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HUGO BELLEN

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    Collapse Overview 
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    Investigator, Howard Hughes Medical Institute, Baylor College of Medicine
    Professor, Departments of Molecular and Human Genetics and Neuroscience
    Director, Program in Developmental Biology

    I am interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.

    Collapse Research 
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    R01AG073260     (BELLEN, HUGO J)Sep 1, 2021 - May 31, 2026
    NIH
    IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
    Role: Principal Investigator
    R01HG011795     (BELLEN, HUGO J ;WANGLER, MICHAEL FRANCIS)Jul 13, 2021 - Apr 30, 2026
    NIH
    Genomic medicine and gene function implementation for an underserved population
    Role: Principal Investigator
    U01AG072439     (BELLEN, HUGO J;BOTAS, JUAN ;MILOSAVLJEVIC, ALEKSANDAR ;SHULMAN, JOSHUA M)Jul 1, 2021 - Jun 30, 2026
    NIH
    Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models
    Role: Co-Principal Investigator
    R24OD031447     (BELLEN, HUGO J)Jul 1, 2021 - Mar 31, 2025
    NIH
    A Comprehensive Resource for Manipulating the Drosophila Genome
    Role: Principal Investigator
    R24OD026435     (PERRIMON, NORBERT)Jul 1, 2018 - Jun 30, 2022
    NIH
    Using CRISPR technology to study the function of paralogous genes
    Role: Co-Principal Investigator
    R01DC014932     (GROVES, ANDREW K)Dec 1, 2016 - Nov 30, 2021
    NIH
    A multi-species approach to find regulators of deafness genes
    Role: Co-Principal Investigator
    R24OD022005     (BELLEN, HUGO J)Jun 1, 2016 - May 31, 2024
    NIH
    A Human cDNA Library for Functional Gene Replacement in Drosophila
    Role: Principal Investigator
    U54NS093793     (BELLEN, HUGO J)Sep 15, 2015 - Jun 30, 2023
    NIH
    Center for functional analysis of human UDN gene homologs in Drosophila and zebrafish
    Role: Principal Investigator
    RC4GM096355     (BELLEN, HUGO J.)Sep 30, 2010 - Sep 29, 2013
    NIH
    Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Role: Principal Investigator
    R01GM080415     (BELLEN, HUGO J.)Aug 1, 2007 - Nov 30, 2010
    NIH
    Molecularly defined duplications for the X-chromosome and large autosomal genes
    Role: Principal Investigator
    T32HD055200     (BELLEN, HUGO J.)Jun 5, 2007 - Apr 30, 2013
    NIH
    Developmental Biology Training Program
    Role: Principal Investigator
    R01GM068949     (BELLEN, HUGO J)Jul 1, 2003 - Jun 30, 2007
    NIH
    Hrs and Endocytic Regulation of Notch and Wingless
    Role: Principal Investigator
    R01GM067858     (BELLEN, HUGO J)May 1, 2003 - May 31, 2021
    NIH
    A Comprehensive Resource for Manipulating the Drosophila Genome
    Role: Principal Investigator
    T32ES007332     (BELLEN, HUGO J)Jul 1, 2000 - Jun 30, 2007
    NIH
    DEVELOPMENT BIOLOGY TRAINING PROGRAM
    Role: Principal Investigator
    R01GM053571     (BELLEN, HUGO J)Jul 1, 1996 - Jun 30, 2001
    NIH
    NEUROTRANSMITTER RELEASE IN DROSOPHILA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Goodman LD, Moulton MJ, Bellen HJ. Glial lipid droplets resolve ROS during sleep. Nat Neurosci. 2024 Apr; 27(4):610-612. PMID: 38360945.
      Citations:    Fields:    
    2. Ma M, Ganapathi M, Zheng Y, Tan KL, Kanca O, Bove KE, Quintanilla N, Sag SO, Temel SG, LeDuc CA, McPartland AJ, Pereira EM, Shen Y, Hagen J, Thomas CP, Galv?n NTN, Pan X, Lu S, Rosenfeld JA, Calame DG, Wangler MF, Lupski JR, Pehlivan D, Hertel PM, Chung WK, Bellen HJ. Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genet Med. 2024 Mar 21; 101125. PMID: 38522068.
      Citations:    Fields:    
    3. Park YJ, Lu TC, Jackson T, Goodman LD, Ran L, Chen J, Liang CY, Harrison E, Ko C, Hsu AL, Yamamoto S, Qi Y, Bellen HJ, Li H, Park YJ, Lu TC, Jackson T, Goodman LD, Ran L, Chen J, Liang CY, Harrison E, Ko C, Hsu AL, Yamamoto S, Qi Y, Bellen HJ, Li H. Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models. bioRxiv. 2024 Mar 13. PMID: 38559164; PMCID: PMC10979927.
      Citations:    
    4. Pan X, Tao AM, Lu S, Ma M, Hannan SB, Slaugh R, Drewes Williams S, O'Grady L, Kanca O, Person R, Carter MT, Platzer K, Schnabel F, Abou Jamra R, Roberts AE, Newburger JW, Revah-Politi A, Granadillo JL, Stegmann APA, Sinnema M, Accogli A, Salpietro V, Capra V, Ghaloul-Gonzalez L, Brueckner M, Simon MEH, Sweetser DA, Glinton KE, Kirk SE, Baylor College of Medicine Center for Precision Medicine Models, Wangler MF, Yamamoto S, Chung WK, Bellen HJ. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Am J Hum Genet. 2024 Apr 04; 111(4):742-760. PMID: 38479391.
      Citations:    Fields:    
    5. Vuocolo B, German RJ, Lalani SR, Murali CN, Bacino CA, Baskin S, Littlejohn R, Odom JD, McLean S, Schmid C, Nutter M, Stuebben M, Magness E, Juarez O, El Achi D, Mitchell B, Glinton KE, Robak L, Nagamani SC, Saba L, Ritenour A, Zhang L, Streff H, Chan K, Kemere KJ, Carter K, Texome Project, Owen N, Vossaert L, Liu P, Bellen H, Wangler M. Improving access to exome sequencing in a medically underserved population through the Texome Project. Genet Med. 2024 Feb 28; 101102. PMID: 38431799.
      Citations:    Fields:    
    6. Martelli F, Lin J, Mele S, Imlach W, Kanca O, Barlow CK, Paril J, Schittenhelm RB, Christodoulou J, Bellen HJ, Piper MDW, Johnson TK. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Cell Rep. 2024 Mar 26; 43(3):113861. PMID: 38416643.
      Citations:    Fields:    Translation:HumansAnimals
    7. Dutta D, Kanca O, Shridharan RV, Marcogliese PC, Steger B, Morimoto M, Frost FG, Macnamara E, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Jenny A, Adams D, Malicdan MC, Bellen HJ. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2322582121. PMID: 38381787; PMCID: PMC10907268.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser AA, Lan J, Afenjar A, Chawla G, Brem RB, Campeau PM, Bellen HJ, Schilling B, Seyfried NT, Ellerby LM, Kapahi P. OXR1 maintains the retromer to delay brain aging under dietary restriction. Nat Commun. 2024 Jan 11; 15(1):467. PMID: 38212606; PMCID: PMC10784588.
      Citations:    Fields:    Translation:HumansCells
    9. Ma M, Zheng Y, Lu S, Pan X, Worley KC, Burrage LC, Blieden LS, Allworth A, Chen WL, Merla G, Mandriani B, Rosenfeld JA, Li-Kroeger D, Dutta D, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Glass IA, Strohbehn S, Blue E, Prontera P, Lalani SR, Bellen HJ, Ma M, Zheng Y, Lu S, Pan X, Worley KC, Burrage LC, Blieden LS, Allworth A, Chen WL, Merla G, Mandriani B, Rosenfeld JA, Li-Kroeger D, Dutta D, Yamamoto S, Wangler MF, Glass IA, Strohbehn S, Blue E, Prontera P, Lalani SR, Bellen HJ. De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects. medRxiv. 2024 Jan 09. PMID: 38260438; PMCID: PMC10802640.
      Citations:    
    10. Pan X, Alvarez AN, Ma M, Lu S, Crawford MW, Briere LC, Kanca O, Yamamoto S, Sweetser DA, Wilson JL, Napier RJ, Pruneda JN, Bellen HJ. Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. Elife. 2023 Dec 11; 12. PMID: 38079206; PMCID: PMC10712953.
      Citations: 2     Fields:    Translation:HumansAnimals
    11. Nil Z, Deshwar AR, Huang Y, Barish S, Zhang X, Choufani S, Le Quesne Stabej P, Hayes I, Yap P, Haldeman-Englert C, Wilson C, Prescott T, Tveten K, V?llo A, Haynes D, Wheeler PG, Zon J, Cytrynbaum C, Jobling R, Blyth M, Banka S, Afenjar A, Mignot C, Robin-Renaldo F, Keren B, Kanca O, Mao X, Wegner DJ, Sisco K, Shinawi M, Undiagnosed Disease Network, Wangler MF, Weksberg R, Yamamoto S, Costain G, Bellen HJ. Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies. Am J Hum Genet. 2023 11 02; 110(11):1919-1937. PMID: 37827158; PMCID: PMC10645550.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Pan X, Alvarez AN, Ma M, Lu S, Crawford MW, Briere LC, Kanca O, Yamamoto S, Sweetser DA, Wilson JL, Napier RJ, Pruneda JN, Bellen HJ. Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. medRxiv. 2023 Oct 02. PMID: 37502976; PMCID: PMC10371176.
      Citations:    
    13. Dutta D, Kanca O, Byeon SK, Marcogliese PC, Zuo Z, Shridharan RV, Park JH, Undiagnosed Diseases Network, Lin G, Ge M, Heimer G, Kohler JN, Wheeler MT, Kaipparettu BA, Pandey A, Bellen HJ. A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels. Nat Metab. 2023 09; 5(9):1595-1614. PMID: 37653044.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Wang CY, Zuo Z, Jo J, Kim KI, Madamba C, Ye Q, Jung SY, Bellen HJ, Lee HK. Daam2 phosphorylation by CK2a negatively regulates Wnt activity during white matter development and injury. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2304112120. PMID: 37607236; PMCID: PMC10469030.
      Citations: 1     Fields:    Translation:Cells
    15. Hieter P, Andrews B, Fowler D, Bellen H. Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases. Genetics. 2023 08 09; 224(4). PMID: 37556311; PMCID: PMC10411596.
      Citations:    Fields:    Translation:Humans
    16. Hieter P, Andrews B, Fowler D, Bellen H. Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases. G3 (Bethesda). 2023 08 09; 13(8). PMID: 37556359; PMCID: PMC10411584.
      Citations:    Fields:    Translation:Humans
    17. Yamamoto S, Kanca O, Wangler MF, Bellen HJ. Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans. Nat Rev Genet. 2024 Jan; 25(1):46-60. PMID: 37491400.
      Citations: 4     Fields:    Translation:HumansAnimals
    18. Guichard A, Lu S, Kanca O, Bressan D, Huang Y, Ma M, Sanz Juste S, Andrews JC, Jay KL, Sneider M, Schwartz R, Huang MC, Bei D, Pan H, Ma L, Lin WW, Auradkar A, Bhagwat P, Park S, Wan KH, Ohsako T, Takano-Shimizu T, Celniker SE, Wangler MF, Yamamoto S, Bellen HJ, Bier E. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Cell Rep. 2023 08 29; 42(8):112842. PMID: 37480566; PMCID: PMC10962759.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Ravenscroft TA, Jacobs A, Gu M, Eberl DF, Bellen HJ. The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons. eNeuro. 2023 Jun; 10(6). PMID: 37328295; PMCID: PMC10316460.
      Citations:    Fields:    Translation:AnimalsCells
    20. Lu TC, Brbic M, Park YJ, Jackson T, Chen J, Kolluru SS, Qi Y, Katheder NS, Cai XT, Lee S, Chen YC, Auld N, Liang CY, Ding SH, Welsch D, D'Souza S, Pisco AO, Jones RC, Leskovec J, Lai EC, Bellen HJ, Luo L, Jasper H, Quake SR, Li H. Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution. Science. 2023 06 16; 380(6650):eadg0934. PMID: 37319212; PMCID: PMC10829769.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Chung HL, Ye Q, Park YJ, Zuo Z, Mok JW, Kanca O, Tattikota SG, Lu S, Perrimon N, Lee HK, Bellen HJ. Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell Metab. 2023 05 02; 35(5):855-874.e5. PMID: 37084732; PMCID: PMC10160010.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Srivastava S, Shaked HM, Gable K, Gupta SD, Pan X, Somashekarappa N, Han G, Mohassel P, Gotkine M, Doney E, Goldenberg P, Tan QKG, Gong Y, Kleinstiver B, Wishart B, Cope H, Pires CB, Stutzman H, Spillmann RC, Sadjadi R, Elpeleg O, Lee CH, Bellen HJ, Edvardson S, Eichler F, Dunn TM, Undiagnosed Disease Network . SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia. Brain. 2023 04 19; 146(4):1420-1435. PMID: 36718090; PMCID: PMC10319774.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    23. Tepe B, Macke EL, Niceta M, Weisz Hubshman M, Kanca O, Schultz-Rogers L, Zarate YA, Schaefer GB, Granadillo De Luque JL, Wegner DJ, Cogne B, Gilbert-Dussardier B, Le Guillou X, Wagner EJ, Pais LS, Neil JE, Mochida GH, Walsh CA, Magal N, Drasinover V, Shohat M, Schwab T, Schmitz C, Clark K, Fine A, Lanpher B, Gavrilova R, Blanc P, Burglen L, Afenjar A, Steel D, Kurian MA, Prabhakar P, G??wein S, Di Donato N, Bertini ES, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Tartaglia M, Klee EW, Bellen HJ. Bi-allelic variants in INTS11 are associated with a complex neurological disorder. Am J Hum Genet. 2023 05 04; 110(5):774-789. PMID: 37054711; PMCID: PMC10183469.
      Citations: 2     Fields:    Translation:HumansAnimals
    24. Wang CY, Zuo Z, Kim KI, Bellen HJ, Lee HK. CK2a-dependent regulation of Wnt activity governs white matter development and repair. bioRxiv. 2023 Apr 11. PMID: 37090554; PMCID: PMC10120613.
      Citations:    
    25. Ralhan I, Chang J, Moulton MJ, Goodman LD, Lee NYJ, Plummer G, Pasolli HA, Matthies D, Bellen HJ, Ioannou MS. Autolysosomal exocytosis of lipids protect neurons from ferroptosis. J Cell Biol. 2023 06 05; 222(6). PMID: 37036445; PMCID: PMC10098143.
      Citations:    Fields:    Translation:HumansCells
    26. Undiagnosed Diseases Network, Andrews JC, Mok JW, Kanca O, Jangam S, Tifft C, Macnamara EF, Russell BE, Wang LK, Nelson SF, Bellen HJ, Yamamoto S, Malicdan MCV, Wangler MF. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. Genet Med. 2023 06; 25(6):100833. PMID: 37013900.
      Citations: 1     Fields:    Translation:HumansAnimals
    27. Scott H, Allen B, Mertsalov I, Monagas-Valentin P, Koff M, Baas Robinson S, Aoki K, Tiemeyer M, Panin V, Novikov B, Ugur B, Veizaj R, Lefeber DJ, Bellen H. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. Elife. 2023 03 22; 12. PMID: 36946697; PMCID: PMC10110239.
      Citations:    Fields:    Translation:AnimalsCells
    28. Ma M, Zheng Y, Lu S, Pan X, Pan H, Chung HL, Bellen HJ, Zhang X, Mao X, Wang H, Guo H. The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Hum Mol Genet. 2023 03 06; 32(6):984-997. PMID: 36255738; PMCID: PMC9991001.
      Citations: 2     Fields:    Translation:Animals
    29. Pan X, Dutta D, Lu S, Bellen HJ. Sphingolipids in neurodegenerative diseases. Front Neurosci. 2023; 17:1137893. PMID: 36875645; PMCID: PMC9978793.
      Citations: 4     
    30. Lin G, Tepe B, McGrane G, Tipon RC, Croft G, Panwala L, Hope A, Liang AJH, Zuo Z, Byeon SK, Wang L, Pandey A, Bellen HJ. Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14). Elife. 2023 01 16; 12. PMID: 36645408; PMCID: PMC9889087.
      Citations: 2     Fields:    Translation:AnimalsCells
    31. Mele S, Martelli F, Lin J, Kanca O, Christodoulou J, Bellen HJ, Piper MDW, Johnson TK. Drosophila as a diet discovery tool for treating amino acid disorders. Trends Endocrinol Metab. 2023 02; 34(2):85-105. PMID: 36567227.
      Citations:    Fields:    Translation:HumansAnimals
    32. Sinha Ray S, Dutta D, Dennys C, Powers S, Roussel F, Lisowski P, Gla?ar P, Zhang X, Biswas P, Caporale JR, Rajewsky N, Bickle M, Wein N, Bellen HJ, Likhite S, Marcogliese PC, Meyer KC. Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy. Cell Rep. 2022 12 06; 41(10):111751. PMID: 36476864.
      Citations: 1     Fields:    
    33. Bosch JA, Ugur B, Pichardo-Casas I, Rabasco J, Escobedo F, Zuo Z, Brown B, Celniker S, Sinclair DA, Bellen HJ, Perrimon N. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Elife. 2022 11 08; 11. PMID: 36346220; PMCID: PMC9681215.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Huang Y, Lemire G, Briere LC, Liu F, Wessels MW, Wang X, Osmond M, Kanca O, Lu S, High FA, Walker MA, Rodan LH, Undiagnosed Diseases Network, Care4Rare Canada Consortium, Wangler MF, Yamamoto S, Kernohan KD, Sweetser DA, Boycott KM, Bellen HJ. The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. Am J Hum Genet. 2022 Nov 03; 109(11):2092. PMID: 36332614; PMCID: PMC9674957.
      Citations:    Fields:    
    35. Lu S, Ma M, Mao X, Bacino CA, Jankovic J, Sutton VR, Bartley JA, Wang X, Rosenfeld JA, Beleza-Meireles A, Chauhan J, Pan X, Li M, Liu P, Prescott K, Amin S, Davies G, Wangler MF, Dai Y, Bellen HJ. De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement. Am J Hum Genet. 2022 10 06; 109(10):1932-1943. PMID: 36206744; PMCID: PMC9606480.
      Citations: 4     Fields:    Translation:HumansAnimals
    36. Chung HL, Rump P, Lu D, Glassford MR, Mok JW, Fatih J, Basal A, Marcogliese PC, Kanca O, Rapp M, Fock JM, Kamsteeg EJ, Lupski JR, Larson A, Haninbal MC, Bellen H, Harel T. De novo variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila. Hum Mol Genet. 2022 09 29; 31(19):3231-3244. PMID: 35234901; PMCID: PMC9523557.
      Citations:    Fields:    
    37. Karagas NE, Gupta R, Rastegari E, Tan KL, Leung HH, Bellen HJ, Venkatachalam K, Wong CO. Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS. J Neurosci. 2022 10 19; 42(42):8019-8037. PMID: 36261266; PMCID: PMC9617612.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Huang Y, Lemire G, Briere LC, Liu F, Wessels MW, Wang X, Osmond M, Kanca O, Lu S, High FA, Walker MA, Rodan LH, Undiagnosed Diseases Network, Care4Rare Canada Consortium, Kernohan KD, Sweetser DA, Boycott KM, Bellen HJ. The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. Am J Hum Genet. 2022 10 06; 109(10):1923-1931. PMID: 36067766; PMCID: PMC9606386.
      Citations:    
    39. Cheng KC, Burdine RD, Dickinson ME, Ekker SC, Lin AY, Lloyd KCK, Lutz CM, MacRae CA, Morrison JH, O'Connor DH, Postlethwait JH, Rogers CD, Sanchez S, Simpson JH, Talbot WS, Wallace DC, Weimer JM, Bellen HJ. Promoting validation and cross-phylogenetic integration in model organism research. Dis Model Mech. 2022 09 01; 15(9). PMID: 36125045; PMCID: PMC9531892.
      Citations:    
    40. Barish S, Senturk M, Schoch K, Minogue AL, Lopergolo D, Fallerini C, Harland J, Seemann JH, Stong N, Kranz PG, Kansagra S, Mikati MA, Jasien J, El-Dairi M, Galluzzi P, Undiagnosed Diseases Network, Ariani F, Renieri A, Mari F, Wangler MF, Arur S, Jiang YH, Yamamoto S, Shashi V, Bellen HJ. The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder. Hum Mol Genet. 2022 08 25; 31(17):2934-2950. PMID: 35405010; PMCID: PMC9433733.
      Citations:    Fields:    
    41. Huang Y, Ma M, Mao X, Pehlivan D, Kanca O, Un-Candan F, Shu L, Akay G, Mitani T, Lu S, Candan S, Wang H, Xiao B, Lupski JR, Bellen HJ. Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms. Hum Mol Genet. 2022 08 23; 31(16):2751-2765. PMID: 35348658; PMCID: PMC9402236.
      Citations:    Fields:    
    42. Thomas AX, Link N, Robak LA, Demmler-Harrison G, Pao EC, Squire AE, Michels S, Cohen JS, Comi A, Prontera P, Verrotti di Pianella A, Di Cara G, Garavelli L, Caraffi SG, Fusco C, Zuntini R, Parks KC, Sherr EH, Hashem MO, Maddirevula S, Alkuraya FS, Contractar IAF, Neil JE, Walsh CA, Bellen HJ, Chao HT, Clark RD, Mirzaa GM. ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. Ann Clin Transl Neurol. 2022 08; 9(8):1276-1288. PMID: 35871307; PMCID: PMC9380164.
      Citations:    Fields:    
    43. Wang L, Lin G, Zuo Z, Li Y, Byeon SK, Pandey A, Bellen HJ. Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. Sci Adv. 2022 07 15; 8(28):eabn3326. PMID: 35857503; PMCID: PMC9278864.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Deshpande SA, Rohrbach EW, Asuncion JD, Harrigan J, Eamani A, Schlingmann EH, Suto DJ, Lee PT, Schweizer FE, Bellen HJ, Krantz DE. Regulation of Drosophila oviduct muscle contractility by octopamine. iScience. 2022 Aug 19; 25(8):104697. PMID: 35880044; PMCID: PMC9307614.
      Citations:    
    45. Kanca O, Zirin J, Hu Y, Tepe B, Dutta D, Lin WW, Ma L, Ge M, Zuo Z, Liu LP, Levis RW, Perrimon N, Bellen HJ. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Elife. 2022 06 20; 11. PMID: 35723254; PMCID: PMC9239680.
      Citations:    Fields:    Translation:AnimalsCells
    46. Manivannan SN, Roovers J, Smal N, Myers CT, Turkdogan D, Roelens F, Kanca O, Chung HL, Scholz T, Hermann K, Bierhals T, Caglayan HS, Stamberger H, MAE Working Group of EuroEPINOMICS RES Consortium, Mefford H, de Jonghe P, Yamamoto S, Weckhuysen S, Bellen HJ. De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies. Brain. 2022 06 03; 145(5):1684-1697. PMID: 34788397; PMCID: PMC9166542.
      Citations: 1     Fields:    Translation:Humans
    47. Wang Y, Lobb-Rabe M, Ashley J, Chatterjee P, Anand V, Bellen HJ, Kanca O, Carrillo RA. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Development. 2022 05 15; 149(10). PMID: 35502740; PMCID: PMC9188756.
      Citations:    Fields:    Translation:AnimalsCells
    48. Ma M, Moulton MJ, Lu S, Bellen HJ. 'Fly-ing' from rare to common neurodegenerative disease mechanisms. Trends Genet. 2022 09; 38(9):972-984. PMID: 35484057; PMCID: PMC9378361.
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    49. Harnish JM, Li L, Rogic S, Poirier-Morency G, Kim SY, Undiagnosed Diseases Network, Boycott KM, Wangler MF, Bellen HJ, Hieter P, Pavlidis P, Liu Z, Yamamoto S. ModelMatcher: A scientist-centric online platform to facilitate collaborations between stakeholders of rare and undiagnosed disease research. Hum Mutat. 2022 06; 43(6):743-759. PMID: 35224820; PMCID: PMC9133126.
      Citations: 3     Fields:    Translation:Humans
    50. Lu S, Hernan R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung HL, Pan X, Sun X, Oguz MM, de Baaij JHF, Ivanisevic J, McGinnis E, Guillen Sacoto MJ, Chung WK, Bellen HJ, Oztoprak U. Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures. Am J Hum Genet. 2022 04 07; 109(4):571-586. PMID: 35240055; PMCID: PMC9069076.
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    51. Bellen HJ. Lord of the fruit flies: an interview with Hugo Bellen. Dis Model Mech. 2022 03 01; 15(3). PMID: 35302163; PMCID: PMC8938401.
      Citations: 2     Fields:    Translation:HumansAnimals
    52. Accogli A, Lu S, Musante I, Scudieri P, Rosenfeld JA, Severino M, Baldassari S, Iacomino M, Riva A, Balagura G, Piccolo G, Minetti C, Roberto D, Xia F, Razak R, Lawrence E, Hussein M, Chang EY, Holick M, Aliberto E, De-Sarro R, Gambardella A, Network UD, Group SS, Emrick L, McCaffery PJA, Clagett-Dame M, Marcogliese PC, Bellen HJ, Lalani SR, Zara F, Striano P, Salpietro V, Cal? E. Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development. Cerebellum. 2023 Apr; 22(2):206-222. PMID: 35218524; PMCID: PMC9985553.
      Citations:    Fields:    
    53. Martelli F, Hernandes NH, Zuo Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Robin C, Venkatachalam K, Perry T, Batterham P, Bellen HJ. Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies. Elife. 2022 02 22; 11. PMID: 35191376; PMCID: PMC8863376.
      Citations: 1     Fields:    Translation:AnimalsCells
    54. Cristobal CD, Wang CY, Zuo Z, Smith JA, Lindeke-Myers A, Bellen HJ, Lee HK. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. J Neurosci. 2022 03 02; 42(9):1679-1691. PMID: 35101966; PMCID: PMC8896627.
      Citations:    Fields:    Translation:AnimalsCells
    55. Marcogliese PC, Dutta D, Ray SS, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung H, Kanca O, Wan J, Douine ED, Network UD, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ. Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Sci Adv. 2022 01 21; 8(3):eabl5613. PMID: 35044823; PMCID: PMC8769555.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    56. Moulton MJ, Barish S, Ralhan I, Chang J, Goodman LD, Harland JG, Marcogliese PC, Johansson JO, Ioannou MS, Bellen HJ. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Proc Natl Acad Sci U S A. 2021 12 28; 118(52). PMID: 34949639; PMCID: PMC8719885.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    57. Bellen HJ, Hubbard EJA, Lehmann R, Madhani HD, Solnica-Krezel L, Southard-Smith EM. Model organism databases are in jeopardy. Development. 2021 10 01; 148(19). PMID: 35231122; PMCID: PMC10656462.
      Citations: 4     Fields:    Translation:HumansAnimals
    58. Goodman LD, Bellen HJ. Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila. Curr Opin Neurobiol. 2022 02; 72:32-38. PMID: 34418791; PMCID: PMC8854453.
      Citations: 1     Fields:    Translation:AnimalsCells
    59. Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Bellen HJ, Tan QK, Cogn? B, Isidor B. TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691. PMID: 34314705; PMCID: PMC8456166.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    60. Park YJ, Kim S, Shim HP, Park JH, Lee G, Kim TY, Jo MC, Kwon AY, Lee M, Lee S, Yeo J, Chung HL, Bellen HJ, Kwon SH, Jeon SH. Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function. iScience. 2021 Aug 20; 24(8):102899. PMID: 34401677; PMCID: PMC8358705.
      Citations:    
    61. Luo X, Schoch K, Jangam SV, Bhavana VH, Graves HK, Kansagra S, Jasien JM, Stong N, Undiagnosed Diseases Network, Bellen HJ, Wangler MF, Shashi V, Yamamoto S, Keren B, Mignot C, Ravelli C. Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features. Hum Mol Genet. 2021 06 26; 30(14):1283-1292. PMID: 33864376; PMCID: PMC8255132.
      Citations: 4     Fields:    Translation:Humans
    62. Ravenscroft TA, Phillips JB, Fieg E, Bajikar SS, Peirce J, Wegner J, Luna AA, Fox EJ, Yan YL, Rosenfeld JA, Zirin J, Kanca O, Undiagnosed Diseases Network, Benke PJ, Cameron ES, Strehlow V, Platzer K, Jamra RA, Osmond M, Licata T, Rojas S, Dyment D, Chong JSC, Lincoln S, Stoler JM, Postlethwait JH, Wangler MF, Yamamoto S, Krier J, Westerfield M, Bellen HJ, Kl?ckner C. Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11. Genet Med. 2021 10; 23(10):1889-1900. PMID: 34113007; PMCID: PMC8487929.
      Citations: 4     Fields:    Translation:HumansAnimals
    63. Baldridge D, Wangler MF, Bowman AN, Yamamoto S, Undiagnosed Diseases Network, Schedl T, Pak SC, Postlethwait JH, Shin J, Solnica-Krezel L, Bellen HJ, Westerfield M. Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision. Orphanet J Rare Dis. 2021 05 07; 16(1):206. PMID: 33962631; PMCID: PMC8103593.
      Citations: 10     Fields:    Translation:HumansAnimals
    64. Cunningham KM, Maulding K, Ruan K, Senturk M, Grima JC, Sung H, Zuo Z, Song H, Gao J, Dubey S, Rothstein JD, Zhang K, Bellen HJ, Lloyd TE. TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS. Elife. 2020 12 10; 9. PMID: 33300868; PMCID: PMC7758070.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    65. Barish S, Barakat TS, Michel BC, Mashtalir N, Phillips JB, Valencia AM, Ugur B, Wegner J, Scott TM, Bostwick B, Undiagnosed Diseases Network, Murdock DR, Dai H, Perenthaler E, Nikoncuk A, van Slegtenhorst M, Brooks AS, Douglas J, Rodan L, Nowak C, Ellard S, Stals K, Lynch SA, Engleman KL, Zhou D, Thiffault I, Herriges J, Gass J, Louie RJ, Stolerman E, Washington C, Vetrini F, Otsubo A, Pratt VM, Conboy E, Treat K, Shannon N, Camacho J, Wakeling E, Yuan B, Chen CA, Rosenfeld JA, Westerfield M, Wangler M, Yamamoto S, Kadoch C, Scott DA, Bellen HJ, Keren B, Nava C, Mignot C, Faoucher M, Lesca G, Edery P. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Am J Hum Genet. 2020 12 03; 107(6):1096-1112. PMID: 33232675; PMCID: PMC7820627.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    66. Link N, Bellen HJ. Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Development. 2020 09 28; 147(21). PMID: 32988995; PMCID: PMC7541339.
      Citations: 8     Fields:    Translation:HumansAnimals
    67. Martelli F, Zhongyuan Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Venkatachalam K, Perry T, Bellen HJ, Batterham P. Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25840-25850. PMID: 32989137; PMCID: PMC7568275.
      Citations: 12     Fields:    Translation:AnimalsCells
    68. Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes TC, Aerts S, Bellen HJ. Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains. J Neurosci. 2020 10 14; 40(42):7999-8024. PMID: 32928889; PMCID: PMC7574647.
      Citations: 10     Fields:    Translation:AnimalsCells
    69. Ding X, Jo J, Wang CY, Cristobal CD, Zuo Z, Ye Q, Wirianto M, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen HJ, Yoo SH, Lee HK. The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Genes Dev. 2020 09 01; 34(17-18):1177-1189. PMID: 32792353; PMCID: PMC7462057.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    70. Kao CY, Xu M, Wang L, Lin SC, Lee HJ, Duraine L, Bellen HJ, Goldstein DS, Tsai SY, Tsai MJ. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS Genet. 2020 06; 16(6):e1008868. PMID: 32579581; PMCID: PMC7340320.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    71. Huang Y, Mao X, van Jaarsveld RH, Shu L, Terhal PA, Jia Z, Xi H, Peng Y, Yan H, Yuan S, Li Q, Wang H, Bellen HJ. Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay. Hum Mol Genet. 2020 06 03; 29(9):1537-1546. PMID: 32338762; PMCID: PMC7268783.
      Citations: 5     Fields:    Translation:HumansCells
    72. Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Network UD, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ. De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Hum Mol Genet. 2020 06 03; 29(9):1568-1579. PMID: 32356556; PMCID: PMC7268787.
      Citations: 11     Fields:    Translation:HumansCells
    73. Chung HL, Mao X, Wang H, Park YJ, Marcogliese PC, Rosenfeld JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ, Xiao B. De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Am J Hum Genet. 2020 05 07; 106(5):717-725. PMID: 32330417; PMCID: PMC7212481.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    74. Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 06; 34(6):8265-8282. PMID: 32294302; PMCID: PMC7336545.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    75. Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L, Li Y, Gu JY, Tepass U, Rodal AA, Bellen HJ, Shulman JM. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. Elife. 2020 04 14; 9. PMID: 32286230; PMCID: PMC7182434.
      Citations: 12     Fields:    Translation:AnimalsCells
    76. Mao D, Reuter CM, Ruzhnikov MRZ, Beck AE, Farrow EG, Emrick LT, Rosenfeld JA, Mackenzie KM, Robak L, Wheeler MT, Burrage LC, Jain M, Liu P, Calame D, Sillesen M, Schmitz-Abe K, Tonduti D, Spaccini L, Iascone M, Genetti CA, Koenig MK, Graf M, Tran A, Alejandro M, Undiagnosed Diseases Network, Lee BH, Thiffault I, Agrawal PB, Bernstein JA, Bellen HJ, Chao HT, K?ry S. De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation. Am J Hum Genet. 2020 04 02; 106(4):570-583. PMID: 32197074; PMCID: PMC7118694.
      Citations: 15     Fields:    Translation:Humans
    77. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Members of Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Neuron. 2020 05 20; 106(4):589-606.e6. PMID: 32169171; PMCID: PMC7289150.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    78. Bosch JA, Knight S, Kanca O, Zirin J, Yang-Zhou D, Hu Y, Rodiger J, Amador G, Bellen HJ, Perrimon N, Mohr SE. Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes. Curr Protoc Mol Biol. 2020 Mar; 130(1):e112. PMID: 31869524; PMCID: PMC7213786.
      Citations: 4     Fields:    Translation:AnimalsCells
    79. Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, Duraine L, Zuo Z, Park YJ, Li-Kroeger D, Bi W, Wong LJ, Rosenfeld J, Gleeson J, Faqeih E, Alkuraya FS, Wierenga KJ, Chen J, Juusola J, Grompe M, Bellen HJ, Campeau PM, Afenjar A, Nava C, Doummar D, Keren B. Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Am J Hum Genet. 2019 12 05; 105(6):1237-1253. PMID: 31785787; PMCID: PMC6904826.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    80. Bellen HJ, Wangler MF, Yamamoto S. The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases. Hum Mol Genet. 2019 11 21; 28(R2):R207-R214. PMID: 31227826; PMCID: PMC6872428.
      Citations: 28     Fields:    Translation:HumansAnimals
    81. Link N, Chung H, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ. Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. Dev Cell. 2019 12 16; 51(6):713-729.e6. PMID: 31735666; PMCID: PMC6917859.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    82. Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung H, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ. An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. Elife. 2019 11 01; 8. PMID: 31674908; PMCID: PMC6855806.
      Citations: 34     Fields:    Translation:AnimalsCells
    83. Kanca O, Bellen HJ. La CaSSA da Drosophila: A Versatile Expansion of the Tool Box. Neuron. 2019 10 23; 104(2):177-179. PMID: 31647888.
      Citations:    Fields:    Translation:AnimalsCells
    84. Guo H, Bettella E, Marcogliese PC, Zhao R, Andrews JC, Nowakowski TJ, Gillentine MA, Hoekzema K, Wang T, Wu H, Jangam S, Liu C, Ni H, Willemsen MH, van Bon BW, Rinne T, Stevens SJC, Kleefstra T, Brunner HG, Yntema HG, Long M, Zhao W, Hu Z, Colson C, Richard N, Schwartz CE, Romano C, Castiglia L, Bottitta M, Dhar SU, Erwin DJ, Emrick L, Zhu B, Bai B, Stankiewicz P, Herman K, University of Washington Center for Mendelian Genomics, Mercimek-Andrews S, Juusola J, Wilfert AB, Abou Jamra R, Mefford HC, Muir AM, Scheffer IE, Regan BM, Malone S, Gecz J, Cobben J, Weiss MM, Waisfisz Q, Bijlsma EK, Ruivenkamp CAL, Sartori S, Xia F, Rosenfeld JA, Bernier RA, Wangler MF, Yamamoto S, Xia K, Stegmann APA, Bellen HJ, Murgia A, Eichler EE, Keren B, Afenjar A, B?ttner B, Hoffer MJV. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Nat Commun. 2019 10 15; 10(1):4679. PMID: 31616000; PMCID: PMC6794285.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    85. Ansar M, Chung HL, Al-Otaibi A, Ravenscroft TA, Paracha SA, Scholz R, Abdel Magid T, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcogliese PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Bellen HJ, Antonarakis SE, Elagabani MN, Kornau HC. Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. Am J Hum Genet. 2019 11 07; 105(5):907-920. PMID: 31607425; PMCID: PMC6848997.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    86. Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC, Undiagnosed Diseases Network, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV. De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Am J Hum Genet. 2019 Sep 05; 105(3):672-674. PMID: 31491411; PMCID: PMC6732524.
      Citations: 4     Fields:    
    87. Wang J, Mao D, Fazal F, Kim SY, Yamamoto S, Bellen H, Liu Z. Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity. Curr Protoc Bioinformatics. 2019 09; 67(1):e85. PMID: 31524990; PMCID: PMC6750039.
      Citations: 6     Fields:    Translation:Humans
    88. Wang J, Liu Z, Bellen HJ, Yamamoto S. Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information. J Vis Exp. 2019 08 15; (150). PMID: 31475990; PMCID: PMC7401700.
      Citations: 8     Fields:    Translation:HumansAnimals
    89. Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 08 13; 28(7):1799-1813.e5. PMID: 31412248; PMCID: PMC6703184.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    90. Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC, Undiagnosed Diseases Network, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV. De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Am J Hum Genet. 2019 08 01; 105(2):413-424. PMID: 31327508; PMCID: PMC6699142.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    91. Mao D, Bellen HJ, Sent?rk M. Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes. Autophagy. 2019 08; 15(8):1467-1469. PMID: 31032688; PMCID: PMC6613899.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    92. Lin G, Zuo Z, Mao D, Watson E, Mikos AG, Bellen HJ, Sent?rk M. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019 03; 21(3):384-396. PMID: 30804504; PMCID: PMC6534127.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    93. Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ. VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy. 2019 07; 15(7):1214-1233. PMID: 30741620; PMCID: PMC6613884.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    94. Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ, H?ttenhain R, Iglesias GN, Gamarnik AV. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18. PMID: 30550790; PMCID: PMC6474419.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    95. Lin G, Wang L, Marcogliese PC, Bellen HJ. Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism. Trends Endocrinol Metab. 2019 02; 30(2):106-117. PMID: 30528460.
      Citations: 33     Fields:    Translation:HumansAnimals
    96. Xu S, Xiao Q, Cosmanescu F, Sergeeva AP, Yoo J, Lin Y, Katsamba PS, Ahlsen G, Kaufman J, Linaval NT, Lee PT, Bellen HJ, Shapiro L, Honig B, Tan L, Zipursky SL. Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits. Neuron. 2018 12 19; 100(6):1369-1384.e6. PMID: 30467079; PMCID: PMC7501880.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    97. Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel SD, Brewer JJ, Tan L, Xu S, Xiao Q, Nagarkar-Jaiswal S, Nern A, Bellen HJ, Zipursky SL, Honig B, Shapiro L. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. 2018 12 19; 100(6):1385-1400.e6. PMID: 30467080; PMCID: PMC6309224.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    98. Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA, Undiagnosed Diseases Network. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. N Engl J Med. 2018 11 29; 379(22):2131-2139. PMID: 30304647; PMCID: PMC6481166.
      Citations: 97     Fields:    Translation:HumansAnimals
    99. Ansar M, Chung HL, Taylor RL, Nazir A, Imtiaz S, Sarwar MT, Manousopoulou A, Makrythanasis P, Saeed S, Falconnet E, Guipponi M, Pournaras CJ, Ansari MA, Ranza E, Santoni FA, Ahmed J, Shah I, Gul K, Black GC, Bellen HJ, Antonarakis SE. Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts. Am J Hum Genet. 2018 10 04; 103(4):568-578. PMID: 30290152; PMCID: PMC6174361.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    100. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Program for Undiagnosed Diseases (UD-PrOZA), Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM, Mart?nez-Agosto JA. IRF2BPL Is Associated with Neurological Phenotypes. Am J Hum Genet. 2018 09 06; 103(3):456. PMID: 30193138; PMCID: PMC6128320.
      Citations: 4     Fields:    
    101. Li-Kroeger D, Kanca O, Lee PT, Cowan S, Lee MT, Jaiswal M, Salazar JL, He Y, Zuo Z, Bellen HJ. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Elife. 2018 08 09; 7. PMID: 30091705; PMCID: PMC6095692.
      Citations: 25     Fields:    Translation:AnimalsCells
    102. Ansar M, Chung H, Waryah YM, Makrythanasis P, Falconnet E, Rao AR, Guipponi M, Narsani AK, Fingerhut R, Santoni FA, Ranza E, Waryah AM, Bellen HJ, Antonarakis SE. Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Hum Mol Genet. 2018 08 01; 27(15):2703-2711. PMID: 29771303; PMCID: PMC6048992.
      Citations: 10     Fields:    Translation:HumansAnimals
    103. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. PMID: 30053424; PMCID: PMC6247911.
      Citations: 47     Fields:    Translation:Humans
    104. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Program for Undiagnosed Diseases (UD-PrOZA), Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM, Mart?nez-Agosto JA. IRF2BPL Is Associated with Neurological Phenotypes. Am J Hum Genet. 2018 08 02; 103(2):245-260. PMID: 30057031; PMCID: PMC6081494.
      Citations: 25     Fields:    
    105. Liu N, Schoch K, Luo X, Pena LDM, Bhavana VH, Kukolich MK, Stringer S, Radtke K, Mroske C, Deak KL, McDonald MT, McConkie-Rosell A, Markert ML, Kranz PG, Stong N, Need AC, Bick D, Amaral MD, Worthey EA, Levy S, Undiagnosed Diseases Network (UDN), Wangler MF, Bellen HJ, Shashi V, Yamamoto S, Powis Z. Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. Hum Mol Genet. 2018 07 15; 27(14):2454-2465. PMID: 29726930; PMCID: PMC6030957.
      Citations: 25     Fields:    Translation:HumansAnimals
    106. Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z, Lin WW, Wang L, Bellen HJ. Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain. Cell Metab. 2018 10 02; 28(4):605-618.e6. PMID: 29909971.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    107. Li T, Bellen HJ, Groves AK. Using Drosophila to study mechanisms of hereditary hearing loss. Dis Model Mech. 2018 05 31; 11(6). PMID: 29853544; PMCID: PMC6031363.
      Citations: 2     Fields:    Translation:HumansAnimals
    108. Tan KL, Haelterman NA, Kwartler CS, Regalado ES, Lee PT, Nagarkar-Jaiswal S, Guo DC, Duraine L, Wangler MF, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Lin G, Milewicz DM, Bellen HJ. Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Dev Cell. 2018 04 23; 45(2):226-244.e8. PMID: 29689197; PMCID: PMC5920516.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    109. Wangler MF, Assia Batzir N, Robak LA, Koenig MK, Bacino CA, Scaglia F, Bellen HJ. The expanding neurological phenotype of DNM1L-related disorders. Brain. 2018 04 01; 141(4):e28. PMID: 29529134.
      Citations: 3     Fields:    Translation:Humans
    110. Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ. A gene-specific T2A-GAL4 library for Drosophila. Elife. 2018 03 22; 7. PMID: 29565247; PMCID: PMC5898912.
      Citations: 71     Fields:    Translation:Animals
    111. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ. Correction: Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2018 03; 16(3):e1002622. PMID: 29509758; PMCID: PMC5839534.
      Citations:    Fields:    
    112. Lee PT, Lin G, Lin WW, Diao F, White BH, Bellen HJ. A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. Elife. 2018 02 23; 7. PMID: 29473541; PMCID: PMC5825208.
      Citations: 11     Fields:    Translation:Animals
    113. Yoon WH, Thompson K, Jangam S, Fernandez L, Davidson JM, Kyle JE, Grove ME, Fisk DG, Kohler JN, Holmes M, Dries AM, Huang Y, Zhao C, Zappala Z, Waggott D, Zink EM, Kim YM, Heyman HM, Stratton KG, Webb-Robertson BM, Undiagnosed Diseases Network, Snyder M, Merker JD, Montgomery SB, Fisher PG, Mayr JA, Hall J, Barbosa IA, Simpson MA, Deshpande C, Waters KM, Koeller DM, Metz TO, Morris AA, Schelley S, Cowan T, Friederich MW, McFarland R, Van Hove JLK, Enns GM, Yamamoto S, Ashley EA, Wangler MF, Taylor RW, Bellen HJ, Bernstein JA, Wheeler MT, Ol?hov? M, Contrepois K, Fr?sard L, Feichtinger RG. Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. Am J Hum Genet. 2018 03 01; 102(3):494-504. PMID: 29478781; PMCID: PMC6117612.
      Citations: 33     Fields:    Translation:HumansCells
    114. Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Rep. 2017 12 26; 21(13):3794-3806. PMID: 29281828; PMCID: PMC5747319.
      Citations: 14     Fields:    Translation:AnimalsCells
    115. Landrock KK, Sullivan P, Martini-Stoica H, Goldstein DS, Graham BH, Yamamoto S, Bellen HJ, Gibbs RA, Chen R, D'Amelio M, Stoica G. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain Res. 2018 01 15; 1679:155-170. PMID: 29217155; PMCID: PMC7696654.
      Citations: 7     Fields:    Translation:AnimalsCells
    116. Bellen HJ, Sent?rk M. Genetic strategies to tackle neurological diseases in fruit flies. Curr Opin Neurobiol. 2018 06; 50:24-32. PMID: 29128849; PMCID: PMC5940587.
      Citations: 25     Fields:    Translation:HumansAnimals
    117. Kanca O, Bellen HJ, Schnorrer F. Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila. Genetics. 2017 10; 207(2):389-412. PMID: 28978772; PMCID: PMC5629313.
      Citations: 26     Fields:    Translation:Animals
    118. Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6. PMID: 28965825; PMCID: PMC5677551.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    119. Wangler MF, Yamamoto S, Chao HT, Posey JE, Westerfield M, Postlethwait J, Members of the Undiagnosed Diseases Network (UDN), Hieter P, Boycott KM, Campeau PM, Bellen HJ. Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Genetics. 2017 09; 207(1):9-27. PMID: 28874452; PMCID: PMC5586389.
      Citations: 84     Fields:    Translation:HumansAnimals
    120. Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF, Members of the UDN. Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 2017 Jul; 13(7):e1006905. PMID: 28742085; PMCID: PMC5557584.
      Citations: 36     Fields:    Translation:HumansAnimals
    121. Wangler MF, Chao YH, Bayat V, Giagtzoglou N, Shinde AB, Putluri N, Coarfa C, Donti T, Graham BH, Faust JE, McNew JA, Moser A, Sardiello M, Baes M, Bellen HJ. Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse. PLoS Genet. 2017 Jun; 13(6):e1006825. PMID: 28640802; PMCID: PMC5480855.
      Citations: 14     Fields:    Translation:AnimalsCells
    122. Wong CO, Gregory S, Hu H, Chao Y, He Y, Li-Kroeger D, Goldman WE, Bellen HJ, Venkatachalam K, Sep?lveda VE. Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages. Cell Host Microbe. 2017 Jun 14; 21(6):719-730.e6. PMID: 28579255; PMCID: PMC5540652.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    123. Chao HT, Liu L, Bellen HJ. Building dialogues between clinical and biomedical research through cross-species collaborations. Semin Cell Dev Biol. 2017 10; 70:49-57. PMID: 28579453; PMCID: PMC5623622.
      Citations: 6     Fields:    Translation:HumansAnimals
    124. Nagarkar-Jaiswal S, Manivannan SN, Zuo Z, Bellen HJ. A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells. Elife. 2017 05 31; 6. PMID: 28561736; PMCID: PMC5493436.
      Citations: 15     Fields:    Translation:Animals
    125. Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Comjean A, Mohr SE, UDN, Perrimon N, Liu Z, Bellen HJ. MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. Am J Hum Genet. 2017 Jun 01; 100(6):843-853. PMID: 28502612; PMCID: PMC5670038.
      Citations: 82     Fields:    Translation:Humans
    126. Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B, Dupont C, Bauderlique H. Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models. Sci Rep. 2017 01 23; 7:40764. PMID: 28112163; PMCID: PMC5256094.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    127. Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ. Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 2017 Jan 04; 93(1):115-131. PMID: 28017472; PMCID: PMC5242142.
      Citations: 55     Fields:    Translation:AnimalsCells
    128. Chao HT, Davids M, Burke E, Pappas JG, Rosenfeld JA, McCarty AJ, Davis T, Wolfe L, Toro C, Tifft C, Xia F, Stong N, Johnson TK, Warr CG, Undiagnosed Diseases Network, Yamamoto S, Adams DR, Markello TC, Gahl WA, Bellen HJ, Wangler MF, Malicdan MCV. A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3. Am J Hum Genet. 2017 Jan 05; 100(1):128-137. PMID: 28017372; PMCID: PMC5223093.
      Citations: 50     Fields:    Translation:HumansCells
    129. Chen K, Ho TS, Lin G, Tan KL, Rasband MN, Bellen HJ. Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals. Elife. 2016 11 30; 5. PMID: 27901468; PMCID: PMC5130293.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    130. Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi SH, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Ripatti S, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T, Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM, Varga TV, Franks PW, Hallmans G, Rolandsson O, Jansson JH, Alzheimer?s Disease Genetic Consortium, Genetic and Environmental Risk in Alzheimer?s Disease consortium. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet. 2016 Oct; 12(10):e1006327. PMID: 27764101; PMCID: PMC5072721.
      Citations: 23     Fields:    Translation:HumansAnimals
    131. Harel T, Yoon WH, Garone C, Gu S, Coban-Akdemir Z, Eldomery MK, Posey JE, Jhangiani SN, Rosenfeld JA, Cho MT, Fox S, Withers M, Brooks SM, Chiang T, Duraine L, Erdin S, Yuan B, Shao Y, Moussallem E, Lamperti C, Donati MA, Smith JD, McLaughlin HM, Eng CM, Walkiewicz M, Xia F, Pippucci T, Magini P, Seri M, Zeviani M, Hirano M, Hunter JV, Srour M, Zanigni S, Lewis RA, Muzny DM, Lotze TE, Boerwinkle E, Baylor-Hopkins Center for Mendelian Genomics, University of Washington Center for Mendelian Genomics, Gibbs RA, Hickey SE, Graham BH, Yang Y, Buhas D, Martin DM, Potocki L, Graziano C, Bellen HJ, Lupski JR. Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. Am J Hum Genet. 2016 Oct 06; 99(4):831-845. PMID: 27640307; PMCID: PMC5065660.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    132. Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. Elife. 2016 06 25; 5. PMID: 27343351; PMCID: PMC4956409.
      Citations: 32     Fields:    Translation:Animals
    133. Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson GR, Bellen HJ, Shulman JM. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathol Commun. 2016 06 23; 4(1):62. PMID: 27338814; PMCID: PMC4918017.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    134. Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, Groves AK, Bellen HJ. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. Elife. 2016 06 22; 5. PMID: 27331610; PMCID: PMC4978524.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    135. Ali YO, Allen HM, Yu L, Li-Kroeger D, Bakhshizadehmahmoudi D, Hatcher A, McCabe C, Xu J, Bjorklund N, Taglialatela G, Bennett DA, De Jager PL, Shulman JM, Bellen HJ, Lu HC. NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biol. 2016 06; 14(6):e1002472. PMID: 27254664; PMCID: PMC4890852.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    136. Li T, Fan J, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Zhang J, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ, Blanco-S?nchez B. Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016 05; 12(5):e1006054. PMID: 27195754; PMCID: PMC4873228.
      Citations: 11     Fields:    Translation:AnimalsCells
    137. Ugur B, Chen K, Bellen HJ. Drosophila tools and assays for the study of human diseases. Dis Model Mech. 2016 Mar; 9(3):235-44. PMID: 26935102; PMCID: PMC4833332.
      Citations: 143     Fields:    Translation:HumansAnimals
    138. Chao YH, Robak LA, Xia F, Koenig MK, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF. Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila. Hum Mol Genet. 2016 05 01; 25(9):1846-56. PMID: 26931468; PMCID: PMC5007591.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    139. David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Dev Cell. 2016 Jan 25; 36(2):139-51. PMID: 26812014; PMCID: PMC4730548.
      Citations: 22     Fields:    Translation:AnimalsCells
    140. Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Zipursky SL, Morey M. Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila. Cell. 2015 Dec 17; 163(7):1756-69. PMID: 26687360; PMCID: PMC4804707.
      Citations: 67     Fields:    Translation:AnimalsCells
    141. Carrillo RA, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K, ?zkan E. Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell. 2015 Dec 17; 163(7):1770-1782. PMID: 26687361; PMCID: PMC4720259.
      Citations: 63     Fields:    Translation:AnimalsCells
    142. Bellen HJ, Yamamoto S. Morgan's legacy: fruit flies and the functional annotation of conserved genes. Cell. 2015 Sep 24; 163(1):12-4. PMID: 26406362; PMCID: PMC4783153.
      Citations: 44     Fields:    Translation:HumansAnimals
    143. Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SY. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015 Sep 10; 6:8245. PMID: 26356605; PMCID: PMC4568566.
      Citations: 33     Fields:    Translation:AnimalsCells
    144. Wang F, Jiang L, Chen Y, Haelterman NA, Bellen HJ, Chen R. FlyVar: a database for genetic variation in Drosophila melanogaster. Database (Oxford). 2015; 2015. PMID: 26289428; PMCID: PMC4541374.
      Citations: 5     Fields:    Translation:Animals
    145. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113; PMCID: PMC4692367.
      Citations: 108     Fields:    Translation:AnimalsCells
    146. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ. Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2015 Jul; 13(7):e1002197. PMID: 26176594; PMCID: PMC4503542.
      Citations: 24     Fields:    Translation:AnimalsCells
    147. Wang S, Bellen HJ. The retromer complex in development and disease. Development. 2015 Jul 15; 142(14):2392-6. PMID: 26199408; PMCID: PMC4510866.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    148. Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ. A genetic toolkit for tagging intronic MiMIC containing genes. Elife. 2015 Jun 23; 4. PMID: 26102525; PMCID: PMC4499919.
      Citations: 59     Fields:    Translation:Animals
    149. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2015 May; 13(5):e1002170. PMID: 26020534; PMCID: PMC4447419.
      Citations:    Fields:    
    150. Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Gutierrez MC, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Elife. 2015 Mar 31; 4. PMID: 25824290; PMCID: PMC4379497.
      Citations: 156     Fields:    Translation:AnimalsCells
    151. Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015 Mar; 13(3):e1002103. PMID: 25811491; PMCID: PMC4374850.
      Citations: 48     Fields:    Translation:AnimalsCells
    152. Rui YN, Xu Z, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Zhang S, Patel B, Cuervo AM. Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar; 17(3):262-75. PMID: 25686248; PMCID: PMC4344873.
      Citations: 186     Fields:    Translation:HumansAnimalsCells
    153. Wangler MF, Yamamoto S, Bellen HJ. Fruit flies in biomedical research. Genetics. 2015 Mar; 199(3):639-53. PMID: 25624315; PMCID: PMC4349060.
      Citations: 71     Fields:    Translation:HumansAnimals
    154. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Hui J, Graham BH, Quintana A, Bellen HJ. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015 Jan 15; 160(1-2):177-90. PMID: 25594180; PMCID: PMC4377295.
      Citations: 245     Fields:    Translation:AnimalsCells
    155. Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K, Lu Z. A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron. 2014 Nov 19; 84(4):764-77. PMID: 25451193; PMCID: PMC4254599.
      Citations: 37     Fields:    Translation:AnimalsCells
    156. Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B, Zhang K, David G, Charng WL, Yamamoto S, Duraine L, Graham BH, Bellen HJ. Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. Elife. 2014 Oct 14; 3. PMID: 25313867; PMCID: PMC4215535.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    157. Bellen HJ. Survival of the fittest tools. Genetics. 2014 Oct; 198(2):427-8. PMID: 25316776; PMCID: PMC4196594.
      Citations: 2     Fields:    Translation:Animals
    158. Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng WL, Busby T, Jawaid A, David G, Jaiswal M, Venken KJ, Yamamoto S, Chen R, Bellen HJ. Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res. 2014 Oct; 24(10):1707-18. PMID: 25258387; PMCID: PMC4199363.
      Citations: 40     Fields:    Translation:AnimalsCells
    159. Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LELM, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014 Sep 25; 159(1):200-214. PMID: 25259927; PMCID: PMC4298142.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    160. Halstead JM, Lin YQ, Durraine L, Hamilton RS, Ball G, Neely GG, Bellen HJ, Davis I. Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse. Biol Open. 2014 Aug 29; 3(9):839-49. PMID: 25171887; PMCID: PMC4163661.
      Citations: 18     Fields:    
    161. Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ. A mitocentric view of Parkinson's disease. Annu Rev Neurosci. 2014; 37:137-59. PMID: 24821430; PMCID: PMC4659514.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    162. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014 Apr; 12(4):e1001847. PMID: 24781186; PMCID: PMC4004542.
      Citations: 35     Fields:    Translation:AnimalsCells
    163. Charng WL, Yamamoto S, Bellen HJ. Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases. Curr Opin Neurobiol. 2014 Aug; 27:158-64. PMID: 24762652; PMCID: PMC4122633.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    164. Venken KJ, Bellen HJ. Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods. 2014 Jun 15; 68(1):15-28. PMID: 24583113; PMCID: PMC4061744.
      Citations: 29     Fields:    Translation:AnimalsCells
    165. Charng WL, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu HC, Chen K, Giagtzoglou N, Bellen HJ. Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777. PMID: 24492843; PMCID: PMC3904817.
      Citations: 27     Fields:    Translation:AnimalsCells
    166. Yamamoto S, Bellen HJ. Preface. Notch signaling. Methods Mol Biol. 2014; 1187:v. PMID: 25187920.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    167. Yamamoto S, Schulze KL, Bellen HJ. Introduction to Notch signaling. Methods Mol Biol. 2014; 1187:1-14. PMID: 25053477.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    168. Cassidy JJ, Posadas DM, Giri R, Venken KJ, Ji J, Jiang H, Bellen HJ, Carthew RW, Jha AR, White KP. miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013 Dec 19; 155(7):1556-67. PMID: 24360277; PMCID: PMC3891883.
      Citations: 53     Fields:    Translation:Animals
    169. Moustaqim-Barrette A, Lin YQ, Pradhan S, Neely GG, Bellen HJ, Tsuda H. The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Hum Mol Genet. 2014 Apr 15; 23(8):1975-89. PMID: 24271015; PMCID: PMC3959812.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    170. Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA. VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. PLoS Genet. 2013; 9(9):e1003738. PMID: 24039594; PMCID: PMC3764199.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    171. Xiong B, Bellen HJ. Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends Neurosci. 2013 Nov; 36(11):652-60. PMID: 24012059; PMCID: PMC3955215.
      Citations: 33     Fields:    Translation:HumansAnimals
    172. Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC. NMNATs, evolutionarily conserved neuronal maintenance factors. Trends Neurosci. 2013 Nov; 36(11):632-40. PMID: 23968695; PMCID: PMC3857727.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    173. Yamamoto S, Bayat V, Bellen HJ, Tan C. Protein phosphatase 1? limits ring canal constriction during Drosophila germline cyst formation. PLoS One. 2013; 8(7):e70502. PMID: 23936219; PMCID: PMC3723691.
      Citations: 15     Fields:    Translation:AnimalsCells
    174. Giagtzoglou N, Li T, Yamamoto S, Bellen HJ. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J Cell Sci. 2013 Aug 15; 126(Pt 16):3686-96. PMID: 23788431; PMCID: PMC3744027.
      Citations: 6     Fields:    Translation:AnimalsCells
    175. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng WL, David G, Haueter C, Yamamoto S, Graham BH, Bellen HJ. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013 Mar 18; 200(6):807-20. PMID: 23509070; PMCID: PMC3601355.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    176. Jiao W, Vorontsova O, Rees KA, Koh TW, Sopova E, Schulze KL, Bellen HJ, Shupliakov O, Winther ?M. The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses. J Cell Sci. 2013 Feb 15; 126(Pt 4):1021-31. PMID: 23321638; PMCID: PMC4067270.
      Citations: 16     Fields:    Translation:AnimalsCells
    177. Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng WL, Li T, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ. Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biol. 2012; 10(12):e1001438. PMID: 23226104; PMCID: PMC3514319.
      Citations: 47     Fields:    Translation:AnimalsCells
    178. Yamamoto S, Charng WL, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ. A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science. 2012 Nov 30; 338(6111):1229-32. PMID: 23197537; PMCID: PMC3663443.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    179. Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MA. Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci. 2012 Nov 07; 32(45):16018-30. PMID: 23136438; PMCID: PMC3508708.
      Citations: 37     Fields:    Translation:AnimalsCells
    180. Szabad J, Bellen HJ, Venken KJ. An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells. G3 (Bethesda). 2012 Sep; 2(9):1095-102. PMID: 22973547; PMCID: PMC3429924.
      Citations: 5     Fields:    Translation:AnimalsCells
    181. Alves-Silva J, Beaven R, Klein M, Parkin J, Millard TH, Bellen HJ, Venken KJ, Ballestrem C, Kammerer RA, Prokop A, S?nchez-Soriano N. Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 2012 Jul 04; 32(27):9143-58. PMID: 22764224; PMCID: PMC3666083.
      Citations: 56     Fields:    Translation:AnimalsCells
    182. Bayat V, Thiffault I, Jaiswal M, Donti T, Sasarman F, Demers-Lamarche J, Mathieu J, Vanasse M, Bouchard JP, Rioux MF, Lourenco CM, Li Z, Haueter C, Shoubridge EA, Graham BH, Brais B, Bellen HJ, T?treault M, Bernard G, Dicaire MJ. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 2012; 10(3):e1001288. PMID: 22448145; PMCID: PMC3308940.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    183. Han SM, Tsuda H, Yang Y, Vibbert J, Cottee P, Lee SJ, Winek J, Haueter C, Bellen HJ, Miller MA. Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors. Dev Cell. 2012 Feb 14; 22(2):348-62. PMID: 22264801; PMCID: PMC3298687.
      Citations: 40     Fields:    Translation:AnimalsCells
    184. Giagtzoglou N, Yamamoto S, Zitserman D, Graves HK, Schulze KL, Wang H, Klein H, Roegiers F, Bellen HJ. dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol. 2012 Jan 09; 196(1):65-83. PMID: 22213802; PMCID: PMC3255984.
      Citations: 19     Fields:    Translation:AnimalsCells
    185. Venken KJ, Bellen HJ. Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase. Methods Mol Biol. 2012; 859:203-28. PMID: 22367874.
      Citations: 37     Fields:    Translation:AnimalsCells
    186. Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N, Neum?ller RA. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012 Mar; 190(3):931-40. PMID: 22174071; PMCID: PMC3296255.
      Citations: 51     Fields:    Translation:AnimalsCells
    187. Xue M, Giagtzoglou N, Bellen HJ. Dueling Ca2+ sensors in neurotransmitter release. Cell. 2011 Oct 28; 147(3):491-3. PMID: 22036557; PMCID: PMC4061741.
      Citations: 3     Fields:    
    188. Venken KJ, Simpson JH, Bellen HJ. Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron. 2011 Oct 20; 72(2):202-30. PMID: 22017985; PMCID: PMC3232021.
      Citations: 188     Fields:    Translation:AnimalsCells
    189. Spradling AC, Bellen HJ, Hoskins RA. Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15948-53. PMID: 21896744; PMCID: PMC3179094.
      Citations: 50     Fields:    Translation:AnimalsCells
    190. Venken KJ, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJ. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods. 2011 Sep; 8(9):737-43. PMID: 21985007; PMCID: PMC3191940.
      Citations: 319     Fields:    Translation:AnimalsCells
    191. Tong C, Ohyama T, Tien AC, Rajan A, Haueter CM, Bellen HJ. Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Neuron. 2011 Aug 11; 71(3):447-59. PMID: 21835342; PMCID: PMC3166630.
      Citations: 18     Fields:    Translation:AnimalsCells
    192. Zheng L, Michelson Y, Freger V, Avraham Z, Venken KJ, Bellen HJ, Justice MJ, Wides R. Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011; 6(8):e22956. PMID: 21857973; PMCID: PMC3152545.
      Citations: 32     Fields:    Translation:AnimalsCells
    193. Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M, Mitne-Neto M. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet. 2011 Sep 15; 20(18):3642-52. PMID: 21685205; PMCID: PMC3159551.
      Citations: 104     Fields:    Translation:HumansCells
    194. Bellen HJ, Levis RW, He Y, Carlson JW, Evans-Holm M, Bae E, Kim J, Metaxakis A, Savakis C, Schulze KL, Hoskins RA, Spradling AC. The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics. 2011 Jul; 188(3):731-43. PMID: 21515576; PMCID: PMC3176542.
      Citations: 184     Fields:    Translation:AnimalsCells
    195. Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP, N?gre N. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31. PMID: 21430782; PMCID: PMC3179250.
      Citations: 295     Fields:    Translation:AnimalsCells
    196. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12; 143(4):628-38. PMID: 21074052; PMCID: PMC3040441.
      Citations: 143     Fields:    Translation:HumansAnimals
    197. Venken KJ, Popodi E, Holtzman SL, Schulze KL, Park S, Carlson JW, Hoskins RA, Bellen HJ, Kaufman TC. A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics. 2010 Dec; 186(4):1111-25. PMID: 20876565; PMCID: PMC2998297.
      Citations: 58     Fields:    Translation:AnimalsCells
    198. Bayat V, Jaiswal M, Bellen HJ. The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases. Curr Opin Neurobiol. 2011 Feb; 21(1):182-8. PMID: 20832291; PMCID: PMC3095363.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    199. Bellen HJ, Tong C, Tsuda H. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci. 2010 Jul; 11(7):514-22. PMID: 20383202; PMCID: PMC4022039.
      Citations: 158     Fields:    Translation:HumansAnimals
    200. Yamamoto S, Charng WL, Bellen HJ. Endocytosis and intracellular trafficking of Notch and its ligands. Curr Top Dev Biol. 2010; 92:165-200. PMID: 20816395; PMCID: PMC6233319.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    201. Giagtzoglou N, Mahoney T, Yao CK, Bellen HJ. Rab3 GTPase lands Bruchpilot. Neuron. 2009 Dec 10; 64(5):595-7. PMID: 20005815; PMCID: PMC5687091.
      Citations: 3     Fields:    Translation:AnimalsCells
    202. Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C. Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron. 2009 Nov 12; 64(3):367-80. PMID: 19914185; PMCID: PMC2790209.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    203. Giagtzoglou N, Ly CV, Bellen HJ. Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol. 2009 Oct; 1(4):a003079. PMID: 20066100; PMCID: PMC2773626.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    204. Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell. 2009 Sep 04; 138(5):947-60. PMID: 19737521; PMCID: PMC2749961.
      Citations: 70     Fields:    Translation:AnimalsCells
    205. Verstreken P, Ohyama T, Haueter C, Habets RL, Lin YQ, Swan LE, Ly CV, Venken KJ, De Camilli P, Bellen HJ. Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron. 2009 Jul 30; 63(2):203-15. PMID: 19640479; PMCID: PMC2759194.
      Citations: 55     Fields:    Translation:AnimalsCells
    206. Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol. 2009 Jun 29; 185(7):1181-94. PMID: 19546244; PMCID: PMC2712966.
      Citations: 37     Fields:    Translation:AnimalsCells
    207. Rajan A, Tien AC, Haueter CM, Schulze KL, Bellen HJ. The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009 Jul; 11(7):815-24. PMID: 19543274; PMCID: PMC3132077.
      Citations: 51     Fields:    Translation:AnimalsCells
    208. Venken KJ, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RA. Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods. 2009 Jun; 6(6):431-4. PMID: 19465919; PMCID: PMC2784134.
      Citations: 227     Fields:    Translation:AnimalsCells
    209. Fotowat H, Fayyazuddin A, Bellen HJ, Gabbiani F. A novel neuronal pathway for visually guided escape in Drosophila melanogaster. J Neurophysiol. 2009 Aug; 102(2):875-85. PMID: 19474177; PMCID: PMC3817277.
      Citations: 38     Fields:    Translation:AnimalsCells
    210. Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ. Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Rep. 2009 Jun; 10(6):636-41. PMID: 19444309; PMCID: PMC2711842.
      Citations: 8     Fields:    Translation:AnimalsCells
    211. Giagtzoglou N, Lin YQ, Haueter C, Bellen HJ. Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. J Neurosci. 2009 Apr 29; 29(17):5628-39. PMID: 19403829; PMCID: PMC4011492.
      Citations: 15     Fields:    Translation:AnimalsCells
    212. Tien AC, Rajan A, Bellen HJ. A Notch updated. J Cell Biol. 2009 Mar 09; 184(5):621-9. PMID: 19255248; PMCID: PMC2686403.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    213. Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ. Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol. 2008 Sep 22; 182(6):1113-25. PMID: 18809725; PMCID: PMC2542473.
      Citations: 42     Fields:    Translation:AnimalsCells
    214. Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ. The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell. 2008 Jun 13; 133(6):963-77. PMID: 18555774; PMCID: PMC2494862.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    215. Ly CV, Yao CK, Verstreken P, Ohyama T, Bellen HJ. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008 Apr 07; 181(1):157-70. PMID: 18391075; PMCID: PMC2287295.
      Citations: 39     Fields:    Translation:AnimalsCells
    216. Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature. 2008 Apr 17; 452(7189):887-91. PMID: 18344983; PMCID: PMC3150538.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    217. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008 Jan 25; 132(2):247-58. PMID: 18243100; PMCID: PMC2275919.
      Citations: 142     Fields:    Translation:AnimalsCells
    218. Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 2008 Jan 10; 57(1):27-40. PMID: 18184562; PMCID: PMC2277511.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    219. Verstreken P, Ohyama T, Bellen HJ. FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction. Methods Mol Biol. 2008; 440:349-69. PMID: 18369958; PMCID: PMC2712823.
      Citations: 57     Fields:    Translation:AnimalsCells
    220. Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ. Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol. 2007 Dec 31; 179(7):1481-96. PMID: 18158335; PMCID: PMC2373489.
      Citations: 54     Fields:    Translation:AnimalsCells
    221. Zhang W, Wang D, Volk E, Bellen HJ, Hiesinger PR, Quiocho FA. V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. J Biol Chem. 2008 Jan 04; 283(1):294-300. PMID: 17933871; PMCID: PMC4249936.
      Citations: 17     Fields:    Translation:AnimalsCells
    222. Venken KJ, Bellen HJ. Transgenesis upgrades for Drosophila melanogaster. Development. 2007 Oct; 134(20):3571-84. PMID: 17905790.
      Citations: 72     Fields:    Translation:AnimalsCells
    223. Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ. Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol. 2007 Jul 16; 178(2):309-22. PMID: 17620409; PMCID: PMC2064449.
      Citations: 71     Fields:    Translation:AnimalsCells
    224. Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP. Thirty-one flavors of Drosophila rab proteins. Genetics. 2007 Jun; 176(2):1307-22. PMID: 17409086; PMCID: PMC1894592.
      Citations: 171     Fields:    Translation:Animals
    225. Venken KJ, He Y, Hoskins RA, Bellen HJ. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006 Dec 15; 314(5806):1747-51. PMID: 17138868.
      Citations: 440     Fields:    Translation:AnimalsCells
    226. Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ. Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol. 2006 Nov; 4(12):e416. PMID: 17132048; PMCID: PMC1665629.
      Citations: 91     Fields:    Translation:AnimalsCells
    227. Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006 Sep 19; 16(18):1835-43. PMID: 16979562; PMCID: PMC3351197.
      Citations: 57     Fields:    Translation:AnimalsCells
    228. Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ. Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development. 2006 May; 133(10):1979-89. PMID: 16624856.
      Citations: 37     Fields:    Translation:AnimalsCells
    229. Seto ES, Bellen HJ. Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol. 2006 Apr 10; 173(1):95-106. PMID: 16606693; PMCID: PMC2063794.
      Citations: 77     Fields:    Translation:AnimalsCells
    230. Jafar-Nejad H, Tien AC, Acar M, Bellen HJ. Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development. 2006 May; 133(9):1683-92. PMID: 16554363.
      Citations: 31     Fields:    Translation:AnimalsCells
    231. Fayyazuddin A, Zaheer MA, Hiesinger PR, Bellen HJ. The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. PLoS Biol. 2006 Mar; 4(3):e63. PMID: 16494528; PMCID: PMC1382016.
      Citations: 70     Fields:    Translation:AnimalsCells
    232. Giagtzoglou N, Bellen HJ. Fighting anthrax with flies. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3013-4. PMID: 16492749; PMCID: PMC1413949.
      Citations:    Fields:    Translation:HumansAnimalsCells
    233. Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HY. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15; 19(20):2412-7. PMID: 16230531; PMCID: PMC1257395.
      Citations: 140     Fields:    Translation:AnimalsCells
    234. Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA. Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nat Struct Mol Biol. 2005 Oct; 12(10):879-85. PMID: 16155582.
      Citations: 135     Fields:    Translation:AnimalsCells
    235. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005 Sep; 9(3):351-63. PMID: 16137928.
      Citations: 99     Fields:    Translation:AnimalsCells
    236. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. PMID: 16122429.
      Citations: 97     Fields:    Translation:AnimalsCells
    237. Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron. 2005 Aug 04; 47(3):365-78. PMID: 16055061.
      Citations: 388     Fields:    Translation:AnimalsCells
    238. Dermaut B, Norga KK, Kania A, Verstreken P, Pan H, Zhou Y, Callaerts P, Bellen HJ. Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J Cell Biol. 2005 Jul 04; 170(1):127-39. PMID: 15998804; PMCID: PMC2171373.
      Citations: 73     Fields:    Translation:AnimalsCells
    239. Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell. 2005 May 20; 121(4):607-620. PMID: 15907473; PMCID: PMC3351201.
      Citations: 134     Fields:    Translation:AnimalsCells
    240. Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron. 2005 Apr 21; 46(2):219-32. PMID: 15848801.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    241. Venken KJ, Bellen HJ. Emerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet. 2005 Mar; 6(3):167-78. PMID: 15738961.
      Citations: 96     Fields:    Translation:AnimalsCells
    242. Caminero E, Schulze KL, Bellen HJ, Modolell J, Escudero LM. Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development. 2005 Mar; 132(6):1211-22. PMID: 15703278.
      Citations: 19     Fields:    Translation:AnimalsCells
    243. Zhai RG, Bellen HJ. Hauling t-SNAREs on the microtubule highway. Nat Cell Biol. 2004 Oct; 6(10):918-9. PMID: 15459718.
      Citations: 3     Fields:    Translation:Cells
    244. Kazanjian A, Wallis D, Au N, Nigam R, Venken KJ, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HL. Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Res. 2004 Oct 01; 64(19):6874-82. PMID: 15466176.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    245. Jafar-Nejad H, Bellen HJ. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol. 2004 Oct; 24(20):8803-12. PMID: 15456856; PMCID: PMC517899.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    246. Zhai RG, Bellen HJ. The architecture of the active zone in the presynaptic nerve terminal. Physiology (Bethesda). 2004 Oct; 19:262-70. PMID: 15381754.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    247. Koh TW, Verstreken P, Bellen HJ. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron. 2004 Jul 22; 43(2):193-205. PMID: 15260956.
      Citations: 132     Fields:    Translation:AnimalsCells
    248. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, Hoskins RA, Spradling AC. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics. 2004 Jun; 167(2):761-81. PMID: 15238527; PMCID: PMC1470905.
      Citations: 492     Fields:    Translation:AnimalsCells
    249. Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development. 2004 May; 131(9):2183-94. PMID: 15073152.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    250. Bellen HJ. Hugo J. Bellen. Curr Biol. 2004 Mar 23; 14(6):R218. PMID: 15043825.
      Citations:    Fields:    Translation:Animals
    251. Hiesinger PR, Bellen HJ. Flying in the face of total disruption. Nat Genet. 2004 Mar; 36(3):211-2. PMID: 14988715.
      Citations: 2     Fields:    Translation:AnimalsCells
    252. Seto ES, Bellen HJ. The ins and outs of Wingless signaling. Trends Cell Biol. 2004 Jan; 14(1):45-53. PMID: 14729180.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    253. Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ. Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003 Dec 01; 17(23):2966-78. PMID: 14665671; PMCID: PMC289154.
      Citations: 70     Fields:    Translation:AnimalsCells
    254. Fabian-Fine R, Verstreken P, Hiesinger PR, Horne JA, Kostyleva R, Zhou Y, Bellen HJ, Meinertzhagen IA. Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. J Neurosci. 2003 Nov 19; 23(33):10732-44. PMID: 14627659; PMCID: PMC6740933.
      Citations: 42     Fields:    Translation:AnimalsCells
    255. Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ. Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron. 2003 Nov 13; 40(4):733-48. PMID: 14622578.
      Citations: 204     Fields:    Translation:AnimalsCells
    256. Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ. Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10860-5. PMID: 12960394; PMCID: PMC196893.
      Citations: 66     Fields:    Translation:AnimalsCells
    257. Norga KK, Gurganus MC, Dilda CL, Yamamoto A, Lyman RF, Patel PH, Rubin GM, Hoskins RA, Mackay TF, Bellen HJ. Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol. 2003 Aug 19; 13(16):1388-96. PMID: 12932322.
      Citations: 72     Fields:    Translation:Animals
    258. Koh TW, Bellen HJ. Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends Neurosci. 2003 Aug; 26(8):413-22. PMID: 12900172.
      Citations: 84     Fields:    Translation:AnimalsCells
    259. Verstreken P, Bellen HJ. Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends Neurosci. 2002 Aug; 25(8):383-5. PMID: 12127745.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    260. Pennetta G, Hiesinger PR, Fabian-Fine R, Meinertzhagen IA, Bellen HJ. Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron. 2002 Jul 18; 35(2):291-306. PMID: 12160747.
      Citations: 101     Fields:    Translation:AnimalsCells
    261. Chen S, Zheng X, Schulze KL, Morris T, Bellen H, Stanley EF. Enhancement of presynaptic calcium current by cysteine string protein. J Physiol. 2002 Jan 15; 538(Pt 2):383-9. PMID: 11790807; PMCID: PMC2290073.
      Citations: 15     Fields:    Translation:AnimalsCells
    262. Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Galibert F, Borkova D, Kafatos FC, Bolshakov S, Papagiannakis G, Spanos L, Louis C, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Peter A, Sch?ttler P, Mottier S, Mi?ana B, Sid?n-Kiamos I, Madue?o E, J?ckle H, Sch?fer U. Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep. 2002 Jan; 3(1):34-8. PMID: 11751581; PMCID: PMC1083931.
      Citations: 60     Fields:    Translation:AnimalsCells
    263. Kania A, Bellen HJ. Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects. Rouxs Arch Dev Biol. 1995 Mar; 204(4):259-270. PMID: 28306121.
      Citations: 2     
    264. Whitehouse-Hills S, Bellen HJ, Kiger JA. Embryonic cAMP and developmental potential in Drosophila melanogaster. Rouxs Arch Dev Biol. 1992 Jun; 201(4):257-264. PMID: 28305849.
      Citations: 1     
    265. Weigel D, Bellen HJ, J?rgens G, J?ckle H. Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo. Rouxs Arch Dev Biol. 1989 Nov; 198(4):201-210. PMID: 28305483.
      Citations: 11     
    266. Bellen HJ, Kiger JA. Maternal effects of general and regional specificity on embryos of Drosophila melanogaster caused by dunce and rutabaga mutant combinations. Rouxs Arch Dev Biol. 1988 Aug; 197(5):258-268. PMID: 28305785.
      Citations: 8     
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