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KARL-DIMITER BISSIG

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address905 S Lasalle St.
Durham, NC 77030
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    Other Positions
    TitleAdjunct Associate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleAdjunct Associate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


    Collapse Research 
    Collapse research activities and funding
    R01DK115461     (BISSIG, KARL-DIMITER)Sep 14, 2018 - Aug 31, 2021
    NIH
    Therapeutic pathway reprogramming for metabolic liver disease
    Role: Principal Investigator
    R56DK115461     (BISSIG, KARL-DIMITER)Sep 13, 2017 - Sep 12, 2018
    NIH
    Therapeutic pathway reprogramming for metabolic liver disease
    Role: Principal Investigator
    R01HL134510     (BISSIG, KARL-DIMITER)Jul 1, 2016 - Apr 30, 2021
    NIH
    Therapeutic potential of CRISPR/Cas9 genome engineering in humanized mouse models
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Barzi M, Chen T, Gonzalez TJ, Pankowicz FP, Oh SH, Streff HL, Rosales A, Ma Y, Collias S, Woodfield SE, Diehl AM, Vasudevan SA, Galvan TN, Goss J, Gersbach CA, Bissig-Choisat B, Asokan A, Bissig KD. A humanized mouse model for adeno-associated viral gene therapy. Nat Commun. 2024 Mar 04; 15(1):1955. PMID: 38438373; PMCID: PMC10912671.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Espinoza AF, Patel RH, Patel KR, Badachhape AA, Whitlock R, Srivastava RK, Govindu SR, Duong A, Kona A, Kureti P, Armbruster B, Kats D, Srinivasan RR, Dobrolecki LE, Yu X, Najaf Panah MJ, Zorman B, Sarabia SF, Urbicain M, Major A, Bissig KD, Keller C, Lewis MT, Heczey A, Sumazin P, L?pez-Terrada DH, Woodfield SE, Vasudevan SA. A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma. J Hepatol. 2024 Apr; 80(4):610-621. PMID: 38242326.
      Citations:    Fields:    Translation:HumansAnimals
    3. Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L, Bissig-Choisat B, Bissig KD, Moore DD. Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol. 2024 Feb; 80(2):282-292. PMID: 37890720; PMCID: PMC10929560.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. bioRxiv. 2023 Jul 29. PMID: 37546995; PMCID: PMC10402145.
      Citations:    
    5. Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KD. Rescue of glutaric aciduria type I in mice by liver-directed therapies. Sci Transl Med. 2023 04 19; 15(692):eadf4086. PMID: 37075130; PMCID: PMC10676743.
      Citations:    Fields:    Translation:Animals
    6. Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F. The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice. Eur J Pharm Sci. 2023 Feb 01; 181:106358. PMID: 36513193; PMCID: PMC10395004.
      Citations:    Fields:    Translation:HumansAnimals
    7. Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li F. Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice. Drug Metab Dispos. 2022 02; 50(2):128-139. PMID: 34785568; PMCID: PMC8969139.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JS. Author Correction: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Nat Biomed Eng. 2021 Aug; 5(8):941. PMID: 34135476.
      Citations:    Fields:    
    9. De Giorgi M, Li A, Hurley A, Barzi M, Doerfler AM, Cherayil NA, Smith HE, Brown JD, Lin CY, Bissig KD, Bao G, Lagor WR. Targeting the Apoa1 locus for liver-directed gene therapy. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:656-669. PMID: 34141821; PMCID: PMC8166646.
      Citations: 2     
    10. Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281. PMID: 34036256; PMCID: PMC8138774.
      Citations: 6     
    11. Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig KD. A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. JHEP Rep. 2021 Apr; 3(2):100252. PMID: 33733079; PMCID: PMC7940981.
      Citations: 1     
    12. MacKenzie KR, Zhao M, Barzi M, Wang J, Bissig KD, Maletic-Savatic M, Jung SY, Li F. Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine. Eur J Pharm Sci. 2020 Oct 01; 153:105488. PMID: 32712217; PMCID: PMC7506503.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JS. Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Nat Biomed Eng. 2020 09; 4(9):916-932. PMID: 32601395.
      Citations: 20     Fields:    Translation:HumansCells
    14. Stripecke R, Schuringa JJ, Bissig KD, Soper B, Meeham T, Yao LC, Di Santo JP, Brehm M, Rodriguez E, Wege AK, Bonnet D, Guionaud S, Howard KE, Kitchen S, Klein F, Saeb-Parsy K, Sam J, Sharma AD, Trumpp A, Trusolino L, Bult C, Shultz L, M?nz C. Innovations, challenges, and minimal information for standardization of humanized mice. EMBO Mol Med. 2020 07 07; 12(7):e8662. PMID: 32578942; PMCID: PMC7338801.
      Citations: 35     Fields:    Translation:HumansAnimals
    15. Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL. Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020 03 30; 9(4). PMID: 32235678; PMCID: PMC7226812.
      Citations: 9     Fields:    Translation:HumansCells
    16. Johnson CG, Chen T, Furey N, Hemmingsen MG, Bissig KD. Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing. Curr Protoc Mol Biol. 2020 Mar; 130(1):e117. PMID: 32150344; PMCID: PMC7500866.
      Citations:    Fields:    Translation:AnimalsCells
    17. Akkina R, Barber DL, Bility MT, Bissig KD, Burwitz BJ, Eichelberg K, Endsley JJ, Garcia JV, Hafner R, Karakousis PC, Korba BE, Koshy R, Lambros C, Menne S, Nuermberger EL, Ploss A, Podell BK, Poluektova LY, Sanders-Beer BE, Subbian S, Wahl A. Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop. Curr HIV Res. 2020; 18(1):19-28. PMID: 31870268; PMCID: PMC7403688.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Alves-Bezerra M, Furey N, Johnson CG, Bissig KD. Using CRISPR/Cas9 to model human liver disease. JHEP Rep. 2019 Nov; 1(5):392-402. PMID: 32039390; PMCID: PMC7005665.
      Citations: 7     
    19. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115; PMCID: PMC6420307.
      Citations: 9     Fields:    Translation:AnimalsCells
    20. Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz FP, Zhang QY, Ding X. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metab Dispos. 2018 11; 46(11):1734-1744. PMID: 30093418; PMCID: PMC6199624.
      Citations: 13     Fields:    Translation:HumansAnimals
    21. Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH. Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet. 2018 08 02; 103(2):276-287. PMID: 30075114; PMCID: PMC6080833.
      Citations: 6     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    22. Valanejad L, Cast A, Wright M, Bissig KD, Karns R, Weirauch MT, Timchenko N. PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. Commun Biol. 2018; 1:67. PMID: 30271949; PMCID: PMC6123626.
      Citations: 14     
    23. Kruse RL, Shum T, Tashiro H, Barzi M, Yi Z, Whitten-Bauer C, Legras X, Bissig-Choisat B, Garaigorta U, Gottschalk S, Bissig KD. HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. Cytotherapy. 2018 05; 20(5):697-705. PMID: 29631939; PMCID: PMC6038120.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    24. Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, Vasudevan SA, L?pez-Terrada D. A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma. Sci Rep. 2017 12 19; 7(1):17751. PMID: 29259231; PMCID: PMC5736579.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984. PMID: 29042563; PMCID: PMC5645338.
      Citations: 1     Fields:    
    26. Kruse RL, Shum T, Legras X, Barzi M, Pankowicz FP, Gottschalk S, Bissig KD. In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:32-41. PMID: 29018834; PMCID: PMC5626922.
      Citations: 5     
    27. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39. PMID: 28659616; PMCID: PMC5489481.
      Citations: 14     Fields:    Translation:HumansAnimals
    28. Velasquez-Mao AJ, Tsao CJM, Monroe MN, Legras X, Bissig-Choisat B, Bissig KD, Ruano R, Jacot JG. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12(5):e0177824. PMID: 28545044; PMCID: PMC5435315.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340. PMID: 28487442; PMCID: PMC5878048.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    30. Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624. PMID: 28300165; PMCID: PMC5353616.
      Citations: 43     Fields:    Translation:AnimalsCells
    31. Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KD. Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. Nat Commun. 2016 08 30; 7:12642. PMID: 27572891; PMCID: PMC5013601.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    32. Bissig KD, Paust S, Barzi M. Liver is liver and blood is blood, and finally the twain have met. J Hepatol. 2016 08; 65(2):245-8. PMID: 27221221.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    33. Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, Bissig KD, L?pez-Terrada D. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. J Hepatol. 2016 08; 65(2):325-33. PMID: 27117591; PMCID: PMC5668139.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    34. Billioud G, Kruse RL, Carrillo M, Whitten-Bauer C, Gao D, Kim A, Chen L, McCaleb ML, Crosby JR, Hamatake R, Hong Z, Garaigorta U, Swayze E, Bissig KD, Wieland S. In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides. J Hepatol. 2016 Apr; 64(4):781-9. PMID: 26658683.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    35. Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH. Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice. Sci Rep. 2015 Oct 20; 5:15259. PMID: 26482836; PMCID: PMC4612501.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    36. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744; PMCID: PMC4557302.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    37. Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B. The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology. 2015 Aug; 62(2):505-20. PMID: 25847065; PMCID: PMC4515151.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    38. Bissig KD, Grompe M. Response to "Can 'humanized' mice improve drug development in the 21st century?". Trends Pharmacol Sci. 2013 Aug; 34(8):425. PMID: 23876405.
      Citations: 2     Fields:    Translation:HumansAnimals
    39. Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton DN, Bissig KD, Kalir T, Jacobs A, Evans T, Evans MJ, Gouon-Evans V. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013 Jun 06; 12(6):748-60. PMID: 23746980; PMCID: PMC3922205.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    40. Ruiz S, Panopoulos AD, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JC, Herrer?as A. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol. 2011 Jan 11; 21(1):45-52. PMID: 21167714; PMCID: PMC3034649.
      Citations: 145     Fields:    Translation:HumansCells
    41. Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IM. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010 Mar; 120(3):924-30. PMID: 20179355; PMCID: PMC2827952.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    42. Bissig KD, Le TT, Woods NB, Verma IM. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20507-11. PMID: 18077355; PMCID: PMC2154461.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    43. Bissig KD, Honer M, Zimmermann K, Summer KH, Solioz M. Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study. Biometals. 2005 Feb; 18(1):83-8. PMID: 15865413.
      Citations: 7     Fields:    Translation:Animals
    44. Bissig KD, Zimmermann A, Bernasch D, Furrer H, Dufour JF. Herpes simplex virus hepatitis 4 years after liver transplantation. J Gastroenterol. 2003; 38(10):1005-8. PMID: 14614611.
      Citations: 8     Fields:    Translation:HumansCells
    45. Bissig KD, Voegelin TC, Solioz M. Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett. 2001 Nov 02; 507(3):367-70. PMID: 11696373.
      Citations: 9     Fields:    
    46. Multhaup G, Strausak D, Bissig KD, Solioz M. Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):172-7. PMID: 11594769.
      Citations: 18     Fields:    Translation:Cells
    47. Bissig KD, Wunderli-Ye H, Duda PW, Solioz M. Structure-function analysis of purified Enterococcus hirae CopB copper ATPase: effect of Menkes/Wilson disease mutation homologues. Biochem J. 2001 Jul 01; 357(Pt 1):217-23. PMID: 11415452; PMCID: PMC1221944.
      Citations: 13     Fields:    Translation:HumansCells
    48. Bissig KD, La Fontaine S, Mercer JF, Solioz M. Expression of the human Menkes ATPase in Xenopus laevis oocytes. Biol Chem. 2001 Apr; 382(4):711-4. PMID: 11405236.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    49. Bissig KD, Marti U, Solioz M, Forestier M, Zimmermann H, Reichen J, L?thi M. Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy. J Hepatol. 2000 Aug; 33(2):275-81. PMID: 10952245.
      Citations: 3     Fields:    Translation:Animals
    50. Bissig KD, Solioz M. [How (deficient) copper causes illness]. Schweiz Med Wochenschr. 1998 Aug 04; 128(31-32):1175-80. PMID: 9738276.
      Citations:    Fields:    Translation:HumansAnimals
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