"Disintegrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
| Descriptor ID |
D019483
|
| MeSH Number(s) |
D12.644.138
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Disintegrins".
Below are MeSH descriptors whose meaning is more specific than "Disintegrins".
This graph shows the total number of publications written about "Disintegrins" by people in this website by year, and whether "Disintegrins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Disintegrins" by people in Profiles.
-
Expression, purification, and analysis of three recombinant ECD disintegrins (r-colombistatins) from P-III class snake venom metalloproteinases affecting platelet aggregation and SK-MEL-28 cell adhesion. Toxicon. 2016 Nov; 122:43-49.
-
The characterization of trans-pecos copperhead (Agkistrodon contortrix pictigaster) venom and isolation of two new dimeric disintegrins. Biologicals. 2016 Jul; 44(4):191-197.
-
Ovulation: new factors that prepare the oocyte for fertilization. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):75-9.
-
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55.
-
Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor. Mol Endocrinol. 2004 Oct; 18(10):2463-78.
-
Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes. Endocrinology. 2004 Oct; 145(10):4603-14.
-
Regulation of transcripts encoding ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin-like motifs-1) and progesterone receptor by human chorionic gonadotropin in equine preovulatory follicles. J Mol Endocrinol. 2003 Dec; 31(3):473-85.
-
Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem. 2003 Oct 24; 278(43):42330-9.
-
Shedding light on sheddases: role in growth and development. Bioessays. 2002 Jan; 24(1):8-12.
-
Ovulation: a multi-gene, multi-step process. Steroids. 2000 Oct-Nov; 65(10-11):559-70.