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JUAN C. MARINI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Critical Care
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    1. Didelija IC, Mohammad MA, Marini JC. Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice. J Nutr. 2017 Jul 05. PMID: 28679627.
      View in: PubMed
    2. Marini JC, Agarwal U, Robinson JL, Yuan Y, Cajo Didelija I, Stoll B, Burrin DG. THE INTESTINAL-RENAL AXIS FOR ARGININE SYNTHESIS IS PRESENT AND FUNCTIONAL IN THE NEONATAL PIG. Am J Physiol Endocrinol Metab. 2017 Jun 13; ajpendo.00055.2017. PMID: 28611027.
      View in: PubMed
    3. Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC. Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study. J Nutr. 2017 Mar 08. PMID: 28275102.
      View in: PubMed
    4. Agarwal U, Didelija IC, Yuan Y, Wang X, Marini JC. Supplemental Citrulline Is More Efficient than Arginine in Increasing Systemic Arginine Availability in Mice. J Nutr. 2017 Feb 08. PMID: 28179487.
      View in: PubMed
    5. Achreja A, Zhao H, Yang L, Yun TH, Marini J, Nagrath D. Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism. Metab Eng. 2017 Jan 11. PMID: 28087332.
      View in: PubMed
    6. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of Glutaredoxin 3 Impedes Mammary Lobuloalveolar Development during Pregnancy and Lactation. Am J Physiol Endocrinol Metab. 2016 Nov 15; ajpendo.00150.2016. PMID: 27894063.
      View in: PubMed
    7. Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T, Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metab. 2016 Nov 08; 24(5):685-700. PMID: 27829138.
      View in: PubMed
    8. Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 2016; 5. PMID: 26920219; PMCID: PMC4841778.
    9. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-7. PMID: 26874300; PMCID: PMC4808600 [Available on 04/01/17].
    10. Marini JC. Interrelationships between glutamine and citrulline metabolism. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):62-6. PMID: 26560519.
      View in: PubMed
    11. Marini JC, Agarwal U, Didelija IC. Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. J Nutr. 2015 Jun; 145(6):1227-31. PMID: 25855119.
      View in: PubMed
    12. Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? Am J Clin Nutr. 2015 Apr; 101(4):890-2. PMID: 25833987.
      View in: PubMed
    13. Marini JC, Didelija IC. Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PLoS One. 2015; 10(3):e0119801. PMID: 25775142; PMCID: PMC4361593.
    14. Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Lauridsen C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2015 Jan 16. PMID: 25596209.
      View in: PubMed
    15. Castro D., G. Briassoulis, J.W. Hsu, J.C. Marini, M. Wu, W.E. Gordon, I.D. Esangbedo, J. Palmattan and L. Castillo. The effect of Fentanyl administration on plasma agmatine concentration in critically ill patients. J. Pediatr. Neonatal Care. 2015; (3):00118.
    16. Marini JC. Protein requirements: are we ready for new recommendations? J Nutr. 2015 Jan; 145(1):5-6. PMID: 25342701.
      View in: PubMed
    17. Marini JC, Didelija IC, Fiorotto ML. Extrarenal citrulline disposal in mice with impaired renal function. Am J Physiol Renal Physiol. 2014 Sep 15; 307(6):F660-5. PMID: 25056350; PMCID: PMC4166726.
    18. Caneba CA, Yang L, Baddour J, Curtis R, Win J, Hartig S, Marini J, Nagrath D. Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells. Cell Death Dis. 2014; 5:e1302. PMID: 24967964; PMCID: PMC4611736.
    19. Sinder BP, White LE, Salemi JD, Ominsky MS, Caird MS, Marini JC, Kozloff KM. Adult Brtl/+ mouse model of osteogenesis imperfecta demonstrates anabolic response to sclerostin antibody treatment with increased bone mass and strength. Osteoporos Int. 2014 Aug; 25(8):2097-107. PMID: 24803333; PMCID: PMC4415164.
    20. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol. 2014; 10:728. PMID: 24799285; PMCID: PMC4188042.
    21. Radley-Crabb HG, Marini JC, Sosa HA, Castillo LI, Grounds MD, Fiorotto ML. Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy. PLoS One. 2014; 9(2):e89277. PMID: 24586653; PMCID: PMC3929705.
    22. Meganck JA, Begun DL, McElderry JD, Swick A, Kozloff KM, Goldstein SA, Morris MD, Marini JC, Caird MS. Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta. Bone. 2013 Sep; 56(1):204-12. PMID: 23774443; PMCID: PMC3999166.
    23. Marini JC, Stoll B, Didelija IC, Burrin DG. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1348-53. PMID: 23074237; PMCID: PMC3774079.
    24. Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, Kleppe S, Erez A, O'Brian Smith E, Marini JC. A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria. Mol Genet Metab. 2012 Nov; 107(3):315-21. PMID: 23040521; PMCID: PMC3483446.
    25. Benight NM, Stoll B, Marini JC, Burrin DG. Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jul; 303(1):G71-82. PMID: 22556140; PMCID: PMC3404577.
    26. Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B. Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet. 2012 May 4; 90(5):836-46. PMID: 22541557; PMCID: PMC3376491.
    27. Chacko SK, Haymond MW, Sun Y, Marini JC, Sauer PJ, Ma X, Sunehag AL. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab. 2012 May 15; 302(9):E1055-62. PMID: 22338071.
      View in: PubMed
    28. Marini JC. Arginine and ornithine are the main precursors for citrulline synthesis in mice. J Nutr. 2012 Mar; 142(3):572-80. PMID: 22323761; PMCID: PMC3278269.
    29. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec; 17(12):1619-26. PMID: 22081021; PMCID: PMC3348956.
    30. Valli M, Barnes AM, Gallanti A, Cabral WA, Viglio S, Weis MA, Makareeva E, Eyre D, Leikin S, Antoniazzi F, Marini JC, Mottes M. Deficiency of CRTAP in non-lethal recessive osteogenesis imperfecta reduces collagen deposition into matrix. Clin Genet. 2012 Nov; 82(5):453-9. PMID: 21955071; PMCID: PMC3748815.
    31. Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59. PMID: 21596995; PMCID: PMC3154603.
    32. Marini JC. Quantitative analysis of 15N-labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid Commun Mass Spectrom. 2011 May 15; 25(9):1291-6. PMID: 21491530.
      View in: PubMed
    33. Marini JC, Lanpher BC, Scaglia F, O'Brien WE, Sun Q, Garlick PJ, Jahoor F, Lee B. Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase-deficient patients. Am J Clin Nutr. 2011 Jun; 93(6):1248-54. PMID: 21490144; PMCID: PMC3095500.
    34. Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B. Phenylbutyrate therapy for maple syrup urine disease. Hum Mol Genet. 2011 Feb 15; 20(4):631-40. PMID: 21098507; PMCID: PMC3024040.
    35. Thame MM, Fletcher HM, Baker TM, Marini JC, Kao CC, Jahoor F. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. J Nutr. 2011 Jan; 141(1):71-4. PMID: 21084652.
      View in: PubMed
    36. Marini JC, Keller B, Didelija IC, Castillo L, Lee B. Enteral arginase II provides ornithine for citrulline synthesis. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E188-94. PMID: 20978229; PMCID: PMC3023202.
    37. Marini JC, Didelija IC, Castillo L, Lee B. Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets. J Nutr. 2010 Aug; 140(8):1432-7. PMID: 20573946; PMCID: PMC2903302.
    38. Marini JC, Didelija IC, Castillo L, Lee B. Glutamine: precursor or nitrogen donor for citrulline synthesis? Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E69-79. PMID: 20407005; PMCID: PMC2904050.
    39. Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Butte NF, Marini J, Jahoor F, Sterchi EE. Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice. J Nutr. 2009 Apr; 139(4):684-90. PMID: 19193815; PMCID: PMC2666363.
    40. Blair-Levy JM, Watts CE, Fiorentino NM, Fiorientino NM, Dimitriadis EK, Marini JC, Lipsky PE. A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse model. Arthritis Rheum. 2008 Apr; 58(4):1096-106. PMID: 18383364.
      View in: PubMed
    41. Marini JC, Fox DG, Murphy MR. Nitrogen transactions along the gastrointestinal tract of cattle: A meta-analytical approach. J Anim Sci. 2008 Mar; 86(3):660-79. PMID: 18073282.
      View in: PubMed
    42. Marini JC, Erez A, Castillo L, Lee B. Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1764-71. PMID: 17925451.
      View in: PubMed
    43. Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB, Loor JJ, Marini JC, Rund LA, Schook LB, Van Kessel AG, Gaskins HR. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genomics. 2007; 8:215. PMID: 17615075; PMCID: PMC1949829.
    44. Marini JC, Lee B, Garlick PJ. Non-surgical alternatives to invasive procedures in mice. Lab Anim. 2006 Jul; 40(3):275-81. PMID: 16803644.
      View in: PubMed
    45. Marini JC, Lee B, Garlick PJ. Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice. J Nutr. 2006 Jul; 136(7):1834-8. PMID: 16772445.
      View in: PubMed
    46. Imoberdorf R, Garlick PJ, McNurlan MA, Casella GA, Marini JC, Turgay M, Bärtsch P, Ballmer PE. Skeletal muscle protein synthesis after active or passive ascent to high altitude. Med Sci Sports Exerc. 2006 Jun; 38(6):1082-7. PMID: 16775549.
      View in: PubMed
    47. Marini JC, Lee B, Garlick PJ. Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice. J Nutr. 2006 Apr; 136(4):1017-20. PMID: 16549467.
      View in: PubMed
    48. Marini JC, Broussard SR. Hyperammonemia increases sensitivity to LPS. Mol Genet Metab. 2006 Jun; 88(2):131-7. PMID: 16497529.
      View in: PubMed
    49. Marini JC, Attene-Ramos MS. An improved analytical method for the determination of urea nitrogen isotopomers in biological samples utilizing continuous flow isotope ratio mass spectrometry. Rapid Commun Mass Spectrom. 2006; 20(24):3736-40. PMID: 17099932.
      View in: PubMed
    50. Marini JC, Lee B, Garlick PJ. In vivo urea kinetic studies in conscious mice. J Nutr. 2006 Jan; 136(1):202-6. PMID: 16365083.
      View in: PubMed
    51. Marini JC, Van Amburgh ME. Partition of nitrogen excretion in urine and the feces of holstein replacement heifers. J Dairy Sci. 2005 May; 88(5):1778-84. PMID: 15829671.
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    52. Scaglia F, Brunetti-Pierri N, Kleppe S, Marini J, Carter S, Garlick P, Jahoor F, O'Brien W, Lee B. Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. J Nutr. 2004 Oct; 134(10 Suppl):2775S-2782S; discussion 2796S-2797S. PMID: 15465784.
      View in: PubMed
    53. Marini JC, Klein JD, Sands JM, Van Amburgh ME. Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs. J Anim Sci. 2004 Apr; 82(4):1157-64. PMID: 15080338.
      View in: PubMed
    54. Scaglia F, Marini J, Rosenberger J, Henry J, Garlick P, Lee B, Reeds P. Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers. Am J Clin Nutr. 2003 Oct; 78(4):749-55. PMID: 14522733.
      View in: PubMed
    55. Marini JC, Van Amburgh ME. Nitrogen metabolism and recycling in Holstein heifers. J Anim Sci. 2003 Feb; 81(2):545-52. PMID: 12643500.
      View in: PubMed
    56. Ruiz R, Tedeschl LO, Marini JC, Fox DG, Pell AN, Jarvis G, Russell JB. The effect of a ruminal nitrogen (N) deficiency in dairy cows: evaluation of the cornell net carbohydrate and protein system ruminal N deficiency adjustment. J Dairy Sci. 2002 Nov; 85(11):2986-99. PMID: 12487464.
      View in: PubMed
    57. Dawson PA, Kelly TE, Marini JC. Extension of phenotype associated with structural mutations in type I collagen: siblings with juvenile osteoporosis have an alpha2(I)Gly436 --> Arg substitution. J Bone Miner Res. 1999 Mar; 14(3):449-55. PMID: 10027910.
      View in: PubMed
    58. O'Connell AC, Marini JC. Evaluation of oral problems in an osteogenesis imperfecta population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Feb; 87(2):189-96. PMID: 10052375.
      View in: PubMed
    59. Forlino A, Keene DR, Schmidt K, Marini JC. An alpha2(I) glycine to aspartate substitution is responsible for the presence of a kink in type I collagen in a lethal case of osteogenesis imperfecta. Matrix Biol. 1998 Dec; 17(8-9):575-84. PMID: 9923651.
      View in: PubMed
    60. Marini JC, Gerber NL. Osteogenesis imperfecta. Rehabilitation and prospects for gene therapy. JAMA. 1997 Mar 5; 277(9):746-50. PMID: 9042848.
      View in: PubMed
    61. Grassi G, Marini JC. Ribozymes: structure, function, and potential therapy for dominant genetic disorders. Ann Med. 1996 Dec; 28(6):499-510. PMID: 9017109.
      View in: PubMed
    62. Byers PH, Marini JC, Gerber L. Frontiers in rehabilitation medicine: osteogenesis imperfecta, overview of a conference. Connect Tissue Res. 1995; 31(4):253-5. PMID: 15612362.
      View in: PubMed
    63. Bouzas EA, Krasnewich D, Koutroumanidis M, Papadimitriou A, Marini JC, Kaiser-Kupfer MI. Ophthalmologic examination in the diagnosis of Proteus syndrome. Ophthalmology. 1993 Mar; 100(3):334-8. PMID: 8460002.
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    64. Marini JC, Lewis MB, Chen K. Moderately severe osteogenesis imperfecta associated with substitutions of serine for glycine in the alpha 1(I) chain of type I collagen. Am J Med Genet. 1993 Jan 15; 45(2):241-5. PMID: 8456809.
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    65. Marini JC, Bordenick S, Heavner G, Rose S, Chrousos GP. Evaluation of growth hormone axis and responsiveness to growth stimulation of short children with osteogenesis imperfecta. Am J Med Genet. 1993 Jan 15; 45(2):261-4. PMID: 8456815.
      View in: PubMed
    66. Binder H, Conway A, Hason S, Gerber LH, Marini J, Berry R, Weintrob J. Comprehensive rehabilitation of the child with osteogenesis imperfecta. Am J Med Genet. 1993 Jan 15; 45(2):265-9. PMID: 8456816.
      View in: PubMed
    67. Hoffman GS, Filie JD, Schumacher HR, Ortiz-Bravo E, Tsokos MG, Marini JC, Kerr GS, Ling QH, Trentham DE. Intractable vasculitis, resorptive osteolysis, and immunity to type I collagen in type VIII Ehlers-Danlos syndrome. Arthritis Rheum. 1991 Nov; 34(11):1466-75. PMID: 1953824.
      View in: PubMed
    68. Grange DK, Lewis MB, Marini JC. Analysis of cultured chorionic villi in a case of osteogenesis imperfecta type II: implications for prenatal diagnosis. Am J Med Genet. 1990 Jun; 36(2):258-64. PMID: 2368816.
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    69. Gerber LH, Binder H, Weintrob J, Grange DK, Shapiro J, Fromherz W, Berry R, Conway A, Nason S, Marini J. Rehabilitation of children and infants with osteogenesis imperfecta. A program for ambulation. Clin Orthop Relat Res. 1990 Feb; (251):254-62. PMID: 2295183.
      View in: PubMed
    70. Crofford LJ, Brahim JS, Zasloff MA, Marini JC. Failure of surgery and isotretinoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva: report of two cases. J Oral Maxillofac Surg. 1990 Feb; 48(2):204-8. PMID: 2299462.
      View in: PubMed
    71. Marini JC, Grange DK, Gottesman GS, Lewis MB, Koeplin DA. Osteogenesis imperfecta type IV. Detection of a point mutation in one alpha 1(I) collagen allele (COL1A1) by RNA/RNA hybrid analysis. J Biol Chem. 1989 Jul 15; 264(20):11893-900. PMID: 2745420.
      View in: PubMed
    72. Reinig JW, Hill SC, Fang M, Marini J, Zasloff MA. Fibrodysplasia ossificans progressiva: CT appearance. Radiology. 1986 Apr; 159(1):153-7. PMID: 3952301.
      View in: PubMed
    73. Fang MA, Reinig JW, Hill SC, Marini J, Zasloff MA. Technetium-99m MDP demonstration of heterotopic ossification in fibrodysplasia ossificans progressiva. Clin Nucl Med. 1986 Jan; 11(1):8-9. PMID: 3080267.
      View in: PubMed
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