KEVIN MACKENZIE

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khalil SM, MacKenzie KR, Maletic-Savatic M, Li F. Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity. Drug Metab Rev. 2024 Feb 04; 1-38. PMID: 38311829.
      Citations:    Fields:    
    2. Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DW. Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024 Jan 11; 15(1):107-115. PMID: 38229743; PMCID: PMC10788937.
      Citations:    
    3. Han X, Wang W, Ma LH, Ai-Ramahi I, Botas J, MacKenzie K, Allen GI, Young DW, Liu Z, Maletic-Savatic M. SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra. Bioinformatics. 2023 10 03; 39(10). PMID: 37792497; PMCID: PMC10568371.
      Citations:    Fields:    Translation:HumansAnimals
    4. Viveki AB, Mansfield TM, Tran KA, Lenkeit E, MacKenzie KR, Young DW, Chamakuri S. Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles. Chemistry. 2023 Oct 02; 29(55):e202301888. PMID: 37462979.
      Citations:    Fields:    
    5. Qin X, Wang Y, MacKenzie KR, Hakenjos JM, Chen S, Khalil SM, Jung SY, Young DW, Guo L, Li F. Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC-MS-Based Metabolomic Approaches. Chem Res Toxicol. 2023 08 21; 36(8):1427-1438. PMID: 37531179; PMCID: PMC10445284.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Han X, Wang W, Ma LH, Al-Ramahi I, Botas J, MacKenzie K, Allen GI, Young DW, Liu Z, Maletic-Savatic M. SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra. bioRxiv. 2023 Feb 22. PMID: 36865102; PMCID: PMC9980041.
      Citations:    
    7. Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F. The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice. Eur J Pharm Sci. 2023 Feb 01; 181:106358. PMID: 36513193; PMCID: PMC10395004.
      Citations:    Fields:    Translation:HumansAnimals
    8. Ye Q, Belabed H, Wang Y, Yu Z, Palaniappan M, Li JY, Kalovidouris SA, MacKenzie KR, Teng M, Young DW, Fujihara Y, Matzuk MM. Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections. Andrology. 2023 07; 11(5):808-815. PMID: 36209044.
      Citations:    Fields:    Translation:HumansAnimals
    9. Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim C. An auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 08 05; 11. PMID: 35929723; PMCID: PMC9417419.
      Citations:    
    10. Chamakuri S, Tang SA, Tran KA, Guduru SKR, Bolin PK, MacKenzie KR, Young DW. A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines. Molecules. 2022 May 25; 27(11). PMID: 35684357; PMCID: PMC9182393.
      Citations:    Fields:    
    11. Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Venken K, Moore DD, Young DW, Maletic-Savatic M, Jim?nez-Panizo A, Est?banez-Perpi?? E. Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2023784119. PMID: 35333654; PMCID: PMC9060471.
      Citations: 1     Fields:    Translation:Animals
    12. Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li F. Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice. Drug Metab Dispos. 2022 02; 50(2):128-139. PMID: 34785568; PMCID: PMC8969139.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579. PMID: 34552088; PMCID: PMC8458463.
      Citations: 3     Fields:    Translation:HumansCells
    14. Chang L, Campbell J, Raji IO, Guduru SKR, Kandel P, Nguyen M, Liu S, Tran K, Venugopal NK, Taylor BC, Holt MV, Young NL, Samuel ELG, Jain P, Santini C, Sankaran B, MacKenzie KR, Young DW. Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery. Sci Rep. 2021 01 13; 11(1):1121. PMID: 33441849; PMCID: PMC7806715.
      Citations: 4     Fields:    Translation:Cells
    15. Li F, MacKenzie KR, Jain P, Santini C, Young DW, Matzuk MM. Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes?. Biol Reprod. 2020 08 04; 103(2):427-436. PMID: 32285106; PMCID: PMC7401416.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    16. MacKenzie KR, Zhao M, Barzi M, Wang J, Bissig KD, Maletic-Savatic M, Jung SY, Li F. Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine. Eur J Pharm Sci. 2020 Oct 01; 153:105488. PMID: 32712217; PMCID: PMC7506503.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Del Valle I, Webster TM, Cheng HY, Thies JE, Miller MK, Ball ZT, MacKenzie KR, Masiello CA, Silberg JJ, Lehmann J, Kessler A. Soil organic matter attenuates the efficacy of flavonoid-based plant-microbe communication. Sci Adv. 2020 01; 6(5):eaax8254. PMID: 32064339; PMCID: PMC6989149.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    18. Jain P, Raji IO, Chamakuri S, MacKenzie KR, Ebright BT, Santini C, Young DW. Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 05 17; 84(10):6040-6064. PMID: 30848904.
      Citations: 3     Fields:    
    19. Chamakuri S, Jain P, Guduru SRK, Arney JW, MacKenzie KR, Santini C, Young DW. Correction to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 Apr 05; 84(7):4575. PMID: 30855144.
      Citations:    Fields:    
    20. Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 10 05; 83(19):11777-11793. PMID: 30180575.
      Citations: 5     Fields:    
    21. Trusch F, Loebach L, Wawra S, Durward E, Wuensch A, Iberahim NA, de Bruijn I, MacKenzie K, Willems A, Toloczko A, Rasmussen T, Schrader T, Bayer P, Secombes CJ, van West P, Di?guez-Uribeondo J. Cell entry of a host-targeting protein of oomycetes requires gp96. Nat Commun. 2018 06 14; 9(1):2347. PMID: 29904064; PMCID: PMC6002402.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Chamakuri S, Jain P, Reddy Guduru SK, Arney JW, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 06 15; 83(12):6541-6555. PMID: 29751727.
      Citations: 5     Fields:    
    23. Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC. Acetylation Disfavors Tau Phase Separation. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734651; PMCID: PMC5983838.
      Citations: 45     Fields:    Translation:HumansCells
    24. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Corrigendum: Quantitative real-time imaging of glutathione. Nat Commun. 2017 10 03; 8:16163. PMID: 28972204; PMCID: PMC5628253.
      Citations: 2     Fields:    
    25. Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6. PMID: 28965825; PMCID: PMC5677551.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    26. Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding. Angew Chem Int Ed Engl. 2017 10 02; 56(41):12590-12593. PMID: 28833982.
      Citations: 23     Fields:    Translation:HumansCells
    27. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. 2017 Sep 22; 2(9):1257-1261. PMID: 28809477; PMCID: PMC5771714.
      Citations: 28     Fields:    
    28. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127; PMCID: PMC5511354.
      Citations: 47     Fields:    Translation:HumansCells
    29. Koppenol-Raab M, Harwig MC, Posey AE, Egner JM, MacKenzie KR, Hill RB. A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission. J Biol Chem. 2016 09 23; 291(39):20329-44. PMID: 27496949; PMCID: PMC5034033.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Hill RB, MacKenzie KR, Harwig MC. The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XL. J Mol Biol. 2015 Jul 03; 427(13):2257-61. PMID: 25896456.
      Citations: 5     Fields:    Translation:HumansCells
    31. Joshi MK, Moran S, Beckingham KM, MacKenzie KR. Structure of androcam supports specialized interactions with myosin VI. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13290-5. PMID: 22851764; PMCID: PMC3421203.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Joshi MK, Moran S, MacKenzie KR. NMR chemical shift assignments for androcam, a testis-specific myosin VI light chain in D. melanogaster. Biomol NMR Assign. 2013 Oct; 7(2):167-9. PMID: 22706933.
      Citations: 1     Fields:    Translation:AnimalsCells
    33. Joshi MK, Moran S, MacKenzie KR. ?H, ?5N and ??C chemical shifts of the D. melanogaster myosin VI light chain androcam in high calcium. Biomol NMR Assign. 2013 Oct; 7(2):171-4. PMID: 22706934.
      Citations: 1     Fields:    Translation:AnimalsCells
    34. Lawrie CM, Sulistijo ES, MacKenzie KR. Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes. J Mol Biol. 2010 Mar 05; 396(4):924-36. PMID: 20026130; PMCID: PMC2836233.
      Citations: 11     Fields:    Translation:HumansCells
    35. Zaykov AN, MacKenzie KR, Ball ZT. Controlling peptide structure with coordination chemistry: robust and reversible peptide-dirhodium ligation. Chemistry. 2009 Sep 14; 15(36):8961-5. PMID: 19637261.
      Citations: 6     Fields:    Translation:Cells
    36. Sulistijo ES, Mackenzie KR. Structural basis for dimerization of the BNIP3 transmembrane domain. Biochemistry. 2009 Jun 16; 48(23):5106-20. PMID: 19415897.
      Citations: 25     Fields:    Translation:Cells
    37. MacKenzie KR, Fleming KG. Association energetics of membrane spanning alpha-helices. Curr Opin Struct Biol. 2008 Aug; 18(4):412-9. PMID: 18539023; PMCID: PMC7127525.
      Citations: 48     Fields:    
    38. Dews IC, Mackenzie KR. Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20782-7. PMID: 18093920; PMCID: PMC2410079.
      Citations: 42     Fields:    Translation:HumansCells
    39. Duong MT, Jaszewski TM, Fleming KG, MacKenzie KR. Changes in apparent free energy of helix-helix dimerization in a biological membrane due to point mutations. J Mol Biol. 2007 Aug 10; 371(2):422-34. PMID: 17570394; PMCID: PMC2693063.
      Citations: 37     Fields:    Translation:Cells
    40. Maximciuc AA, Putkey JA, Shamoo Y, Mackenzie KR. Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode. Structure. 2006 Oct; 14(10):1547-56. PMID: 17027503.
      Citations: 54     Fields:    Translation:Cells
    41. Sulistijo ES, MacKenzie KR. Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions. J Mol Biol. 2006 Dec 15; 364(5):974-90. PMID: 17049556.
      Citations: 33     Fields:    Translation:HumansCells
    42. Mackenzie KR. Folding and stability of alpha-helical integral membrane proteins. Chem Rev. 2006 May; 106(5):1931-77. PMID: 16683762.
      Citations: 92     Fields:    Translation:Cells
    43. Sulistijo ES, Jaszewski TM, MacKenzie KR. Sequence-specific dimerization of the transmembrane domain of the "BH3-only" protein BNIP3 in membranes and detergent. J Biol Chem. 2003 Dec 19; 278(51):51950-6. PMID: 14532263.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    44. Petrache HI, Grossfield A, MacKenzie KR, Engelman DM, Woolf TB. Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations. J Mol Biol. 2000 Sep 22; 302(3):727-46. PMID: 10986130.
      Citations: 38     Fields:    Translation:Cells
    45. MacKenzie KR, Engelman DM. Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3583-90. PMID: 9520409; PMCID: PMC19879.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    46. Arkin IT MACKENZIE KR Brunger AT. Site directed dichroism as a method for obtaining rotational and orientational constraints for oriented polymers. Journal of the American Chemical Society. 1997; 38(119):8973-8980. View Publication.
    47. MacKenzie KR, Prestegard JH, Engelman DM. A transmembrane helix dimer: structure and implications. Science. 1997 Apr 04; 276(5309):131-3. PMID: 9082985.
      Citations: 348     Fields:    Translation:Cells
    48. MacKenzie KR, Prestegard JH, Engelman DM. Leucine side-chain rotamers in a glycophorin A transmembrane peptide as revealed by three-bond carbon-carbon couplings and 13C chemical shifts. J Biomol NMR. 1996 May; 7(3):256-60. PMID: 8785502.
      Citations: 13     Fields:    Translation:HumansCells
    49. Arkin IT, MacKenzie KR, Fisher L, Aimoto S, Engelman DM, Smith SO. Mapping the lipid-exposed surfaces of membrane proteins. Nat Struct Biol. 1996 Mar; 3(3):240-3. PMID: 8605625.
      Citations: 3     Fields:    Translation:Cells
    50. Hill RB, MacKenzie KR, Flanagan JM, Cronan JE, Prestegard JH. Overexpression, purification, and characterization of Escherichia coli acyl carrier protein and two mutant proteins. Protein Expr Purif. 1995 Aug; 6(4):394-400. PMID: 8527922.
      Citations: 5     Fields:    Translation:Cells
    51. Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Engelman DM, Br?nger AT. Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J. 1994 Oct 17; 13(20):4757-64. PMID: 7525269; PMCID: PMC395414.
      Citations: 32     Fields:    Translation:HumansCells
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