| Item Type | Name |
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Academic Article
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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
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Academic Article
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Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression.
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Academic Article
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BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
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Academic Article
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ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.
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Academic Article
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FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.
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Academic Article
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BRIT1/MCPH1: a guardian of genome and an enemy of tumors.
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Academic Article
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BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.
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Academic Article
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Multiple tumor suppressor pathways negatively regulate telomerase.
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Academic Article
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DNA damage response pathways in tumor suppression and cancer treatment.
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Academic Article
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TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs.
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Academic Article
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DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
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Academic Article
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Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.
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Academic Article
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Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection.
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Concept
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DNA-Binding Proteins
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Concept
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DNA Topoisomerases, Type II
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Concept
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DNA-Activated Protein Kinase
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Concept
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DNA
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Concept
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DNA Repair-Deficiency Disorders
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Concept
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DNA Damage
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Concept
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DNA Helicases
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Concept
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DNA Copy Number Variations
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Concept
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DNA Breaks, Double-Stranded
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Concept
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DNA Replication
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Concept
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DNA Mismatch Repair
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Concept
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DNA Repair
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Academic Article
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Genome-wide transcriptome profiling of homologous recombination DNA repair.
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Academic Article
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Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model.
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Academic Article
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Differential regulation of centrosome integrity by DNA damage response proteins.
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Academic Article
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Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction.
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Academic Article
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DNA damage response: the players, the network and the role in tumor suppression.
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Academic Article
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The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1.
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Academic Article
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The DNA damage response: Balancing the scale between cancer and ageing.
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Academic Article
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Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
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Academic Article
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Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage.
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Academic Article
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Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells.
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Academic Article
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BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.
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Academic Article
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BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
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Academic Article
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BRIT1/MCPH1 links chromatin remodelling to DNA damage response.
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Academic Article
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Monoubiquitination of H2AX protein regulates DNA damage response signaling.
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Academic Article
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BRIT1/MCPH1 is a multifunctional DNA damage responsive protein mediating DNA repair-associated chromatin remodeling.
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Academic Article
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Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
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Academic Article
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Exploiting the homologous recombination DNA repair network for targeted cancer therapy.
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Academic Article
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DNA damage and breast cancer.
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Academic Article
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Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.
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Academic Article
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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
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Academic Article
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New insights into tumor dormancy: Targeting DNA repair pathways.
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Academic Article
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mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
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Academic Article
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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
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Academic Article
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Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response
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Academic Article
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Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
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Academic Article
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Connecting the Dots: From DNA Damage and Repair to Aging.
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Academic Article
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Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
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Academic Article
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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
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Academic Article
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Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
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Academic Article
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Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.
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Academic Article
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PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer.
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Academic Article
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Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.
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Grant
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Chk2--Roles in Checkpoint and Breast Tumor Suppression
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Grant
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Signature-guided therapy for mismatch repair defective cancers
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Grant
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BRIT 1: Roles in Immortalization, Checkpoints and Cancer
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Grant
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Functional and Clinical Analysis of Rak in Breast Cancer Suppression
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Grant
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Characterizing and Targeting CHD4 Deficiency in Endometrial Cancer
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Academic Article
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Corrigendum: FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.
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Concept
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Recombinational DNA Repair
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Academic Article
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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
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Academic Article
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Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress.
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Academic Article
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer.
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Academic Article
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PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
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Academic Article
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The Tale of CHD4 in DNA Damage Response and Chemotherapeutic Response.
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Academic Article
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Role of DNA repair defects in predicting immunotherapy response.
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Grant
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Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
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Academic Article
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Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.
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Academic Article
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A Gene Expression Signature to Predict Nucleotide Excision Repair Defects and Novel Therapeutic Approaches.
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Grant
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RNase H2 is a novel therapeutic target in triple negative breast cancer
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Academic Article
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CNGPLD: case-control copy-number analysis using Gaussian process latent difference.
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Academic Article
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Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer.
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Academic Article
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Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway.
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Academic Article
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Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response.
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