| Item Type | Name |
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Academic Article
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Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.
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Academic Article
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Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.
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Concept
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Proto-Oncogene Proteins c-myc
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Concept
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Oncogene Protein v-akt
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Concept
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Oncogenes
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Concept
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Proto-Oncogene Proteins c-bcl-2
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Concept
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Proto-Oncogene Proteins c-raf
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Concept
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Proto-Oncogene Proteins pp60(c-src)
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Concept
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Oncogene Protein p55(v-myc)
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Concept
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Proto-Oncogene Proteins p21(ras)
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Concept
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Proto-Oncogene Proteins c-mdm2
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Concept
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Proto-Oncogene Proteins c-met
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Concept
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Proto-Oncogene Proteins
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Concept
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Proto-Oncogene Proteins c-abl
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Concept
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Proto-Oncogene Proteins c-kit
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Concept
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Proto-Oncogene Proteins c-akt
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Academic Article
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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
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Academic Article
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Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
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Academic Article
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Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
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Academic Article
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Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
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Academic Article
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EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors.
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Academic Article
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A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer.
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Academic Article
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Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
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Academic Article
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Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer.
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Academic Article
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Inhibition of intratracheal lung cancer development by systemic delivery of E1A.
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Academic Article
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Safety studies of the intraperitoneal injection of E1A--liposome complex in mice.
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Academic Article
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Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.
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Academic Article
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High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.
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Academic Article
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Dysregulation of cellular signaling by HER2/neu in breast cancer.
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Academic Article
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Determinants of rapamycin sensitivity in breast cancer cells.
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Academic Article
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A delayed chemically induced tumorigenesis in Brca2 mutant mice.
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Academic Article
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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
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Academic Article
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MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
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Academic Article
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Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.
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Academic Article
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Vimentin is a novel AKT1 target mediating motility and invasion.
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Academic Article
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BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment.
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Academic Article
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Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.
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Academic Article
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Signaling cross-talk in the resistance to HER family receptor targeted therapy.
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Academic Article
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Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
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Academic Article
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Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.
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Academic Article
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Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol.
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Academic Article
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Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
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Academic Article
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Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
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Academic Article
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Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
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Academic Article
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Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
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Academic Article
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Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway.
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Academic Article
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The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.
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Academic Article
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A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
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Academic Article
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Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
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Academic Article
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Signaling intricacies take center stage in cancer cells.
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Academic Article
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Cancer-specific gene therapy.
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Academic Article
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The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
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Academic Article
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EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
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Academic Article
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Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
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Academic Article
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Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells.
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Academic Article
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Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776.
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Academic Article
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Deubiquitylation and stabilization of PTEN by USP13.
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Academic Article
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Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains.
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Academic Article
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Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu.
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Academic Article
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Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202.
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Academic Article
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Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer.
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Academic Article
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Overexpression of ErbB2 in cancer and ErbB2-targeting strategies.
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Academic Article
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E1A is an oncogene and may immortalize normal cells, especially in combination with other oncoproteins.
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Academic Article
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Novel targets of Akt, p21(Cipl/WAF1), and MDM2.
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Academic Article
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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
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Academic Article
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Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
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Academic Article
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Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.
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Academic Article
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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
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Academic Article
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Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.
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Academic Article
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Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
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Academic Article
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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
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Academic Article
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Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
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Academic Article
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A new mutational AKTivation in the PI3K pathway.
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Academic Article
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Rapamycin regulates the phosphorylation of rictor.
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Academic Article
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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
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Academic Article
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Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
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Academic Article
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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
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Academic Article
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Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.
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Academic Article
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Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
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Academic Article
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EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling.
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Academic Article
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Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
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Academic Article
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The crosstalk of mTOR/S6K1 and Hedgehog pathways.
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Academic Article
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Dysregulation of microRNAs in cancer.
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Academic Article
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Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking.
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Academic Article
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Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis.
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Academic Article
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Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression.
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Academic Article
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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
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Academic Article
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HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
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Academic Article
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Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.
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Academic Article
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p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis.
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Academic Article
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Enhancement of Bik antitumor effect by Bik mutants.
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Academic Article
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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
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Academic Article
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ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
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Academic Article
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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
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Academic Article
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Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
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Academic Article
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KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
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Academic Article
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TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
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Academic Article
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Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.
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Academic Article
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Triplex formation at the rat neu oncogene promoter.
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Academic Article
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Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.
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Academic Article
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A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
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Academic Article
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Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.
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Academic Article
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The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
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Academic Article
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Rodent p53 suppresses the transforming activity of the activated Neu oncogene by modulating the Basal promoter activity of Neu.
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Academic Article
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The microfocus assay system (mfas) - a simple quantitative assay to identify inhibitory drugs targeted against specific oncogenes.
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Academic Article
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Suppressed autophosphorylation and tyrosine kinase-activity in revertant cell-lines expressing rat Neu oncogene.
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Academic Article
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MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
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Academic Article
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Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
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Academic Article
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AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation.
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Academic Article
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TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.
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Academic Article
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The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to?hyperactivate AKT?and confer resistance to AKT?inhibitors.
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Academic Article
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Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
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Academic Article
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High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma
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Academic Article
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Erratum
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Academic Article
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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
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Academic Article
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Aurora A kinase activates YAP signaling in triple-negative breast cancer
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Academic Article
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Suppressed autophosphorylation and tyrosine kinase activity in revertant cell lines expressing rat neu oncogene
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Academic Article
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Rodent p53 suppresses the transforming activity of the activated neu oncogene by modulating the basal promoter activity of neu
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Academic Article
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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
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Academic Article
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Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
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Academic Article
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Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
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Academic Article
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A Positive TGF-?/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
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Academic Article
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GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.
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Academic Article
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Aurora A kinase activates YAP signaling in triple-negative breast cancer.
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Academic Article
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POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.
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Academic Article
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EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
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Academic Article
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Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.
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Academic Article
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Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer.
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Academic Article
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EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
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Academic Article
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
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Academic Article
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H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism.
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Academic Article
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Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
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Academic Article
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A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics.
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Academic Article
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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
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Academic Article
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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
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Academic Article
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Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma.
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Academic Article
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Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC.
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Academic Article
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PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
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Academic Article
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PKCd-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
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Academic Article
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Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer.
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Academic Article
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PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy.
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Academic Article
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Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
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Academic Article
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Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer.
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Academic Article
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Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
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