"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 1999 | 2 | 2 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 3 | 2 | 5 |
| 2004 | 3 | 0 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 3 | 4 |
| 2008 | 4 | 3 | 7 |
| 2009 | 2 | 1 | 3 |
| 2010 | 2 | 1 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 3 | 4 |
| 2013 | 1 | 2 | 3 |
| 2014 | 11 | 3 | 14 |
| 2015 | 6 | 3 | 9 |
| 2016 | 8 | 6 | 14 |
| 2017 | 9 | 6 | 15 |
| 2018 | 5 | 7 | 12 |
| 2019 | 3 | 13 | 16 |
| 2020 | 8 | 4 | 12 |
| 2021 | 2 | 5 | 7 |
| 2022 | 1 | 10 | 11 |
| 2023 | 1 | 5 | 6 |
| 2024 | 6 | 2 | 8 |
| 2025 | 3 | 4 | 7 |
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click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors. Nat Commun. 2025 May 21; 16(1):4713.
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Update on Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome. Clin Cancer Res. 2025 May 15; 31(10):1831-1840.
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Update on Retinoblastoma Predisposition and Surveillance Recommendations for Children. Clin Cancer Res. 2025 May 01; 31(9):1573-1579.
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Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition. Clin Cancer Res. 2025 Apr 14; 31(8):1491-1503.
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Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndrome. Br J Haematol. 2025 Apr; 206(4):1109-1120.
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Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases. Nat Commun. 2025 Feb 19; 16(1):1779.
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Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome. Cancer Genet. 2025 Apr; 292-293:106-110.
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Polygenic Score for Clinicopathologic Features and Survival Outcomes in Papillary Thyroid Carcinoma. JAMA Otolaryngol Head Neck Surg. 2025 Feb 01; 151(2):113-120.
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Different phenotypes with different endings-Telomere biology disorders and cancer predisposition with long telomeres. Br J Haematol. 2025 Jan; 206(1):69-73.
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SDHB-Associated Pheochromocytomas: What is Their Clinical Behavior? Ann Surg Oncol. 2024 Dec; 31(13):9007-9013.