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KEVIN MACKENZIE

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jain P, Raji IO, Chamakuri S, MacKenzie KR, Ebright BT, Santini C, Young DW. Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 May 17; 84(10):6040-6064. PMID: 30848904.
      View in: PubMed
    2. Chamakuri S, Jain P, Guduru SRK, Arney JW, MacKenzie KR, Santini C, Young DW. Correction to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 Apr 05; 84(7):4575. PMID: 30855144.
      View in: PubMed
    3. Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 10 05; 83(19):11777-11793. PMID: 30180575.
      View in: PubMed
    4. Trusch F, Loebach L, Wawra S, Durward E, Wuensch A, Iberahim NA, de Bruijn I, MacKenzie K, Willems A, Toloczko A, Diéguez-Uribeondo J, Rasmussen T, Schrader T, Bayer P, Secombes CJ, van West P. Cell entry of a host-targeting protein of oomycetes requires gp96. Nat Commun. 2018 06 14; 9(1):2347. PMID: 29904064.
      View in: PubMed
    5. Chamakuri S, Jain P, Reddy Guduru SK, Arney JW, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 06 15; 83(12):6541-6555. PMID: 29751727.
      View in: PubMed
    6. Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC. Acetylation Disfavors Tau Phase Separation. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734651.
      View in: PubMed
    7. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Corrigendum: Quantitative real-time imaging of glutathione. Nat Commun. 2017 10 03; 8:16163. PMID: 28972204.
      View in: PubMed
    8. Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6. PMID: 28965825.
      View in: PubMed
    9. Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding. Angew Chem Int Ed Engl. 2017 10 02; 56(41):12590-12593. PMID: 28833982.
      View in: PubMed
    10. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. 2017 Sep 22; 2(9):1257-1261. PMID: 28809477.
      View in: PubMed
    11. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127.
      View in: PubMed
    12. Koppenol-Raab M, Harwig MC, Posey AE, Egner JM, MacKenzie KR, Hill RB. A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission. J Biol Chem. 2016 09 23; 291(39):20329-44. PMID: 27496949.
      View in: PubMed
    13. Hill RB, MacKenzie KR, Harwig MC. The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XL. J Mol Biol. 2015 Jul 03; 427(13):2257-61. PMID: 25896456.
      View in: PubMed
    14. Joshi MK, Moran S, Beckingham KM, MacKenzie KR. Structure of androcam supports specialized interactions with myosin VI. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13290-5. PMID: 22851764.
      View in: PubMed
    15. Joshi MK, Moran S, MacKenzie KR. NMR chemical shift assignments for androcam, a testis-specific myosin VI light chain in D. melanogaster. Biomol NMR Assign. 2013 Oct; 7(2):167-9. PMID: 22706933.
      View in: PubMed
    16. Joshi MK, Moran S, MacKenzie KR. ¹H, ¹5N and ¹³C chemical shifts of the D. melanogaster myosin VI light chain androcam in high calcium. Biomol NMR Assign. 2013 Oct; 7(2):171-4. PMID: 22706934.
      View in: PubMed
    17. Lawrie CM, Sulistijo ES, MacKenzie KR. Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes. J Mol Biol. 2010 Mar 05; 396(4):924-36. PMID: 20026130.
      View in: PubMed
    18. Zaykov AN, MacKenzie KR, Ball ZT. Controlling peptide structure with coordination chemistry: robust and reversible peptide-dirhodium ligation. Chemistry. 2009 Sep 14; 15(36):8961-5. PMID: 19637261.
      View in: PubMed
    19. Sulistijo ES, Mackenzie KR. Structural basis for dimerization of the BNIP3 transmembrane domain. Biochemistry. 2009 Jun 16; 48(23):5106-20. PMID: 19415897.
      View in: PubMed
    20. MacKenzie KR, Fleming KG. Association energetics of membrane spanning alpha-helices. Curr Opin Struct Biol. 2008 Aug; 18(4):412-9. PMID: 18539023.
      View in: PubMed
    21. Dews IC, Mackenzie KR. Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20782-7. PMID: 18093920.
      View in: PubMed
    22. Duong MT, Jaszewski TM, Fleming KG, MacKenzie KR. Changes in apparent free energy of helix-helix dimerization in a biological membrane due to point mutations. J Mol Biol. 2007 Aug 10; 371(2):422-34. PMID: 17570394.
      View in: PubMed
    23. Maximciuc AA, Putkey JA, Shamoo Y, Mackenzie KR. Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode. Structure. 2006 Oct; 14(10):1547-56. PMID: 17027503.
      View in: PubMed
    24. Sulistijo ES, MacKenzie KR. Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions. J Mol Biol. 2006 Dec 15; 364(5):974-90. PMID: 17049556.
      View in: PubMed
    25. Mackenzie KR. Folding and stability of alpha-helical integral membrane proteins. Chem Rev. 2006 May; 106(5):1931-77. PMID: 16683762.
      View in: PubMed
    26. Sulistijo ES, Jaszewski TM, MacKenzie KR. Sequence-specific dimerization of the transmembrane domain of the "BH3-only" protein BNIP3 in membranes and detergent. J Biol Chem. 2003 Dec 19; 278(51):51950-6. PMID: 14532263.
      View in: PubMed
    27. Petrache HI, Grossfield A, MacKenzie KR, Engelman DM, Woolf TB. Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations. J Mol Biol. 2000 Sep 22; 302(3):727-46. PMID: 10986130.
      View in: PubMed
    28. MacKenzie KR, Engelman DM. Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3583-90. PMID: 9520409.
      View in: PubMed
    29. Arkin IT MacKenzie KR Brunger AT. Site directed dichroism as a method for obtaining rotational and orientational constraints for oriented polymers. Journal of the American Chemical Society. 1997; 38(119):8973-8980.
    30. MacKenzie KR, Prestegard JH, Engelman DM. A transmembrane helix dimer: structure and implications. Science. 1997 Apr 04; 276(5309):131-3. PMID: 9082985.
      View in: PubMed
    31. MacKenzie KR, Prestegard JH, Engelman DM. Leucine side-chain rotamers in a glycophorin A transmembrane peptide as revealed by three-bond carbon-carbon couplings and 13C chemical shifts. J Biomol NMR. 1996 May; 7(3):256-60. PMID: 8785502.
      View in: PubMed
    32. Arkin IT, MacKenzie KR, Fisher L, Aimoto S, Engelman DM, Smith SO. Mapping the lipid-exposed surfaces of membrane proteins. Nat Struct Biol. 1996 Mar; 3(3):240-3. PMID: 8605625.
      View in: PubMed
    33. Hill RB, MacKenzie KR, Flanagan JM, Cronan JE, Prestegard JH. Overexpression, purification, and characterization of Escherichia coli acyl carrier protein and two mutant proteins. Protein Expr Purif. 1995 Aug; 6(4):394-400. PMID: 8527922.
      View in: PubMed
    34. Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Brünger AT, Engelman DM. Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J. 1994 Oct 17; 13(20):4757-64. PMID: 7525269.
      View in: PubMed
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