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FRANK T. HORRIGAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152; PMCID: PMC4280298.
    2. Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec; 140(6):625-34. PMID: 23183698; PMCID: PMC3514727.
    3. Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 3; 287(6):4014-22. PMID: 22074915; PMCID: PMC3281680.
    4. Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug; 3(4):249-58. PMID: 19617704; PMCID: PMC2824562.
    5. Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28; 284(35):23353-63. PMID: 19561088; PMCID: PMC2749109.
    6. Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov; 15(11):1130-2. PMID: 18985066.
      View in: PubMed
    7. Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May; 131(5):483-502. PMID: 18443360; PMCID: PMC2346571.
    8. Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan; 131(1):13-32. PMID: 18166624; PMCID: PMC2174156.
    9. Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18270-5. PMID: 17984060; PMCID: PMC2084332.
    10. Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec; 39(12):918-24. PMID: 17176030.
      View in: PubMed
    11. Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar; 127(3):309-28. PMID: 16505150; PMCID: PMC2151507.
    12. Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul; 126(1):7-21. PMID: 15955873; PMCID: PMC2266614.
    13. Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb; 125(2):213-36. PMID: 15684095; PMCID: PMC2217493.
    14. Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10488-93. PMID: 12925732; PMCID: PMC193588.
    15. Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep; 120(3):267-305. PMID: 12198087; PMCID: PMC2229516.
    16. Lou XJ, Schena M, Horrigan FT, Lawn RM, Davis RW. Expression monitoring using cDNA microarrays. A general protocol. Methods Mol Biol. 2001; 175:323-40. PMID: 11462845.
      View in: PubMed
    17. Horrigan FT, Aldrich RW. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):305-36. PMID: 10436004; PMCID: PMC2230644.
    18. Horrigan FT, Cui J, Aldrich RW. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):277-304. PMID: 10436003; PMCID: PMC2230643.
    19. Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12591-5. PMID: 9770530; PMCID: PMC22875.
    20. Horrigan FT, Gilly WF. Methadone block of K+ current in squid giant fiber lobe neurons. J Gen Physiol. 1996 Feb; 107(2):243-60. PMID: 8833344; PMCID: PMC2219262.
    21. Horrigan FT, Bookman RJ. Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron. 1994 Nov; 13(5):1119-29. PMID: 7946349.
      View in: PubMed
    22. Gilly WF, Lucero MT, Horrigan FT. Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid. Neuron. 1990 Nov; 5(5):663-74. PMID: 2171590.
      View in: PubMed
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