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JUAN C. MARINI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Critical Care
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC. Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study. J Nutr. 2017 Mar 08. PMID: 28275102.
      View in: PubMed
    2. Agarwal U, Didelija IC, Yuan Y, Wang X, Marini JC. Supplemental Citrulline Is More Efficient than Arginine in Increasing Systemic Arginine Availability in Mice. J Nutr. 2017 Feb 08. PMID: 28179487.
      View in: PubMed
    3. Achreja A, Zhao H, Yang L, Yun TH, Marini J, Nagrath D. Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism. Metab Eng. 2017 Jan 11. PMID: 28087332.
      View in: PubMed
    4. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of Glutaredoxin 3 Impedes Mammary Lobuloalveolar Development during Pregnancy and Lactation. Am J Physiol Endocrinol Metab. 2016 Nov 15; ajpendo.00150.2016. PMID: 27894063.
      View in: PubMed
    5. Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T, Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metab. 2016 Nov 08; 24(5):685-700. PMID: 27829138.
      View in: PubMed
    6. Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 2016; 5. PMID: 26920219; PMCID: PMC4841778.
    7. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-7. PMID: 26874300; PMCID: PMC4808600 [Available on 04/01/17].
    8. Marini JC. Interrelationships between glutamine and citrulline metabolism. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):62-6. PMID: 26560519.
      View in: PubMed
    9. Marini JC, Agarwal U, Didelija IC. Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. J Nutr. 2015 Jun; 145(6):1227-31. PMID: 25855119.
      View in: PubMed
    10. Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? Am J Clin Nutr. 2015 Apr; 101(4):890-2. PMID: 25833987.
      View in: PubMed
    11. Marini JC, Didelija IC. Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PLoS One. 2015; 10(3):e0119801. PMID: 25775142; PMCID: PMC4361593.
    12. Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Lauridsen C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2015 Jan 16. PMID: 25596209.
      View in: PubMed
    13. Castro D., G. Briassoulis, J.W. Hsu, J.C. Marini, M. Wu, W.E. Gordon, I.D. Esangbedo, J. Palmattan and L. Castillo. The effect of Fentanyl administration on plasma agmatine concentration in critically ill patients. J. Pediatr. Neonatal Care. 2015; (3):00118.
    14. Marini JC. Protein requirements: are we ready for new recommendations? J Nutr. 2015 Jan; 145(1):5-6. PMID: 25342701.
      View in: PubMed
    15. Marini JC, Didelija IC, Fiorotto ML. Extrarenal citrulline disposal in mice with impaired renal function. Am J Physiol Renal Physiol. 2014 Sep 15; 307(6):F660-5. PMID: 25056350; PMCID: PMC4166726.
    16. Caneba CA, Yang L, Baddour J, Curtis R, Win J, Hartig S, Marini J, Nagrath D. Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells. Cell Death Dis. 2014; 5:e1302. PMID: 24967964; PMCID: PMC4611736.
    17. Sinder BP, White LE, Salemi JD, Ominsky MS, Caird MS, Marini JC, Kozloff KM. Adult Brtl/+ mouse model of osteogenesis imperfecta demonstrates anabolic response to sclerostin antibody treatment with increased bone mass and strength. Osteoporos Int. 2014 Aug; 25(8):2097-107. PMID: 24803333; PMCID: PMC4415164.
    18. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol. 2014; 10:728. PMID: 24799285; PMCID: PMC4188042.
    19. Radley-Crabb HG, Marini JC, Sosa HA, Castillo LI, Grounds MD, Fiorotto ML. Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy. PLoS One. 2014; 9(2):e89277. PMID: 24586653; PMCID: PMC3929705.
    20. Meganck JA, Begun DL, McElderry JD, Swick A, Kozloff KM, Goldstein SA, Morris MD, Marini JC, Caird MS. Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta. Bone. 2013 Sep; 56(1):204-12. PMID: 23774443; PMCID: PMC3999166.
    21. Marini JC, Stoll B, Didelija IC, Burrin DG. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1348-53. PMID: 23074237; PMCID: PMC3774079.
    22. Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, Kleppe S, Erez A, O'Brian Smith E, Marini JC. A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria. Mol Genet Metab. 2012 Nov; 107(3):315-21. PMID: 23040521; PMCID: PMC3483446.
    23. Benight NM, Stoll B, Marini JC, Burrin DG. Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jul; 303(1):G71-82. PMID: 22556140; PMCID: PMC3404577.
    24. Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B. Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet. 2012 May 4; 90(5):836-46. PMID: 22541557; PMCID: PMC3376491.
    25. Chacko SK, Haymond MW, Sun Y, Marini JC, Sauer PJ, Ma X, Sunehag AL. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab. 2012 May 15; 302(9):E1055-62. PMID: 22338071.
      View in: PubMed
    26. Marini JC. Arginine and ornithine are the main precursors for citrulline synthesis in mice. J Nutr. 2012 Mar; 142(3):572-80. PMID: 22323761; PMCID: PMC3278269.
    27. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec; 17(12):1619-26. PMID: 22081021; PMCID: PMC3348956.
    28. Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59. PMID: 21596995; PMCID: PMC3154603.
    29. Marini JC. Quantitative analysis of 15N-labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid Commun Mass Spectrom. 2011 May 15; 25(9):1291-6. PMID: 21491530.
      View in: PubMed
    30. Marini JC, Lanpher BC, Scaglia F, O'Brien WE, Sun Q, Garlick PJ, Jahoor F, Lee B. Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase-deficient patients. Am J Clin Nutr. 2011 Jun; 93(6):1248-54. PMID: 21490144; PMCID: PMC3095500.
    31. Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B. Phenylbutyrate therapy for maple syrup urine disease. Hum Mol Genet. 2011 Feb 15; 20(4):631-40. PMID: 21098507; PMCID: PMC3024040.
    32. Thame MM, Fletcher HM, Baker TM, Marini JC, Kao CC, Jahoor F. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. J Nutr. 2011 Jan; 141(1):71-4. PMID: 21084652.
      View in: PubMed
    33. Marini JC, Keller B, Didelija IC, Castillo L, Lee B. Enteral arginase II provides ornithine for citrulline synthesis. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E188-94. PMID: 20978229; PMCID: PMC3023202.
    34. Marini JC, Didelija IC, Castillo L, Lee B. Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets. J Nutr. 2010 Aug; 140(8):1432-7. PMID: 20573946; PMCID: PMC2903302.
    35. Marini JC, Didelija IC, Castillo L, Lee B. Glutamine: precursor or nitrogen donor for citrulline synthesis? Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E69-79. PMID: 20407005; PMCID: PMC2904050.
    36. Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Butte NF, Marini J, Jahoor F, Sterchi EE. Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice. J Nutr. 2009 Apr; 139(4):684-90. PMID: 19193815; PMCID: PMC2666363.
    37. Marini JC, Fox DG, Murphy MR. Nitrogen transactions along the gastrointestinal tract of cattle: A meta-analytical approach. J Anim Sci. 2008 Mar; 86(3):660-79. PMID: 18073282.
      View in: PubMed
    38. Marini JC, Erez A, Castillo L, Lee B. Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1764-71. PMID: 17925451.
      View in: PubMed
    39. Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB, Loor JJ, Marini JC, Rund LA, Schook LB, Van Kessel AG, Gaskins HR. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genomics. 2007; 8:215. PMID: 17615075; PMCID: PMC1949829.
    40. Marini JC, Lee B, Garlick PJ. Non-surgical alternatives to invasive procedures in mice. Lab Anim. 2006 Jul; 40(3):275-81. PMID: 16803644.
      View in: PubMed
    41. Marini JC, Lee B, Garlick PJ. Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice. J Nutr. 2006 Jul; 136(7):1834-8. PMID: 16772445.
      View in: PubMed
    42. Imoberdorf R, Garlick PJ, McNurlan MA, Casella GA, Marini JC, Turgay M, Bärtsch P, Ballmer PE. Skeletal muscle protein synthesis after active or passive ascent to high altitude. Med Sci Sports Exerc. 2006 Jun; 38(6):1082-7. PMID: 16775549.
      View in: PubMed
    43. Marini JC, Lee B, Garlick PJ. Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice. J Nutr. 2006 Apr; 136(4):1017-20. PMID: 16549467.
      View in: PubMed
    44. Marini JC, Broussard SR. Hyperammonemia increases sensitivity to LPS. Mol Genet Metab. 2006 Jun; 88(2):131-7. PMID: 16497529.
      View in: PubMed
    45. Marini JC, Attene-Ramos MS. An improved analytical method for the determination of urea nitrogen isotopomers in biological samples utilizing continuous flow isotope ratio mass spectrometry. Rapid Commun Mass Spectrom. 2006; 20(24):3736-40. PMID: 17099932.
      View in: PubMed
    46. Marini JC, Lee B, Garlick PJ. In vivo urea kinetic studies in conscious mice. J Nutr. 2006 Jan; 136(1):202-6. PMID: 16365083.
      View in: PubMed
    47. Marini JC, Van Amburgh ME. Partition of nitrogen excretion in urine and the feces of holstein replacement heifers. J Dairy Sci. 2005 May; 88(5):1778-84. PMID: 15829671.
      View in: PubMed
    48. Scaglia F, Brunetti-Pierri N, Kleppe S, Marini J, Carter S, Garlick P, Jahoor F, O'Brien W, Lee B. Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. J Nutr. 2004 Oct; 134(10 Suppl):2775S-2782S; discussion 2796S-2797S. PMID: 15465784.
      View in: PubMed
    49. Marini JC, Klein JD, Sands JM, Van Amburgh ME. Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs. J Anim Sci. 2004 Apr; 82(4):1157-64. PMID: 15080338.
      View in: PubMed
    50. Scaglia F, Marini J, Rosenberger J, Henry J, Garlick P, Lee B, Reeds P. Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers. Am J Clin Nutr. 2003 Oct; 78(4):749-55. PMID: 14522733.
      View in: PubMed
    51. Marini JC, Van Amburgh ME. Nitrogen metabolism and recycling in Holstein heifers. J Anim Sci. 2003 Feb; 81(2):545-52. PMID: 12643500.
      View in: PubMed
    52. Ruiz R, Tedeschl LO, Marini JC, Fox DG, Pell AN, Jarvis G, Russell JB. The effect of a ruminal nitrogen (N) deficiency in dairy cows: evaluation of the cornell net carbohydrate and protein system ruminal N deficiency adjustment. J Dairy Sci. 2002 Nov; 85(11):2986-99. PMID: 12487464.
      View in: PubMed
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