STAT6 Transcription Factor
"STAT6 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-4. Stat6 has been shown to partner with NF-KAPPA B and CCAAT-ENHANCER-BINDING PROTEINS to regulate GENETIC TRANSCRIPTION of interleukin-4 responsive GENES.
| Descriptor ID |
D050800
|
| MeSH Number(s) |
D12.644.360.024.342.600 D12.776.157.057.186.600 D12.776.476.024.430.600 D12.776.930.840.600
|
| Concept/Terms |
STAT6 Transcription Factor- STAT6 Transcription Factor
- Transcription Factor, STAT6
- STAT6 Protein
- Signal Transducer and Activator of Transcription 6
|
Below are MeSH descriptors whose meaning is more general than "STAT6 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT6 Transcription Factor".
This graph shows the total number of publications written about "STAT6 Transcription Factor" by people in this website by year, and whether "STAT6 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 3 | 0 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "STAT6 Transcription Factor" by people in Profiles.
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Epigenomic and Transcriptomic Profiling of Solitary Fibrous Tumors Identifies Site-Specific Patterns and Candidate Genes Regulated by DNA Methylation. Lab Invest. 2024 11; 104(11):102146.
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Thoracic solitary fibrous tumors with small cell features: A clinicopathological and immunohistochemical analysis of 5 cases. Ann Diagn Pathol. 2024 Dec; 73:152353.
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Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer. Cancer Immunol Res. 2023 04 03; 11(4):486-500.
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STAT6 Blockade Abrogates Aspergillus-Induced Eosinophilic Chronic Rhinosinusitis and Asthma, A Model of Unified Airway Disease. Front Immunol. 2022; 13:818017.
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Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease. J Biol Chem. 2018 06 29; 293(26):10026-10040.
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IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol. 2019 02; 16(2):126-137.
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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys. 2018 03 15; 100(4):1034-1043.
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The IL-4 receptor a has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 12; 92(6):1433-1443.
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Ibrutinib modifies the function of monocyte/macrophage population in chronic lymphocytic leukemia. Oncotarget. 2016 Oct 04; 7(40):65968-65981.
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Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 07 01; 126(7):2465-81.