"Genes, Tumor Suppressor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
| Descriptor ID |
D016147
|
| MeSH Number(s) |
G05.360.340.024.340.375.249 G05.360.340.024.340.415.400
|
| Concept/Terms |
Genes, Tumor Suppressor- Genes, Tumor Suppressor
- Gene, Tumor Suppressor
- Tumor Suppressor Gene
- Antioncogenes
- Antioncogene
- Emerogenes
- Emerogene
- Genes, Onco-Suppressor
- Gene, Onco-Suppressor
- Genes, Onco Suppressor
- Onco-Suppressor Gene
- Onco-Suppressor Genes
- Cancer Suppressor Genes
- Cancer Suppressor Gene
- Gene, Cancer Suppressor
- Suppressor Gene, Cancer
- Suppressor Genes, Cancer
- Oncogenes, Recessive
- Oncogene, Recessive
- Recessive Oncogene
- Recessive Oncogenes
- Anti-Oncogenes
- Anti Oncogenes
- Anti-Oncogene
- Tumor Suppressing Genes
- Gene, Tumor Suppressing
- Genes, Tumor Suppressing
- Tumor Suppressing Gene
- Genes, Cancer Suppressor
- Tumor Suppressor Genes
Metastasis Suppressor Genes- Metastasis Suppressor Genes
- Gene, Metastasis Suppressor
- Metastasis Suppressor Gene
- Suppressor Gene, Metastasis
- Suppressor Genes, Metastasis
- Genes, Metastasis Suppressor
Growth Suppressor Genes- Growth Suppressor Genes
- Gene, Growth Suppressor
- Growth Suppressor Gene
- Suppressor Gene, Growth
- Suppressor Genes, Growth
- Genes, Growth Suppressor
|
Below are MeSH descriptors whose meaning is more general than "Genes, Tumor Suppressor".
Below are MeSH descriptors whose meaning is more specific than "Genes, Tumor Suppressor".
- Genes, Tumor Suppressor
- Genes, APC
- Genes, BRCA1
- Genes, BRCA2
- Genes, DCC
- Genes, MCC
- Genes, Neurofibromatosis 1
- Genes, Neurofibromatosis 2
- Genes, p16
- Genes, p53
- Genes, Retinoblastoma
- Genes, Wilms Tumor
This graph shows the total number of publications written about "Genes, Tumor Suppressor" by people in this website by year, and whether "Genes, Tumor Suppressor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 6 | 2 | 8 |
| 1999 | 3 | 2 | 5 |
| 2000 | 4 | 4 | 8 |
| 2001 | 5 | 2 | 7 |
| 2002 | 5 | 3 | 8 |
| 2003 | 5 | 2 | 7 |
| 2004 | 0 | 12 | 12 |
| 2005 | 1 | 4 | 5 |
| 2006 | 2 | 2 | 4 |
| 2007 | 3 | 4 | 7 |
| 2008 | 0 | 6 | 6 |
| 2009 | 2 | 1 | 3 |
| 2010 | 2 | 3 | 5 |
| 2011 | 4 | 8 | 12 |
| 2012 | 3 | 1 | 4 |
| 2013 | 2 | 3 | 5 |
| 2014 | 4 | 7 | 11 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 1 | 3 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 3 | 4 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, Tumor Suppressor" by people in Profiles.
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NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer. JCI Insight. 2026 Jun 08; 11(11).
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EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes. Cancer Res. 2023 12 01; 83(23):3956-3973.
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Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2121779119.
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Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Sci Adv. 2022 05 13; 8(19):eabm6638.
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Extracellular domain of semaphorin 5A serves a tumor-suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells. Int J Oncol. 2022 Feb; 60(2).
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Tumor suppressor function of WT1 in acute promyelocytic leukemia. Haematologica. 2022 01 01; 107(1):342-346.
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Ichthyosis, psoriasiform dermatitis, and recurrent fungal infections in patients with biallelic mutations in PERP. J Eur Acad Dermatol Venereol. 2022 Mar; 36(3):472-479.
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Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics. Cancer Res Commun. 2021 12; 1(3):178-193.
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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin?D. Nature. 2021 04; 592(7856):794-798.
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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. Mol Cell. 2020 11 05; 80(3):452-469.e9.