Ribonucleoprotein, U1 Small Nuclear
"Ribonucleoprotein, U1 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
| Descriptor ID |
D017412
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| MeSH Number(s) |
D12.776.157.725.500.875.600 D12.776.157.725.829.313 D12.776.664.962.500.875.600 D12.776.664.962.829.313
|
| Concept/Terms |
Ribonucleoprotein, U1 Small Nuclear- Ribonucleoprotein, U1 Small Nuclear
- U1 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U1
- Small Nuclear Ribonucleoproteins, U1
- U1 snRNP
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U1 Small Nuclear".
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This graph shows the total number of publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U1 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in Profiles.
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Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression. Proteomics. 2016 12; 16(23):3042-3053.
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U1A regulates 3' processing of the survival motor neuron mRNA. J Biol Chem. 2014 Feb 07; 289(6):3703-12.
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Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum. 2010 Feb; 62(2):589-98.
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Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera. J Immunol Methods. 2006 May 30; 312(1-2):79-93.
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An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites. Mol Cell Biol. 2000 Dec; 20(24):9225-35.
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Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol. 1998 Sep; 18(9):4977-85.
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An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev. 1996 Jan 15; 10(2):208-19.