TitleAdjunct Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address3517 Cullen Blvd, SERC Building 545,
Houston, TX 77204
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11; 67(7):5333-5350. PMID: 38551814; PMCID: PMC11105966.
      Citations:    Fields:    Translation:HumansCells
    2. Lumahan LEV, Arif M, Whitener AE, Yi P. Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications. Cells. 2024 01 19; 13(2). PMID: 38275816; PMCID: PMC10814774.
      Citations:    Fields:    Translation:HumansCells
    3. Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, Yang F. Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. PLoS Biol. 2023 08; 21(8):e3002227. PMID: 37531320; PMCID: PMC10395914.
      Citations:    Fields:    Translation:HumansCells
    4. Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2218229120. PMID: 37155905; PMCID: PMC10193960.
      Citations: 2     Fields:    Translation:HumansCells
    5. Yu X, Yi P, Panigrahi AK, Lumahan LEV, Lydon JP, Lonard DM, Lutdke SJ, Wang Z, O'Malley BW. Spatial definition of the human progesterone receptor-B transcriptional complex. iScience. 2022 Nov 18; 25(11):105321. PMID: 36325049; PMCID: PMC9618773.
      Citations: 2     
    6. Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nat Commun. 2022 01 11; 13(1):245. PMID: 35017531; PMCID: PMC8752662.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Yi P, Yu X, Wang Z, O'Malley BW. Steroid receptor-coregulator transcriptional complexes: new insights from CryoEM. Essays Biochem. 2021 12 17; 65(6):857-866. PMID: 34061186; PMCID: PMC8845409.
      Citations: 1     Fields:    Translation:Cells
    8. Yu W, Singh R, Wang Z, O'Malley BW, Yi P. The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1. J Biol Chem. 2021 Jan-Jun; 296:100739. PMID: 33991522; PMCID: PMC8191236.
      Citations: 2     Fields:    Translation:HumansCells
    9. Yu X, Yi P, Hamilton RA, Shen H, Chen M, Foulds CE, Mancini MA, Ludtke SJ, Wang Z, O'Malley BW. Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. Mol Cell. 2020 09 03; 79(5):812-823.e4. PMID: 32668201; PMCID: PMC7483370.
      Citations: 23     Fields:    Translation:HumansCells
    10. Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018 07 02; 128(7):3129-3143. PMID: 29715200; PMCID: PMC6026011.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Panigrahi AK, Foulds CE, Lanz RB, Hamilton RA, Yi P, Lonard DM, Tsai MJ, Tsai SY, O'Malley BW. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7. PMID: 29775582; PMCID: PMC5966282.
      Citations: 17     Fields:    Translation:HumansCells
    12. Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598. PMID: 29748621; PMCID: PMC6095836.
      Citations: 28     Fields:    Translation:HumansCells
    13. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254. PMID: 29615789; PMCID: PMC5895503.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    14. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863; PMCID: PMC5657569.
      Citations: 33     Fields:    Translation:HumansCells
    15. Yi P, Feng Q, Foulds CE, Lanz RB, O'Malley BW, Wang Z, Pintilie GD, Ludtke SJ, Schmid MF, Chiu W. Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell. 2015 Mar 19; 57(6):1047-1058. PMID: 25728767; PMCID: PMC4369429.
      Citations: 61     Fields:    Translation:HumansCells
    16. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87. PMID: 23388826; PMCID: PMC3576513.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    17. Fu X, Yucer N, Liu S, Li M, Yi P, Mu JJ, Yang T, Chu J, Jung SY, O'Malley BW, Gu W, Qin J, Wang Y. RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4579-84. PMID: 20173098; PMCID: PMC2842028.
      Citations: 37     Fields:    Translation:HumansCells
    18. Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12; 37(3):321-32. PMID: 20159552; PMCID: PMC2824333.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    19. Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76. PMID: 18313384; PMCID: PMC2293272.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    20. Feng Q, Yi P, Wong J, O'Malley BW. Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol. 2006 Nov; 26(21):7846-57. PMID: 16923966; PMCID: PMC1636757.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    21. Yi P, Wu RC, Sandquist J, Wong J, Tsai SY, Tsai MJ, Means AR, O'Malley BW. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005 Nov; 25(21):9687-99. PMID: 16227615; PMCID: PMC1265806.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    22. Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24; 15(6):937-49. PMID: 15383283.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
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