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JIN WANG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
DivisionPharmacology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    2011 - 2015CPRIT Scholar, CPRIT

    Collapse Overview 
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    chemical biology, sensors and probes, drug discovery, antibody drug conjugates


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 May 11. PMID: 29748621.
      View in: PubMed
    2. Jiang X, Chen J, Wang J. Reply to 'Pitfalls in the quantitative imaging of glutathione in living cells'. Nat Commun. 2018 Apr 23; 9(1):1589. PMID: 29686249.
      View in: PubMed
    3. Jiang X, Wang L, Carroll SL, Chen J, Wang MC, Wang J. Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications. Antioxid Redox Signal. 2018 Feb 16. PMID: 29320869.
      View in: PubMed
    4. Rothmiller S, Schröder S, Strobelt R, Wolf M, Wang J, Jiang X, Worek F, Steinritz D, Thiermann H, Schmidt A. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. Toxicol Lett. 2018 Sep 01; 293:51-61. PMID: 29183814.
      View in: PubMed
    5. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. 2017 Aug 18. PMID: 28809477.
      View in: PubMed
    6. Jiang X, Chen J, Baji? A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maleti?-Savati? M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 Jul 13; 8:16087. PMID: 28703127.
      View in: PubMed
    7. Han B, Sivaramakrishnan P, Lin CJ, Neve IAA, He J, Tay LWR, Sowa JN, Sizovs A, Du G, Wang J, Herman C, Wang MC. Microbial Genetic Composition Tunes Host Longevity. Cell. 2017 Jun 15; 169(7):1249-1262.e13. PMID: 28622510.
      View in: PubMed
    8. Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC coactivators blocks the tumor-initiating capacity of cancer stem-like cells. Cancer Res. 2017 Jun 13. PMID: 28611048.
      View in: PubMed
    9. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of Glutaredoxin 3 Impedes Mammary Lobuloalveolar Development during Pregnancy and Lactation. Am J Physiol Endocrinol Metab. 2016 Nov 15; ajpendo.00150.2016. PMID: 27894063.
      View in: PubMed
    10. Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3; 113(18):4970-5. PMID: 27084884.
      View in: PubMed
    11. Liu X, Lu YF, Guan X, Zhao M, Wang J, Li F. Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 Jun 1; 109:70-82. PMID: 27021842.
      View in: PubMed
    12. Chen J, Zhao M, Jiang X, Sizovs A, Wang MC, Provost CR, Huang J, Wang J. Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide. Analyst. 2016 Feb 21; 141(4):1209-13. PMID: 26806071; PMCID: PMC4747831.
    13. Chen J, Jiang X, Carroll SL, Huang J, Wang J. Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells. Org Lett. 2015 Dec 18; 17(24):5978-81. PMID: 26606171.
      View in: PubMed
    14. Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011. PMID: 26431029.
      View in: PubMed
    15. Zhang Y, Wang Y, Zhang C, Wang J, Pan D, Liu J, Feng F. Targeted Gene Delivery to Macrophages by Biodegradable Star-Shaped Polymers. ACS Appl Mater Interfaces. 2015 Oct 1. PMID: 26420603.
      View in: PubMed
    16. Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu J. NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription. Oncotarget. 2015 Sep 15; 6(27):23890-904. PMID: 26287601.
      View in: PubMed
    17. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 1; 97(1):111-21. PMID: 26212543.
      View in: PubMed
    18. Jiang X, Yu Y, Chen J, Zhao M, Chen H, Song X, Matzuk AJ, Carroll SL, Tan X, Sizovs A, Cheng N, Wang MC, Wang J. Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe. ACS Chem Biol. 2015 Mar 20; 10(3):864-74. PMID: 25531746; PMCID: PMC4371605.
    19. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 1; 74(5):1506-17. PMID: 24390736; PMCID: PMC3947477.
    20. Sizovs A, Song X, Waxham MN, Jia Y, Feng F, Chen J, Wicker AC, Xu J, Yu Y, Wang J. Precisely tunable engineering of sub-30 nm monodisperse oligonucleotide nanoparticles. J Am Chem Soc. 2014 Jan 8; 136(1):234-40. PMID: 24344996; PMCID: PMC3912943.
    21. Xu J, Luft JC, Yi X, Tian S, Owens G, Wang J, Johnson A, Berglund P, Smith J, Napier ME, DeSimone JM. RNA replicon delivery via lipid-complexed PRINT protein particles. Mol Pharm. 2013 Sep 3; 10(9):3366-74. PMID: 23924216.
      View in: PubMed
    22. Chen J, Zhao M, Feng F, Sizovs A, Wang J. Tunable thioesters as "reduction" responsive functionality for traceless reversible protein PEGylation. J Am Chem Soc. 2013 Jul 31; 135(30):10938-41. PMID: 23848502.
      View in: PubMed
    23. Xu J, Wang J, Luft JC, Tian S, Owens G, Pandya AA, Berglund P, Pohlhaus P, Maynor BW, Smith J, Hubby B, Napier ME, DeSimone JM. Rendering protein-based particles transiently insoluble for therapeutic applications. J Am Chem Soc. 2012 May 30; 134(21):8774-7. PMID: 22568387; PMCID: PMC3365610.
    24. Dunn SS, Tian S, Blake S, Wang J, Galloway AL, Murphy A, Pohlhaus PD, Rolland JP, Napier ME, DeSimone JM. Reductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing. J Am Chem Soc. 2012 May 2; 134(17):7423-30. PMID: 22475061; PMCID: PMC3357068.
    25. Wang J, Byrne JD, Napier ME, DeSimone JM. More effective nanomedicines through particle design. Small. 2011 Jul 18; 7(14):1919-31. PMID: 21695781; PMCID: PMC3136586.
    26. Xue J, Vyas S, Du Y, Luk HL, Chuang YP, But TY, Toy PH, Wang J, Winter AH, Phillips DL, Hadad CM, Platz MS. Time-resolved resonance Raman and computational investigation of the influence of 4-acetamido and 4-N-methylacetamido substituents on the chemistry of phenylnitrene. J Phys Chem A. 2011 Jul 7; 115(26):7521-30. PMID: 21648388.
      View in: PubMed
    27. Kubicki J, Zhang Y, Vyas S, Burdzinski G, Luk HL, Wang J, Xue J, Peng HL, Pritchina EA, Sliwa M, Buntinx G, Gritsan NP, Hadad CM, Platz MS. Photochemistry of 2-naphthoyl azide. An ultrafast time-resolved UV-vis and IR spectroscopic and computational study. J Am Chem Soc. 2011 Jun 29; 133(25):9751-61. PMID: 21548657.
      View in: PubMed
    28. Burdzinski G, Zhang Y, Wang J, Platz MS. Concerted Wolff rearrangement in two simple acyclic diazocarbonyl compounds. J Phys Chem A. 2010 Dec 23; 114(50):13065-8. PMID: 21117638.
      View in: PubMed
    29. Wang J, Tian S, Petros RA, Napier ME, Desimone JM. The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies. J Am Chem Soc. 2010 Aug 18; 132(32):11306-13. PMID: 20698697; PMCID: PMC2923393.
    30. Kubicki J, Zhang Y, Wang J, Luk HL, Peng HL, Vyas S, Platz MS. Direct observation of acyl azide excited states and their decay processes by ultrafast time resolved infrared spectroscopy. J Am Chem Soc. 2009 Apr 1; 131(12):4212-3. PMID: 19317497.
      View in: PubMed
    31. Wang YT, Jin KJ, Leopold SH, Wang J, Peng HL, Platz MS, Xue J, Phillips DL, Glover SA, Novak M. Characterization of reactive intermediates generated during photolysis of 4-acetoxy-4-aryl-2,5-cyclohexadienones: oxenium ions and aryloxy radicals. J Am Chem Soc. 2008 Nov 26; 130(47):16021-30. PMID: 18975865.
      View in: PubMed
    32. Zhang Y, Kubicki J, Wang J, Platz MS. 2-Naphthyl(carbomethoxy)carbene revisited: combination of ultrafast UV-vis and infrared spectroscopic study. J Phys Chem A. 2008 Nov 6; 112(44):11093-8. PMID: 18844332.
      View in: PubMed
    33. Burdzinski G, Réhault J, Wang J, Platz MS. A study of the photochemistry of Diazo Meldrum's acid by ultrafast time-resolved spectroscopies. J Phys Chem A. 2008 Oct 16; 112(41):10108-12. PMID: 18816025.
      View in: PubMed
    34. Wang J, Burdzinski G, Kubicki J, Platz MS. Ultrafast UV-vis and IR studies of p-biphenylyl acetyl and carbomethoxy carbenes. J Am Chem Soc. 2008 Aug 20; 130(33):11195-209. PMID: 18656918.
      View in: PubMed
    35. Wang J, Kubicki J, Peng H, Platz MS. Influence of solvent on carbene intersystem crossing rates. J Am Chem Soc. 2008 May 21; 130(20):6604-9. PMID: 18433130.
      View in: PubMed
    36. Wang J, Burdzinski G, Kubicki J, Gustafson TL, Platz MS. Ultrafast carbene-carbene isomerization. J Am Chem Soc. 2008 Apr 23; 130(16):5418-9. PMID: 18366167.
      View in: PubMed
    37. Wang J, Zhang Y, Kubicki J, Platz MS. Ultrafast studies of some diarylcarbenes. Photochem Photobiol Sci. 2008 May; 7(5):552-7. PMID: 18465011.
      View in: PubMed
    38. Burdzinski GT, Wang J, Gustafson TL, Platz MS. Study of concerted and sequential photochemical Wolff Rearrangement by femtosecond UV-vis and IR spectroscopy. J Am Chem Soc. 2008 Mar 26; 130(12):3746-7. PMID: 18311982.
      View in: PubMed
    39. Xue J, Du Y, Chuang YP, Phillips DL, Wang J, Luk C, Hadad CM, Platz MS. Time-resolved resonance Raman observation of the dimerization of didehydroazepines in solution. J Phys Chem A. 2008 Feb 21; 112(7):1502-10. PMID: 18225870.
      View in: PubMed
    40. Wang J, Kubicki J, Gustafson TL, Platz MS. The dynamics of carbene solvation: an ultrafast study of p-biphenylyltrifluoromethylcarbene. J Am Chem Soc. 2008 Feb 20; 130(7):2304-13. PMID: 18215044.
      View in: PubMed
    41. Wang J, Burdzinski G, Platz MS. Solvent effects on intermolecular proton transfer: the rates of nitrene protonation and their correlation with Swain acity. Org Lett. 2007 Dec 6; 9(25):5211-4. PMID: 18001041.
      View in: PubMed
    42. Wang YT, Wang J, Platz MS, Novak M. Direct detection of a transient oxenium ion in water generated by laser flash photolysis. J Am Chem Soc. 2007 Nov 28; 129(47):14566-7. PMID: 17985908.
      View in: PubMed
    43. Wang J, Kubicki J, Hilinski EF, Mecklenburg SL, Gustafson TL, Platz MS. Ultrafast study of 9-diazofluorene: direct observation of the first two singlet states of fluorenylidene. J Am Chem Soc. 2007 Nov 7; 129(44):13683-90. PMID: 17935331.
      View in: PubMed
    44. Wang J, Kubicki J, Burdzinski G, Hackett JC, Gustafson TL, Hadad CM, Platz MS. Early events in the photochemistry of 2-naphthyl azide from femtosecond UV/Vis spectroscopy and quantum chemical calculations: direct observation of a very short-lived singlet nitrene. J Org Chem. 2007 Sep 28; 72(20):7581-6. PMID: 17824713.
      View in: PubMed
    45. Wang J, Kubicki J, Platz MS. An ultrafast study of phenyl azide: the direct observation of phenylnitrenium ion. Org Lett. 2007 Sep 27; 9(20):3973-6. PMID: 17718577.
      View in: PubMed
    46. Wang J, Burdzinski G, Zhu Z, Platz MS, Carra C, Bally T. Ultrafast spectroscopic and matrix isolation studies of p-biphenylyl, o-biphenylyl, and 1-naphthylnitrenium cations. J Am Chem Soc. 2007 Jul 4; 129(26):8380-8. PMID: 17567009.
      View in: PubMed
    47. Wang J, Burdzinski G, Gustafson TL, Platz MS. Ultrafast study of p-biphenylyldiazoethane. The chemistry of the diazo excited state and the relaxed carbene. J Am Chem Soc. 2007 Mar 7; 129(9):2597-606. PMID: 17290992.
      View in: PubMed
    48. Wang J, Burdzinski G, Kubicki J, Platz MS, Moss RA, Fu X, Piotrowiak P, Myahkostupov M. Ultrafast spectroscopic study of the photochemistry and photophysics of arylhalodiazirines: direct observation of carbene and zwitterion formation. J Am Chem Soc. 2006 Dec 27; 128(51):16446-7. PMID: 17177362.
      View in: PubMed
    49. Burdzinski G, Hackett JC, Wang J, Gustafson TL, Hadad CM, Platz MS. Early events in the photochemistry of aryl azides from femtosecond UV/Vis spectroscopy and quantum chemical calculations. J Am Chem Soc. 2006 Oct 18; 128(41):13402-11. PMID: 17031952.
      View in: PubMed
    50. Wang J, Burdzinski G, Gustafson TL, Platz MS. Ultrafast study of p-biphenylyldiazomethane and p-biphenylylcarbene. J Org Chem. 2006 Aug 4; 71(16):6221-8. PMID: 16872208.
      View in: PubMed
    51. Tang FL, Yuan G, Wang J. Synthesis and photoinduced DNA cleaving activity of hairpin polyamide-chlorobenzenesulfonyl conjugates. Photochem Photobiol. 2003 Aug; 78(2):175-9. PMID: 12945586.
      View in: PubMed
    52. Tang F, Wang J, Liu D, Yuan G, Liu Y, Jin Zhu C, Fen Zhao Y. Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues. Rapid Commun Mass Spectrom. 2002; 16(11):1035-9. PMID: 11992504.
      View in: PubMed
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