"Disintegrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
| Descriptor ID |
D019483
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| MeSH Number(s) |
D12.644.138
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Disintegrins".
Below are MeSH descriptors whose meaning is more specific than "Disintegrins".
This graph shows the total number of publications written about "Disintegrins" by people in this website by year, and whether "Disintegrins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Disintegrins" by people in Profiles.
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Expression, purification, and analysis of three recombinant ECD disintegrins (r-colombistatins) from P-III class snake venom metalloproteinases affecting platelet aggregation and SK-MEL-28 cell adhesion. Toxicon. 2016 Nov; 122:43-49.
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The characterization of trans-pecos copperhead (Agkistrodon contortrix pictigaster) venom and isolation of two new dimeric disintegrins. Biologicals. 2016 Jul; 44(4):191-197.
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Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor. Mol Endocrinol. 2004 Oct; 18(10):2463-78.
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Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31; 8(5):578-84.