STAT6 Transcription Factor
"STAT6 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-4. Stat6 has been shown to partner with NF-KAPPA B and CCAAT-ENHANCER-BINDING PROTEINS to regulate GENETIC TRANSCRIPTION of interleukin-4 responsive GENES.
| Descriptor ID |
D050800
|
| MeSH Number(s) |
D12.644.360.024.342.600 D12.776.157.057.186.600 D12.776.476.024.430.600 D12.776.930.840.600
|
| Concept/Terms |
STAT6 Transcription Factor- STAT6 Transcription Factor
- Transcription Factor, STAT6
- STAT6 Protein
- Signal Transducer and Activator of Transcription 6
|
Below are MeSH descriptors whose meaning is more general than "STAT6 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT6 Transcription Factor".
This graph shows the total number of publications written about "STAT6 Transcription Factor" by people in this website by year, and whether "STAT6 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 3 | 0 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "STAT6 Transcription Factor" by people in Profiles.
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LKB1 activated by NaB inhibits the IL-4/STAT6 axis and ameliorates renal fibrosis through the suppression of M2 macrophage polarization. Life Sci. 2025 Jun 01; 370:123564.
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STAT6 Blockade Abrogates Aspergillus-Induced Eosinophilic Chronic Rhinosinusitis and Asthma, A Model of Unified Airway Disease. Front Immunol. 2022; 13:818017.
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Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease. J Biol Chem. 2018 06 29; 293(26):10026-10040.
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IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol. 2019 02; 16(2):126-137.
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The IL-4 receptor a has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 12; 92(6):1433-1443.
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Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 07 01; 126(7):2465-81.
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Long-Acting Beta Agonists Enhance Allergic Airway Disease. PLoS One. 2015; 10(11):e0142212.
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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25; 58(22):8970-84.
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JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol. 2015 Dec; 26(12):3060-71.
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Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Am J Respir Crit Care Med. 2014 Jan 01; 189(1):16-29.