Fields:    
    7. Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Network UD, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ. De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Hum Mol Genet. 2020 Jun 03; 29(9):1568-1579. PMID: 32356556.
      Citations:    Fields:    
    8. Chung HL, Mao X, Wang H, Park YJ, Marcogliese PC, Rosenfeld JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ, Xiao B. De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Am J Hum Genet. 2020 05 07; 106(5):717-725. PMID: 32330417.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 Jun; 34(6):8265-8282. PMID: 32294302.
      Citations:    Fields:    
    10. Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L, Li Y, Gu JY, Tepass U, Rodal AA, Bellen HJ, Shulman JM. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. Elife. 2020 Apr 14; 9. PMID: 32286230.
      Citations: 1     Fields:    
    11. Mao D, Reuter CM, Ruzhnikov MRZ, Beck AE, Farrow EG, Emrick LT, Rosenfeld JA, Mackenzie KM, Robak L, Wheeler MT, Burrage LC, Jain M, Liu P, Calame D, Küry S, Sillesen M, Schmitz-Abe K, Tonduti D, Spaccini L, Iascone M, Genetti CA, Koenig MK, Graf M, Tran A, Alejandro M, Lee BH, Thiffault I, Agrawal PB, Bernstein JA, Bellen HJ, Chao HT. De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation. Am J Hum Genet. 2020 04 02; 106(4):570-583. PMID: 32197074.
      Citations:    Fields:    Translation:Humans
    12. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Neuron. 2020 05 20; 106(4):589-606.e6. PMID: 32169171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    13. Bosch JA, Knight S, Kanca O, Zirin J, Yang-Zhou D, Hu Y, Rodiger J, Amador G, Bellen HJ, Perrimon N, Mohr SE. Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes. Curr Protoc Mol Biol. 2020 03; 130(1):e112. PMID: 31869524.
      Citations: 1     Fields:    
    14. Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, Duraine L, Zuo Z, Park YJ, Li-Kroeger D, Bi W, Wong LJ, Rosenfeld J, Gleeson J, Faqeih E, Alkuraya FS, Wierenga KJ, Chen J, Afenjar A, Nava C, Doummar D, Keren B, Juusola J, Grompe M, Bellen HJ, Campeau PM. Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Am J Hum Genet. 2019 12 05; 105(6):1237-1253. PMID: 31785787.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    15. Bellen HJ, Wangler MF, Yamamoto S. The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases. Hum Mol Genet. 2019 11 21; 28(R2):R207-R214. PMID: 31227826.
      Citations: 8     Fields:    Translation:HumansAnimals
    16. Link N, Chung H, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ. Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. Dev Cell. 2019 12 16; 51(6):713-729.e6. PMID: 31735666.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung H, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ. An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. Elife. 2019 11 01; 8. PMID: 31674908.
      Citations: 10     Fields:    Translation:AnimalsCells
    18. Kanca O, Bellen HJ. La CaSSA da Drosophila: A Versatile Expansion of the Tool Box. Neuron. 2019 10 23; 104(2):177-179. PMID: 31647888.
      Citations:    Fields:    Translation:AnimalsCells
    19. Guo H, Bettella E, Marcogliese PC, Zhao R, Andrews JC, Nowakowski TJ, Gillentine MA, Hoekzema K, Wang T, Wu H, Jangam S, Liu C, Ni H, Willemsen MH, van Bon BW, Rinne T, Stevens SJC, Kleefstra T, Brunner HG, Yntema HG, Long M, Zhao W, Hu Z, Colson C, Richard N, Schwartz CE, Romano C, Castiglia L, Bottitta M, Dhar SU, Erwin DJ, Emrick L, Keren B, Afenjar A, Zhu B, Bai B, Stankiewicz P, Herman K, Mercimek-Andrews S, Juusola J, Wilfert AB, Abou Jamra R, Büttner B, Mefford HC, Muir AM, Scheffer IE, Regan BM, Malone S, Gecz J, Cobben J, Weiss MM, Waisfisz Q, Bijlsma EK, Hoffer MJV, Ruivenkamp CAL, Sartori S, Xia F, Rosenfeld JA, Bernier RA, Wangler MF, Yamamoto S, Xia K, Stegmann APA, Bellen HJ, Murgia A, Eichler EE. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Nat Commun. 2019 10 15; 10(1):4679. PMID: 31616000.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    20. Ansar M, Chung HL, Al-Otaibi A, Elagabani MN, Ravenscroft TA, Paracha SA, Scholz R, Abdel Magid T, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcogliese PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Kornau HC, Bellen HJ, Antonarakis SE. Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. Am J Hum Genet. 2019 11 07; 105(5):907-920. PMID: 31607425.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    21. Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV. De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Am J Hum Genet. 2019 Sep 05; 105(3):672-674. PMID: 31491411.
      Citations: 2     Fields:    
    22. Wang J, Mao D, Fazal F, Kim SY, Yamamoto S, Bellen H, Liu Z. Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity. Curr Protoc Bioinformatics. 2019 09; 67(1):e85. PMID: 31524990.
      Citations: 2     Fields:    Translation:Humans
    23. Wang J, Liu Z, Bellen HJ, Yamamoto S. Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information. J Vis Exp. 2019 08 15; (150). PMID: 31475990.
      Citations: 3     Fields:    Translation:HumansAnimals
    24. Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 08 13; 28(7):1799-1813.e5. PMID: 31412248.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV. De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Am J Hum Genet. 2019 08 01; 105(2):413-424. PMID: 31327508.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Sentürk M, Mao D, Bellen HJ. Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes. Autophagy. 2019 08; 15(8):1467-1469. PMID: 31032688.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    27. Sentürk M, Lin G, Zuo Z, Mao D, Watson E, Mikos AG, Bellen HJ. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019 03; 21(3):384-396. PMID: 30804504.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    28. Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ. VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy. 2019 07; 15(7):1214-1233. PMID: 30741620.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18. PMID: 30550790.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    30. Lin G, Wang L, Marcogliese PC, Bellen HJ. Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism. Trends Endocrinol Metab. 2019 02; 30(2):106-117. PMID: 30528460.
      Citations: 8     Fields:    Translation:HumansAnimals
    31. Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel SD, Brewer JJ, Tan L, Xu S, Xiao Q, Nagarkar-Jaiswal S, Nern A, Bellen HJ, Zipursky SL, Honig B, Shapiro L. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. 2018 12 19; 100(6):1385-1400.e6. PMID: 30467080.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    32. Xu S, Xiao Q, Cosmanescu F, Sergeeva AP, Yoo J, Lin Y, Katsamba PS, Ahlsen G, Kaufman J, Linaval NT, Lee PT, Bellen HJ, Shapiro L, Honig B, Tan L, Zipursky SL. Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits. Neuron. 2018 12 19; 100(6):1369-1384.e6. PMID: 30467079.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    33. Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. N Engl J Med. 2018 11 29; 379(22):2131-2139. PMID: 30304647.
      Citations: 31     Fields:    Translation:HumansAnimals
    34. Ansar M, Chung HL, Taylor RL, Nazir A, Imtiaz S, Sarwar MT, Manousopoulou A, Makrythanasis P, Saeed S, Falconnet E, Guipponi M, Pournaras CJ, Ansari MA, Ranza E, Santoni FA, Ahmed J, Shah I, Gul K, Black GC, Bellen HJ, Antonarakis SE. Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts. Am J Hum Genet. 2018 10 04; 103(4):568-578. PMID: 30290152.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    35. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM. IRF2BPL Is Associated with Neurological Phenotypes. Am J Hum Genet. 2018 09 06; 103(3):456. PMID: 30193138.
      Citations: 1     Fields:    
    36. Li-Kroeger D, Kanca O, Lee PT, Cowan S, Lee MT, Jaiswal M, Salazar JL, He Y, Zuo Z, Bellen HJ. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Elife. 2018 08 09; 7. PMID: 30091705.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Ansar M, Chung H, Waryah YM, Makrythanasis P, Falconnet E, Rao AR, Guipponi M, Narsani AK, Fingerhut R, Santoni FA, Ranza E, Waryah AM, Bellen HJ, Antonarakis SE. Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Hum Mol Genet. 2018 08 01; 27(15):2703-2711. PMID: 29771303.
      Citations: 8     Fields:    Translation:HumansAnimals
    38. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. PMID: 30053424.
      Citations: 14     Fields:    Translation:Humans
    39. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM. IRF2BPL Is Associated with Neurological Phenotypes. Am J Hum Genet. 2018 08 02; 103(2):245-260. PMID: 30057031.
      Citations: 10     Fields:    
    40. Liu N, Schoch K, Luo X, Pena LDM, Bhavana VH, Kukolich MK, Stringer S, Powis Z, Radtke K, Mroske C, Deak KL, McDonald MT, McConkie-Rosell A, Markert ML, Kranz PG, Stong N, Need AC, Bick D, Amaral MD, Worthey EA, Levy S, Wangler MF, Bellen HJ, Shashi V, Yamamoto S. Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. Hum Mol Genet. 2018 07 15; 27(14):2454-2465. PMID: 29726930.
      Citations: 11     Fields:    Translation:HumansAnimals
    41. Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z, Lin WW, Wang L, Bellen HJ. Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain. Cell Metab. 2018 10 02; 28(4):605-618.e6. PMID: 29909971.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    42. Li T, Bellen HJ, Groves AK. Using Drosophila to study mechanisms of hereditary hearing loss. Dis Model Mech. 2018 05 31; 11(6). PMID: 29853544.
      Citations: 1     Fields:    Translation:HumansAnimals
    43. Tan KL, Haelterman NA, Kwartler CS, Regalado ES, Lee PT, Nagarkar-Jaiswal S, Guo DC, Duraine L, Wangler MF, Bamshad MJ, Nickerson DA, Lin G, Milewicz DM, Bellen HJ. Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Dev Cell. 2018 04 23; 45(2):226-244.e8. PMID: 29689197.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    44. Wangler MF, Assia Batzir N, Robak LA, Koenig MK, Bacino CA, Scaglia F, Bellen HJ. The expanding neurological phenotype of DNM1L-related disorders. Brain. 2018 04 01; 141(4):e28. PMID: 29529134.
      Citations: 1     Fields:    Translation:Humans
    45. Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ. A gene-specific T2A-GAL4 library for Drosophila. Elife. 2018 03 22; 7. PMID: 29565247.
      Citations: 15     Fields:    Translation:Animals
    46. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ. Correction: Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2018 03; 16(3):e1002622. PMID: 29509758.
      Citations:    Fields:    
    47. Lee PT, Lin G, Lin WW, Diao F, White BH, Bellen HJ. A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. Elife. 2018 02 23; 7. PMID: 29473541.
      Citations: 4     Fields:    Translation:Animals
    48. Oláhová M, Yoon WH, Thompson K, Jangam S, Fernandez L, Davidson JM, Kyle JE, Grove ME, Fisk DG, Kohler JN, Holmes M, Dries AM, Huang Y, Zhao C, Contrepois K, Zappala Z, Frésard L, Waggott D, Zink EM, Kim YM, Heyman HM, Stratton KG, Webb-Robertson BM, Snyder M, Merker JD, Montgomery SB, Fisher PG, Feichtinger RG, Mayr JA, Hall J, Barbosa IA, Simpson MA, Deshpande C, Waters KM, Koeller DM, Metz TO, Morris AA, Schelley S, Cowan T, Friederich MW, McFarland R, Van Hove JLK, Enns GM, Yamamoto S, Ashley EA, Wangler MF, Taylor RW, Bellen HJ, Bernstein JA, Wheeler MT. Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. Am J Hum Genet. 2018 03 01; 102(3):494-504. PMID: 29478781.
      Citations: 12     Fields:    Translation:HumansCells
    49. Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Rep. 2017 12 26; 21(13):3794-3806. PMID: 29281828.
      Citations: 4     Fields:    Translation:AnimalsCells
    50. Landrock KK, Sullivan P, Martini-Stoica H, Goldstein DS, Graham BH, Yamamoto S, Bellen HJ, Gibbs RA, Chen R, D'Amelio M, Stoica G. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain Res. 2018 01 15; 1679:155-170. PMID: 29217155.
      Citations: 1     Fields:    Translation:AnimalsCells
    51. Sentürk M, Bellen HJ. Genetic strategies to tackle neurological diseases in fruit flies. Curr Opin Neurobiol. 2018 06; 50:24-32. PMID: 29128849.
      Citations: 10     Fields:    Translation:HumansAnimals
    52. Kanca O, Bellen HJ, Schnorrer F. Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila. Genetics. 2017 10; 207(2):389-412. PMID: 28978772.
      Citations: 11     Fields:    Translation:Animals
    53. Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6. PMID: 28965825.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    54. Wangler MF, Yamamoto S, Chao HT, Posey JE, Westerfield M, Postlethwait J, Hieter P, Boycott KM, Campeau PM, Bellen HJ. Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Genetics. 2017 09; 207(1):9-27. PMID: 28874452.
      Citations: 40     Fields:    Translation:HumansAnimals
    55. Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF. Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 2017 Jul; 13(7):e1006905. PMID: 28742085.
      Citations: 16     Fields:    Translation:HumansAnimals
    56. Wangler MF, Chao YH, Bayat V, Giagtzoglou N, Shinde AB, Putluri N, Coarfa C, Donti T, Graham BH, Faust JE, McNew JA, Moser A, Sardiello M, Baes M, Bellen HJ. Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse. PLoS Genet. 2017 Jun; 13(6):e1006825. PMID: 28640802.
      Citations: 10     Fields:    Translation:AnimalsCells
    57. Chao HT, Liu L, Bellen HJ. Building dialogues between clinical and biomedical research through cross-species collaborations. Semin Cell Dev Biol. 2017 10; 70:49-57. PMID: 28579453.
      Citations: 3     Fields:    Translation:HumansAnimals
    58. Wong CO, Gregory S, Hu H, Chao Y, Sepúlveda VE, He Y, Li-Kroeger D, Goldman WE, Bellen HJ, Venkatachalam K. Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages. . 2017 Jun 14; 21(6):719-730.e6. PMID: 28579255.
      Citations:    
    59. Nagarkar-Jaiswal S, Manivannan SN, Zuo Z, Bellen HJ. A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells. Elife. 2017 05 31; 6. PMID: 28561736.
      Citations: 9     Fields:    Translation:Animals
    60. Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Comjean A, Mohr SE, Perrimon N, Liu Z, Bellen HJ. MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. Am J Hum Genet. 2017 Jun 01; 100(6):843-853. PMID: 28502612.
      Citations: 35     Fields:    Translation:Humans
    61. Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B. Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models. Sci Rep. 2017 01 23; 7:40764. PMID: 28112163.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    62. Chao HT, Davids M, Burke E, Pappas JG, Rosenfeld JA, McCarty AJ, Davis T, Wolfe L, Toro C, Tifft C, Xia F, Stong N, Johnson TK, Warr CG, Yamamoto S, Adams DR, Markello TC, Gahl WA, Bellen HJ, Wangler MF, Malicdan MCV. A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3. Am J Hum Genet. 2017 Jan 05; 100(1):128-137. PMID: 28017372.
      Citations: 30     Fields:    Translation:HumansCells
    63. Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ. Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 2017 Jan 04; 93(1):115-131. PMID: 28017472.
      Citations: 31     Fields:    Translation:AnimalsCells
    64. Chen K, Ho TS, Lin G, Tan KL, Rasband MN, Bellen HJ. Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals. Elife. 2016 11 30; 5. PMID: 27901468.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    65. Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi SH, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Varga TV, Ripatti S, Franks PW, Hallmans G, Rolandsson O, Jansson JH, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T, O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet. 2016 Oct; 12(10):e1006327. PMID: 27764101.
      Citations: 16     Fields:    Translation:HumansAnimals
    66. Harel T, Yoon WH, Garone C, Gu S, Coban-Akdemir Z, Eldomery MK, Posey JE, Jhangiani SN, Rosenfeld JA, Cho MT, Fox S, Withers M, Brooks SM, Chiang T, Duraine L, Erdin S, Yuan B, Shao Y, Moussallem E, Lamperti C, Donati MA, Smith JD, McLaughlin HM, Eng CM, Walkiewicz M, Xia F, Pippucci T, Magini P, Seri M, Zeviani M, Hirano M, Hunter JV, Srour M, Zanigni S, Lewis RA, Muzny DM, Lotze TE, Boerwinkle E, Gibbs RA, Hickey SE, Graham BH, Yang Y, Buhas D, Martin DM, Potocki L, Graziano C, Bellen HJ, Lupski JR. Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. Am J Hum Genet. 2016 Oct 06; 99(4):831-845. PMID: 27640307.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    67. Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. Elife. 2016 06 25; 5. PMID: 27343351.
      Citations: 23     Fields:    Translation:Animals
    68. Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson GR, Bellen HJ, Shulman JM. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathol Commun. 2016 06 23; 4(1):62. PMID: 27338814.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    69. Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, Groves AK, Bellen HJ. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. Elife. 2016 06 22; 5. PMID: 27331610.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    70. Ali YO, Allen HM, Yu L, Li-Kroeger D, Bakhshizadehmahmoudi D, Hatcher A, McCabe C, Xu J, Bjorklund N, Taglialatela G, Bennett DA, De Jager PL, Shulman JM, Bellen HJ, Lu HC. NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biol. 2016 06; 14(6):e1002472. PMID: 27254664.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    71. Li T, Fan J, Blanco-Sánchez B, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Zhang J, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ. Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016 05; 12(5):e1006054. PMID: 27195754.
      Citations: 6     Fields:    Translation:AnimalsCells
    72. Ugur B, Chen K, Bellen HJ. Drosophila tools and assays for the study of human diseases. Dis Model Mech. 2016 Mar; 9(3):235-44. PMID: 26935102.
      Citations: 59     Fields:    Translation:HumansAnimals
    73. Chao YH, Robak LA, Xia F, Koenig MK, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF. Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila. Hum Mol Genet. 2016 05 01; 25(9):1846-56. PMID: 26931468.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    74. David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Dev Cell. 2016 Jan 25; 36(2):139-51. PMID: 26812014.
      Citations: 16     Fields:    Translation:AnimalsCells
    75. Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL. Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila. Cell. 2015 Dec 17; 163(7):1756-69. PMID: 26687360.
      Citations: 29     Fields:    Translation:AnimalsCells
    76. Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K. Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell. 2015 Dec 17; 163(7):1770-1782. PMID: 26687361.
      Citations: 24     Fields:    Translation:AnimalsCells
    77. Bellen HJ, Yamamoto S. Morgan's legacy: fruit flies and the functional annotation of conserved genes. Cell. 2015 Sep 24; 163(1):12-4. PMID: 26406362.
      Citations: 33     Fields:    Translation:HumansAnimals
    78. Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SY. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015 Sep 10; 6:8245. PMID: 26356605.
      Citations: 17     Fields:    Translation:AnimalsCells
    79. Wang F, Jiang L, Chen Y, Haelterman NA, Bellen HJ, Chen R. FlyVar: a database for genetic variation in Drosophila melanogaster. Database (Oxford). 2015; 2015. PMID: 26289428.
      Citations: 3     Fields:    Translation:Animals
    80. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113.
      Citations: 63     Fields:    Translation:AnimalsCells
    81. Wang S, Bellen HJ. The retromer complex in development and disease. Development. 2015 Jul 15; 142(14):2392-6. PMID: 26199408.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    82. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ. Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2015 Jul; 13(7):e1002197. PMID: 26176594.
      Citations: 16     Fields:    Translation:AnimalsCells
    83. Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ. A genetic toolkit for tagging intronic MiMIC containing genes. Elife. 2015 Jun 23; 4. PMID: 26102525.
      Citations: 37     Fields:    Translation:Animals
    84. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2015 May; 13(5):e1002170. PMID: 26020534.
      Citations:    Fields:    
    85. Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Gutierrez MC, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Elife. 2015 Mar 31; 4. PMID: 25824290.
      Citations: 97     Fields:    Translation:AnimalsCells
    86. Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015 Mar; 13(3):e1002103. PMID: 25811491.
      Citations: 21     Fields:    Translation:AnimalsCells
    87. Rui YN, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S. Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar; 17(3):262-75. PMID: 25686248.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    88. Wangler MF, Yamamoto S, Bellen HJ. Fruit flies in biomedical research. Genetics. 2015 Mar; 199(3):639-53. PMID: 25624315.
      Citations: 52     Fields:    Translation:HumansAnimals
    89. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Hui J, Graham BH, Quintana A, Bellen HJ. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015 Jan 15; 160(1-2):177-90. PMID: 25594180.
      Citations: 108     Fields:    Translation:AnimalsCells
    90. Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K. A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron. 2014 Nov 19; 84(4):764-77. PMID: 25451193.
      Citations: 21     Fields:    Translation:AnimalsCells
    91. Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B, Zhang K, David G, Charng WL, Yamamoto S, Duraine L, Graham BH, Bellen HJ. Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. Elife. 2014 Oct 14; 3. PMID: 25313867.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    92. Bellen HJ. Survival of the fittest tools. Genetics. 2014 Oct; 198(2):427-8. PMID: 25316776.
      Citations: 2     Fields:    Translation:Animals
    93. Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng WL, Busby T, Jawaid A, David G, Jaiswal M, Venken KJ, Yamamoto S, Chen R, Bellen HJ. Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res. 2014 Oct; 24(10):1707-18. PMID: 25258387.
      Citations: 31     Fields:    Translation:AnimalsCells
    94. Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LELM, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014 Sep 25; 159(1):200-214. PMID: 25259927.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    95. Halstead JM, Lin YQ, Durraine L, Hamilton RS, Ball G, Neely GG, Bellen HJ, Davis I. Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse. Biol Open. 2014 Aug 29; 3(9):839-49. PMID: 25171887.
      Citations:    
    96. Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ. A mitocentric view of Parkinson's disease. Annu Rev Neurosci. 2014; 37:137-59. PMID: 24821430.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    97. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014 Apr; 12(4):e1001847. PMID: 24781186.
      Citations: 19     Fields:    Translation:AnimalsCells
    98. Charng WL, Yamamoto S, Bellen HJ. Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases. Curr Opin Neurobiol. 2014 Aug; 27:158-64. PMID: 24762652.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    99. Venken KJ, Bellen HJ. Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods. 2014 Jun 15; 68(1):15-28. PMID: 24583113.
      Citations: 25     Fields:    Translation:AnimalsCells
    100. Charng WL, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu HC, Chen K, Giagtzoglou N, Bellen HJ. Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777. PMID: 24492843.
      Citations: 20     Fields:    Translation:AnimalsCells
    101. Yamamoto S, Schulze KL, Bellen HJ. Introduction to Notch signaling. Methods Mol Biol. 2014; 1187:1-14. PMID: 25053477.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    102. Yamamoto S, Bellen HJ. Preface. Notch signaling. Methods Mol Biol. 2014; 1187:v. PMID: 25187920.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    103. Cassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJ, Ji J, Jiang H, Bellen HJ, White KP, Carthew RW. miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013 Dec 19; 155(7):1556-67. PMID: 24360277.
      Citations: 38     Fields:    Translation:Animals
    104. Moustaqim-Barrette A, Lin YQ, Pradhan S, Neely GG, Bellen HJ, Tsuda H. The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Hum Mol Genet. 2014 Apr 15; 23(8):1975-89. PMID: 24271015.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    105. Xiong B, Bellen HJ. Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends Neurosci. 2013 Nov; 36(11):652-60. PMID: 24012059.
      Citations: 21     Fields:    Translation:HumansAnimals
    106. Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA. VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. PLoS Genet. 2013; 9(9):e1003738. PMID: 24039594.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    107. Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC. NMNATs, evolutionarily conserved neuronal maintenance factors. Trends Neurosci. 2013 Nov; 36(11):632-40. PMID: 23968695.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    108. Yamamoto S, Bayat V, Bellen HJ, Tan C. Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation. PLoS One. 2013; 8(7):e70502. PMID: 23936219.
      Citations: 13     Fields:    Translation:AnimalsCells
    109. Giagtzoglou N, Li T, Yamamoto S, Bellen HJ. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J Cell Sci. 2013 Aug 15; 126(Pt 16):3686-96. PMID: 23788431.
      Citations: 4     Fields:    Translation:AnimalsCells
    110. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng WL, David G, Haueter C, Yamamoto S, Graham BH, Bellen HJ. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013 Mar 18; 200(6):807-20. PMID: 23509070.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    111. Winther ÅM, Jiao W, Vorontsova O, Rees KA, Koh TW, Sopova E, Schulze KL, Bellen HJ, Shupliakov O. The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses. J Cell Sci. 2013 Feb 15; 126(Pt 4):1021-31. PMID: 23321638.
      Citations: 12     Fields:    Translation:AnimalsCells
    112. Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng WL, Li T, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ. Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biol. 2012; 10(12):e1001438. PMID: 23226104.
      Citations: 37     Fields:    Translation:AnimalsCells
    113. Yamamoto S, Charng WL, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ. A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science. 2012 Nov 30; 338(6111):1229-32. PMID: 23197537.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    114. Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MA. Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci. 2012 Nov 07; 32(45):16018-30. PMID: 23136438.
      Citations: 30     Fields:    Translation:AnimalsCells
    115. Szabad J, Bellen HJ, Venken KJ. An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells. G3 (Bethesda). 2012 Sep; 2(9):1095-102. PMID: 22973547.
      Citations: 3     Fields:    Translation:AnimalsCells
    116. Alves-Silva J, Sánchez-Soriano N, Beaven R, Klein M, Parkin J, Millard TH, Bellen HJ, Venken KJ, Ballestrem C, Kammerer RA, Prokop A. Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 2012 Jul 04; 32(27):9143-58. PMID: 22764224.
      Citations: 44     Fields:    Translation:AnimalsCells
    117. Bayat V, Thiffault I, Jaiswal M, Tétreault M, Donti T, Sasarman F, Bernard G, Demers-Lamarche J, Dicaire MJ, Mathieu J, Vanasse M, Bouchard JP, Rioux MF, Lourenco CM, Li Z, Haueter C, Shoubridge EA, Graham BH, Brais B, Bellen HJ. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 2012; 10(3):e1001288. PMID: 22448145.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    118. Han SM, Tsuda H, Yang Y, Vibbert J, Cottee P, Lee SJ, Winek J, Haueter C, Bellen HJ, Miller MA. Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors. Dev Cell. 2012 Feb 14; 22(2):348-62. PMID: 22264801.
      Citations: 34     Fields:    Translation:AnimalsCells
    119. Giagtzoglou N, Yamamoto S, Zitserman D, Graves HK, Schulze KL, Wang H, Klein H, Roegiers F, Bellen HJ. dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol. 2012 Jan 09; 196(1):65-83. PMID: 22213802.
      Citations: 13     Fields:    Translation:AnimalsCells
    120. Venken KJ, Bellen HJ. Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase. Methods Mol Biol. 2012; 859:203-28. PMID: 22367874.
      Citations: 33     Fields:    Translation:AnimalsCells
    121. Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012 Mar; 190(3):931-40. PMID: 22174071.
      Citations: 41     Fields:    Translation:AnimalsCells
    122. Xue M, Giagtzoglou N, Bellen HJ. Dueling Ca2+ sensors in neurotransmitter release. Cell. 2011 Oct 28; 147(3):491-3. PMID: 22036557.
      Citations: 2     Fields:    
    123. Venken KJ, Simpson JH, Bellen HJ. Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron. 2011 Oct 20; 72(2):202-30. PMID: 22017985.
      Citations: 148     Fields:    Translation:AnimalsCells
    124. Spradling AC, Bellen HJ, Hoskins RA. Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15948-53. PMID: 21896744.
      Citations: 38     Fields:    Translation:AnimalsCells
    125. Venken KJ, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJ. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods. 2011 Sep; 8(9):737-43. PMID: 21985007.
      Citations: 219     Fields:    Translation:AnimalsCells
    126. Tong C, Ohyama T, Tien AC, Rajan A, Haueter CM, Bellen HJ. Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Neuron. 2011 Aug 11; 71(3):447-59. PMID: 21835342.
      Citations: 16     Fields:    Translation:AnimalsCells
    127. Zheng L, Michelson Y, Freger V, Avraham Z, Venken KJ, Bellen HJ, Justice MJ, Wides R. Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011; 6(8):e22956. PMID: 21857973.
      Citations: 27     Fields:    Translation:AnimalsCells
    128. Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet. 2011 Sep 15; 20(18):3642-52. PMID: 21685205.
      Citations: 79     Fields:    Translation:HumansCells
    129. Bellen HJ, Levis RW, He Y, Carlson JW, Evans-Holm M, Bae E, Kim J, Metaxakis A, Savakis C, Schulze KL, Hoskins RA, Spradling AC. The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics. 2011 Jul; 188(3):731-43. PMID: 21515576.
      Citations: 137     Fields:    Translation:AnimalsCells
    130. Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31. PMID: 21430782.
      Citations: 243     Fields:    Translation:AnimalsCells
    131. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12; 143(4):628-38. PMID: 21074052.
      Citations: 103     Fields:    Translation:HumansAnimals
    132. Venken KJ, Popodi E, Holtzman SL, Schulze KL, Park S, Carlson JW, Hoskins RA, Bellen HJ, Kaufman TC. A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics. 2010 Dec; 186(4):1111-25. PMID: 20876565.
      Citations: 46     Fields:    Translation:AnimalsCells
    133. Bayat V, Jaiswal M, Bellen HJ. The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases. Curr Opin Neurobiol. 2011 Feb; 21(1):182-8. PMID: 20832291.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    134. Bellen HJ, Tong C, Tsuda H. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci. 2010 Jul; 11(7):514-22. PMID: 20383202.
      Citations: 109     Fields:    Translation:HumansAnimals
    135. Yamamoto S, Charng WL, Bellen HJ. Endocytosis and intracellular trafficking of Notch and its ligands. Curr Top Dev Biol. 2010; 92:165-200. PMID: 20816395.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    136. Giagtzoglou N, Mahoney T, Yao CK, Bellen HJ. Rab3 GTPase lands Bruchpilot. Neuron. 2009 Dec 10; 64(5):595-7. PMID: 20005815.
      Citations: 3     Fields:    Translation:AnimalsCells
    137. Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C. Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron. 2009 Nov 12; 64(3):367-80. PMID: 19914185.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    138. Giagtzoglou N, Ly CV, Bellen HJ. Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol. 2009 Oct; 1(4):a003079. PMID: 20066100.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    139. Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell. 2009 Sep 04; 138(5):947-60. PMID: 19737521.
      Citations: 54     Fields:    Translation:AnimalsCells
    140. Verstreken P, Ohyama T, Haueter C, Habets RL, Lin YQ, Swan LE, Ly CV, Venken KJ, De Camilli P, Bellen HJ. Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron. 2009 Jul 30; 63(2):203-15. PMID: 19640479.
      Citations: 38     Fields:    Translation:AnimalsCells
    141. Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol. 2009 Jun 29; 185(7):1181-94. PMID: 19546244.
      Citations: 32     Fields:    Translation:AnimalsCells
    142. Rajan A, Tien AC, Haueter CM, Schulze KL, Bellen HJ. The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009 Jul; 11(7):815-24. PMID: 19543274.
      Citations: 46     Fields:    Translation:AnimalsCells
    143. Venken KJ, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RA. Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods. 2009 Jun; 6(6):431-4. PMID: 19465919.
      Citations: 176     Fields:    Translation:AnimalsCells
    144. Fotowat H, Fayyazuddin A, Bellen HJ, Gabbiani F. A novel neuronal pathway for visually guided escape in Drosophila melanogaster. J Neurophysiol. 2009 Aug; 102(2):875-85. PMID: 19474177.
      Citations: 28     Fields:    Translation:AnimalsCells
    145. Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ. Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. . 2009 Jun; 10(6):636-41. PMID: 19444309.
      Citations:    
    146. Giagtzoglou N, Lin YQ, Haueter C, Bellen HJ. Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. J Neurosci. 2009 Apr 29; 29(17):5628-39. PMID: 19403829.
      Citations: 13     Fields:    Translation:AnimalsCells
    147. Tien AC, Rajan A, Bellen HJ. A Notch updated. J Cell Biol. 2009 Mar 09; 184(5):621-9. PMID: 19255248.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    148. Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ. Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol. 2008 Sep 22; 182(6):1113-25. PMID: 18809725.
      Citations: 35     Fields:    Translation:AnimalsCells
    149. Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ. The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell. 2008 Jun 13; 133(6):963-77. PMID: 18555774.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    150. Ly CV, Yao CK, Verstreken P, Ohyama T, Bellen HJ. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008 Apr 07; 181(1):157-70. PMID: 18391075.
      Citations: 35     Fields:    Translation:AnimalsCells
    151. Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature. 2008 Apr 17; 452(7189):887-91. PMID: 18344983.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    152. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008 Jan 25; 132(2):247-58. PMID: 18243100.
      Citations: 117     Fields:    Translation:AnimalsCells
    153. Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 2008 Jan 10; 57(1):27-40. PMID: 18184562.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    154. Verstreken P, Ohyama T, Bellen HJ. FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction. Methods Mol Biol. 2008; 440:349-69. PMID: 18369958.
      Citations: 46     Fields:    Translation:AnimalsCells
    155. Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ. Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol. 2007 Dec 31; 179(7):1481-96. PMID: 18158335.
      Citations: 43     Fields:    Translation:AnimalsCells
    156. Zhang W, Wang D, Volk E, Bellen HJ, Hiesinger PR, Quiocho FA. V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. J Biol Chem. 2008 Jan 04; 283(1):294-300. PMID: 17933871.
      Citations: 14     Fields:    Translation:AnimalsCells
    157. Venken KJ, Bellen HJ. Transgenesis upgrades for Drosophila melanogaster. Development. 2007 Oct; 134(20):3571-84. PMID: 17905790.
      Citations: 61     Fields:    Translation:AnimalsCells
    158. Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ. Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol. 2007 Jul 16; 178(2):309-22. PMID: 17620409.
      Citations: 58     Fields:    Translation:AnimalsCells
    159. Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP. Thirty-one flavors of Drosophila rab proteins. Genetics. 2007 Jun; 176(2):1307-22. PMID: 17409086.
      Citations: 142     Fields:    Translation:Animals
    160. Venken KJ, He Y, Hoskins RA, Bellen HJ. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006 Dec 15; 314(5806):1747-51. PMID: 17138868.
      Citations: 371     Fields:    Translation:AnimalsCells
    161. Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ. Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol. 2006 Nov; 4(12):e416. PMID: 17132048.
      Citations: 80     Fields:    Translation:AnimalsCells
    162. Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006 Sep 19; 16(18):1835-43. PMID: 16979562.
      Citations: 47     Fields:    Translation:AnimalsCells
    163. Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ. Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development. 2006 May; 133(10):1979-89. PMID: 16624856.
      Citations: 31     Fields:    Translation:AnimalsCells
    164. Seto ES, Bellen HJ. Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol. 2006 Apr 10; 173(1):95-106. PMID: 16606693.
      Citations: 66     Fields:    Translation:AnimalsCells
    165. Jafar-Nejad H, Tien AC, Acar M, Bellen HJ. Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development. 2006 May; 133(9):1683-92. PMID: 16554363.
      Citations: 21     Fields:    Translation:AnimalsCells
    166. Fayyazuddin A, Zaheer MA, Hiesinger PR, Bellen HJ. The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. PLoS Biol. 2006 Mar; 4(3):e63. PMID: 16494528.
      Citations: 49     Fields:    Translation:AnimalsCells
    167. Giagtzoglou N, Bellen HJ. Fighting anthrax with flies. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3013-4. PMID: 16492749.
      Citations:    Fields:    Translation:HumansAnimalsCells
    168. Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HY. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15; 19(20):2412-7. PMID: 16230531.
      Citations: 118     Fields:    Translation:AnimalsCells
    169. Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA. Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nat Struct Mol Biol. 2005 Oct; 12(10):879-85. PMID: 16155582.
      Citations: 120     Fields:    Translation:AnimalsCells
    170. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005 Sep; 9(3):351-63. PMID: 16137928.
      Citations: 91     Fields:    Translation:AnimalsCells
    171. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. PMID: 16122429.
      Citations: 87     Fields:    Translation:AnimalsCells
    172. Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron. 2005 Aug 04; 47(3):365-78. PMID: 16055061.
      Citations: 300     Fields:    Translation:AnimalsCells
    173. Dermaut B, Norga KK, Kania A, Verstreken P, Pan H, Zhou Y, Callaerts P, Bellen HJ. Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J Cell Biol. 2005 Jul 04; 170(1):127-39. PMID: 15998804.
      Citations: 59     Fields:    Translation:AnimalsCells
    174. Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell. 2005 May 20; 121(4):607-620. PMID: 15907473.
      Citations: 113     Fields:    Translation:AnimalsCells
    175. Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron. 2005 Apr 21; 46(2):219-32. PMID: 15848801.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    176. Venken KJ, Bellen HJ. Emerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet. 2005 Mar; 6(3):167-78. PMID: 15738961.
      Citations: 85     Fields:    Translation:AnimalsCells
    177. Escudero LM, Caminero E, Schulze KL, Bellen HJ, Modolell J. Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development. 2005 Mar; 132(6):1211-22. PMID: 15703278.
      Citations: 18     Fields:    Translation:AnimalsCells
    178. Zhai RG, Bellen HJ. Hauling t-SNAREs on the microtubule highway. Nat Cell Biol. 2004 Oct; 6(10):918-9. PMID: 15459718.
      Citations: 2     Fields:    Translation:Cells
    179. Zhai RG, Bellen HJ. The architecture of the active zone in the presynaptic nerve terminal. Physiology (Bethesda). 2004 Oct; 19:262-70. PMID: 15381754.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    180. Jafar-Nejad H, Bellen HJ. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol. 2004 Oct; 24(20):8803-12. PMID: 15456856.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    181. Kazanjian A, Wallis D, Au N, Nigam R, Venken KJ, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HL. Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Res. 2004 Oct 01; 64(19):6874-82. PMID: 15466176.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    182. Koh TW, Verstreken P, Bellen HJ. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron. 2004 Jul 22; 43(2):193-205. PMID: 15260956.
      Citations: 112     Fields:    Translation:AnimalsCells
    183. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, Hoskins RA, Spradling AC. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics. 2004 Jun; 167(2):761-81. PMID: 15238527.
      Citations: 417     Fields:    Translation:AnimalsCells
    184. Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development. 2004 May; 131(9):2183-94. PMID: 15073152.
      Citations: 157     Fields:    Translation:HumansAnimalsCells
    185. Bellen HJ. Hugo J. Bellen. Curr Biol. 2004 Mar 23; 14(6):R218. PMID: 15043825.
      Citations:    Fields:    Translation:Animals
    186. Hiesinger PR, Bellen HJ. Flying in the face of total disruption. Nat Genet. 2004 Mar; 36(3):211-2. PMID: 14988715.
      Citations: 2     Fields:    Translation:AnimalsCells
    187. Seto ES, Bellen HJ. The ins and outs of Wingless signaling. Trends Cell Biol. 2004 Jan; 14(1):45-53. PMID: 14729180.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    188. Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ. Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003 Dec 01; 17(23):2966-78. PMID: 14665671.
      Citations: 59     Fields:    Translation:AnimalsCells
    189. Fabian-Fine R, Verstreken P, Hiesinger PR, Horne JA, Kostyleva R, Zhou Y, Bellen HJ, Meinertzhagen IA. Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. J Neurosci. 2003 Nov 19; 23(33):10732-44. PMID: 14627659.
      Citations: 41     Fields:    Translation:AnimalsCells
    190. Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ. Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron. 2003 Nov 13; 40(4):733-48. PMID: 14622578.
      Citations: 154     Fields:    Translation:AnimalsCells
    191. Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ. Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10860-5. PMID: 12960394.
      Citations: 62     Fields:    Translation:AnimalsCells
    192. Norga KK, Gurganus MC, Dilda CL, Yamamoto A, Lyman RF, Patel PH, Rubin GM, Hoskins RA, Mackay TF, Bellen HJ. Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol. 2003 Aug 19; 13(16):1388-96. PMID: 12932322.
      Citations: 67     Fields:    Translation:Animals
    193. Koh TW, Bellen HJ. Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends Neurosci. 2003 Aug; 26(8):413-22. PMID: 12900172.
      Citations: 74     Fields:    Translation:AnimalsCells
    194. Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan; 130(1):221-32. PMID: 12441305.
      Citations: 103     Fields:    Translation:AnimalsCells
    195. Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development. 2002 Dec; 129(24):5719-30. PMID: 12421711.
      Citations: 119     Fields:    Translation:AnimalsCells
    196. Kjaerulff O, Verstreken P, Bellen HJ. Synaptic vesicle retrieval: still time for a kiss. Nat Cell Biol. 2002 Nov; 4(11):E245-8. PMID: 12415277.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    197. Wang VY, Hassan BA, Bellen HJ, Zoghbi HY. Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts. Curr Biol. 2002 Sep 17; 12(18):1611-6. PMID: 12372255.
      Citations: 42     Fields:    Translation:Animals
    198. Jafar-Nejad H, Norga K, Bellen H. Numb: "Adapting" notch for endocytosis. Dev Cell. 2002 Aug; 3(2):155-6. PMID: 12194846.
      Citations: 8     Fields:    Translation:AnimalsCells
    199. Verstreken P, Bellen HJ. Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends Neurosci. 2002 Aug; 25(8):383-5. PMID: 12127745.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    200. Pennetta G, Hiesinger PR, Fabian-Fine R, Meinertzhagen IA, Bellen HJ. Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron. 2002 Jul 18; 35(2):291-306. PMID: 12160747.
      Citations: 79     Fields:    Translation:AnimalsCells
    201. Seto ES, Bellen HJ, Lloyd TE. When cell biology meets development: endocytic regulation of signaling pathways. Genes Dev. 2002 Jun 01; 16(11):1314-36. PMID: 12050111.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    202. Verstreken P, Kjaerulff O, Lloyd TE, Atkinson R, Zhou Y, Meinertzhagen IA, Bellen HJ. Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell. 2002 Apr 05; 109(1):101-12. PMID: 11955450.
      Citations: 105     Fields:    Translation:AnimalsCells
    203. Izaddoost S, Nam SC, Bhat MA, Bellen HJ, Choi KW. Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature. 2002 Mar 14; 416(6877):178-83. PMID: 11850624.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    204. Lloyd TE, Atkinson R, Wu MN, Zhou Y, Pennetta G, Bellen HJ. Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell. 2002 Jan 25; 108(2):261-9. PMID: 11832215.
      Citations: 176     Fields:    Translation:AnimalsCells
    205. Chen S, Zheng X, Schulze KL, Morris T, Bellen H, Stanley EF. Enhancement of presynaptic calcium current by cysteine string protein. J Physiol. 2002 Jan 15; 538(Pt 2):383-9. PMID: 11790807.
      Citations: 12     Fields:    Translation:AnimalsCells
    206. Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, Schäfer U. Mapping and identification of essential gene functions on the X chromosome of Drosophila. . 2002 Jan; 3(1):34-8. PMID: 11751581.
      Citations:    
    207. Kania A, Bellen HJ. Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects. Rouxs Arch Dev Biol. 1995 Mar; 204(4):259-270. PMID: 28306121.
      Citations:    
    208. Whitehouse-Hills S, Bellen HJ, Kiger JA. Embryonic cAMP and developmental potential in Drosophila melanogaster. Rouxs Arch Dev Biol. 1992 Jun; 201(4):257-264. PMID: 28305849.
      Citations:    
    209. Weigel D, Bellen HJ, Jürgens G, Jäckle H. Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo. Rouxs Arch Dev Biol. 1989 Nov; 198(4):201-210. PMID: 28305483.
      Citations:    
    210. Bellen HJ, Kiger JA. Maternal effects of general and regional specificity on embryos of Drosophila melanogaster caused by dunce and rutabaga mutant combinations. Rouxs Arch Dev Biol. 1988 Aug; 197(5):258-268. PMID: 28305785.
      Citations:    
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